Biochemical aspects of motor neurone disease—Madras pattern

J Neurol Neurosurg Psychiatry. 1973 October; 36(5): 753–756.

PMCID: PMC494453

K. Valmikinathan,¹ Mercy Mascreen, E. Meenakshisundaram, and C. Snehalatha

Institute of Neurology, Madras Medical College, Madras-3, India

¹ Requests for reprints.

This article has been cited by other articles in PMC.

Abstract

A detailed study of four cases of MND-Madras has shown a significantly low plasma citrate level in these subjects. Comparison with other related groups of neurological disorders indicates the citrate/pyruvate ratio to be of diagnostic value in MND-Madras. This seems to suggest that the pathophysiology of MND-Madras may centre round altered citrate metabolism.

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Selected References

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