ChemIDPlus/HSDB 59-30-3 Chemical - National Toxicology Program

CAS Registry Number: 59-30-3

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http://ntp.niehs.nih.gov/go/21802

Selected information from two of the National Library of Medicine's databases: ChemIDPlus¹ and HSDB².

Names (NTP)

Folic acid
N-(4-(((2-AMINO-1,4-DIHYDRO-4-OXO-6-PTERIDINYL)METHYL)AMINO)BENZOYL)-L-GLUTAMIC ACID (9CI)

Structure

Chemical Structure for CAS Registry Number 59-30-3 from NLM

Chemical Properties²

Property	Description
Color/Form	Yellowish-orange crystals; extremely thin platelets (elongated @ 2 ends) from hot water
Odor	Odorless or almost odorless
Taste	Tasteless
Boiling Point	None found
Melting Point	None found
Molecular Weight	441.40
Corrosivity	None found
Critical Temperature & Pressure	None found
Density/Specific Gravity	None found
Disassociation Constants	pKa = 3.5, 4.3 (carboxylic acid moieties) /Estimated/
Heat of Combustion	None found
Heat of Vaporization	None found
log P (octanol-water)	log Kow = -2.81 /Estimated/
pH	A suspension of 1 g of folic acid in 10 ml of water has a pH of 4.0-4.8. Aq solutions prepared with sodium bicarbonate have a pH between 6.5 and 6.8.
Solubilities	Slightly sol in methanol, less in ethanol and butanol; insol in acetone, chloroform, ether, benzene; relatively sol in acetic acid, phenol, pyridine, and in soln of alkali hydroxides and carbonates. Soluble in hot dil HCl and H2SO4. In water, 1.6 mg/L at 25 deg C; soluble up to about 1% in boiling water
Spectral Properties	Specific optical rotation: +23 deg at 25 deg C/D (c= 0.5 in 0.1 N sodium hyroxide) UV max (pH 13): 256, 283, 368 nm (log E 4.43, 4.40, 3.96) MASS: 76456 44 (NIST/EPA/MSDC Mass Specral Database 1990 Version) IR: 5025 (Coblentz Society Spectral Collection) UV: 2-601 (Organic Electronic Spectral Data, Phillips et al, John Wiley & Sons, New York)
Surface Tension	None found
Vapor Density	None found
Vapor Pressure	6.2X10-20 mm Hg at 25 deg C /Estimated/
Relative Evaporation Rate	None found
Viscosity	None found
Other Properties	Darkens and chars from about 250 deg C Folic acid elixir ... incompatible with chloral hydrate, ferrous sulfate, sulfonamides, acacia mucilage, sol calcium salts, acidic vitamin preparations, & cherry & raspberry syrups. Soluble in dilute solutions of alkali hydroxides and carbonates, yielding a clear orange-brown solution; soluble in hydrochloric acid and in sulphuric acid, yielding very pale yellow solutions. A solution in 0.1 M sodium hydroxide is dextrorotatory. Solutions of the sodium salt are sterilized by filtration. Henry's Law constant = 3.6X10-33 atm-cu m/mol at 25 deg C /Estimated/ Hydroxyl radical reaction rate constant = 8.5X10-11 cu cm/molec-sec at 25 deg C /Estimated/

Uses²

MEDICATION **PEER REVIEWED**
MEDICATION (VET) **PEER REVIEWED**
Food additive
Vitamin. Nutritional factor.

Superlist Classes¹

None found

Notes (Sources: NTP,HSDB,RTECS,MESH)¹

None found

Other Registry Numbers¹

33609-88-0

Synonyms (Sources: NTP, HSDB,RTECS,MESH)¹

Acfol (Spain)
Acifolic
Antianemia factor
Cytofol
Factor U
Folacid
Folacin
Folasic (Australia)
Folbal
Folcidin
Folcysteine
Folettes
Foliamin
Folico (Italy)
Folina (Italy)
Folipac
Folsan
Folsaure
Folsav
Folvite
L-Glutamic acid, N-(4-((2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-
Glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, L-
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
Glutamic acid, pteroyl-, L-
HSDB 2002
Incafolic
Liver Lactobacillus casei factor
Millafol
Mittafol
NSC 3073
PGA
Pteglu
4-Pteridinol, 2-amino-6-((p-((1,3-dicarboxypropyl)carbamoyl)anilino)methyl)-
Pteroylglutamic acid
Pteroyl-L-glutamic acid
Pteroylmonoglutamic acid
Pteroyl-L-monoglutamic acid
USAF CB-13
Vitamin B11
Vitamin M
Vitamin Bc
Vitamin Be