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Nelson Textbook of Pediatrics 18th Edition Table of Contents Part I: The Field of Pediatrics 1 Overview of Pediatrics Richard E. Behrman and Bonnie Stanton 2 Quality Improvement and Patient Care and Safety Carole Lannon 3 Ethics in Pediatric Care Robert M. Nelson 4 Cultural Issues in Pediatric Care Bonita Stanton 5 Maximizing Children¿s Health: Anticipatory Guidance, Screening, and Counseling Paula Duncan (new) Part II: Growth, Development, and Behavior (new title) 6 Overview and Assessment of Variability Susan Feigelman (new) 6.1 Assessment of Fetal Growth and Development Susan Feigelman (new) 7 The Newborn John Olsson 8 The First Year Susan Feigelman (new) 9 The Second Year Susan Feigelman (new) 10 Preschool Years Susan Feigelman (new) 11 Middle Childhood Susan Feigelman (new) 12 Adolescence Arik V Marcell 13 Sexual Behavior (Chapter Head, not chap) 13.1 The Development of Sexual Behavior Richard Dalton 13.2 Gender Identity Disorder (GID) Ligia Peralta 13.3 Adolescent Homosexuality Gary Remafedi (new) 14 Assessment of Growth Virgina Keane (new) 15 Developmental Screening and Surveillance Frances Pag Glascoe (new) 16 Child Care: How Pediatricians Can Support Children and Famillies Laura Stout Sasinsky; Walter S. Gilliam (new) 17 Separation, Loss, and Bereavement Janet R Serwint 18 Sleep Medicine Judith A. Owens Part III: Child and Adolescent Psychology (new title) Neil W. Boris 19 Assessment and Interviewing Neil W. Boris 20 Psychological Treatment of Children and Adolescents Neil W. Boris 20.1 Psychopharmacology Neil W. Boris 20.2 Psychotherapy Neil W. Boris 20.3 Psychiatric Hospitalization Neil W. Boris 21 Psychosomatic Illness Neil W. Boris 22 Vegetative Disorders Neil W. Boris 22.1 Rumination Disorders Neil W. Boris 22.2 Pica Neil W. Boris 22.3 Enuresis (Bedwetting) Neil W. Boris 22.4 Encopresis Neil W. Boris 23 Habit Disorders Neil W. Boris 24 Anxiety Disorders Neil W. Boris 25 Mood Disorders Neil W. Boris 25.1 Dysthymic Disorder Neil W. Boris 25.2 Bipolar Disorder Neil W. Boris 26 Suicide and Attempted Suicide Neil W. Boris 27 Anorexia Nervosa and Bulimia Neil W. Boris 28 Disruptive Behavioral Disorders Neil W. Boris 29 Pervasive Developmental Disorders and Childhood Psychosis Neil W. Boris 29.1 Autistic Disorder Neil W. Boris 29.2 Asperger¿s Disorder Neil W. Boris 29.3 Childhood Disintegrative Disorder Neil W. Boris 29.4 Rett Disorder Neil W. Boris 29.5 Childhood Schizophrenia Neil W. Boris 30 Patterns of Development and Function in the School-Aged Child Desmond P. Kelly 31 Attention Deficit Hyperactivity Disorder Peter Jensen (new) 32 Reading and Language Disabilities 32.1 Dyslexia G.Reid Lyon 32.2 Language Disorders Mark Simms PART IV: Children with Special Needs (new working title; eds to mull over) 33 Adoption Mark Simms, Madelyn Freundlich 34 Foster Care Mark Simms, Madelyn Freundlich 35 Impact of Violence on Children Marilyn Augustyn, Barry Zuckerman 35.1 School Violence and Bullying Douglas Vanderbilt, Marilyn Augustyn 35.2 Effect of War on Children Isaiah D Wexler, Eitan Kerem 36 Abuse and Neglect of Children Charles F. Johnson 36.1 Sexual Abuse Charles F. Johnson 36.2 Munchausen Syndrome by Proxy Charles F. Johnson 36.3 Parental Styles Charles F. Johnson 37 Failure to Thrive Howard Bauchner 38 Developmental Disabilities and Chronic Illness: An Overview Paul Wise (new) 38.1 Chronic Illness in Childhood Paul Wise (new) 38.2 Mental Retardation (Intellectual Disability) Bruce K. Shapiro and Mark L. Batshaw 39 Organ Transplantation Laurence H. Mathers and Lorry R. Frankel 40 Pediatric Palliative Care: The Care of Children with Life-Limiting Illness Stephen Liben 40.1 Grief and Bereavement Stephen Liben Part V: Nutrition 41 Nutritional Requirements William C. Heird 42 The Feeding of Infants and Children William C. Heird 43 Food Insecurity, Hunger, and Undernutrition William C. Heird 44 Obesity Colin D. Rudolph (new), Joseph A. Skelton (new) 45 Vitamin A Deficiency and Excess Maija Zile (new) 46 Vitamin B Complex Deficiency and Excess Maija Zile (new) 47 Vitamin C Deficiency (Scurvy) Maija Zile (new) 48 Rickets and Hypervitaminosis D Larry A. Greenbaum 49 Vitamin E Deficiency Larry A. Greenbaum 50 Vitamin K Deficiency Larry A. Greenbaum 51 Micronutrient Deficiency Larry A. Greenbaum Part VI: Body Fluids and Fluid Therapy 52 Electrolyte and Acid-Base Disorders Larry A. Greenbaum 52.1 Composition of Body Fluids Larry A. Greenbaum 52.2 Regulation of Osmolality and Volume Larry A. Greenbaum 52.3 Sodium Larry A. Greenbaum 52.4 Potassium Larry A. Greenbaum 52.5 Magnesium Larry A. Greenbaum 52.6 Phosphorus Larry A. Greenbaum 52.7 Acid-Base Balance Larry A. Greenbaum 53 Maintenance and Replacement Therapy Larry A. Greenbaum 54 Deficit Therapy Larry A. Greenbaum 55 Fluids and Electrolyte Treatment of Specific Disorders Larry A. Greenbaum 55.1 Acute Diarrhea and Oral Rehydration Larry A. Greenbaum 55.2 Diarrhea in Chronically Malnourished Children Larry A. Greenbaum 55.32 Pyloric Stenosis Larry A. Greenbaum 55.4 Perioperative Fluids Larry A. Greenbaum Part VII: Pediatric Drug Therapy (NEW) 56 Pharmacogenetics Jacob V. Aranda (new) 57 Principles of Drug Therapy Michael D. Reed and Peter Gal 58 Poisonings Michael D. Reed and Peter Gal 59 Herbal Medicines Kathi J. Kemper and Paula Gardiner Part VIII: Critical Care Medicine (NEW title) 60 Evaluation of the Sick Child in the Office and Clinic Paul L. McCarthy 61 Injury Control Frederick P. Rivara and David Grossman 62 Emergency Medical Services for Children M. Denise Dowd and Frederick P. Rivara 63 Interfacility Transfer of the Critically Ill Infant and Child Lorry R. Frankel 64 Monitoring Techniques for the Critically Ill Infant and Child Lorry R. Frankel 65 Scoring Systems and Predictors of Mortality Joseph DiCarlo and Lorry R. Frankel 66 Pediatric Emergencies and Resuscitation Lawrence H. Mathers and Lorry R. Frankel 67 Neurologic Injury Lorry R. Frankel 67.1 Brain Death Lorry R. Frankel 68 Shock Lorry R. Frankel 69 Respiratory Distress and Failure Lorry R. Frankel 70 Mechanical Ventilation Lorry R. Frankel and Saraswati Kache 70.1 Chronic Mechanical Ventilation Lorry R. Frankel and Saraswati Kache 71 Acute Care of the Multiple Trauma Victim Peter S Dayan and Bruce L. Klein 72 Nutritional Stabilization Joseph V. DiCarlo 73 Drowning Harry J. Kallas 74 Burn injuries Alia Y. Antoon and Mary K. Donovan 75 Cold Injuries Alia Y. Antoon and Mary K. Donovan 76 Anesthesia and Perioperative Care Randall C. Wetzell 77 Pediatric Pain Management Lonnie K. Zeltzer and Heather Krell Part IX: Human Genetics 78 The Genetic Approach Bruce R. Korf (new) 79 The Human Genome Bruce R. Korf (new) 80 Patterns of Genetic Transmission Nathaniel Robin (new) 81 Clinical Cytogenetics Maria Descartes and Andrew Carroll (new) 82 Genetics of Common Disorders Helen Lyon (new) 83 Integration of Genetics into Pediatric Practice Bruce R. Korf (new) Part X: Metabolic Diseases 84 An Approach to Inborn Errors of Metabolism Iraj Rezvani 85 Defects in Metabolism of Amino Acids Iraj Rezvani 85.1 Phenylalanine Iraj Rezvani, Grant Mitchell 85.2 Tyrosine Iraj Rezvani, Grant Mitchell 85.3 Methionine Iraj Rezvani, David Rosenblatt 85.4 Cysteine/Cystine Iraj Rezvani 85.5 Tryptophan Iraj Rezvani 85.6 Valine, Leucine, Isoleucine, and Related Organic Acidemias Iraj Rezvani, David Rosenblatt 85.7 Glycine Iraj Rezvani 85.8 Serine Iraj Rezvani 85.9 Proline and Hydroxyproline Iraj Rezvani 85.1 Glutamic Acid Iraj Rezvani 85.11 Urea Cycle and Hyperammonemia (Arginine, Citrulline, Ornithine) Iraj Rezvani, Grant Mitchell 85.12 Histidine Iraj Rezvani 85.13 Lysine Iraj Rezvani 85.14 Aspartic Acid (Canavan Disease) Reuben K. Matalon 86 Defects in Metabolism of Lipids (Summary head; not a chapter) 86.1 Disorders of Mitochondrial Fatty Acid Oxidation Charles A. Stanley and Michael Bennett (new) 86.2 Disorders of Very Long Chain Fatty Acids Hugo W. Moser 86.3 Disorders of Lipoprotein Metabolism and Transport William A. Neal (new) 86.4 Lipidoses Margaret M. McGovern and Robert J. Desnick 86.5 Mucolipidoses Margaret M. McGovern and Robert J. Desnick 87 Defects in Metabolism of Carbohydrates Yuan-Tsong Chen 87.1 Glycogen Storage Diseases Yuan-Tsong Chen 87.2 Defects in Galactose Metabolism Yuan-Tsong Chen 87.3 Defects in Fructose Metabolism Yuan-Tsong Chen 87.4 Defects in Intermediary Carbohydrate Metabolism Associated with Lactic Acidosis Yuan-Tsong Chen 87.5 Deficiency of Xylulose Dehydrogenase (Essential Benign Pentosuria) Yuan-Tsong Chen 87.6 Disorders of Glycoprotein Degradation and Structure Margaret M. McGovern and Robert J. Desnick 88 Mucopolysaccharidoses Jurgen Spranger (new; int'l) 89 Disorders of Purine and Pyrimidine Metabolism James C. Harris 90 Progeria W. Ted Brown 91 The Porphyrias Karl E. Anderson (new) 92 Hypoglycemia Mark A. Sperling Part XI: Perinatal and Neonatal Medicine (new title) 93 Overview of Mortality and Morbidity Barbara J. Stoll 94 The Newborn Infant Barbara J. Stoll 94.1 History in Neonatal Pediatrics Barbara J. Stoll 94.2 Physical Examination of the Newborn Infant Barbara J. Stoll 94.3 Routine Delivery Room Care Barbara J. Stoll 94.4 Nursery Care Barbara J. Stoll 94.5 Parent-Infant Bonding Barbara J. Stoll 95 High-Risk Pregnancies Barbara J. Stoll 96 The Fetus Barbara J. Stoll, Ira Adams-Chapman 96.1 Fetal Growth and Maturity Barbara J. Stoll, Ira Adams-Chapman 96.2 Fetal Distress Barbara J. Stoll, Ira Adams-Chapman 96.3 Maternal Disease and the Fetus Barbara J. Stoll, Ira Adams-Chapman 96.4 Maternal Medication and Toxin Exposure and the Fetus Barbara J. Stoll, Ira Adams-Chapman 96.5 Teratogens Barbara J. Stoll, Ira Adams-Chapman 96.6 Radiation Barbara J. Stoll, Ira Adams-Chapman 96.7 Intrauterine Diagnosis of Fetal Disease Barbara J. Stoll, Ira Adams-Chapman 96.8 Treatment and Prevention