Pathology Tables for Peer Review
The National Toxicology Program
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:24:09
FINAL#1/RATS
Facility: Southern Research Institute
Chemical CAS #: 7775-09-9
Lock Date: 10/16/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:24:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Natural Death 3 3 6 5
Moribund Sacrifice 10 11 11 4
Survivors
Terminal Sacrifice 37 34 32 40
Natural Death 1 1
Moribund Sacrifice 2
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (48) (46) (49)
Leiomyosarcoma 1 (2%)
Intestine Small, Jejunum (49) (47) (44) (45)
Leiomyoma 1 (2%)
Liver (50) (50) (50) (50)
Cholangiocarcinoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Histiocytic Sarcoma, Metastatic, Skeletal
Muscle 1 (2%)
Mesentery (18) (10) (13) (16)
Carcinoma 1 (6%)
Oral Mucosa (1) (1)
Squamous Cell Carcinoma 1 (100%)
Pancreas (50) (49) (49) (49)
Acinus, Adenoma 2 (4%)
Salivary Glands (50) (50) (50) (50)
Stomach, Forestomach (50) (50) (50) (50)
Tooth (2) (2) (1)
Odontoma 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:24:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adrenal Medulla (50) (50) (50) (50)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Islets, Pancreatic (50) (49) (49) (50)
Adenoma 2 (4%) 1 (2%)
Carcinoma 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (49) (49) (50) (50)
Pars Distalis, Adenoma 23 (47%) 18 (37%) 17 (34%) 24 (48%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Pars Distalis, Carcinoma 1 (2%) 3 (6%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%) 1 (2%)
Thyroid Gland (47) (47) (43) (46)
Bilateral, C-Cell, Adenoma 1 (2%) 2 (4%)
C-Cell, Adenoma 11 (23%) 8 (17%) 11 (26%) 9 (20%)
C-Cell, Carcinoma 1 (2%) 3 (6%) 1 (2%) 3 (7%)
Follicular Cell, Adenoma 2 (4%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (2) (4) (6)
Mediastinum, Carcinoma, Metastatic, Thyroid
Gland 1 (50%)
Mediastinum, Carcinoma, Metastatic, Zymbal's
Gland 1 (25%)
Mediastinum, Histiocytic Sarcoma 1 (25%)
Mediastinum, Sarcoma 1 (17%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (50) (50) (49)
Adenoma 11 (22%) 5 (10%) 12 (24%) 4 (8%)
Carcinoma 3 (6%) 1 (2%)
Sarcoma 1 (2%)
Ovary (50) (50) (49) (50)
Granulosa Cell Tumor Benign 1 (2%)
Sarcoma 1 (2%)
Oviduct (2)
Page 3
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:24:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Uterus (50) (50) (49) (50)
Carcinoma, Metastatic, Mesentery 1 (2%)
Sarcoma Stromal 1 (2%)
Endometrium, Polyp Stromal 8 (16%) 8 (16%) 7 (14%) 7 (14%)
Endometrium, Polyp Stromal, Multiple 1 (2%) 2 (4%)
Endometrium, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50) (50)
Lymph Node (36) (34) (30) (39)
Mediastinal, Histiocytic Sarcoma 1 (3%)
Mediastinal, Sarcoma 1 (3%)
Lymph Node, Mandibular (4) (6) (4) (5)
Lymph Node, Mesenteric (50) (49) (49) (50)
Spleen (50) (50) (50) (50)
Sarcoma 1 (2%)
Thymus (49) (48) (48) (48)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Adenoma 3 (6%) 2 (4%)
Carcinoma 2 (4%) 1 (2%) 2 (4%)
Carcinoma, Multiple 1 (2%)
Fibroadenoma 23 (46%) 26 (52%) 23 (46%) 27 (54%)
Fibroadenoma, Multiple 10 (20%) 3 (6%) 8 (16%) 6 (12%)
Histiocytic Sarcoma, Metastatic, Skeletal
Muscle 1 (2%)
Skin (50) (50) (50) (50)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 1 (2%)
Trichoepithelioma 2 (4%)
Pinna, Neural Crest Tumor 1 (2%)
Subcutaneous Tissue, Carcinoma, Metastatic,
Mammary Gland 1 (2%)
Subcutaneous Tissue, Fibroma 4 (8%) 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Histiocytic Sarcoma,
Page 4
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:24:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Metastatic, Skeletal Muscle 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%)
