Feregrino-Goyos FG, Alvarado-Diez Rocio AD, R C RC, Gomez-Caro Humberto GC; International Conference on AIDS.
Int Conf AIDS. 2002 Jul 7-12; 14: abstract no. B10531.
CITAID, SC. Centro de Investigacion y Terapeutica Avanzada en Inmunodeficiencias, SC., Mexico, City, D.F., Mexico
BACKGROUND. Wasting syndrome (WS) is the most frequent and late clinical presentation of HIV/AIDS in people of Mexico. The causes were serious: very advanced HIV disease, diarrhea and opportunistic infections and is frequent cause of bad evolution and bad response to treatment with HAART. OBJECTIVES. To compare the rol of the Human Growth Hormone (r-hGH) treatment in the salvage of very advanced HIV/AIDS patients with more than 20% of lost of current weigth in less than 3 months. METHODS. Open label for adults HIV+ with lost of more than 20% of current weight in short time (4-12 weeks), All the patients received HAART and nutritional support and opportunistic infections treatment until control of viral load. Treatment with Recombinant Human Growth Hormone started in some patients with severe wasting. The doses of r-hGH was 0.1 mg/kg of body weight. Group 1: Only HAART. Group 2: r-hGH plus HAART. Key point for evaluation at 30 days: 1) Death rate. 2) CD4 evolution, basal and day 30 . 3) Body weigth gain. 4) Body Cell Mass (BCM) daily evaluation by BIA and graphical reporte were edited in each cases. RESULTS. Ten patients in group one and 10 patients in group 2. Death rate: 10% in group 1 and 0% in group 2. CD4 evolution: Group 1: Basal CD4 35, Group 2: 28, p=ns. CD4 at day 30: Group 1: 120 and Group 2: 140, p=0.06. Body weight evolution: Group 1: +3kg, Group 2: +6kg, p=0.01. BCM evolution: Group 1: +1kg, Group 2: +4kg, p=0.005. CONCLUSIONS. Recombinat Growth Hormone increase the weight gain, BCM and CD4 count when is associated with HAART and nutritional support in very advanced disease with wasting syndrome.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Adult
- Antiretroviral Therapy, Highly Active
- CD4 Lymphocyte Count
- Growth Hormone
- HIV Infections
- HIV Seropositivity
- HIV Wasting Syndrome
- Human Growth Hormone
- Humans
- Mexico
- Nutritional Status
- Nutritional Support
- Weight Gain
Other ID:
UI: 102254522
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