of Fetal Disease Barbara J. Stoll, Ira Adams-Chapman 97 The High-Risk Infant Barbara J. Stoll, Ira Adams-Chapman 97.1 Multiple Gestation Pregnancies Barbara J. Stoll, Ira Adams-Chapman 97.2 Prematurity and Intrauterine Growth Retardation Barbara J. Stoll, Ira Adams-Chapman 97.3 Post-Term Infants Barbara J. Stoll, Ira Adams-Chapman 97.4 Large for Gestational Age Barbara J. Stoll, Ira Adams-Chapman 97.5 Infant Transport Barbara J. Stoll, Ira Adams-Chapman 98 Clinical Manifestations of Diseases in the Newborn Period Barbara J. Stoll 99 Nervous System Disorders Ira Adams-Chapman, Barbara J. Stoll 99.1 The Cranium Ira Adams-Chapman, Barbara J. Stoll 99.2 Traumatic, Epidural, Subdural, and Subarachnoid Hemorrhage Ira Adams-Chapman, Barbara J. Stoll 99.3 Intracranial-Intraventricular Hemorrhage and Periventricular Leukomalacia Ira Adams-Chapman, Barbara J. Stoll 99.4 Brain Injury from Inflammation, Infection, and Medications Ira Adams-Chapman, Barbara J. Stoll 99.5 Hypoxia-Ischemia Ira Adams-Chapman, Barbara J. Stoll 99.6 Spine and Spinal Cord Ira Adams-Chapman, Barbara J. Stoll 99.7 Peripheral Nerve Injuries Ira Adams-Chapman, Barbara J. Stoll 100 Delivery Room Emergencies Barbara J. Stoll, Ira Adams-Chapman 101 Respiratory Tract Disorders Golde G Dudell, Barbara J. Stoll 101.1 Transition to Pulmonary Respiration Golde G Dudell, Barbara J. Stoll 101.2 Apnea Golde G Dudell, Barbara J. Stoll 101.3 Congenital Central Hypoventilation Syndrome Gabriel G. Haddad 101.4 Respiratory Distress Syndrome (Hyaline Membrane Disease) Golde G Dudell, Barbara J. Stoll 101.5 Transient Tachypnea of the Newborn Golde G Dudell, Barbara J. Stoll 101.6 Aspiration of Foreign Material (Fetal Aspiration Syndrome, Aspiration Pneumonia) Golde G Dudell, Barbara J. Stoll 101.7 Meconium Aspiration Golde G Dudell, Barbara J. Stoll 101.8 Persistent Pulmonary Hypertension of the Newborn (Persistent Fetal Circulation) Golde G Dudell, Barbara J. Stoll 101.9 Diaphragmatic Hernia Peter F. Ehrlich (new), Arnold G. Coran (new) 101.10 Foramen of Morgagni Hernia Peter F. Ehrlich (new), Arnold G. Coran (new) 101.11 Paraesophageal Hernia Peter F. Ehrlich (new), Arnold G. Coran (new) 101.12 Eventration Peter F. Ehrlich (new), Arnold G. Coran (new) 101.13 Extrapulmonary Extravasation of Air (Pneumothorax, Pneumomediastinum, Pulmonary Interstitial Emphysema) Golde G Dudell, Barbara J. Stoll 101.14 Pulmonary Hemorrhage Golde G Dudell, Barbara J. Stoll 102 Digestive System Disorders Anthony J Piazza, Barbara J. Stoll 102.1 Meconium Ileus in Cystic Fibrosis Anthony J Piazza, Barbara J. Stoll 102.2 Neonatal Necrotizing Enterocolitis (NEC) Anthony J Piazza, Barbara J. Stoll 102.3 Jaundice and Hyperbilirubinemia in the Newborn Anthony J Piazza, Barbara J. Stoll 102.4 Kernicterus Anthony J Piazza, Barbara J. Stoll 103 Blood Disorders (Chapter Head, not chap) 103.1 Anemia in the Newborn Infant Barbara J. Stoll 103.2 Hemolytic Disease of the Newborn (Erythroblastosis Fetalis) Barbara J. Stoll 103.3 Plethora in the Newborn Infant (Polycythemia) Barbara J. Stoll 103.4 Hemorrhage in the Newborn Infant Barbara J. Stoll 104 Genitourinary System Barbara J. Stoll 105 The Umbilicus Barbara J. Stoll 106 Metabolic Disturbances Barbara J. Stoll 106.1 Maternal Selective Serotonin Reuptake Inhibitors and Neonatal Behavioral Syndromes Barbara J. Stoll 106.2 Fetal Alcohol Syndrome Barbara J. Stoll 107 The Endocrine System Barbara J. Stoll 107.1 Infants of Diabetic Mothers Barbara J. Stoll 107.2 Hypoglycemia Barbara J. Stoll 108 Dysmorphology Anthony Wynshaw-Boris (new) and Leslie G Biesecker (new) 109 Infections of the Neonatal Infant Ch head; not chapter 109.1 Pathogenesis and Epidemiology Barbara J. Stoll 109.2 Modes of Transmission and Pathogenesis Barbara J. Stoll 109.3 Immunity Barbara J. Stoll 109.4 Etiology of Fetal and Neonatal Infection Barbara J. Stoll 109.5 Epidemiology of Early- and Late-Onset Neonatal Infections Barbara J. Stoll 109.6 Clinical Manifestations of Transplacental Intrauterine Infections Barbara J. Stoll 109.7 Diagnosis Barbara J. Stoll 109.8 Treatment Barbara J. Stoll 109.9 Complications and Prognosis Barbara J. Stoll 109.1'0 Prevention Barbara J. Stoll Part XII: Adolescent Medicine (new title) 110 The Epidemiology of Adolescent Health Problems Renée R. Jenkins 111 Delivery of Health Care to Adolescents Renée R. Jenkins 111.1 Legal Issues Renée R. Jenkins 111.2 Screening Procedures Renée R. Jenkins 111.3 Health Enhancement Renée R. Jenkins 112 Violent Behavior Renée R. Jenkins 113 Substance Abuse Renée R. Jenkins and Hoover Adger, Jr 113.1 Alcohol Renée R. Jenkins 113.2 Marijuana Renée R. Jenkins 113.3 Tobacco Renée R. Jenkins 113.4 Volatile Substances Renée R. Jenkins 113.5 Hallucinogens Renée R. Jenkins 113.6 Cocaine Renée R. Jenkins 113.7 Amphetamines Renée R. Jenkins 113.8 Opiates Renée R. Jenkins 113.9 Anabolic Steroids Renée R. Jenkins 114 The Breast Renée R. Jenkins 115 Menstrual Problems Renée R. Jenkins 115.1 Amenorrhea Renée R. Jenkins 115.2 Abnormal Uterine Bleeding Renée R. Jenkins 115.3 Dysmenorrhea Renée R. Jenkins 115.4 Premenstrual Syndrome Renée R. Jenkins 116 Contraception Renée R. Jenkins 116.1 Barrier Methods Renée R. Jenkins 1162 Spermicides Renée R. Jenkins 116.3 Combination Methods Renée R. Jenkins 116.4 Hormonal Methods Renée R. Jenkins 116.5 Emergency Contraception Renée R. Jenkins 116.6 Intrauterine Devices Renée R. Jenkins 117 Pregnancy (see note at Ch 116) Marianne E. Felice (new), Dianne Elfenbein (new) 118 Rape Marianne E. Felice (new), Christine Barron (new) 119 Sexually Transmitted Diseases (see note at Ch 116) Renée R. Jenkins 120 Chronic Fatigue Syndrome Hal B. Jenson Part XIII: Immunology (new title) Section 1. Evaluation of the Immune Systems 121 Evaluation of Suspected Immunodeficiency Rebecca H. Buckley Section 2: The T-, B-, and NK-Cell Systems 122 T Lymphocytes, B Lymphocytes, and Natural Killer Cells Rebecca H. Buckley 123 Primary Defects of Antibody Production Rebecca H. Buckley 123.1 Treatment of B-Cell Defects Rebecca H. Buckley 124 Primary Defects of Cellular Immunity Rebecca H. Buckley 125 Primary Combined Antibody and Cellular Immunodeficiencies Rebecca H. Buckley 125.1 Severe Combined Immunodeficiency (SCID) Rebecca H. Buckley 125.2 Combined Immunodeficiency (CID) Rebecca H. Buckley 125.3 Treatment of Cellular or Combined Immunodeficiency Rebecca H. Buckley Section 3: The Phagocytic System 126 Neutrophils Laurence A. Boxer 127 Monocytes and Macrophages Richard B. Johnston, Jr. 128 Eosinophils Laurence A. Boxer 129 Disorders of Phagocyte Function Laurence A. Boxer 130 Leukopenia Laurence A. Boxer 131 Leukocytosis Laurence A. Boxer Section 4: The Complement System 132 The Complement System Richard B. Johnston, Jr. 133 Disorders of the Complement System Richard B. Johnston, Jr. 133.1 Evaluation of the Complement System Richard B. Johnston, Jr. 133.2 Primary Deficiencies of Complement Components Richard B. Johnston, Jr. 133.3 Deficiencies of Plasma, Membrane, or Serosal Complement Control Proteins Richard B. Johnston, Jr. 133.4 Secondary Disorders of Complement Richard B. Johnston, Jr. 133.5 Treatment of Disorders of the Complement System Richard B. Johnston, Jr. Section 5. 134 Clinical Indications Andrea Velardi (new, int¿l) 135 Matching and Rejection Andrea Velardi (new, int¿l) 136 Graft vs Host Disease (GVHD) Andrea Velardi (new, int¿l) 137 Principles of Immune Suppression Andrea Velardi (new, int¿l) 138 Late Effects of Bone Marrow Transplantation Andrea Velardi (new, int¿l) Part XIV: Allergy 139 Allergy and the Immunologic Basis of Atopic Disease Donald Y.M. Leung 140 Diagnosis of Allergic Disease Dan Atkins and Donald Y.M. Leung 141 Principles of Treatment of Allergic Disease Dan Atkins and Donald Y.M. Leung 142 Allergic Rhinitis Henry Milgrom and Donald Y.M. Leung 143 Childhood Asthma Andrew H. Liu, Ronina Covar (new), and Donald Y.M. Leung 144 Atopic Dermatitis (Atopic Eczema) Donald Y.M. Leung 145 Insect Allergy Scott H. Sicherer and Donald Y.M. Leung 146 Ocular Allergies Mark Boguniewicz and Donald YM Leung 147 Urticaria and Angioedema (Hives) Donald Y.M. Leung 148 Anaphylaxis Hugh A. Sampson and Donald Y.M. Leung 149 Serum Sickness Scott H. Sicherer and Donald Y.M. Leung 150 Adverse Reactions to Drugs Mark Boguniewicz and Donald YM Leung 151 Adverse Reactions to Foods Hugh A. Sampson and Donald Y.M. Leung Part XV: Rheumatology (New Title) 152 Evaluation of Suspected Rheumatic Disease Michael L. Miller 153 Treatment of Rheumatic Diseases Daniel J. Lovell, Michael L. Miller, James T. Cassidy 154 Juvenile Rheumatoid Arthritis Michael L. Miller, James T. Cassidy 155 Ankylosing Spondylitis and Other Spondyloarthropathies Michael L. Miller, Ross E. Petty 156 Postinfectious Arthritis and Related Conditions Michael L. Miller, James T. Cassidy 157 Systemic Lupus Erythematosus Marisa S. Klein-Gitelman, Michael L. Miller 157.1 Neonatal Lupus Marisa S. Klein-Gitelman, Michael L. Miller 158 Juvenile Dermatomyositis Lauren M. Pachman 159 Scleroderma Michael L. Miller 160 Beh?et¿s Disease Abraham Gedalia 161 Sjögren¿s Syndrome Abraham Gedalia 162 Periodic Fever Syndromes Abraham Gedalia 162.1 Familial Mediterranean Fever Abraham Gedalia 163 Amyloidosis Abraham Gedalia 164 Sarcoidosis Margaret W. Leigh 165 Kawasaki Disease Anne H. Rowley, Stanford T. Shulman 166 Vasculitis Syndromes Michael L. Miller, Lauren M. Pachman 166.1 Henoch-Schönlein Purpura Michael L. Miller, Lauren M. Pachman 166.2 Takayasu Arteritis Michael L. Miller, Lauren M. Pachman 166.3 Polyarteritis Nodosa Michael L. Miller, Lauren M. Pachman 166.4 Wegener Granulomatosis Michael L. Miller, Lauren M. Pachman 166.5 Other Vasculitic Syndromes Michael L. Miller, Lauren M. Pachman 167 Musculoskeletal Pain Syndromes Michael L. Miller 167.1 Fibromyalgia Michael L. Miller 167.2 Complex Regional Pain