GLUPCZYNSKI Y, DELMEE M, GOOSSENS H, IEVEN G, NONHOFF C, STRUELENS M; on Behalf of a Belgian Multicenter Study Group; Interscience Conference on Antimicrobial Agents and Chemotherapy (43rd: 2003: Chicago, Ill.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2003 Sep 14-17; 43: abstract no. C2-1972.

UCL Mont-Godinne University Hospital, Yvoir, Belgium.

BACKGROUND: To compare the in vitro activity of imipenem (IMP) to that of 11 antibiotics including: ceftazidime (CAZ), cefepime (CPM), piperacillin-tazobactam (PTZ), amikacin (AMK) and ciprofloxacin (CP). METHODS: Survey of 15 general and 6 university belgian hospitals including 1638 non-duplicate, consecutive aerobic GNR isolated from 1260 patients hospitalized in ICUs for >48h between 09/00-08/01. Susceptibility testing was performed in each center by E-test and following NCCLS guidelines. RESULTS: MIC[90 (micro-]g/ml)/% susceptible are listed in the Table [table: see text]. A higher percentage of E. coli isolates was observed in general hospitals (24.7% vs 15,6% in univ. hospitals; p<10[-5)] while a higher percentage of inducible Enterobacteriaceae (IE) was observed in university hospitals (32.3% vs 26.6% in general hospitals; p=0.01). There were no significant geographical differences in the distribution of organisms nor in resistance rates except for a higher percentage of E. aerogenes isolates in the Southern part as compared to the Northern part (13.7% vs 8.6%, p=0.003) and a higher proportion of P. aeruginosa isolates resistant to CAZ and PTZ in hospitals from the Northern region. CONCLUSIONS: Multiple antimicrobial drug resistance was mainly observed in P. aeruginosa and in E.aerogenes isolates. Overall, IMI, CPM and AMK appeared as the three agents retaining the best activity against most species of GNR. No significant resistance trends were observed in comparison to three previous similar surveys performed in 1994/5, 1996/7 and 1998/9.

Publication Types:

• Meeting Abstracts

Keywords:

• Anti-Bacterial Agents
• Data Collection
• Drug Resistance, Microbial
• Enterobacteriaceae
• Gram-Negative Bacteria
• Humans
• Imipenem
• In Vitro
• Intensive Care Units
• Microbial Sensitivity Tests
• Piperacillin
• Sentinel Surveillance
• piperacillin-tazobactam combination product

Other ID:

• GWAIDS0026518

UI: 102266142

From Meeting Abstracts