Skeletal Muscle (2) (1) (1)
Histiocytic Sarcoma 1 (50%)
Rhabdomyosarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Carcinoma, Metastatic, Pituitary Gland 2 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
Histiocytic Sarcoma, Metastatic, Skeletal
Muscle 1 (2%)
Sarcoma 1 (2%)
Nose (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (49) (47) (50)
Harderian Gland (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (2%)
Zymbal's Gland (1) (1) (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:24:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (47) (47)
Sarcoma 1 (2%)
Urinary Bladder (50) (48) (50) (50)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 2 (4%) 1 (2%)
Leukemia Mononuclear 11 (22%) 9 (18%) 13 (26%) 9 (18%)
Lymphoma Malignant 1 (2%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:24:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 48 46 48
Total Primary Neoplasms 133 102 101 118
Total Animals with Benign Neoplasms 46 42 44 47
Total Benign Neoplasms 107 77 82 87
Total Animals with Malignant Neoplasms 21 22 19 22
Total Malignant Neoplasms 25 25 19 31
Total Animals with Metastatic Neoplasms 1 5 2 2
Total Metastatic Neoplasm 1 8 2 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:24:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 10 13 11 14
Natural Death 3 10 8 8
Accidently Killed 1
Survivors
Terminal Sacrifice 36 27 31 28
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (47) (44) (49)
Intestine Large, Cecum (47) (46) (43) (47)
Intestine Small, Duodenum (49) (46) (46) (47)
Intestine Small, Jejunum (47) (46) (42) (44)
Intestine Small, Ileum (47) (46) (42) (47)
Liver (50) (50) (48) (50)
Hemangiosarcoma 1 (2%)
Hepatocellular Adenoma 3 (6%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Mesentery (19) (20) (19) (23)
Carcinoma, Metastatic, Pancreas 1 (5%)
Hemangiosarcoma, Metastatic, Liver 1 (5%)
Histiocytic Sarcoma 1 (5%) 1 (5%)
Osteosarcoma 1 (5%)
Pancreas (49) (49) (49) (50)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Acinus, Adenoma 2 (4%) 1 (2%)
Acinus, Adenoma, Multiple 1 (2%)
Acinus, Carcinoma 1 (2%)
Salivary Glands (49) (50) (50) (50)
Fibrosarcoma 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Schwannoma Malignant 1 (2%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (49) (48) (48) (50)
Tongue (1) (1) (1) (1)
Sarcoma 1 (100%)
Squamous Cell Carcinoma 1 (100%)
Page 8
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:24:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (2)
Aorta, Osteosarcoma 1 (100%)
Heart (50) (50) (50) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Schwannoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (49) (50) (50)
Carcinoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Adrenal Medulla (49) (49) (50) (50)
Ganglioneuroma 1 (2%)
Pheochromocytoma Malignant 3 (6%) 1 (2%) 1 (2%)
Pheochromocytoma Benign 6 (12%) 3 (6%) 3 (6%) 5 (10%)
Bilateral, Ganglioneuroma 1 (2%)
Bilateral, Pheochromocytoma Benign 1 (2%) 3 (6%)
Islets, Pancreatic (50) (49) (49) (50)
Adenoma 3 (6%) 4 (8%) 3 (6%) 5 (10%)
Carcinoma 2 (4%) 1 (2%) 2 (4%)
Pituitary Gland (48) (50) (49) (50)
Pars Distalis, Adenoma 16 (33%) 15 (30%) 20 (41%) 15 (30%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%)
Thyroid Gland (47) (44) (43) (47)
Bilateral, C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Adenoma 9 (19%) 9 (20%) 5 (12%) 9 (19%)
C-Cell, Carcinoma 2 (4%) 2 (5%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 2 (4%)
Follicular Cell, Carcinoma 4 (9%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1) (1)
Tissue NOS (5) (6) (2) (7)