Syndrome (Reflex Sympathetic Dystrophy Michael L. Miller 167.3 Erythromelalgia Michael L. Miller 167.2 Reflex Sympathetic Dystrophy (RSD still the current term, or change to Complex Regional Pain Syndrome?) Michael L. Miller 167.3 Erythromelalgia Michael L. Miller 168 Miscellaneous Conditions Associated With Arthritis Michael L. Miller Part XVI: Infectious Diseases Section 1. General Considerations 169 Diagnostic Microbiology Anita K. Zaidi and Donald A. Goldmann Section 2. Preventive Measures (NEW) 170 (NEW) Immunization Practices Walter Orenstein (new) 170.1 (NEW) International Vaccines Walter Orenstein (new) 171 Infection Control and Prophylaxis Margaret C. Fisher 172 Childcare and Communicable Diseases Linda A. Waggoner-Fountain (new) 173 Health Advice for Children Traveling Internationally Chandy C. John and Robert A. Salata 174 Fever Keith R. Powell 175 Fever Without a Focus Keith R. Powell 176 Sepsis and Shock Maria Enrione (new), Keith R. Powell 177 Infections in Immunocompromised Persons Marian G. Michaels, Michael Green 178 Infections Associated with Medical Devices Patricia M. Flynn, Fred F. Barrett Section 3. Antibiotic Therapy (NEW) 179 Principles of Antibacterial Therapy Mark R. Schleiss (new) Section 4. Gram-Positive Bacterial Infections 180 Staphylococcus James K. Todd 180.1 Staphylococcus aureus James K. Todd 180.2 Toxic Shock Syndrome James K. Todd 180.3 Coagulase-Negative Staphylococci James K. Todd 181 Streptococcus pneumoniae (Pneumococcus) Jon S. Abramson, Gary D. Overturf 182 Group A Streptococcus Michael A. Gerber 182.1 Rheumatic Fever Michael A. Gerber 183 Group B Streptococcus Catherine S. Lachenauer and Michael R. Wessels 184 Non¿Group A or B Streptococcus Michael A. Gerber 184 Enterococcus David B. Haslam 186 Diphtheria (Corynebacterium diphtheriae) E. Stephen Buescher 187 Listeria monocytogenes Robert S. Baltimore 188 Actinomyces Richard F. Jacobs and Gordon E. Schutze 189 Nocardia Richard F. Jacobs and Gordon E. Schutze Section 5. Gram Negative Bacterial Infections 190 Neisseria meningitidis (Meningococcus) Charles R. Woods 191 Neisseria gonorrhoeae (Gonococcus) Toni Darville 192 Haemophilus influenzae Robert S. Daum 193 Chancroid (Haemophilus ducreyi) Parvin Azimi 194 Pertussis (Bordetella pertussis and B. parapertussis) Sarah S. Long 195 Salmonella Zulfiqar Ahmed Bhutta (new, int'l) 195.1 Nontyphoidal Salmonellosis Zulfiqar Ahmed Bhutta (new, int'l) 195.2 Enteric Fever Zulfiqar Ahmed Bhutta (new, int'l) 196 Shigella Thomas G. Cleary 197 Escherichia coli Thomas G. Cleary 198 Cholera (Vibrio cholerae) Jacqueline L. Deen (new, int'l) 199 Campylobacter Gloria P. Heresi and James R. Murphy 200 Yersinia James R. Murphy and Gloria P. Heresi 200.1 Yersinia enterocolitica Gloria P. Heresi and James R. Murphy 200.2 Yersinia pseudotuberculosis James R. Murphy and Gloria P. Heresi 200.3 Yersinia pestis Gloria P. Heresi and James R. Murphy 201 Aeromonas and Plesiomonas James R. Murphy and Gloria P. Heresi 201.1 Aeromonas Gloria P. Heresi and James R. Murphy 201.2 Plesiomonas shigelloides James R. Murphy and Gloria P. Heresi 202 Pseudomonas, Burkholderia, and Stenotrophomonas Robert S. Baltimore 202.1 Pseudomonas aeruginosa Robert S. Baltimore 202.2 Burkholderia Robert S. Baltimore 202.3 Stenotrophomonas Robert S. Baltimore 203 Tularemia (Francisella tularensis) Gordon E. Schutze and Richard F. Jacobs 204 Brucella Gordon E. Schutze and Richard F. Jacobs 205 Legionella Lucy S. Tompkins 206 Bartonella Barbara W. Stechenberg 206.1 Bartonellosis (Bartonella bacilliformis) Barbara W. Stechenberg 206.2 Cat-Scratch Disease (Bartonella henselae) Barbara W. Stechenberg 206.3 Trench Fever (Bartonella quintana) Barbara W. Stechenberg 206.4 Bacillary Angiomatosis and Bacillary Peliosis Hepatis (Bartonellahenselae and Bartonella quintana) Barbara W. Stechenberg Section 6: Anaerobic Bacterial Infections 207 Botulism (Clostridium botulinum) Stephen S. Arnon 208 Tetanus (Clostridium tetani) Stephen S. Arnon 209 Pseudomembranous Colitis (Clostridium difficile) Margaret C. Fisher 210 Other Anaerobic Infections Margaret C. Fisher Section 7: Mycobacterial Infections 211 (NEW) Principles of Antimycobacterial Therapy Mark R. Schleiss (new) 212 Tuberculosis (Mycobacterium tuberculosis) Flor M. Munoz, Jeffery R. Starke 213 Leprosy (Mycobacterium leprae) Dwight A. Powell 214 Nontuberculous Mycobacteria Dwight A. Powell Section 8. Spirochectal Infections 215 Syphilis (Treponema pallidum) Parvin Azimi 216 Nonvenereal Treponemal Infections Parvin Azimi 216.1 Yaws (Treponema pertenue) Parvin Azimi 216.2 Endemic Syphilis (Treponema pallidum subsp. endemicum) Parvin Azimi 216.3 Pinta (Treponema carateum) Parvin Azimi 217 Leptospira Parvin Azimi 218 Relapsing Fever (Borrelia) Parvin Azimi 219 Lyme Disease (Borrelia burgdorferi) Eugene D. Shapiro Section 9. Mycroplasmal Infections 220 Mycoplasma pneumoniae Dwight A. Powell 221 Genital Mycoplasmas (Mycoplasma hominis and Ureaplasma urealyticum) Dwight A. Powell Section 10. Chlamydial Infections 222 Chlamydiophila pneumoniae Margaret R. Hammerschlag 223 Chlamydia trachomatis Margaret R. Hammerschlag 223.1 Trachoma Margaret R. Hammerschlag 223.2 Genital Tract Infections Margaret R. Hammerschlag 223.3 Conjunctivitis and Pneumonia in Newborns Margaret R. Hammerschlag 223.4 Lymphogranuloma Venereum (LGV) Margaret R. Hammerschlag 224 Psittacosis (Chlamydia psittaci) Margaret R. Hammerschlag Section 11. Rickettsial Infections 225 Spotted Fever Group Rickettsioses J. Stephen Dumler 225.1 Rocky Mountain Spotted Fever (Rickettsia rickettsii) J. Stephen Dumler 225.2 Mediterranean Spotted Fever or Boutonneuse Fever (Rickettsia conorii) J. Stephen Dumler 225.3 Rickettsialpox (Rickettsia akari) J. Stephen Dumler 226 Scrub Typhus (Orientia tsutsugamushi) J. Stephen Dumler 227 Typhus Group Rickettsioses J. Stephen Dumler 227.1 Murine Typhus (Rickettsia typhi) J. Stephen Dumler 227.2 Epidemic Typhus (Rickettsia prowazekii) J. Stephen Dumler 228 Ehrlichioses J. Stephen Dumler 229 Q Fever (Coxiella burnetii) J. Stephen Dumler Section 12. Fungal Infections 230 Principles of Antifungal Therapy Mark R. Schleiss (new) 231 Candida Martin E. Weisse , Stephen C. Aronoff 231.1 Neonatal Infections Martin E. Weisse , Stephen C. Aronoff 231.2 Infections in Immunocompetent Children and Adolescents Martin E. Weisse , Stephen C. Aronoff 231.3 Infections in Immunocompromised Children and Adolescents Martin E. Weisse , Stephen C. Aronoff 231.4 Chronic Mucocutaneous Candidiasis Martin E. Weisse , Stephen C. Aronoff 232 Cryptococcus neoformans Stephen C. Aronoff 233 Malassezia Martin E Weisse 234 Aspergillus Stephen C. Aronoff 234.1 Hypersensitivity Syndromes Stephen C. Aronoff 234.2 Saprophytic (Noninvasive) Syndromes Stephen C. Aronoff 234.3 Invasive Disease Stephen C. Aronoff 235 Histoplasmosis (Histoplasma capsulatum) Stephen C. Aronoff 236 Blastomycosis (Blastomyces dermatitidis) Stephen C. Aronoff 237 Coccidioidomycosis (Coccidioides immitis) Demosthenes Pappagianis 238 Paracoccidioides brasiliensis Stephen C. Aronoff 239 Sporotrichosis (Sporothrix schenckii) Stephen C. Aronoff 240 Zygomycosis Stephen C. Aronoff 241 Pneumocystis jirovecii Frank Gigliotti (new) Section 13. Viral Infections 242 Principles of Antiviral Therapy Mark R. Schleiss (new) 243 Measles Wilbert H. Mason (new) 243.1 Subacute Sclerosing Panencephalitis Wilbert H. Mason (new) 244 Rubella Wilbert H. Mason (new) 244.1 Progressive Rubella Panencephalitis Wilbert H. Mason (new) 245 Mumps Wilbert H. Mason (new) 246 Polioviruses Eric A.F. Simoes 247 Nonpolio Enteroviruses Mark J. Abzug 248 Parvovirus B19 William C. Koch 249 Herpes Simplex Virus Lawrence R. Stanberry 250 Varicella-Zoster Virus Martin G. Myers, Jane F. Seward, Phil LaRussa 251 Epstein-Barr Virus Hal B. Jenson 252 Cytomegalovirus Sergio Stagno 253 Roseola (Human Herpesviruses 6, 7) Charles T. Leach 254 Human Herpesvirus 8 Charles T. Leach 255 Influenza Viruses Peter F. Wright 256 Parainfluenza Viruses Peter F. Wright 257 Respiratory Syncytial Virus Kenneth McIntosh 258 Human Metapneumovirus James E. Crowe, Jr. (new) 259 Adenoviruses Kenneth McIntosh 260 Rhinoviruses Kenneth McIntosh 261 Coronavirus Stanley E. Read (new) 261.1 SARS Stanley E. Read (new) 262 Rotaviruses, Calicivirus, and Astrovirus (new title) Dorsey M. Bass 263 Papillomaviruses Anna-Barbara Moscicki 264 Arboviral Encephalitis of North America Scott B. Halstead 265 Arboviral Encephalitis Outside North America Scott B. Halstead 265.1 Venezuelan Equine Encephalitis Scott B. Halstead 265.2 Japanese Encephalitis Scott B. Halstead 265.3 Tick-Borne Encephalitis Scott B. Halstead 266 Dengue Fever and Dengue Hemorrhagic Fever Scott B. Halstead 267 Yellow Fever Scott B. Halstead 268 Other Viral Hemorrhagic Fevers Scott B. Halstead 269 Lymphocytic Choriomeningitis Virus Hal B. Jenson 270 Hantaviruses Scott B. Halstead 271 Rabies Philip Toltzis (new) 272 Polyomaviruses Hal B. Jenson 273 Acquired Immunodeficiency Syndrome (Human Immunodeficiency Virus) Ram Yogev, Ellen Gould Chadwick 274 Human T-Cell Lymphotropic Viruses Types I and II Hal B. Jenson 275 Transmissible Spongiform Encephalopathies David M. Asher Section 14. Antiparasitic Therapy (NEW) 276 Principles of Antiparasitic Therapy Mark R. Schleiss (new) Section 15. Protozoan Diseases 277 Primary Amebic Meningoencephalitis Martin E. Weisse and Stephen C. Aronoff 278 Amebiasis Chandy C. John, Robert A. Salata (new) 279 Giardiasis and Balantidiasis Chandy C. John (new) 279.1 Giardia lamblia Chandy C. John (new) 279.2 Balantidiasis Chandy C. John (new) 280 Spore-Forming Intestinal Protozoa Patricia M. Flynn 281 Trichomoniasis (Trichomonas vaginalis) Chandy C. John, Robert A. Salata 282 Leishmaniasis (Leishmania) Peter C. Melby 283 African Trypanosomiasis (Sleeping Sickness; Trypanosoma brucei complex) Robert A. Bonomo, Robert