NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 FINAL #1 MICE Facility: Southern Research Institute Chemical CAS #: 693-13-0 Lock Date: 03/14/03 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1| | 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + I + + + + M + + A + + + + + + + + A + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + A + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + A + + + +| Adenoma | X | Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + A + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + A + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X X X| Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X X X X X | Histiocytic Sarcoma | X | Lymphoma Malignant | X X X | |__________________________________________________________________________| Mesentery | + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1| | 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Histiocytic Sarcoma | | Lymphoma Malignant | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | | Peridontal Tissue, Histiocytic | | Sarcoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| Lymphoma Malignant | | Pars Distalis, Adenoma | X X X | Pars Distalis, Carcinoma | | __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1| | 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, Follicular Cell, Adenoma | | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + | Mediastinum, Histiocytic Sarcoma | | Mediastinum, Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + M + + + + + + + + + + + +| Cystadenoma | | Granulosa Cell Tumor Benign | X | Hemangiosarcoma | X | Histiocytic Sarcoma | | Lymphoma Malignant | | |__________________________________________________________________________| Oviduct | + | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Histiocytic Sarcoma | X | Lymphoma Malignant | | Endometrium, Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1| | 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymph Node | + + + + + +| Lymphoma Malignant | | Deep Cervical, Lymphoma Malignant | | Iliac, Lymphoma Malignant | X | Mediastinal, Histiocytic Sarcoma | | Mediastinal, Lymphoma Malignant | X X | Pancreatic, Lymphoma Malignant | X | Renal, Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Histiocytic Sarcoma | | Lymphoma Malignant | X X X | |__________________________________________________________________________| Thymus | + + + + + + + I + + + + I + + + + + + + + + + + +| Lymphoma Malignant | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Hemangioma | X X | Subcutaneous Tissue, Hemangiosarcoma | X | Subcutaneous Tissue, Lymphoma | | Malignant | | __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1| | 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Peripheral Nerve | | |__________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X | Carcinoma, Metastatic, Harderian | | Gland | X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant | X | Mediastinum, Lymphoma Malignant | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + A + + + + + + + + A + + + +| Retrobulbar, Carcinoma, Metastatic, | | Harderian Gland | X | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1| | 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X X X X | __________________________________________|__________________________________________________________________________| Page 7 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3| | | 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + A + + + + + + + I + + A + + + + + + + + M + + +| 42 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + A + + + + + + + + + + A + + + + + + + + + + + +| 46 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + A + + + + + + + + + + A + + + + + + + + + + + +| 46 | Adenoma | | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +| 47 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + + + + + + + A + + + + + + + + + + + +| 46 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | X X X | 8 | Hepatocellular Carcinoma, Multiple | X | 2 | Hepatocellular Adenoma | X X X X X X X X X| 13 | Hepatocellular Adenoma, Multiple | X X X | 8 | Histiocytic Sarcoma | X X | 3 | Lymphoma Malignant | X X X | 6 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + +| 23 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3| | | 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X | 4 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | X | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Tooth | + | 1 | Peridontal Tissue, Histiocytic | | | Sarcoma, Metastatic, Uncertain | | | Primary Site | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3| | | 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + M I + + + + + + + + M + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + + + + +| 48 | Lymphoma Malignant | X | 1 | Pars Distalis, Adenoma | X | 4 | Pars Distalis, Carcinoma | X | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, Follicular Cell, Adenoma | X | 1 | Follicular Cell, Adenoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + M + + + | 5 | Mediastinum, Histiocytic Sarcoma | X | 1 | Mediastinum, Lymphoma Malignant | X X | 3 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + I + + + + + + + + + + + M + + + M + + +| 46 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cystadenoma | X | 1 | Granulosa Cell Tumor Benign | | 1 | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X | 2 | |__________________________________________________________________________|____________| Oviduct | + + | 3 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3| | | 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Histiocytic Sarcoma | X X | 3 | Lymphoma Malignant | X | 1 | Endometrium, Polyp Stromal | X X X | 4 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | X | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Lymph Node | + + + + + | 11 | Lymphoma Malignant | X | 1 | Deep Cervical, Lymphoma Malignant | X | 1 | Iliac, Lymphoma Malignant | X X | 3 | Mediastinal, Histiocytic Sarcoma | X | 1 | Mediastinal, Lymphoma Malignant | X X | 4 | Pancreatic, Lymphoma Malignant | | 1 | Renal, Lymphoma Malignant | X X | 2 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + + + I + + + + + + + + + + + + + + + + +| 47 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X | 5 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + I + M + + +| 47 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X X | 6 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 | Hemangiosarcoma | X | 1 | Histiocytic Sarcoma | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3| | | 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphoma Malignant | X X X X | 7 | |__________________________________________________________________________|____________| Thymus | + + + + M + + + + + + + + + + + + + + + + M + + +| 46 | Lymphoma Malignant | X X X X | 7 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Hemangioma | | 2 | Subcutaneous Tissue, Hemangiosarcoma | X | 2 | Subcutaneous Tissue, Lymphoma | | | Malignant | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Peripheral Nerve | + | 1 | |__________________________________________________________________________|____________| Spinal Cord | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3| | | 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | | 3 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | Lymphoma Malignant | X X | 3 | Mediastinum, Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + A + + + + + + + + + + + + + + + + + + + + + + +| 47 | Retrobulbar, Carcinoma, Metastatic, | | | Harderian Gland | | 1 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X X X X X | 9 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X | 4 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3| | | 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X X | 3 | Lymphoma Malignant | X X X X | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| | 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Gallbladder | + + + A + + + + + + + + + + + A + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + M + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + A + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + A + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + + + + + + + + A + + + + + A + + +| Adenoma | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + A + + + + + + + + + + + A + + + + + A + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X| Hepatocellular Adenoma | X X X X X X | Hepatocellular Adenoma, Multiple | X X X X X X X | Liposarcoma, Metastatic, Tissue NOS | | Lymphoma Malignant | X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + +| Lymphoma Malignant | X X | |__________________________________________________________________________| Oral Mucosa | | |__________________________________________________________________________| Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 15 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| | 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Squamous Cell Papilloma | | |__________________________________________________________________________| Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | |__________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + + + + + + + + I + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X| Pars Intermedia, Adenoma | X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 16 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| | 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + + + | Abdominal, Pelvic, Liposarcoma | | Mediastinum, Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X | Lymphoma Malignant | X | |__________________________________________________________________________| Oviduct | + | Lymphoma Malignant | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | | Endometrium, Carcinoma | X | Endometrium, Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Liposarcoma, Metastatic, Tissue NOS | | Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node | + + + + + + | Lymphoma Malignant | | Iliac, Carcinoma, Metastatic, Uterus | X | Iliac, Lymphoma Malignant | X X | Inguinal, Lymphoma Malignant | X | Mediastinal, Lymphoma Malignant | | Pancreatic, Lymphoma Malignant | | Renal, Lymphoma Malignant | X X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 17 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| | 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + I + + +| Hemangioma | X | Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant | X X X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Site of Application, Lymphoma | | Malignant | | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Hemangioma | X | Subcutaneous Tissue, Hemangiosarcoma | X | Subcutaneous Tissue, Lymphoma | | Malignant | | Subcutaneous Tissue, Melanoma | | Malignant | | Subcutaneous Tissue, Site of | | Application, Myxoma | X| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | __________________________________________|__________________________________________________________________________| Page 18 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| | 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | |__________________________________________________________________________| Skeletal Muscle | + + | Lipoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Peripheral Nerve | + + | |__________________________________________________________________________| Spinal Cord | + + | Lymphoma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X | Liposarcoma, Metastatic, Tissue NOS | | Lymphoma Malignant | X | Osteosarcoma, Metastatic, Uncertain | | Primary Site | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + I + + +| Lymphoma Malignant | | Retrobulbar, Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 19 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| | 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Lymphoma Malignant | | |__________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Ureter | + | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X X | __________________________________________|__________________________________________________________________________| Page 20 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3| | | 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + A M + + +| 45 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + A + + + +| 46 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + A + + + +| 45 | Adenoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + A + M + +| 44 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | | 2 | Hepatocellular Adenoma | X X X X X X X X X X | 16 | Hepatocellular Adenoma, Multiple | X X X X| 11 | Liposarcoma, Metastatic, Tissue NOS | X | 1 | Lymphoma Malignant | X X X X | 5 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + +| 20 | Lymphoma Malignant | X X X X | 6 | |__________________________________________________________________________|____________| Oral Mucosa | + | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3| | | 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X | 2 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Lymphoma Malignant | X | 1 | Squamous Cell Papilloma | X | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | | 2 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3| | | 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Parathyroid Gland | + + + + + I + + + + + M M + M + + + + + + I + + +| 43 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X X X X X X| 12 | Pars Intermedia, Adenoma | | 2 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + + + + + | 8 | Abdominal, Pelvic, Liposarcoma | X | 1 | Mediastinum, Lymphoma Malignant | X X X X | 5 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cystadenoma | X | 2 | Lymphoma Malignant | X X | 3 | |__________________________________________________________________________|____________| Oviduct | | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X | 2 | Endometrium, Carcinoma | | 1 | Endometrium, Polyp Stromal | X X | 2 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3| | | 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Liposarcoma, Metastatic, Tissue NOS | X | 1 | Lymphoma Malignant | X X X X | 4 | |__________________________________________________________________________|____________| Lymph Node | + + + + + + +| 13 | Lymphoma Malignant | X X | 2 | Iliac, Carcinoma, Metastatic, Uterus | | 1 | Iliac, Lymphoma Malignant | X X X X | 6 | Inguinal, Lymphoma Malignant | X | 2 | Mediastinal, Lymphoma Malignant | X X X | 3 | Pancreatic, Lymphoma Malignant | X X X | 3 | Renal, Lymphoma Malignant | X X X | 5 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Lymphoma Malignant | X X X | 5 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Hemangioma | | 1 | Lymphoma Malignant | X X X X | 5 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | Hemangiosarcoma | | 1 | Lymphoma Malignant | X X X X X | 8 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + I + + + + + I + + + + + + + + +| 48 | Lymphoma Malignant | X X X | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3| | | 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Lymphoma Malignant | X | 1 | Site of Application, Lymphoma | | | Malignant | X | 1 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Hemangioma | | 1 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | Subcutaneous Tissue, Lymphoma | | | Malignant | X | 1 | Subcutaneous Tissue, Melanoma | | | Malignant | X | 1 | Subcutaneous Tissue, Site of | | | Application, Myxoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Osteosarcoma | X | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | + + | 4 | Lipoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X | 2 | |__________________________________________________________________________|____________| Peripheral Nerve | + | 3 | |__________________________________________________________________________|____________| Spinal Cord | + | 3 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3| | | 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X | 2 | Alveolar/Bronchiolar Carcinoma | | 1 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | | 1 | Liposarcoma, Metastatic, Tissue NOS | X | 1 | Lymphoma Malignant | X X X X | 5 | Osteosarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X | 2 