domain:The amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.,
domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,
function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.,
similarity:Belongs to the potassium channel family. A (Shaker) subfamily.,
subcellular location:Membrane; Multi-pass membrane protein.,
subunit:Heterotetramer of potassium channel proteins. Interacts via its PDZ-binding motif with DLG1. Forms a ternary complex with DLG1 and CAV3.,
tissue specificity:Highly expressed in heart and moderately in brain. Low levels in thymus, skeletal muscle and spleen. Not expressed in liver, lung or kidney.,
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.,
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