A. Salata 284 American Trypanosomiasis (Chagas Disease; Trypanosoma cruzi) Robert A. Bonomo, Robert A. Salata 285 Malaria (Plasmodium) Peter J. Krause 286 Babesiosis (Babesia) Peter J. Krause 287 Toxoplasmosis (Toxoplasma gondii) Rima McLeod, Jack S. Remington Section 16. Helminthic Diseases 288 Ascariasis (Ascaris lumbricoides) James W. Kazura 289 Hookworms (Ancylostoma and Necator americanus) Peter J. Hotez 289.1 Cutaneous Larva Migrans 290 Trichuriasis (Trichuris trichuria) James W. Kazura 291 Enterobiasis (Enterobius vermicularis) James W. Kazura 292 Strongyloidiasis (Strongyloides stercoralis) James W. Kazura 293 Lymphatic Filariasis (Brugia malayi, B. timori, and Wuchereria bancrofti) James W. Kazura 294 Other Tissue Nematodes James W. Kazura 295 Toxocariasis (Visceral and Ocular Larva Migrans) James W. Kazura 296 Trichinosis (Trichinella spiralis) James W. Kazura 297 Schistosomiasis (Schistosoma) Charles H. King 298 Flukes: (Liver, Lung, and Intestinal) Charles H. King 299 Adult Tapeworm Infections Ronald Blanton 300 Cysticercosis Ronald Blanton 301 Echinococcosis (Echinococcus granulosus and E. multilocularis) Ronald Blanton Part XVII: The Digestive System Section 1. Clinical Manifestations of Gastrointestinal Disease 302 Normal Digestive Tract Phenomena Robert Wyllie 303 Major Symptoms and Signs of Digestive Tract Disorders Robert Wyllie Section 2. The Oral Cavity 304 Development and Developmental Anomalies of the teeth Norman Tinanoff 305 Disorders of the Oral Cavity Associated with Other Conditions Norman Tinanoff 306 Malocclusion Norman Tinanoff 307 Cleft Lip and Palate Norman Tinanoff 308 Syndromes with Oral Manifestations Norman Tinanoff 309 Dental Caries Norman Tinanoff 310 Periodontal Diseases Norman Tinanoff 311 Dental Trauma Norman Tinanoff 312 Common Lesions of the Oral Soft Tissues Norman Tinanoff 313 Diseases of the Salivary Glands and Jaws Norman Tinanoff 314 Diagnostic Radiology in Dental Assessment Norman Tinanoff Section 3. The Esophagus 315 Embryology, Anatomy, and Function of the Esophagus Susan Orenstein 315.1 Common Clinical Manifestations and Diagnostic Aids Susan Orenstein 316 Congenital Anomalies: Esophageal Atresia and Tracheoesophageal Fistula Susan Orenstein 316.1 Congenital Anomalies: Laryngotracheoesophageal Clefts Susan Orenstein 317 Obstructing and Motility Disorders of the Esophagus Susan Orenstein 318 Dysmotility Susan Orenstein 319 Hiatal Hernia Susan Orenstein 320 Dysmotility Susan Orenstein 320.1 Gastroesophageal Reflux Disease (GERD) Susan Orenstein 321 Non-GERD Esophagitis Susan Orenstein 322 Esophageal Perforation Susan Orenstein 323 Esophageal Varices Susan Orenstein 324 Ingestions Susan Orenstein 324.1 Foreign Bodies in the Esophagus Susan Orenstein 324.2 Caustic Ingestions Susan Orenstein Section 4. Stomach and Intestines 325 Normal Development, Structure, and Function Robert Wyllie 326 Pyloric Stenosis and Other Congenital Anomalies of the Stomach Robert Wyllie 326.1 Hypertropic Pyloric Stenosis Robert Wyllie 326.2 Congenital Gastric Outlet Obstruction Robert Wyllie 326.3 Gastric Duplication Robert Wyllie 326.4 Gastric Volvulus Robert Wyllie 326.5 Hypertrophic Gastropathy Robert Wyllie 327 Intestinal Atresia, Stenosis, and Malrotation Robert Wyllie 327.1 Duodenal Obstruction Robert Wyllie 327.2 Jejunal and Ileal Atresia and Obstruction Robert Wyllie 327.3 Malrotation Robert Wyllie 328 Intestinal Duplications, Meckel Diverticulum, and Other Robert Wyllie 328.1 Intestinal Duplication Robert Wyllie 328.2 Meckel Diverticulum and Other Remnants of the Omphalomesenteric Duct Robert Wyllie 329 Motility Disorders and Hirschsprung Disease Robert Wyllie 329.1 Chronic Intestinal Pseudo-Obstruction Robert Wyllie 329.2 Functional Constipation Robert Wyllie 330 Ileus, Adhesions, Intussusception, and Closed-Loop Obstructions Robert Wyllie 330.1 Ileus Robert Wyllie 330.2 Adhesions Robert Wyllie 330.3 Intussusception Robert Wyllie 330.4 Closed-Loop Obstructions Robert Wyllie 331 Foreign Bodies and Bezoars Robert Wyllie 331.1 Foreign Bodies in the Stomach and Intestine Robert Wyllie 331.2 Bezoars Robert Wyllie 332 Peptic Ulcer Disease on Children Steve Czinn (new) 332.1 Secondary or Stress (Peptic) Ulcer Disease Steve Czinn (new) 332.2 Zollinger-Ellison Syndrome Steve Czinn (new) 333 Inflammatory Bowel Disease Jeffrey Hyams 333.1 Chronic Ulcerative Colitis Jeffrey Hyams 333.2 Crohn Disease (Regional Enteritis, Regional lleitis, Granulomatous Colitis) Jeffrey Hyams 334 Food Allergy (Food Hypersensitivity) and Eosinophilic Gastrointestinal Disorders Jeffrey Hyams 335 Disorders of Malabsorption Manu Sood (new) 335.1 Evaluation of Children with Suspected Intestinal Malabsorption Manu Sood (new) 335.2 Gluten-Sensitive Enteropathy (Celiac Disease, Celiac Sprue) Manu Sood (new) 335.3 Other Malabsorptive Snydromes Manu Sood (new) 335.4 Intestinal Infections Manu Sood (new) 335.5 Immunodeficiency Manu Sood (new) 335.6 Immunoproliferative Small Intestinal Disease Manu Sood (new) 335.7 Short Bowel Syndrome Manu Sood (new) 335.8 Chronic Malnutrition Manu Sood (new) 335.9 Enzyme Deficiencies Manu Sood (new) 335.1-0 Liver and Biliary Disorders Manu Sood (new) 335.11 Defects of Absorption or Transport Manu Sood (new) 336 Small Intestinal Transplantation Jorges D. Reyes (new) 337 Gastroenteritis and Probiotics (new) Zulfiqar Ahmed Bhutta (new, int'l) 338 Chronic Diarrhea Fayez K. Ghishan 338.1 Diarrhea from Hormone-Secreting Tumors Joel Shilyansky 339 Recurrent Abdominal Pain of Childhood Robert Wyllie 340 Acute Appendicitis Keith Oldham (new) and John J. Aiken 341 Surgical Conditions of the Anus, Rectum, and Colon Michael D. Klein (new) 341.1 Anorectal Malformations Michael D. Klein (new) 341.2 Anal Fissure Michael D. Klein (new) 341.3 Perianal Abscess and Fistula Michael D. Klein (new) 341.4 Hemorrhoids Michael D. Klein (new) 341.5 Rectal Prolapse Michael D. Klein (new) 341.6 Pilonidal Sinus and Abscess Michael D. Klein (new) 342 Benign Tumors of the Digestive Tract Joel Shilyansky 343 Inguinal Hernias John J. Aiken Section 5. Exocrine Pancreas 344 Embryology, Anatomy, and Physiology Steven L. Werlin 344.1 Anatomic Abnormalities Steven L. Werlin 344.2 Physiology Steven L. Werlin 345 Pancreatic Function Tests Steven L. Werlin 346 Disorders of the Exocrine Pancreas Steven L. Werlin 347 Treatment of Pancreatic Insufficiency Steven L. Werlin 348 Pancreatitis Steven L. Werlin 348.1 Acute Pancreatitis Steven L. Werlin 348.2 Chronic Pancreatitis Steven L. Werlin 349 Pseudocyst of the Pancreas Steven L. Werlin 350 Pancreatic Tumors Steven L. Werlin Section 6. The Liver and Biliary System 351 Morphogenesis of the Liver and Biliary System William F. Balistreri 352 Manifestations of Liver Disease William F. Balistreri 352.1 Evaluation of Patients with Possible Liver Dysfunction William F. Balistreri 353 Cholestasis William F. Balistreri 353.1 Neonatal Cholestasis William F. Balistreri 353.2 Cholestasis in the Older Child William F. Balistreri 354 Metabolic Diseases of the Liver William F. Balistreri 354.1 Inherited Deficient Conjugation of Bilirubin (Familial Nonhemolytic Unconjugated Hyperbilirubinemia) William F. Balistreri 354.2 Wilson Disease William F. Balistreri 354.3 Hepatic Copper Overload Syndrome William F. Balistreri 354.4 Indian Childhood Cirrhosis William F. Balistreri 354.5 Neonatal Iron Storage Disease (NISD) William F. Balistreri 354.6 Miscellaneous Metabolic Diseases of the Liver William F. Balistreri 355 Viral Hepatitis William F. Balistreri 355.1 Hepatitis in Neonates William F. Balistreri 356 Liver Abscess William F. Balistreri 357 Liver Disease Associated with Systemic Disorders William F. Balistreri 358 Reye Syndrome and the Mitochondrial Hepatopathies William F. Balistreri 359 Autoimmune (Chronic) Hepatitis Benjamin L. Shneider and Frederick J. Suchy 360 Drug- and Toxin-Induced Liver Injury Frederick J. Suchy 361 Fulminant Hepatic Failure Frederick J. Suchy 362 Cystic Diseases of the Biliary Tract and Liver Frederick J. Suchy 363 Diseases of the Gallbladder Frederick J. Suchy 364 Portal Hypertension and Varices Frederick J. Suchy 365 Liver Transplantation Melissa Hurwitz, Kenneth L. Cox Section 7. Peritoneum 366 Malformations Jeffrey S. Hyams 367 Ascites Jeffrey S. Hyams 367.1 Chylous Ascites Jeffrey S. Hyams 368 Peritonitis Jeffrey S. Hyams 368.1 Acute Primary Peritonitis Jeffrey S. Hyams 368.2 Acute Secondary Peritonitis Jeffrey S. Hyams 368.3 Acute Secondary Localized Peritonitis (Peritoneal Abscess) Jeffrey S. Hyams 369 Epigastric Hernia John Aiken (new) 369.1 Incisional Hernia John Aiken (new) Part XVIII: Respiratory System Section 1. Development and Function 370 Respiratory Pathophysiology and Regulation Ashok Sarnaik (new) 371 Diagnostic Approach to Respiratory Disease Thomas P. Green (new) 372 Sudden Infant Death Syndrome Carl E. Hunt and Fern R. Hauck Section 2. Disorders of the Respiratory Tract (new title) 373 Congenital Disorders of the Nose Joseph Haddad, Jr. 374 Acquired Disorders of the Nose Joseph Haddad, Jr. 374.1 Foreign Body Joseph Haddad, Jr. 374.2 Epistaxis Joseph Haddad, Jr. 375 Nasal Polyps Joseph Haddad, Jr. 376 The Common Cold Ronald B. Turner and Gregory F. Hayden 377 Sinusitis Diane E. Pappas and J. Owen Hendley 378 Acute Pharyngitis Gregory F. Hayden and Ronald B. Turner 379 Retropharyngeal Abscess, Lateral Pharyngeal (Parapharyngeal) Abscess, and Peritonsillar Cellulitis/Abscess Diane E. Pappas and J. Owen Hendley 380 Tonsils and Adenoids Ralph F. Wetmore 381 Chronic or Recurrent Respiratory Symptoms Thomas P. Green (new) 382 Croup, Epiglottitis and Bacterial Tracheitis Genie E. Roosevelt 383 Congenital Anomalies of the Larynx, Trachea, and Bronchi Lauren Holinger 383.1 Laryngomalacia Lauren Holinger 383.2 Congenital Subglottic Stenosis Lauren Holinger 383.3 Vocal Cord Paralysis Lauren