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | Lymphoma Malignant | X | 1 | Retrobulbar, Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | Adenoma | X X | 5 | Lymphoma Malignant | X X X | 3 | |__________________________________________________________________________|____________| Zymbal's Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3| | | 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | Lymphoma Malignant | X X X | 4 | |__________________________________________________________________________|____________| Ureter | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X X X | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | X X X X X X | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 27 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| | 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + A A + + + I + + + + + A + + + + + M + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + A A + + + + + + + + + A + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + A A + + + + + + + + + A + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + A A + + + + + + + + + A + + + + + + + + +| Carcinoma | X | Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + + + + + + + + A + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X X X X X | Histiocytic Sarcoma | X X | Lymphoma Malignant | X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + +| Histiocytic Sarcoma | X X | Lymphoma Malignant | X X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 28 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| | 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Squamous Cell Carcinoma | | Squamous Cell Papilloma | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + A + + + + + + + + + A + + + + + + + + +| |__________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + I + + + + + + + + + +| Histiocytic Sarcoma | X | Epicardium, Lymphoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + M +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X | Pars Intermedia, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + + | Mediastinum, Histiocytic Sarcoma | X | Mediastinum, Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 29 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| | 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + I + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + I + + + + + + + + +| Cystadenoma | X | Histiocytic Sarcoma | X | Teratoma Benign | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X | Endometrium, Polyp Stromal | X X X | Endometrium, Sarcoma Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X | Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node | + + + + + | Bronchial, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X | Iliac, Histiocytic Sarcoma | X | Inguinal, Lymphoma Malignant | X | Mediastinal, Histiocytic Sarcoma | X | Pancreatic, Histiocytic Sarcoma | X | Pancreatic, Lymphoma Malignant | X | Pancreatic, Squamous Cell Carcinoma, | | Metastatic, Stomach, Forestomach| | Renal, Histiocytic Sarcoma | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Harderian | | Gland | | Histiocytic Sarcoma | X | Lymphoma Malignant | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 30 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| | 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymph Node, Mesenteric | + + + + + + + + + + + + + + + A + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X | Lymphoma Malignant | X X X | |__________________________________________________________________________| Thymus | + + + + A + + + + M + + + + I I + + + + M I + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + I + + + + + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basosquamous Tumor Benign | X | Lymphoma Malignant | X | Squamous Cell Carcinoma | | Site of Application, Basal Cell | | Adenoma | | Subcutaneous Tissue, Melanoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Rhabdomyosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 31 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| | 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | X | Alveolar/Bronchiolar Carcinoma, | | Multiple | | Carcinoma, Metastatic, Harderian | | Gland | | Carcinoma, Metastatic, Mammary Gland | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Histiocytic Sarcoma | X X | Lymphoma Malignant | X | Sarcoma Stromal, Metastatic, Uterus | X | Serosa, Lymphoma Malignant | | |__________________________________________________________________________| Nose | + + + + A + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + A + + + + + + + + +| Carcinoma, Metastatic, Harderian | | Gland | | Histiocytic Sarcoma | X | Retrobulbar, Sarcoma | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | | __________________________________________|__________________________________________________________________________| Page 32 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| | 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | |__________________________________________________________________________| Lacrimal Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X X | Lymphoma Malignant | X X X | __________________________________________|__________________________________________________________________________| Page 33 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3| | | 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 | |__________________________________________________________________________|____________| Gallbladder | + + + A + + + + A + + + A + + + + + + + + + + + +| 42 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + A + + + + A + + + A + + + + + + + + + + + +| 44 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + A + + + + A + + + A + + + + + + + + + + + +| 44 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A + + + + A + + + A + + + + + + + + + + + +| 44 | Carcinoma | | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + + + + A + + + A + + + + + + + + + + + +| 45 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X X X X | 7 | Hepatocellular Carcinoma, Multiple | | 1 | Hepatocellular Adenoma | X X X X X X| 10 | Hepatocellular Adenoma, Multiple | X X X X X X | 11 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Mesentery | + + | 14 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant | X | 3 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3| | | 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma | X | 1 | Squamous Cell Papilloma | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | Epicardium, Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X | 3 | Pars Intermedia, Adenoma | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3| | | 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + | 3 | Mediastinum, Histiocytic Sarcoma | | 1 | Mediastinum, Lymphoma Malignant | X | 2 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cystadenoma | X | 2 | Histiocytic Sarcoma | | 1 | Teratoma Benign | | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 2 | Endometrium, Polyp Stromal | X X | 5 | Endometrium, Sarcoma Stromal | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node | + + + + + | 10 | Bronchial, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3| | | 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Iliac, Histiocytic Sarcoma | | 1 | Inguinal, Lymphoma Malignant | | 1 | Mediastinal, Histiocytic Sarcoma | | 1 | Pancreatic, Histiocytic Sarcoma | | 1 | Pancreatic, Lymphoma Malignant | X | 2 | Pancreatic, Squamous Cell Carcinoma, | | | Metastatic, Stomach, Forestomach| X | 1 | Renal, Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma, Metastatic, Harderian | | | Gland | X | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X | 3 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant | X | 4 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma | X X| 2 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3| | | 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basosquamous Tumor Benign | | 1 | Lymphoma Malignant | | 1 | Squamous Cell Carcinoma | X | 1 | Site of Application, Basal Cell | | | Adenoma | X| 1 | Subcutaneous Tissue, Melanoma | | | Malignant | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | Rhabdomyosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | | 2 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 1 | Alveolar/Bronchiolar Carcinoma | | 1 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 1 | Carcinoma, Metastatic, Harderian | | | Gland | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3| | | 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Carcinoma, Metastatic, Mammary Gland | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X | 4 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant | | 1 | Sarcoma Stromal, Metastatic, Uterus | | 1 | Serosa, Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma, Metastatic, Harderian | | | Gland | X | 1 | Histiocytic Sarcoma | | 1 | Retrobulbar, Sarcoma | X| 1 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X | 5 | Carcinoma | X X X X| 4 | |__________________________________________________________________________|____________| Lacrimal Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 2 | |__________________________________________________________________________|____________| Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 39 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3| | | 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | | | | Histiocytic Sarcoma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant | X X X X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 40 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3| | 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + A + + + + + + + + + + I + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + A + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + A + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + A + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + A + + + + + + + + + + A + + + + +| Carcinoma | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + A + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatocellular Carcinoma | | Hepatocellular Adenoma | X X | Hepatocellular Adenoma, Multiple | X X X X X | Hepatocholangiocarcinoma, Multiple | X | Histiocytic Sarcoma | X | Lymphoma Malignant | X | |__________________________________________________________________________| Mesentery | + + + + + + + | Hemangiosarcoma, Metastatic, Liver | | Histiocytic Sarcoma | X | Liposarcoma | | Lymphoma Malignant | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 41 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3| | 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + | Peridontal Tissue, Histiocytic | | Sarcoma, Metastatic, Nose | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcapsular, Adenoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + M + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + I + + + + I I + + + +| Pars Distalis, Adenoma | X X X X X X | Pars Intermedia, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 42 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3| | 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | |__________________________________________________________________________| Tissue NOS | + + + | Mediastinum, | | Hepatocholangiocarcinoma, | | Metastatic, Liver | X | Thoracic, Hepatocholangiocarcinoma, | | Metastatic, Liver | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + I I + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X | Histiocytic Sarcoma | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Histiocytic Sarcoma | X | Leiomyosarcoma | | |__________________________________________________________________________| Vagina | | Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node | + + + + + + + +| Lymphoma Malignant | | Iliac, Lymphoma Malignant | | Inguinal, Lymphoma Malignant | | Mediastinal, Histiocytic Sarcoma | X | Mediastinal, Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 43 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3| | 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Pancreatic, Lymphoma Malignant | | Renal, Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X| |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangioma | | Subcutaneous Tissue, Squamous Cell | | Carcinoma | | Subcutaneous Tissue, Site of | | Application, Melanoma Benign | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Osteosarcoma | X | |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3| | 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X | Osteosarcoma, Metastatic, Bone | X | |__________________________________________________________________________| Peripheral Nerve | | |__________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X | Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma | X | Lymphoma Malignant | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | __________________________________________|__________________________________________________________________________| Page 45 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3| | 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | | |__________________________________________________________________________| Ureter | | Histiocytic Sarcoma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X X| __________________________________________|__________________________________________________________________________| Page 46 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8| | | 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +| 46 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 1 | Hepatocellular Carcinoma | X X X | 3 | Hepatocellular Adenoma | X X X X X X X | 9 | Hepatocellular Adenoma, Multiple | X X X X | 9 | Hepatocholangiocarcinoma, Multiple | | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + +| 18 | Hemangiosarcoma, Metastatic, Liver | X | 1 | Histiocytic Sarcoma | X | 2 | Liposarcoma | X | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 47 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8| | | 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | X | 2 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Tooth | | 2 | Peridontal Tissue, Histiocytic | | | Sarcoma, Metastatic, Nose | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcapsular, Adenoma | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pheochromocytoma Benign | X | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 48 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8| | | 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 46 | Pars Distalis, Adenoma | X X X X | 10 | Pars Intermedia, Adenoma | X | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + | 4 | Mediastinum, | | | Hepatocholangiocarcinoma, | | | Metastatic, Liver | | 1 | Thoracic, Hepatocholangiocarcinoma, | | | Metastatic, Liver | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + I + + + + + +| 47 | |__________________________________________________________________________|____________| Ovary | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 | Cystadenoma | X | 2 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Histiocytic Sarcoma | X | 2 | Leiomyosarcoma | X X | 2 | |__________________________________________________________________________|____________| Vagina | + | 1 | Histiocytic Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 49 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8| | | 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Lymph Node | + + | 10 | Lymphoma Malignant | X | 1 | Iliac, Lymphoma Malignant | X X | 2 | Inguinal, Lymphoma Malignant | X | 1 | Mediastinal, Histiocytic Sarcoma | | 1 | Mediastinal, Lymphoma Malignant | X | 2 | Pancreatic, Lymphoma Malignant | X | 1 | Renal, Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + I + + + + + + + + + + + + + + + + + +| 48 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X | 5 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X X | 4 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X X | 5 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + M + + + + + + M + I + + + + + +| 47 | Lymphoma Malignant | X X | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 50 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8| | | 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Hemangioma | X | 1 | Subcutaneous Tissue, Squamous Cell | | | Carcinoma | X | 1 | Subcutaneous Tissue, Site of | | | Application, Melanoma Benign | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cranium, Osteosarcoma | | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | | 1 | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Peripheral Nerve | + | 1 | |__________________________________________________________________________|____________| Spinal Cord | + + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | | 1 | Alveolar/Bronchiolar Carcinoma | X X X | 4 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 51 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8| | | 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X| 3 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Ureter | + | 1 | Histiocytic Sarcoma | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 52 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8| | | 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2| | _____________________________________________________________________________________________________________________ T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant | X X X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 3| 3| 0| 8| 3| 0| | 1| 0| 0| 9| 1| 9| 0| 9| 9| 1| 1| 9| 1| 2| 1| 9| 2| 5| 1| 2| 1| 2| 2| 0| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + I + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | | Hepatocellular Carcinoma | X X X X X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | X | Histiocytic Sarcoma | X| Lymphoma Malignant | X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Lymphoma Malignant | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 54 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 3| 3| 0| 8| 3| 0| | 1| 0| 0| 9| 1| 9| 0| 9| 9| 1| 1| 9| 1| 2| 1| 9| 2| 5| 1| 2| 1| 2| 2| 0| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Bilateral, Subcapsular, Adenoma | X | Subcapsular, Adenoma | X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 55 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 3| 3| 0| 8| 3| 0| | 1| 0| 0| 9| 1| 9| 0| 9| 9| 1| 1| 9| 1| 2| 1| 9| 2| 5| 1| 2| 1| 2| 2| 0| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Lymphoma Malignant | | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node | + + + + | Iliac, Lymphoma Malignant | X | Mediastinal, Hepatoblastoma, | | Metastatic, Liver | | Mediastinal, Lymphoma Malignant | X | Pancreatic, Lymphoma Malignant | | Renal, Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + M +| Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + I + + + I| __________________________________________|__________________________________________________________________________| Page 56 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 3| 3| 0| 8| 3| 0| | 1| 0| 0| 9| 1| 9| 0| 9| 9| 1| 1| 9| 1| 2| 1| 9| 2| 5| 1| 2| 1| 2| 2| 0| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| Carcinoma | | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Hepatoblastoma, | | Metastatic, Liver | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Lymphoma Malignant | | Rhabdomyosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X | Carcinoma, Metastatic, Mammary Gland | | Cholangiocarcinoma, Metastatic, Liver| | __________________________________________|__________________________________________________________________________| Page 57 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 3| 3| 0| 8| 3| 0| | 1| 0| 0| 9| 1| 9| 0| 9| 9| 1| 1| 9| 1| 2| 1| 9| 2| 5| 1| 2| 1| 2| 2| 0| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Hepatoblastoma, Metastatic, Liver | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Hepatocellular Carcinoma, Metastatic,| | Lung | | Lymphoma Malignant | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Harderian | | Gland | X | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + I| Retrobulbar, Carcinoma, Metastatic, | | Harderian Gland | X | Retrobulbar, Sarcoma | | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X| Carcinoma | X X | Bilateral, Adenoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma, Metastatic, Liver| | Histiocytic Sarcoma | X| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 58 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| | DAY ON TEST | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| | | 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + A + + + + + + + + A + + + + + + + + + A + + + A| 45 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + A| 48 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + A + + + + + + + + A + + + + + + + + + A + + + A| 46 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + A + + + + + + + + A + + + + + + + + + A + + + A| 46 | Adenoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + A + + + + + + + + A + + + + + + + + + A + + + A| 46 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + + + + + A + + + + + + + + + A + + + A| 46 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma | X | 1 | Hepatocellular Carcinoma | X X X X X X X X X| 16 | Hepatocellular Carcinoma, Multiple | X X X | 4 | Hepatocellular Adenoma | X X X X | 9 | Hepatocellular Adenoma, Multiple | X X X X X X X X | 9 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 59 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| | DAY ON TEST | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| | | 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Tooth | + + + + + + + | 18 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Bilateral, Subcapsular, Adenoma | | 1 | Subcapsular, Adenoma | X | 3 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Adenoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 60 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| | DAY ON TEST | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| | | 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Lymph Node | + + | 6 | Iliac, Lymphoma Malignant | X | 2 | Mediastinal, Hepatoblastoma, | | | Metastatic, Liver | X | 1 | Mediastinal, Lymphoma Malignant | | 1 | Pancreatic, Lymphoma Malignant | X | 1 | Renal, Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 61 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| | DAY ON TEST | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| | | 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Thymus | + I + + + + + + + + + + + + + + + + + + + + + + +| 47 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M + M M M M M M M M M M M M M| 1 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 1 | Subcutaneous Tissue, Fibroma | X | 1 | Subcutaneous Tissue, Hepatoblastoma, | | | Metastatic, Liver | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | + | 2 | Lymphoma Malignant | X | 1 | Rhabdomyosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 62 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| | DAY ON TEST | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| | | 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM - cont | | | | | | Brain | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | |__________________________________________________________________________|____________| Peripheral Nerve | | 1 | |__________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X| 6 | Alveolar/Bronchiolar Carcinoma | X | 2 | Carcinoma, Metastatic, Mammary Gland | X | 1 | Cholangiocarcinoma, Metastatic, Liver| X | 1 | Hepatoblastoma, Metastatic, Liver | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X X X | 7 | Hepatocellular Carcinoma, Metastatic,| | | Lung | X | 1 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + A + + + + + + + + A + + + + + + + + + + + + + A| 46 | Retrobulbar, Carcinoma, Metastatic, | | | Harderian Gland | | 1 | Retrobulbar, Sarcoma | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 63 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| | DAY ON TEST | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| | | 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 6 | Carcinoma | | 2 | Bilateral, Adenoma | X | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + A + + + + + + + + + + + + + + + + + + + + + + A| 48 | Cholangiocarcinoma, Metastatic, Liver| X | 1 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangioma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 