Abdominal, Paraganglioma 1 (20%)
Mediastinum, Carcinoma, Metastatic, Zymbal's
Page 9
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:24:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont
Gland 1 (17%)
Mediastinum, Squamous Cell Carcinoma,
Metastatic, Lung 1 (17%)
Pelvic, Leiomyoma 1 (20%)
Thoracic, Fibroma 1 (14%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (48) (49) (50) (50)
Adenoma 1 (2%) 6 (12%) 5 (10%) 5 (10%)
Carcinoma 3 (6%) 1 (2%) 2 (4%) 2 (4%)
Prostate (50) (49) (50) (50)
Seminal Vesicle (50) (49) (50) (50)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 1 (2%)
Bilateral, Interstitial Cell, Adenoma,
Multiple 40 (80%) 43 (86%) 42 (84%) 39 (78%)
Interstitial Cell, Adenoma 2 (4%) 1 (2%) 2 (4%)
Interstitial Cell, Adenoma, Multiple 3 (6%) 5 (10%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (48) (50) (49)
Lymph Node (34) (24) (26) (34)
Histiocytic Sarcoma 1 (3%)
Deep Cervical, Histiocytic Sarcoma 1 (3%)
Mediastinal, Carcinoma, Metastatic, Zymbal's
Gland 1 (4%)
Lymph Node, Mandibular (3) (2) (3) (4)
Lymph Node, Mesenteric (49) (50) (49) (50)
Spleen (48) (49) (49) (50)
Histiocytic Sarcoma 1 (2%)
Capsule, Carcinoma, Metastatic, Pancreas 1 (2%)
Thymus (48) (48) (49) (47)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:24:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (45) (43) (47) (44)
Carcinoma 1 (2%) 1 (2%)
Fibroadenoma 2 (4%) 1 (2%) 4 (9%) 4 (9%)
Skin (50) (50) (50) (50)
Basal Cell Carcinoma 1 (2%) 2 (4%)
Basal Cell Carcinoma, Multiple 1 (2%)
Keratoacanthoma 4 (8%) 2 (4%) 1 (2%) 1 (2%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 9 (18%) 9 (18%) 4 (8%) 7 (14%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 2 (4%)
Subcutaneous Tissue, Histiocytic Sarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Neural Crest Tumor 1 (2%)
Subcutaneous Tissue, Osteosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Osteosarcoma 1 (2%)
Periosteum, Cranium, Fibrosarcoma,
Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Glioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 2 (4%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Histiocytic Sarcoma, Metastatic, Uncertain
Page 11
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:24:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Primary Site 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Nose (49) (49) (49) (50)
Trachea (50) (49) (50) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (48) (46) (50)
Retrobulbar, Fibrosarcoma, Metastatic, Skin 1 (2%)
Harderian Gland (49) (49) (49) (50)
Carcinoma 1 (2%)
Zymbal's Gland (1) (1) (3)
Carcinoma 1 (100%) 1 (100%) 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (47) (46) (49) (49)
Lipoma 1 (2%) 1 (2%)
Mesenchymal Tumor Benign 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (48) (49) (47) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leukemia Mononuclear 13 (26%) 21 (42%) 16 (32%) 23 (46%)
Lymphoma Malignant 1 (2%)
Mesothelioma Malignant 1 (2%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 96010-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) Date: 05/27/03
Route: DOSED WATER Time: 13:24:09
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/L 125 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 50 50 50
Total Primary Neoplasms 135 152 124 150
Total Animals with Benign Neoplasms 48 49 47 47
Total Benign Neoplasms 100 112 97 108
Total Animals with Malignant Neoplasms 27 32 24 32
Total Malignant Neoplasms 34 40 27 42
Total Animals with Metastatic Neoplasms 2 5 1
Total Metastatic Neoplasm 3 10 3
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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