Holinger 383.4 Congenital Laryngeal Webs and Atresia Lauren Holinger 383.5 Congenital Subglottic Hemangioma Lauren Holinger 383.6 Laryngoceles and Saccular Cysts Lauren Holinger 383.7 Posterior Laryngeal Cleft and Laryngoesophageal Cleft Lauren Holinger 383.8 Vascular and Cardiac Anomalies Lauren Holinger 383.9 Tracheal Stenoses, Webs, and Atresia Lauren Holinger 383.1 Foregut Cysts Lauren Holinger 384 Foreign Bodies of the Airway Lauren Holinger 384.1 Laryngeal Foreign Bodies Lauren Holinger 384.2 Tracheal Foreign Bodies Lauren Holinger 384.3 Bronchial Foreign Bodies Lauren Holinger 385 Laryngotracheal Stenosis, Subglottic Stenosis Lauren Holinger 385.1 Congenital Subglottic Stenosis Lauren Holinger 385.2 Acquired Laryngotracheal Stenosis Lauren Holinger 386 Bronchomalacia and Tracheomalacia Jonathan D. Finder 387 Neoplasms of the Larynx, Trachea, and Bronchi Lauren Holinger 387.1 Vocal Nodules Lauren Holinger 387.2 Recurrent Respiratory Papillomatosis Lauren Holinger 387.3 Congenital Subglottic Hemangioma Lauren Holinger 387.4 Vascular Anomalies Lauren Holinger 387.5 Other Laryngeal Neoplasms Lauren Holinger 387.6 Tracheal Neoplasms Lauren Holinger 387.7 Bronchial Tumors Lauren Holinger 388 Wheezing, Bronchiolitis, and Bronchitis Chapter Heading, no text 388.1 Wheezing in Infants and Bronchiolotis Denise Goodman and Kimberly Watts (new) 388.2 Bronchitis Denise Goodman 389 Emphysema and Overinflation Steven Boas and Glenna B. Winnie 390 ?1-Antitrypsin Deficiency and Emphysema Glenna B. Winnie and Steven Boas 391 Other Distal Airway Diseases Steven Boas 391.1 Bronciolitis Obliterans Steven Boas 391.2 Follicular Bronchitis Steven Boas 391.3 Pulmonary Alveolar Microlithiasis Steven Boas 392 Congenital Disorders of the Lung Jonathan D. Finder and Peter Michelson (NEW) 392.1 Pulmonary Agenesis and Aplasia Jonathan D. Finder and Peter Michelson (NEW) 392.2 Pulmonary Hypoplasia Jonathan D. Finder and Peter Michelson (NEW) 392.3 Cystic Adenomatoid Malformation Jonathan D. Finder and Peter Michelson (NEW) 392.4 Pulmonary Sequestration Jonathan D. Finder and Peter Michelson (NEW) 392.5 Bronchogenic Cysts Jonathan D. Finder and Peter Michelson (NEW) 392.6 Congenital Pulmonary Lymphangiectasia Jonathan D. Finder and Peter Michelson (NEW) 392.7 Lung Hernia Jonathan D. Finder and Peter Michelson (NEW) 392.8 Other Congenital Malformations of the Lung Jonathan D. Finder and Peter Michelson (NEW) 393 Pulmonary Edema Robert Mazor and Thomas P. Green 394 Aspiration Syndromes John Columbo 395 Chronic Recurrent Aspiration John Columbo 396 Parenchymal Disease with Prominent Hypersensitivity, Eosinophilic Infiltration, or Toxin- Mediated Injury Oren Lakser 396.1 Hypersensitivity to Inhaled Materials Oren Lakser 396.2 Silo Filler¿s Disease Oren Lakser 396.3 Paraquat Lung Oren Lakser 396.4 Eosinophilic Lung Disease (Formerly Löffler Syndrome) Oren Lakser 397 Pneumonia (including Slowly Resolving Pneumonia) Theodore C. Sectish and Charles G. Prober 398 Bronchiectasis Oren Lakser 399 Pulmonary Abscess Oren Lakser 400 Cystic Fibrosis Thomas F. Boat 401 Primary Ciliary Dyskinesia (Immotile Cilia Syndrome) Gabriel G. Haddad 402 Interstitial Lung Diseases Michelle S. Howenstine 403 Pulmonary Alveolar Proteinosis Aaron Hamvas, Lawrence M. Nogee, and F. Sessions Cole 404 Inherited Disorders of Surfactant Protein Metabolism Aaron Hamvas, Lawrence M. Nogee, and F. Sessions Cole 405 Pulmonary Hemosiderosis Thomas P. Green (new) 406 Pulmonary Hemorrhage, Embolism, and Infarction Thomas P. Green 406.1 Pulmonary Embolism and Infarction Thomas P. Green 406.2 Hemoptysis Thomas P. Green 407 Atelectasis Ranna Rozenfeld 408 Pulmonary Tumors Susanna A. McColley 409 Pleurisy Glenna Winnie 409.1 Dry or Plastic Pleurisy Glenna Winnie 409.2 Serofibrinous Pleurisy Glenna Winnie 409.3 Purulent Pleurisy (Empyema) Glenna Winnie 410 Pneumothorax Glenna B. Winnie 411 Pneumomediastinum Glenna B. Winnie 412 Hydrothorax Glenna B. Winnie 413 Hemothorax Glenna B. Winnie 414 Chylothorax Glenna B. Winnie 415 Bronchopulmonary Dysplasia Steven Lestrud 416 Skeletal Diseases Influencing Pulmonary Function Steven Boas 416.1 Pectus Excavatum (Funnel Chest) Steven Boas 416.2 Pectus Carinatum and Fissuri Sterni Steven Boas 416.3 Asphyxiating Thoracic Dystrophy (Thoracic-Pelvic-Phalangeal Dystrophy) Steven Boas 416.4 Achondroplasia Steven Boas 416.5 Kyphoscoliosis: Adolescent Idiopathic Scoliosis and 417.6 (old 409.6)Congential Scoliosis Steven Boas 416.6 Congential Scoliosis Congenital Rib Anomalies Steven Boas 417 Neuromuscular Diseases with Pulmonary Consequences David Gozal and Leila Kheirandish (new) 418 Extrapulmonary Diseases with Pulmonary Manifestations Susanna A. McColley 419 Chronic Severe Respiratory Insufficiency Zehava Noah and Cynthia Budek Part XIX: The Cardiovascular System Section 1. Developmental Biology of the Cardiovascular System 420 Cardiac Development Daniel Bernstein 420.1 Early Cardiac Morphogenesis Daniel Bernstein 420.2 Cardiac Looping Daniel Bernstein 420.3 Cardiac Septation Daniel Bernstein 420.4 Aortic Arch Development Daniel Bernstein 420.5 Cardiac Differentiation Daniel Bernstein 420.6 Developmental Changes in Cardiac Function Daniel Bernstein 421 The Fetal to Neonatal Circulatory Transition Daniel Bernstein 421.1 The Fetal Circulation Daniel Bernstein 421.2 The Transitional Circulation Daniel Bernstein 421.3 The Neonatal Circulation Daniel Bernstein 421.4 Persistent Pulmonary Hypertension of the Neonate (Persistence of Fetal Circulatory Pathways) Daniel Bernstein Section 2. Evaluation of the Cardiovascular System 422 History and Physical Examination Daniel Bernstein 423 Laboratory Evaluation Daniel Bernstein 423.1 Radiologic Assessment Daniel Bernstein 423.2 Electrocardiography Daniel Bernstein 423.3 Hematologic Data Daniel Bernstein 423.4 Echocardiography Daniel Bernstein 423.5 Exercise Testing Daniel Bernstein 423.6 Magnetic Resonance Imaging, Electron Beam Computed Tomography, and Radionuclide Studies Daniel Bernstein 423.7 Cardiac Catheterization Daniel Bernstein Section 3. Congenital Heart Diseases 424 Epidemiology of Congenital Heart Disease Daniel Bernstein 425 Evaluation of the Infant or Child with Congenital Heart Disease Daniel Bernstein 426 Acyanotic Congenital Heart Disease: The Left-to-Right Shunt Lesions Daniel Bernstein 426.1 Atrial Septal Defect Daniel Bernstein 426.2 Ostium Secundum Defect Daniel Bernstein 426.3 Sinus Venosus Atrial Septal Defect Daniel Bernstein 426.4 Partial Anomalous Pulmonary Venous Return Daniel Bernstein 426.5 Atrioventricular Septal Defects (Ostium Primum and Atrioventricular Canal or Endocardial Cushion Defects) Daniel Bernstein 426.6 Ventricular Septal Defect Daniel Bernstein 426.7 Supracristal Ventricular Septal Defect with Aortic Insufficiency Daniel Bernstein 426.8 Patent Ductus Arteriosus Daniel Bernstein 426.9 Aorticopulmonary Window Defect Daniel Bernstein 426.1 Coronary-Arteriovenous Fistula (Coronary-Cameral Fistula) Daniel Bernstein 426.11 Ruptured Sinus of Valsalva Aneurysm Daniel Bernstein 427 Acyanotic Congenital Heart Disease: The Obstructive Lesions Daniel Bernstein 427.1 Pulmonary Valve Stenosis with Intact Ventricular Septum Daniel Bernstein 427.2 Infundibular Pulmonary Stenosis and Double-Chamber Right Ventricle Daniel Bernstein 427.3 Pulmonary Stenosis in Combination with an Intracardiac Shunt Daniel Bernstein 427.4 Peripheral Pulmonary Stenosis Daniel Bernstein 427.5 Aortic Stenosis Daniel Bernstein 427.6 Coarctation of the Aorta Daniel Bernstein 427.7 Coarctation with Ventricular Septal Defect Daniel Bernstein 427.8 Coarctation with Other Cardiac Anomalies and Interrupted Aortic Arch Daniel Bernstein 427.9 Congenital Mitral Stenosis Daniel Bernstein 427.1 Pulmonary Venous Hypertension Daniel Bernstein 428 Acyanotic Congenital Heart Disease: Regurgitant Lesions Daniel Bernstein 428.1 Pulmonary Valvular Insufficiency and Congenital Absence of the Pulmonary Valve Daniel Bernstein 428.2 Congenital Mitral Insufficiency Daniel Bernstein 428.3 Mitral Valve Prolapse Daniel Bernstein 428.4 Tricuspid Regurgitation Daniel Bernstein 429 Cyanotic Congenital Heart Disease: Evaluation of the Critically Ill Neonate with Cyanosis and Respiratory Distress Daniel Bernstein 430 Cyanotic Congenital Heart Lesions: Lesions Associated with Decreased Pulmonary Blood Flow Daniel Bernstein 430.1 Tetralogy of Fallot Daniel Bernstein 430.2 Pulmonary Atresia with Ventricular Septal Defect Daniel Bernstein 430.3 Pulmonary Atresia with Intact Ventricular Septum Daniel Bernstein 430.4 Tricuspid Atresia Daniel Bernstein 430.5 Double-Outlet Right Ventricle (DORV) with Pulmonary Stenosis Daniel Bernstein 430.6 Transposition of the Great Arteries with Ventricular Septal Defect and Pulmonary Stenosis Daniel Bernstein 430.7 Ebstein Anomaly of the Tricuspid Valve Daniel Bernstein 431 Cyanotic Congenital Heart Disease: Lesions Associated with Increased Pulmonary Blood Flow Daniel Bernstein 431.1 D-Transposition of the Great Arteries Daniel Bernstein 431.2 D-Transposition of the Great Arteries with Intact Ventricular Septum Daniel Bernstein 431.3 Transposition of the Great Arteries with Ventricular Septal Defect Daniel Bernstein 431.4 L-Transposition of the Great Arteries (Corrected Transposition) Daniel Bernstein 431.5 Double-Outlet Right Ventricle Without Pulmonary Stenosis Daniel Bernstein 431.6 Double-Outlet Right Ventricle with Transposition of the Great Arteries (Taussig-Bing Anomaly) Daniel Bernstein 431.7 Total Anomalous Pulmonary Venous Return Daniel Bernstein 431.8 Truncus Arteriosus Daniel Bernstein 431.9 Single Ventricle (Double-Inlet Ventricle, Univentricular Heart) Daniel Bernstein 431.10 Hypoplastic Left Heart Syndrome Daniel Bernstein 431.11 Abnormal Positions of the Heart and the Heterotaxy Syndromes (Asplenia, Polysplenia) Daniel Bernstein 432 Other