64 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 7| 7| 7| 6| 7| 7| 7| 6| 7| DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 5| 3| 2| 2| 7| 2| 1| 3| 0| 3| | 0| 1| 0| 1| 2| 1| 1| 1| 0| 9| 2| 0| 9| 1| 5| 4| 1| 9| 9| 0| 9| 0| 2| 3| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + A + + + + + + + + + + + + I + + + + + + A + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +| |__________________________________________________________________________| Intestine Large, Cecum | + A + + + + + + + + + + + + A + + + + + + A + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + A + + +| Adenoma | X | |__________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + + + A + + + + + + A + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + A + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatoblastoma | | Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple | X X X | Hepatocellular Adenoma | X X X X X X X X X X X| Hepatocellular Adenoma, Multiple | X X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 65 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 7| 7| 7| 6| 7| 7| 7| 6| 7| DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 5| 3| 2| 2| 7| 2| 1| 3| 0| 3| | 0| 1| 0| 1| 2| 1| 1| 1| 0| 9| 2| 0| 9| 1| 5| 4| 1| 9| 9| 0| 9| 0| 2| 3| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Squamous Cell Papilloma | X | |__________________________________________________________________________| Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Subcapsular, Adenoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | __________________________________________|__________________________________________________________________________| Page 66 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 7| 7| 7| 6| 7| 7| 7| 6| 7| DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 5| 3| 2| 2| 7| 2| 1| 3| 0| 3| | 0| 1| 0| 1| 2| 1| 1| 1| 0| 9| 2| 0| 9| 1| 5| 4| 1| 9| 9| 0| 9| 0| 2| 3| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + | |__________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X| |__________________________________________________________________________| Thymus | + M + + + + + + + + + + + + + + + M I + + + I + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 67 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 7| 7| 7| 6| 7| 7| 7| 6| 7| DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 5| 3| 2| 2| 7| 2| 1| 3| 0| 3| | 0| 1| 0| 1| 2| 1| 1| 1| 0| 9| 2| 0| 9| 1| 5| 4| 1| 9| 9| 0| 9| 0| 2| 3| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Hepatocellular Carcinoma, Metastatic,| | Liver | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Mediastinum, Hepatocellular | | Carcinoma, Metastatic, Liver | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + A + + + + + + + + + + + + + + + + + + + A + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 68 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 7| 7| 7| 6| 7| 7| 7| 6| 7| DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 5| 3| 2| 2| 7| 2| 1| 3| 0| 3| | 0| 1| 0| 1| 2| 1| 1| 1| 0| 9| 2| 0| 9| 1| 5| 4| 1| 9| 9| 0| 9| 0| 2| 3| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenoma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X| __________________________________________|__________________________________________________________________________| Page 69 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 0| 3| 6| 3| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| | | 2| 0| 0| 9| 1| 1| 1| 1| 2| 0| 2| 9| 0| 5| 0| 2| 0| 6| 2| 0| 1| 0| 2| 2| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + I + + + A + A + + + A + + + A + + + + + + +| 42 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + A + A + + + + + + + A + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + A + A + + + + + + + A + + + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + A + A + + + A + + + A + + + + + + +| 43 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + A + A + + + A + + + A + + + + + + +| 44 | Adenoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + A + A + + + A + + + A + + + + + + +| 43 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + A + A + + + A + + + A + + + + + + +| 44 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X| 2 | Hepatoblastoma | X | 1 | Hepatocellular Carcinoma | X X X X X | 8 | Hepatocellular Carcinoma, Multiple | X X X X | 7 | Hepatocellular Adenoma | X X X X | 15 | Hepatocellular Adenoma, Multiple | X X X X X| 7 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 70 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 0| 3| 6| 3| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| | | 2| 0| 0| 9| 1| 1| 1| 1| 2| 0| 2| 9| 0| 5| 0| 2| 0| 6| 2| 0| 1| 0| 2| 2| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + A + + + + + + + + + A + + + + + + +| 47 | |__________________________________________________________________________|____________| Tooth | + +| 11 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Subcapsular, Adenoma | X | 2 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pheochromocytoma Benign | X | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + I + I + + + + + + + I + + + + + + +| 47 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 71 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 0| 3| 6| 3| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| | | 2| 0| 0| 9| 1| 1| 1| 1| 2| 0| 2| 9| 0| 5| 0| 2| 0| 6| 2| 0| 1| 0| 2| 2| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node | + + + | 5 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + I + + + + + + + + + + + + + + + + I| 48 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + M + + + + + + I + + + +| 44 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 72 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 0| 3| 6| 3| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| | | 2| 0| 0| 9| 1| 1| 1| 1| 2| 0| 2| 9| 0| 5| 0| 2| 0| 6| 2| 0| 1| 0| 2| 2| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibrosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | + + | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X | 5 | Alveolar/Bronchiolar Adenoma, | | | Multiple | X | 1 | Alveolar/Bronchiolar Carcinoma | X| 3 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X X | 6 | Mediastinum, Hepatocellular | | | Carcinoma, Metastatic, Liver | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 73 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 0| 3| 6| 3| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| | | 2| 0| 0| 9| 1| 1| 1| 1| 2| 0| 2| 9| 0| 5| 0| 2| 0| 6| 2| 0| 1| 0| 2| 2| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + A + A + + + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X X X | 9 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + A + A + + + + + + + + + + + + + + +| 48 | Renal Tubule, Adenoma | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 74 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 0| 0| 7| 6| DAY ON TEST | 3| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 5| 3| 6| 2| 3| 3| 2| 4| 5| 2| 8| | 0| 3| 1| 0| 5| 1| 0| 9| 1| 1| 2| 9| 1| 9| 3| 1| 9| 9| 0| 0| 9| 8| 5| 9| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + A + + + + + + + + + M + + + + A + + + + + A + A| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + A + + + + + + + + + + + + + + A + + + + A + + A| |__________________________________________________________________________| Intestine Small, Duodenum | + A + + + + + + + + + + + + + + A + + + + A + + A| Adenoma | X | Carcinoma | | |__________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + A + + + + A + + A| Carcinoma | X | |__________________________________________________________________________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + A + + + + A + + A| Carcinoma | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatocellular Carcinoma | X X X X X X| Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | X X | Hepatocholangiocarcinoma | | Lymphoma Malignant | X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 75 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 0| 0| 7| 6| DAY ON TEST | 3| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 5| 3| 6| 2| 3| 