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Strain
Number: |
01XJ7 |
Common
Strain Name: |
Akt1, MPAKT |
Strain
Nomenclature: |
FVB-Tg(Pbsn-AKT1)9Wrs |
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Release
Category (Required for MTA form):
B,D
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Animal Health Report in PDF Format |
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Strain
Description: |
Akt Expression and Activation is sufficient for the induction of prostate intraepithelial neoplasia (PIN). Histologic study of the ventral prostate of the Murine Prostate restricted Akt Kinase Transgenic mice (MPAKT) revealed a striking phenotype characterized by a hyperplastic and dysplastic epithelium with disorganized multi-cell layers, intraepithelial lumen formation, loss of cell polarity, nuclear atypia and apoptotic bodies. These histopathologic features are consistent with PIN. |
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Mutation
Information |
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Mutation
Type: |
Transgenic |
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Gene
Name: |
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Gene
Symbol: |
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Transgene
Name: |
Mouse thymoma viral proto-oncogene 1
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Transgene
Symbol: |
Akt1
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Promoter
Name: |
Probasin |
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Promoter
Symbol: |
Pb |
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Current
Genetic Background: |
FVB |
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Approx.
Generation: |
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Organ
Site : |
Prostate |
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Cryopreservation Mating Scheme: |
FVB/N females x hemizygous males |
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Genotyping Information: |
Protocol 1: Allele: Tg(Pb-Akt1)Ak9Wrs
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Donating
Investigator: |
William R. Sellers |
Key
Reference: |
Majumder PK, Yeh JJ, George DJ, Febbo PG, Kum J, Xue Q, Bikoff R, Ma H, Kantoff PW, Golub TR, Loda M, Sellers WA. Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. Proc Natl Acad Sci USA 100, 7841-7846, 2003. PMID: 12799464.
[PubMED
Abstract]
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