Blanco JL, Biglia A, Martinez M, Martinez E, Mallolas J, Milinkovik A, Laguno M, Leon A, Larrousse M, Castro P, Garcia F, Miro JM, Gatell JM; International Conference on AIDS (15th : 2004 : Bangkok, Thailand).
Int Conf AIDS. 2004 Jul 11-16; 15: abstract no. WePeB5928.
Hospital Clinic, Barcelona, Spain
Background: Body fat changes consisting of peripheral fat loss and central fat accumulation (mainly abdomen, breast, and dorsocervical) have been described in HIV-infected patients. The impact of body fat changes on other fat-containing anatomical sites such as mediastinum is unknown. Methods: Case-control study including 27 HIV infected patients (19 on HAART, 8 naive for antiretroviral therapy) (cases) and 19 uninfected individuals (controls). Weight (kg) and height (cm) were measured. Body computed tomography (BCT) was performed in all patients with the same machine by a radiologist blinded to the study. Visceral (VAT) and subcutaneous (SAT) abdominal adipose tissue, mediastinum (MAT) and subcutaneous (TAT) thoracic adipose tissue, and their respectively ratios -as a relative index of intraabdominal (RA= VAT/SAT) and intrathoracic (RT= MAT/TAT) fat accumulation- were calculated. Results: Anthropometric parameters were balanced between both groups. Intrathoracic fat (BCT) was significantly higher in HIV infected patients than in controls (RT 0,200 vs 0,056, p<0,001). Although there was a trend for intraabdominal fat to be higher in HIV-infected patients than in controls, this diferrence was not significant (RA 0.539 vs 0.344, P=0.16). Among HIV-infected patients, no differences were seen in these ratios irrespective of whether or not they were receiving ART therapy. Significant linear correlations were found flanked by RA and RT in group A (r=0.43, P= 0,03) and in HIV infected patients on HAART (r=0,49, P=0,04) respectively but not in HIV-infected naive patients (r=0,46, P=0,29) or group B (r=0,39, P=0,15). Conclusion In HIV-infected patients, mediastinum fat is increased and positively correlated with abdominal fat.
Publication Types:
Keywords:
- Abdomen
- Acquired Immunodeficiency Syndrome
- Adipose Tissue
- Antiretroviral Therapy, Highly Active
- Case-Control Studies
- HIV Infections
- HIV Seropositivity
- Humans
- Mediastinum
- Thorax
Other ID:
UI: 102283855
From Meeting Abstracts