3| 2| 4| 5| 2| 8| | 0| 3| 1| 0| 5| 1| 0| 9| 1| 1| 2| 9| 1| 9| 3| 1| 9| 9| 0| 0| 9| 8| 5| 9| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | |__________________________________________________________________________| Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + A| |__________________________________________________________________________| Tooth | + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcapsular, Adenoma | X X X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | |__________________________________________________________________________| Parathyroid Gland | + M + + + I + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Intermedia, Adenoma | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 76 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 0| 0| 7| 6| DAY ON TEST | 3| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 5| 3| 6| 2| 3| 3| 2| 4| 5| 2| 8| | 0| 3| 1| 0| 5| 1| 0| 9| 1| 1| 2| 9| 1| 9| 3| 1| 9| 9| 0| 0| 9| 8| 5| 9| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tissue NOS | + | Abdominal, Hepatocellular Carcinoma, | | Metastatic, Liver | | Mediastinum, Hepatocellular | | Carcinoma, Metastatic, Liver | | Thoracic, Hepatocellular Carcinoma, | | Metastatic, Liver | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node | + + + | Inguinal, Lymphoma Malignant | X | Mediastinal, Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 77 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 0| 0| 7| 6| DAY ON TEST | 3| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 5| 3| 6| 2| 3| 3| 2| 4| 5| 2| 8| | 0| 3| 1| 0| 5| 1| 0| 9| 1| 1| 2| 9| 1| 9| 3| 1| 9| 9| 0| 0| 9| 8| 5| 9| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant | X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + I + + + + + + + + + + + I| Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Site of | | Application, Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | | |__________________________________________________________________________| Spinal Cord | | __________________________________________|__________________________________________________________________________| Page 78 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 0| 0| 7| 6| DAY ON TEST | 3| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 5| 3| 6| 2| 3| 3| 2| 4| 5| 2| 8| | 0| 3| 1| 0| 5| 1| 0| 9| 1| 1| 2| 9| 1| 9| 3| 1| 9| 9| 0| 0| 9| 8| 5| 9| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Carcinoma | | Alveolar/Bronchiolar Carcinoma, | | Multiple | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X X| Lymphoma Malignant | X | Mediastinum, Hepatocellular | | Carcinoma, Metastatic, Liver | X | Mediastinum, Lymphoma Malignant | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + A + + + + + + + + + + + + + + A + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Lymphoma Malignant | X | Serosa, Hemangiosarcoma | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 79 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9| | | 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + I + + + + + + + A| 43 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + A| 44 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + A| 44 | Adenoma | | 1 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + A| 44 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + A| 44 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 1 | Hepatocellular Carcinoma | X X| 8 | Hepatocellular Carcinoma, Multiple | X X | 3 | Hepatocellular Adenoma | X X X X X X | 11 | Hepatocellular Adenoma, Multiple | X X X X X X | 8 | Hepatocholangiocarcinoma | X | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 80 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9| | | 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | X | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Tooth | + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 2 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X| 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcapsular, Adenoma | X X X | 6 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 81 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9| | | 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Parathyroid Gland | + + M + + + M + + + + + + + + + + + + + + + + + +| 46 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Intermedia, Adenoma | | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Tissue NOS | + +| 3 | Abdominal, Hepatocellular Carcinoma, | | | Metastatic, Liver | X| 1 | Mediastinum, Hepatocellular | | | Carcinoma, Metastatic, Liver | X| 1 | Thoracic, Hepatocellular Carcinoma, | | | Metastatic, Liver | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 82 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9| | | 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node | + + | 5 | Inguinal, Lymphoma Malignant | | 1 | Mediastinal, Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + M M + + + + + + + + + + + + + M| 47 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + I + + + + + + + + + + + + + +| 47 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X| 1 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 83 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9| | | 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Site of | | | Application, Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | + | 2 | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Peripheral Nerve | + | 1 | |__________________________________________________________________________|____________| Spinal Cord | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X | 7 | Alveolar/Bronchiolar Carcinoma | X X | 2 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X X | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X| 4 | Lymphoma Malignant | | 1 | Mediastinum, Hepatocellular | | | Carcinoma, Metastatic, Liver | | 1 | Mediastinum, Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 84 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9| | | 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X X | 10 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X| 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Hemangioma | X | 1 | Lymphoma Malignant | | 1 | Serosa, Hemangiosarcoma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 85 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3| | 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | M A + + + + A + + + + + M + + I + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | A + + + + A + + + + + + A + + + + + + + + + + + +| Leiomyoma | X | |__________________________________________________________________________| Intestine Small, Duodenum | A A + + + + A + I + + + A + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | A A + + + A A + + + + + A + + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Intestine Small, Ileum | A A + + + A A + + + + + A + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X X X | Hepatocellular Carcinoma, Multiple | X| Hepatocellular Adenoma | X X X X X X | Hepatocellular Adenoma, Multiple | X X X X | Squamous Cell Carcinoma, Metastatic, | | Stomach, Forestomach | | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | | Sarcoma | X | Schwannoma Malignant, Metastatic, | | Uncertain Primary Site | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + A + + + + + + + + + + + +| Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________|__________________________________________________________________________| Page 86 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3| | 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Duct, Carcinoma | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | Squamous Cell Papilloma | X | Serosa, Carcinoma, Metastatic, | | Pancreas | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | | |__________________________________________________________________________| Tooth | + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | I + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Subcapsular, Adenoma | X X| |__________________________________________________________________________| Adrenal Medulla | I + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | |__________________________________________________________________________| Parathyroid