Congenital Heart and Vascular Malformations Daniel Bernstein 432.1 Anomalies of the Aortic Arch Daniel Bernstein 432.2 Anomalous Origin of the Coronary Arteries Daniel Bernstein 432.3 Pulmonary Arteriovenous Fistula Daniel Bernstein 432.4 Ectopia Cordis Daniel Bernstein 432.5 Diverticulum of the Left Ventricle Daniel Bernstein 433 Pulmonary Hypertension Daniel Bernstein 433.1 Primary Pulmonary Hypertension Daniel Bernstein 433.2 Pulmonary Vascular Disease (Eisenmenger Syndrome) Daniel Bernstein 434 General Principles of Treatment of Congenital Heart Disease Daniel Bernstein 434.1 The Adult with Congenital Heart Disease Daniel Murphy (new) Section 4. Cardiac Arrhythmias 435 Disturbances of Rate and Rhythm of the Heart Anne Dubin 435.1 Principles of Antiarrhythmic Therapy Anne Dubin 435.2 Sinus Arrhythmias and Extrasystoles Anne Dubin 435.3 Supraventricular Tachycardia Anne Dubin 435.4 Ventricular Tachyarrhythmias Anne Dubin 435.5 Long Q-T Syndrome Anne Dubin 435.6 Bradyarrhythmias Anne Dubin 435.7 Sick Sinus Syndrome Anne Dubin 436 Sudden Death Anne Dubin Section 5. Acquired Heart Disease 437 Infective Endocarditis Daniel Bernstein 438 Rheumatic Heart Disease Daniel Bernstein Section 6. Diseases of the Myocardium and Pericardium 439 Diseases of the Myocardium Daniel Bernstein 439.1 Dilated Cardiomyopathy Daniel Bernstein 439.2 Hypertrophic Cardiomyopathy Daniel Bernstein 439.3 Restrictive Cardiomyopathies Daniel Bernstein 439.4 Myocarditis Daniel Bernstein 439.5 Nonviral Causes of Myocarditis Daniel Bernstein 439.6 Endocardial Fibroelastosis Daniel Bernstein 440 Diseases of the Pericardium Daniel Bernstein 440.1 Constrictive Pericarditis Daniel Bernstein 441 Tumors of the Heart Daniel Bernstein Section 7. Cardiac Therapeutics (Heart Failure and End-Stage Cardiac Disease) 442 Heart Failure Daniel Bernstein 442.1 Cardiogenic Shock Daniel Bernstein 443 Pediatric Heart and Heart-Lung Transplantation Daniel Bernstein 443.1 Pediatric Heart Transplantation Daniel Bernstein 443.2 Heart-Lung and Lung Transplantation Daniel Bernstein Section 8. Diseases of the Peripheral Vascular System 444 Diseases of the Blood Vessels (Aneurysms and Fistulas) Daniel Bernstein 445 Systemic Hypertension Daniel Bernstein Part XX: Hematology Section 1. The Hematopoietic System 446 Development of the Hematopoietic System Robin K. Ohls 447 The Anemias Bertil E. Glader Section 2. Anemias of Inadequate Production 448 Congenital Hypoplastic Anemia (Diamond-Blackfan Anemia ) Bertil E. Glader 449 Pearson Marrow-Pancreas Syndrome Bertil E. Glader 450 Acquired Pure Red Blood Cell Anemias Bertil E. Glader 451 Anemia of Chronic Disorders (ACD) and Renal Disease Bertil E. Glader 452 Congenital Dyserythropoietic Anemias (CDA) Bertil E. Glader 453 Physiologic Anemia of Infancy Bertil E. Glader 454 Megaloblastic Anemias Bertil E. Glader 454.1 Folic Acid Deficiency Bertil E. Glader 454.2 Vitamin B12 (Cobalamin) Deficiency Bertil E. Glader 454.3 Other Rare Megaloblastic Anemias Bertil E. Glader 455 Iron Deficiency Anemia Bertil E. Glader 456 Other Microcytic Anemias Bertil E. Glader Section 3. Hemolytic Anemias 457 Definitions and Classification of Hemolytic Anemias George B. Segel 458 Hereditary Spherocytosis George B. Segel 459 Hereditary Elliptocytosis George B. Segel 460 Hereditary Stomatocytosis George B. Segel 461 Other Membrane Defects George B. Segel 462 Hemoglobinopathies Michael R. DeBaun (new) 462.1 Sickle Cell Disease Michael R. DeBaun (new) 462.2 Sickle Cell Trait (Hemoglobin AS) Michael R. DeBaun (new) 462.3 Other Hemoglobinopathies Michael R. DeBaun (new) 462.4 Unstable Hemoglobin Disorders Michael R. DeBaun (new) 462.5 Abnormal Hemoglobins with Increased Oxygen Affinity Michael R. DeBaun (new) 462.6 Abnormal Hemoglobins Causing Cyanosis Michael R. DeBaun (new) 462.7 Hereditary Methemoglobinemia Michael R. DeBaun (new) 462.8 Syndromes of Hereditary Persistence of Fetal Hemoglobin (HPFH) Michael R. DeBaun (new) 462.9 Thalassemia Syndromes Michael R. DeBaun (new) 463 Enzymatic Defects George B. Segel 463.1 Pyruvate Kinase (PK) Deficiency George B. Segel 463.2 Other Glycolytic Enzyme Deficiencies George B. Segel 463.3 Glucose-6-Phosphate Dehydrogenase (G6PD) and Related Deficiencies George B. Segel 464 Hemolytic Anemias Resulting from Extracellular Factors George B. Segel 465 Hemolytic Anemias Secondary to Other Extracellular Factors George B. Segel Section 4. Polycythemia (Erythrocytosis) 466 Primary Polycythemia (Polycythemia Rubra Vara) Bruce M. Camitta 467 Secondary Polycythemia Bruce M. Camitta Section 5. The Pancytopenias 468 The Constitutional Pancytopenias Melvin Freedman (new) 469 The Acquired Pancytopenias Jeffrey D. Hord Section 6. Risks of Blood Component Transfusions 470 Red Blood Cell Transfusions and Erythropoietin Therapy Ronald G. Strauss 471 Platelet Transfusions Ronald G. Strauss 472 Neutrophil (Granulocyte) Transfusions Ronald G. Strauss 473 Fresh Frozen Plasma Transfusions Ronald G. Strauss 474 Risks of Blood Transfusions Ronald G. Strauss Section 7. Hemorrhage and Thrombotic Diseases 475 Hemostasis J. Paul Scott and Robert R. Montgomery 475.1 Hemostatic Mechanism J. Paul Scott and Robert R. Montgomery 475.2 The Clinical and Laboratory Evaluation J. Paul Scott and Robert R. Montgomery 476 Hereditary Clotting Factor Deficiencies (Bleeding Disorders) J. Paul Scott and Robert R. Montgomery 476.1 Factor VIII or Factor IX Deficiency (Hemophilia A or B) J. Paul Scott and Robert R. Montgomery 476.2 Factor IX Deficiency (Hemophilia C) J. Paul Scott and Robert R. Montgomery 476.3 Deficiencies of the Contact Factors (Nonbleeding Disorders) J. Paul Scott and Robert R. Montgomery 476.4 Factor VII Deficiency J. Paul Scott and Robert R. Montgomery 476.5 Factor X Deficiency J. Paul Scott and Robert R. Montgomery 476.6 Prothrombin (Factor II) Deficiency J. Paul Scott and Robert R. Montgomery 476.7 Factor V Deficiency J. Paul Scott and Robert R. Montgomery 476.8 Combined Deficiency of Factors V and VIII J. Paul Scott and Robert R. Montgomery 476.9 Fibrinogen Deficiency J. Paul Scott and Robert R. Montgomery 476.10 Factor XIII Deficiency (Fibrin-Stabilizing Factor or Transglutaminase Deficiency) J. Paul Scott and Robert R. Montgomery 476.11 Antiplasmin or Plasminogen Activator Inhibitor (PAI) Deficiency J. Paul Scott and Robert R. Montgomery 477 von Willebrand Disease J. Paul Scott and Robert R. Montgomery 478 Hereditary Predisposition to Thrombosis J. Paul Scott and Robert R. Montgomery 479 Acquired Thrombotic Disorders J. Paul Scott and Robert R. Montgomery 480 Postneonatal Vitamin K Deficiency J. Paul Scott and Robert R. Montgomery 481 Liver Disease J. Paul Scott and Robert R. Montgomery 482 Acquired Inhibitors of Coagulation J. Paul Scott and Robert R. Montgomery 483 Disseminated Intravascular Coagulation (Consumptive Coagulopathy) J. Paul Scott and Robert R. Montgomery 484 Platelet and Blood Vessel Disorders J. Paul Scott and Robert R. Montgomery 484.1 Idiopathic Thrombocytopenic Purpura J. Paul Scott and Robert R. Montgomery 484.2 Drug-Induced Thrombocytopenia J. Paul Scott and Robert R. Montgomery 484.3 Nonimmune Platelet Destruction J. Paul Scott and Robert R. Montgomery 484.4 Hemolytic-Uremic Syndrome J. Paul Scott and Robert R. Montgomery 484.5 Thrombotic Thrombocytopenic Purpura (TTP) J. Paul Scott and Robert R. Montgomery 484.6 Kasabach-Merritt Syndrome J. Paul Scott and Robert R. Montgomery 484.7 Sequestration J. Paul Scott and Robert R. Montgomery 484.8 Congenital Thrombocytopenic Syndromes J. Paul Scott and Robert R. Montgomery 484.9 Neonatal Thrombocytopenia J. Paul Scott and Robert R. Montgomery 484.10 Thrombocytopenia Due to Acquired Disorders Causing Decreased Production J. Paul Scott and Robert R. Montgomery 484.11 Platelet Function Disorders J. Paul Scott and Robert R. Montgomery 484.12 Acquired Disorders of Platelet Function J. Paul Scott and Robert R. Montgomery 484.13 Congenital Abnormalities of Platelet Function J. Paul Scott and Robert R. Montgomery 484.14 Disorders of the Blood Vessels J. Paul Scott and Robert R. Montgomery Section 8. The Spleen 485 Anatomy and Function of the Spleen Bruce M. Camitta 486 Splenomegaly Bruce M. Camitta 487 Hyposplenism, Splenic Trauma, and Splenectomy Bruce M. Camitta Section 9. The Lymphatic System 488 Anatomy and Function of the Lymphatic System Bruce M. Camitta 489 Abnormalities of Lymphatic vessels Bruce M. Camitta 490 Lymphadenopathy Bruce M. Camitta Part XXI: Cancer and Benign Tumors 491 Epidemiology of Childhood and Adolescent Cancer Nina S. Kaddan-Lottick (new) 492 Molecular and Cellular Biology of Cancer Laura L. Worth 493 Principles of Diagnosis Archie Bleyer 494 Principles of Treatment Archie Bleyer 495 The Leukemias David G.Tubergen and Archie Bleyer 495.1 Acute Lymphoblastic Leukemia David G.Tubergen and Archie Bleyer 495.2 Acute Myelogenous Leukemia David G.Tubergen and Archie Bleyer 495.3 Down Syndrome and Acute Leukemia and Myeloproliferation David G.Tubergen and Archie Bleyer 495.4 Chronic Myelogenous Leukemia David G.Tubergen and Archie Bleyer 495.5 Juvenile Chronic Myelocytic Leukemia David G.Tubergen and Archie Bleyer 495.6 Infant Leukemia David G.Tubergen and Archie Bleyer 496 Lymphoma Mitchell Cairo (new) and M. Brigid Bradley (new) 496.1 Hodgkin¿s Disease Mitchell Cairo (new) and M. Brigid Bradley (new) 496.2 Non-Hodgkin¿s Lymphoma (NHL) Mitchell Cairo (new) and M. Brigid Bradley (new) 497 Brain Tumors in Children John F. Kuttesch, Jr. and Joann L. Ater 498 Neuroblastoma Joann L. Ater 499 Neoplasms of the Kidney Norman Jaffe and Vicki Huff 500 Soft Tissue Sarcomas Carola A.S. Arndt 501 Neoplasms of Bone Carola A.S. Arndt 501.1 Malignant Tumors of Bone Carola A.S. Arndt 501.2 Benign Tumors and Tumor-like Processes of Bone Carola A.S. Arndt 502 Retinoblastoma Cynthia E. Herzog 503 Gonadal and Germ Cell