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Title Gated thallium scintigraphy in the assessment of coronary artery disease
Creator/Author Martin, W. ; Tweddel, A.C. ; McGhie, A.I. ; McKillop, J.H. ; Hutton, I.
Publication Date1984 Jan 01
OSTI IdentifierOSTI ID: 6844763
Report Number(s)CONF-840619-
Other Number(s)CODEN: JNMEA
Resource TypeConference
Specific TypeJournal Article
Resource RelationJ. Nucl. Med. ; Vol/Issue: 25:5; 31. annual meeting of the Society of Nuclear Medicine; 5 Jun 1984; Los Angeles, CA, USA
Research OrgRoyal Infirmary, Glasgow
Subject550601 -- Medicine-- Unsealed Radionuclides in Diagnostics; CARDIOVASCULAR DISEASES-- DIAGNOSIS;CORONARIES-- SCINTISCANNING;THALLIUM ISOTOPES-- DIAGNOSTIC USES; ACCURACY;BIOMEDICAL RADIOGRAPHY
Related SubjectARTERIES;BLOOD VESSELS;BODY;CARDIOVASCULAR SYSTEM;COUNTING TECHNIQUES;DIAGNOSTIC TECHNIQUES;DISEASES;ISOTOPES;MEDICINE;NUCLEAR MEDICINE;ORGANS;RADIOISOTOPE SCANNING;RADIOLOGY;USES
Description/Abstract This study was aimed at assessing ECG gated images to provide both perfusion and ventricular function information.^18 patients with acute myocardial infarction were studied at rest, and 12 male volunteers and 55 male patients undergoing routine coronary angiography were studied following the injection of 2 mCi (80 MBq) of thallous chloride 30s prior to termination of a symptom limited maximal exercise.^Listmode data gated to the ECG were obtained in 3 projections for 6 minutes using a mobile gamma camera with a high sensitivity collimator.^Three independent observers, on separate occasions analysed firstly standard reconstructed thallium scintigrams and secondly cine display of the gated image for perfusion defects and regional wall motion (RWM) using a 4 point scoring system.^In addition ejection fraction (EF) was calculated from the 45/sup 0/ LAO projection.^The gated thallium EF ranged from 52-65% in the volunteers, from 24-65% in the angiography patients and from 13-61% in the acute infarcts, and correlated well against the gated blood pool (r=.84) and contrast angiography (r=.78).^RWM assessed for 850 segments gave interobserver disagreement of 0.9% and when compared to gated blood pool scans, disagreement occurred in 2 of 77 segments (2.8%).^In the detection of significant coronary disease static thallium images provided a sensitivity of 71% and overall predictive accuracy of 75%.^If the perfusion and wall motion from the gated image were considered the sensitivity was 93% at a predictive accuracy of 90%.^The authors conclude that multiple view gated thallium scintigraphy gives accurate information as to ventricular function and enhances the detection of perfusion defects.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 83
System Entry Date2001 May 13

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