Gland | + + + + + M + + + + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 87 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3| | 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | | Sarcoma | X | |__________________________________________________________________________| Tissue NOS | + | Mediastinum, Hepatocellular | | Carcinoma, Metastatic, Liver | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | |__________________________________________________________________________| Lymph Node | + | Mediastinal, Carcinoma, Metastatic, | | Pancreas | | Mediastinal, Sarcoma, Metastatic, | | __________________________________________|__________________________________________________________________________| Page 88 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3| | 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Uncertain Primary Site | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | Sarcoma, Metastatic, Uncertain | | Primary Site | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + M + + +| Hemangiosarcoma | X | Lymphoma Malignant | X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + I + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Carcinoma, Metastatic, Pancreas | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 89 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3| | 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | |__________________________________________________________________________| Peripheral Nerve | + + + | Schwannoma Malignant | X | |__________________________________________________________________________| Spinal Cord | + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X | Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Pancreas | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Sarcoma, Metastatic, Uncertain | | Primary Site | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pleura | + | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + A + + + + + + + + + + A + + + + + + + + + + + +| |__________________________________________________________________________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X X | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | A + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 90 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 _____________________________________________________________________________________________________________________ | 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3| | 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | Schwannoma Malignant, Metastatic, | | Uncertain Primary Site | | Capsule, Carcinoma, Metastatic, | | Pancreas | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 91 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| | DAY ON TEST | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2| | | 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Gallbladder | + + + + A A A + + + + + + + + + + + + + A + + + +| 41 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + A + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A A A + + + + + + + + + + + + A A + + + +| 42 | Leiomyoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + A A A + + + + + + + + + + + + A A + + + +| 40 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A A A + + + + + + + + + + + + A A + + + +| 40 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A A A + + + + + + + + + + + + A A + + + +| 40 | |__________________________________________________________________________|____________| Liver | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | X X X | 8 | Hepatocellular Carcinoma, Multiple | X X | 3 | Hepatocellular Adenoma | X X X X | 10 | Hepatocellular Adenoma, Multiple | X X X X X | 9 | Squamous Cell Carcinoma, Metastatic, | | | Stomach, Forestomach | X | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Pancreas | X | 1 | Sarcoma | | 1 | Schwannoma Malignant, Metastatic, | | | Uncertain Primary Site | X | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 92 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| | DAY ON TEST | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2| | | 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | Duct, Carcinoma | X | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma | X | 1 | Squamous Cell Papilloma | | 1 | Serosa, Carcinoma, Metastatic, | | | Pancreas | X | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + A + + + +| 47 | Carcinoma, Metastatic, Pancreas | X | 1 | |__________________________________________________________________________|____________| Tooth | + + + + + | 12 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | | 1 | Subcapsular, Adenoma | X X | 4 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pheochromocytoma Malignant | | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 93 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| | DAY ON TEST | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2| | | 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Pancreas | X | 1 | Sarcoma | | 1 | |__________________________________________________________________________|____________| Tissue NOS | + | 2 | Mediastinum, Hepatocellular | | | Carcinoma, Metastatic, Liver | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Pancreas | X | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 94 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| | DAY ON TEST | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2| | | 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 2 | |__________________________________________________________________________|____________| Lymph Node | + + + | 4 | Mediastinal, Carcinoma, Metastatic, | | | Pancreas | X | 1 | Mediastinal, Sarcoma, Metastatic, | | | Uncertain Primary Site | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | I + + + + + + + + + + + + + + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + A + + + +| 48 | Lymphoma Malignant | | 2 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + A + + + + + + + + + + + + + + A + + + +| 47 | Hemangiosarcoma | X | 2 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Thymus | + + + + + M M + + + + + + + + + + I + + + + + + +| 46 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M + M M M M M M M M M M M M M M M M M M A M M M M| 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 95 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| | DAY ON TEST | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2| | | 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Hemangiosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + | 5 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | Carcinoma, Metastatic, Pancreas | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Peripheral Nerve | | 3 | Schwannoma Malignant | | 1 | |__________________________________________________________________________|____________| Spinal Cord | + | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 7 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Alveolar/Bronchiolar Carcinoma | X X | 2 | Carcinoma, Metastatic, Pancreas | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X | 3 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 96 NTP Experiment-Test: 93020-08 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04 Route: SKIN APPLICATION Time: 09:10:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| | DAY ON TEST | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2| | | 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Pleura | | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + + + + A A A + + + + + + + + + + + + + A + + + +| 44 | |__________________________________________________________________________|____________| Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X| 8 | Carcinoma | X X | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Schwannoma Malignant, Metastatic, | | | Uncertain Primary Site | X | 1 | Capsule, Carcinoma, Metastatic, | | | Pancreas | X | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant | X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 97 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------