Neoplasms Cynthia E. Herzog 504 Neoplasms of the Liver Cynthia E. Herzog 505 Benign Vascular Tumors Cynthia E. Herzog 506 Rare Tumors Cynthia E. Herzog 507 Histiocytosis Syndromes of Childhood Stephen Ladisch Part XXII: Nephrology Section 1. Glomerular Disease 508 Introduction to Glomerular Diseases Ellis D. Avner and Ira D. Davis 508.1 Anatomy of the Glomerulus Ellis D. Avner and Ira D. Davis 508.2 Glomerular Filtration Ellis D. Avner and Ira D. Davis 508.3 Glomerular Diseases Ellis D. Avner and Ira D. Davis Section 2. Conditions Particularly Associated with Hematuria 509 Clinical Evaluation of the Child with Hematuria Ellis D. Avner and Ira D. Davis 510 Isolated Glomerular Disease with Recurrent Gross Hematuria Ellis D. Avner and Ira D. Davis 510.1 IgA Nephropathy (Berger Nephropathy) Ellis D. Avner and Ira D. Davis 510.2 Alport Syndrome Ellis D. Avner and Ira D. Davis 510.3 Thin Glomerular Basement Membrane Disease Ellis D. Avner and Ira D. Davis 511 Glomerulonephritis Associated with Infections Ellis D. Avner and Ira D. Davis 511.1 Acute Poststreptococcal Glomerulonephritis Ellis D. Avner and Ira D. Davis 511.2 Other Chronic Infections Ellis D. Avner and Ira D. Davis 512 Membranous Glomerulopathy (Glomerulonephritis) Ellis D. Avner and Ira D. Davis 513 Membranoproliferative (Mesangiocapillary) Glomerulonephritis Ellis D. Avner and Ira D. Davis 514 Glomerulonephritis Associated With Systemic Lupus Erythematosus Ellis D. Avner and Ira D. Davis 515 Henoch-Schonlein Purpura Nephritis Ellis D. Avner and Ira D. Davis 516 Rapidly Progressive (Crescentic) Glomerulonephritis Ellis D. Avner and Ira D. Davis 517 Goodpasture Disease Ellis D. Avner and Ira D. Davis 518 Hemolytic-Uremic Syndrome Ellis D. Avner and Ira D. Davis 519 Upper Urinary Tract Causes of Hematuria Ellis D. Avner and Ira D. Davis 519.1 Interstitial Nephritis Ellis D. Avner and Ira D. Davis 519.2 Toxic Nephropathy Ellis D. Avner and Ira D. Davis 519.3 Cortical Necrosis Ellis D. Avner and Ira D. Davis 519.4 Pyelonephritis Ellis D. Avner and Ira D. Davis 519.5 Nephrocalcinosis Ellis D. Avner and Ira D. Davis 519.6 Vascular Abnormalities Ellis D. Avner and Ira D. Davis 519.7 Renal Vein Thrombosis Ellis D. Avner and Ira D. Davis 519.8 Idiopathic Hypercalciuria Ellis D. Avner and Ira D. Davis 520 Hematologic Diseases Causing Hematuria Ellis D. Avner and Ira D. Davis 520.1 Sickle Cell Nephropathy Ellis D. Avner and Ira D. Davis 520.2 Coagulopathies and Thrombocytopenia Ellis D. Avner and Ira D. Davis 521 Anatomic Abnormalities Associated with Hematuria Ellis D. Avner and Ira D. Davis 521.1 Congenital Anomalies Ellis D. Avner and Ira D. Davis 521.2 Autosomal Recessive Polycystic Kidney Disease Ellis D. Avner and Ira D. Davis 521.3 Autosomal Dominant Polycystic Kidney disease Ellis D. Avner and Ira D. Davis 521.4 Trauma Ellis D. Avner and Ira D. Davis 521.5 Renal Tumors Ellis D. Avner and Ira D. Davis 522 Lower Urinary Tract Causes of Hematuria Ellis D. Avner and Ira D. Davis 522.1 Infectious Causes of Cystitis and Urethritis Ellis D. Avner and Ira D. Davis 522.2 Hemorrhagic Cystitis Ellis D. Avner and Ira D. Davis 522.3 Heavy Exercise Ellis D. Avner and Ira D. Davis 522.4 Munchhausen by Proxy Ellis D. Avner and Ira D. Davis Section 3. Conditions Particularly Associated with Proteinuria 523 Introduction to the Child with Proteinuria Beth A. Vogt, Ellis D. Avner 524 Transient Proteinuria Beth A. Vogt, Ellis D. Avner 525 Orthostatic (Postural) Proteinuria Beth A. Vogt, Ellis D. Avner 526 Fixed Proteinuria Beth A. Vogt, Ellis D. Avner 526.1 Glomerular Proteinuria Beth A. Vogt, Ellis D. Avner 526.2 Tubular Proteinuria Beth A. Vogt, Ellis D. Avner 527 Nephrotic Syndrome Beth A. Vogt, Ellis D. Avner 527.1 Idiopathic Nephrotic Syndrome Beth A. Vogt, Ellis D. Avner 587.2 Secondary Nephrotic Syndrome Beth A. Vogt, Ellis D. Avner 527.3 Congenital Nephrotic Syndrome Beth A. Vogt, Ellis D. Avner Section 4. Tubular Disorders 528 Tubular Function Katherine MacRae Dell, Ellis D. Avner 529 Renal Tubular Acidosis Katherine MacRae Dell, Ellis D. Avner 529.1 Proximal (Type II) Renal Tubular Acidosis Katherine MacRae Dell, Ellis D. Avner 529.2 Distal (Type I) Renal Tubular Acidosis Katherine MacRae Dell, Ellis D. Avner 529.3 Hyperkalemic (Type IV) Renal Tubular Acidosis Katherine MacRae Dell, Ellis D. Avner 529.4 Rickets Associated with Renal Tubular Acidosis Russell W. Chesney 530 Nephrogenic Diabetes Insipidus Katherine MacRae Dell, Ellis D. Avner 531 Bartter/Gitelman Syndromes and Other Inherited Tubular Transport Abnormalities Katherine MacRae Dell, Ellis D. Avner 531.1 Bartter Syndrome Katherine MacRae Dell, Ellis D. Avner 531.2 Gitelman Syndrome Katherine MacRae Dell, Ellis D. Avner 531.3 Other Inherited Tubular Transport Abnormalities Katherine MacRae Dell, Ellis D. Avner 532 Tubulointerstitial Nephritis Katherine MacRae Dell, Ellis D. Avner Section 5. Toxic Nephropathies: Renal Failure 533 Toxic Nephropathy Beth A. Vogt, Ellis D. Avner 534 Cortical Necrosis Beth A. Vogt, Ellis D. Avner 535 Renal Failure Beth A. Vogt, Ellis D. Avner 535.1 Acute Renal Failure 535.2 Chronic Renal Failure 535.3 End-Stage Renal Disease 536 Renal Transplantation Rodrigo E. Urizar Part XXIII: Urologic Disorders in Infants and Children 537 Congenital Anomalies and Dysgenesis of the Kidneys Jack S. Elder 538 Urinary Tract Infections Jack S. Elder 539 Vesicoureteral Reflux Jack S. Elder 540 Obstructions of the Urinary Tract Jack S. Elder 541 Anomalies of the Bladder Jack S. Elder 542 Neuropathic Bladder Jack S. Elder 543 Voiding Dysfunction Jack S. Elder 544 Anomalies of the Penis and Urethra Jack S. Elder 545 Disorders and Anomalies of the Scrotal Contents Jack S. Elder 546 Trauma to the Genitourinary Tract Jack S. Elder 547 Urinary Lithiasis Jack S. Elder Part XXIV: Gynecologic Problems of Childhood 548 History and Physical Examination Joseph S. Sanfilippo 549 Vulvovaginitis Joseph S. Sanfilippo 550 Bleeding Joseph S. Sanfilippo 551 Breast Disorders Joseph S. Sanfilippo 552 Hirsutism Joseph S. Sanfilippo 553 Neoplasms Joseph S. Sanfilippo 554 Vulvovaginal and Müllerian Anomalies Joseph S. Sanfilippo 555 Special Gynecologic Needs Joseph S. Sanfilippo 556 Gynecologic Imaging Joseph S. Sanfilippo Part XXV: The Endocrine System Section 1. Disorders of the Hypothalamus and Pituitary Gland 557 Hormones of the Hypothalamus and Pituitary John S. Parks and Eric Felner (new) 558 Hypopituitarism John S. Parks and Eric Felner (new) 559 Diabetes Insipidus David T. Breault and Joseph A. Majzoub 559.1 Causes of Hypernatremia 560 Other Abnormalities of Arginine Vasopressin Metabolism and Action David T. Breault and Joseph A. Majzoub 561 Hyperpituitarism, Tall Stature, and Overgrowth Syndromes Pinchas Cohen 562 Physiology of Puberty Luigi Garibaldi 563 Disorders of Pubertal Development Luigi Garibaldi 563.1 Gonadotropin-Dependent Precocious Puberty Luigi Garibaldi 563.2 Precocious Puberty Resulting from Organic Brain Lesions Luigi Garibaldi 563.3 Precocious Puberty Following Irradiation of the Brain Luigi Garibaldi 563.4 Syndrome of Precocious Puberty and Hypothyroidism Luigi Garibaldi 563.5 Gonadotropin-Secreting Tumors Luigi Garibaldi 563.6 McCune-Albright Syndrome Luigi Garibaldi 563.7 Familial Male Gonadotropin-Independent Precocious Puberty Luigi Garibaldi 563.8 Incomplete (Partial) Precocious Development Luigi Garibaldi 563.9 Medicational Precocity Luigi Garibaldi Section 2. Disorders of the Thyroid Gland 564 Thyroid Development and Physiology Stephen LaFranchi 564.1 Thyroid Hormone Studies Stephen LaFranchi 565 Defects of Thyroxine-Binding Globulin Stephen LaFranchi 566 Hypothyroidism Stephen LaFranchi 567 Thyroiditis Stephen LaFranchi 568 Goiter Stephen LaFranchi 568.1 Congenital Goiter Stephen LaFranchi 568.2 Endemic Goiter and Cretinism Stephen LaFranchi 568.3 Sporadic Goiter Stephen LaFranchi 568.4 Intratracheal Goiter Stephen LaFranchi 569 Hyperthyroidism Stephen LaFranchi 569.1 Graves Disease Stephen LaFranchi 569.2 Congenital Hyperthyroidism Stephen LaFranchi 570 Carcinoma of the Thyroid Stephen LaFranchi 570.1 Solitary Thyroid Nodule Stephen LaFranchi 570.2 Medullary Carcinoma Stephen LaFranchi Section 3. Disorders of the Parathyroid Glands 571 Hormones and Peptides of Calcium Homeostasis and Bone Metabolism Daniel A. Doyle, Angelo M. DiGeorge 572 Hypoparathyroidism Daniel A. Doyle, Angelo M. DiGeorge 573 Pseudohypoparathyroidism Daniel A. Doyle, Angelo M. DiGeorge 574 Hyperparathyroidism Daniel A. Doyle, Angelo M. DiGeorge Section 4 Disorders of the Adrenal Glands 575 The Physiology of the Adrenal Gland Perrin C White 575.1 Histology and Embryology Perrin C White 575.2 Adrenal Steroid Biosynthesis Perrin C White 575.3 Regulation of the Adrenal Cortex Perrin C White 575.4 Adrenal Steroid Hormone Actions Perrin C White 575.5 Adrenal Medulla Perrin C White 576 Adrenocortical Insufficiency Perrin C White 576.1 Primary Adrenal Insufficiency Perrin C White 576.2 Secondary Adrenal Insufficiency Perrin C White 577 Congenital Adrenal Hyperplasia and Related Disorders Perrin C White 577.1 Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency Perrin C White 577.2 Congenital Adrenal Hyperplasia due to 11?-Hydroxylase Deficiency Perrin C White 577.3 Congenital Adrenal Hyperplasia due to 3?-Hydroxysteriod Dehydrogenase Deficiency Perrin C White 577.4 Congenital Adrenal Hyperplasia due to 17-Hydroxylase Deficiency Perrin C White 577.5 Lipoid Adrenal Hyperplasia Perrin C White 577.6 Aldosterone Synthase Deficiency Perrin C White 577.7 Glucocorticoid-Suppressible Hyperaldosteronism Perrin C White 578 Cushing¿s Syndrome Perrin C White 579 Primary Aldosteronism Perrin C White 580 Adrenal Tumors Perrin C White 580.1 Virilizing Adrenocortical Tumors Perrin C White 580.2 Feminizing Adrenal Tumors Perrin C White 581 Pheochromocytoma Perrin C White 582 Adrenal Masses Perrin C White 582.1 Adrenal Incidentaloma Perrin C White 582.2 Adrenal Calcification Perrin C White Section 5. Disorders of the Gonads 583 Development and Function of the Gonads Robert Rapaport 584 Hypofunction of the Testes Robert Rapaport 584.1 Hypergonadotropic Hypogonadism in the Male (Primary Hypogonadism) Robert Rapaport 584.2 Hypogonadotropic Hypogonadism in the Male (Secondary Hypogonadism) Robert Rapaport 585 Pseudoprecocity Resulting from Tumors of the Testes Robert Rapaport 586 Gynecomastia Robert Rapaport 587 Hypofunction of the Ovaries Robert Rapaport 587.1 Hypergonadotropic Hypogonadism in the Female (Primary Hypogonadism) Robert Rapaport 587.2 Hypogonadotropic Hypogonadism in the Female (Secondary Hypogonadism) Robert Rapaport 588 Pseudoprecocity Due to Lesions of the Ovary Robert Rapaport 589 Intersex Robert Rapaport 589.1 46,XX Intersex (46,XX with Virilization) Robert Rapaport 589.2 46,XY Intersex (46XY under Virilization) Robert Rapaport 589.3 True Gonadal Intersex (TGI) Robert Rapaport Section 6. Diabetes Mellitus In Children 590 Diabetes Mellitus Ramin Alemzadeh and David T. Wyatt 590.1 Introduction and Classification Ramin Alemzadeh and David T. Wyatt 590.2 Type 1 Diabetes Mellitus (Immune Mediated) Ramin Alemzadeh and David T. Wyatt 590.3 Type 2 Diabetes Mellitus Ramin Alemzadeh and David T. Wyatt 590.4 Other Specific Types of Diabetes Ramin Alemzadeh and David T. Wyatt Part XXVI: Neurology 591 Neurologic Evaluation Robert H. A. Haslam 592 Congenital Anomalies of the Central Nervous System Michael V. Johnston and Steven Kinsman 592.1 Neural Tube Defects Michael V. Johnston and Steven Kinsman 592.2 Spina Bifida Occulta Michael V. Johnston and Steven Kinsman 592.3 Meningocele Michael V. Johnston and Steven Kinsman 592.4 Myelomeningocele Michael V. Johnston and Steven Kinsman 592.5 Encephalocele Michael V. Johnston and Steven Kinsman 592.6 Anencephaly Michael V. Johnston and Steven Kinsman 592.7 Disorders of Neuronal Migration Michael V. Johnston and Steven Kinsman 592.8 Agenesis of the Corpus Callosum Michael V. Johnston and Steven Kinsman 592.9 Agenesis of the Cranial Nerves Michael V. Johnston and Steven Kinsman 592.10 Microcephaly Michael V. Johnston and Steven Kinsman 592.11 Hydrocephalus Michael V. Johnston and Steven Kinsman 592.12 Craniosynostosis Michael V. Johnston and Steven Kinsman 593 Seizures in Childhood Michael V. Johnston 593.1 Febrile Seizures Michael V. Johnston 593.2 Unprovoked Seizures Michael V. Johnston 593.3 Partial Seizures Michael V. Johnston 593.4 Generalized Seizures Michael V. Johnston 593.5 Mechanisms of Seizures Michael V. Johnston 593.6 Treatment of Epilepsy Michael V. Johnston 593.7 Neonatal Seizures Michael V. Johnston 593.8 Status Epilepticus Michael V. Johnston 594 Conditions that Mimic Seizures Michael V. Johnston 595 Headaches Robert H. A. Haslam 595.1 Migraine Robert H. A. Haslam 595.2 Organic Headaches Robert H. A. Haslam 595.3 Tension or Stress Headaches Robert H. A. Haslam 596 Neurocutaneous Syndromes Robert H. A. Haslam 596.1 Neurofibromatosis Robert H. A. Haslam 596.2 Tuberous Sclerosis Robert H. A. Haslam 596.3 Sturge-Weber Disease Robert H. A. Haslam 596.4 Von Hippel-Lindau Disease Robert H. A. Haslam 596.5 Linear Nevus Syndrome Robert H. A. Haslam 596.6 PHACE Syndrome Robert H. A. Haslam 597 Movement Disorders Michael V. Johnston 597.1 Ataxias Michael V. Johnston 597.2 Chorea, Athetosis, Tremor Michael V. Johnston 597.3 Dystonia Michael V. Johnston 597.4 Tics Michael V. Johnston 598 Encephalopathies Michael V. Johnston 598.1 Cerebral Palsy Michael V. Johnston 598.2 Mitochondrial Encephalopathies Michael V. Johnston 598.3 Other Encephalopathies Michael V. Johnston 599 Neurodegenerative Disorders of Childhood Michael V. Johnston 599.1 Sphingolipidoses Michael V. Johnston 599.2 Neuronal Ceroid Lipofuscinoses Michael V. Johnston 599.3 Adrenoleukodystrophy Michael V. Johnston 599.4 Sialidosis Michael V. Johnston 599.5 Miscellaneous Disorders Michael V. Johnston 600 Demyelinating Disorders of the CNS Michael V. Johnston 600.1 MS Michael V. Johnston 600.2 ADEM Michael V. Johnston 601 Acute Stroke Syndromes Michael V. Johnston 601.1 Arterial Thrombosis/Embolism Michael V. Johnston 601.2 Venous Thrombosis Michael V. Johnston 601.3 Intracranial Hemorrhage Michael V. Johnston 601.4 Differential Diagnosis of Stroke-Like Events Michael V. Johnston 602 Central Nervous System Infections Charles G. Prober 602.1 Acute Bacterial Meningitis Beyond the Neonatal Period Charles G. Prober 602.2 Viral Meningoencephalitis, Including West Nile Virus Charles G. Prober 602.3 Eosinophilic Meningitis Charles G. Prober 603 Brain Abscess Robert H. A. Haslam 604 Pseudotumor Cerebri Robert H. A. Haslam 605 Spinal Cord Disorders Robert H. A. Haslam 605.1 Tethered Cord Robert H. A. Haslam 605.2 Diastematomyelia Robert H. A. Haslam 605.3 Syringomyelia Robert H. A. Haslam 605.4 Spinal Cord Tumors Robert H. A. Haslam 605.5 Spinal Cord Trauma Robert H. A. Haslam 605.6 Transverse Myelitis Robert H. A. Haslam 605.7 Arteriovenous Malformation Robert H. A. Haslam Part XXVII: Neuromuscular Disorders 606 Evaluation and Investigation Harvey B. Sarnat 607 Developmental Disorders of Muscle Harvey B. Sarnat 607.1 Myotubular Myopathy Harvey B. Sarnat 607.2 Congenital Muscle Fiber-Type Disproportion (CMFTD) Harvey B. Sarnat 607.3 Nemaline Rod Myopathy Harvey B. Sarnat 607.4 Central Core Disease Harvey B. Sarnat 607.5 Brain Malformations and Muscle Development Harvey B. Sarnat 607.6 Amyoplasia Harvey B. Sarnat 607.7 Muscular Dysgenesis (Proteus Syndrome Myopathy) Harvey B. Sarnat 607.8 Benign Congenital Hypotonia Harvey B. Sarnat 607.9 Arthrogryposis Harvey B. Sarnat 608 Muscular Dystrophies Harvey B. Sarnat 608.1 Duchenne and Becker Muscular Dystrophies Harvey B. Sarnat 608.2 Emery-Dreifuss Muscular Dystrophy Harvey B. Sarnat 608.3 Myotonic Muscular Dystrophy Harvey B. Sarnat 608.4 Limb-Girdle Muscular Dystrophy Harvey B. Sarnat 608.5 Facioscapulohumeral Muscular Dystrophy Harvey B. Sarnat 608.6 Congenital Muscular Dystrophy Harvey B. Sarnat 609 Endocrine Myopathies Harvey B. Sarnat 610 Metabolic Myopathies Harvey B. Sarnat 610.1 Periodic Paralyses (Potassium-Related) Harvey B. Sarnat 610.2 Malignant Hyperthermia Harvey B. Sarnat 610.3 Glycogenoses Harvey B. Sarnat 610.4 Mitochondrial Myopathies Harvey B. Sarnat 610.5 Lipid Myopathies Harvey B. Sarnat 610.6 Vitamin E Deficiency Myopathy Harvey B. Sarnat 611 Disorders of Neuromuscular Transmission and of Motor Neurons Harvey B. Sarnat 611.1 Myasthenia Gravis Harvey B. Sarnat 611.2 Spinal Muscular Atrophies Harvey B. Sarnat 612 Hereditary Motor-Sensory Neuropathies Harvey B. Sarnat 612.1 Peroneal Muscular Atrophy (Charcot-Marie-Tooth Disease, HMSN Type I) Harvey B. Sarnat 612.2 Peroneal Muscular Atrophy (Axonal Type) Harvey B. Sarnat 612.3 Déjerine-Sottas Disease (HMSN Type III) Harvey B. Sarnat 612.4 Roussy-Lévy Syndrome Harvey B. Sarnat 612.5 Refsum Disease Harvey B. Sarnat 612.6 Fabry Disease Harvey B. Sarnat 612.7 Giant Axonal Neuropathy Harvey B. Sarnat 612.8 Congenital Hypomyelinating Neuropathy Harvey B. Sarnat 612.9 Tomaculous Neuropathy Harvey B. Sarnat 612.10 Leukodystrophies Harvey B. Sarnat 613 Toxic Neuropathies Harvey B. Sarnat 614 Autonomic Neuropathies Harvey B. Sarnat 614.1 Familial Dysautonomia Harvey B. Sarnat 614.2 Other Autonomic Neuropathies Harvey B. Sarnat 615 Guillain-Barré Syndrome Harvey B. Sarnat 616 Bell Palsy Harvey B. Sarnat Part XXVIII: Disorders of the Eye Scott E. Olitsky, Denise Hug, Laura P. Smith 617 Growth and Development Scott E. Olitsky 618 Examination of the Eye Scott E. Olitsky 619 Abnormalities of Refraction and Accommodation Scott E. Olitsky 620 Disorders of Vision Scott E. Olitsky 621 Abnormalities of Pupil and Iris Scott E. Olitsky 622 Disorders of Eye Movement and Alignment Scott E. Olitsky 623 Abnormalities of the Lids Scott E. Olitsky 624 Disorders of the Lacrimal System Scott E. Olitsky 625 Disorders of the Conjunctiva Scott E. Olitsky 626 Abnormalities of the Cornea Scott E. Olitsky 627 Abnormalities of the Lens Scott E. Olitsky 628 Disorders of the Uveal Tract Scott E. Olitsky 629 Disorders of the Retina and Vitreous Scott E. Olitsky 630 Abnormalities of the Optic Nerve Scott E. Olitsky 631 Childhood Glaucoma Scott E. Olitsky 632 Orbital Abnormalities Scott E. Olitsky 633 Orbital Infections Scott E. Olitsky 633.1 Orbital Cellulitis Scott E. Olitsky 633.2 Dacroadenitis and Dacrocystadenitis Scott E. Olitsky 634 Injuries to the Eye Scott E. Olitsky Part XXIX: The Ear 635 Clinical Manifestations(discuss treatment of otitis media) Joseph Haddad, Jr. 636 Hearing Loss Joseph Haddad, Jr. 637 Congenital Malformations Joseph Haddad, Jr. 638 Diseases of the External Ear Joseph Haddad, Jr. 639 Otitis Media Joseph Kerschner (new) 640 The Inner Ear and Diseases of the Bony Labyrinth Joseph Haddad, Jr. 641 Traumatic Injuries of the Ear and Temporal Bone Joseph Haddad, Jr. 642 Tumors of the Ear and Temporal Bone Joseph Haddad, Jr. Part XXX: The Skin 643 Morphology of the Skin Joseph G. Morelli (new) 644 Evaluation of the Patient Joseph G. Morelli (new) 644.1 Cutaneous Manifestations of Systemic Diseases Joseph G. Morelli (new) 645 Principles of Therapy Joseph G. Morelli (new) 646 Diseases of the Neonate Joseph G. Morelli (new) 647 Cutaneous Defects Joseph G. Morelli (new) 648 Ectodermal Dysplasias Joseph G. Morelli (new) 649 Vascular Disorders Joseph G. Morelli (new) 650 Cutaneous Nevi Joseph G. Morelli (new) 651 Hyperpigmented Lesions Joseph G. Morelli (new) 652 Hypopigmented Lesions Joseph G. Morelli (new) 653 Vesiculobullous Disorders Joseph G. Morelli (new) 654 Eczematous Disorders Joseph G. Morelli (new) 655 Photosensitivity Joseph G. Morelli (new) 656 Diseases of the Epidermis Joseph G. Morelli (new) 657 Disorders of Keratinization Joseph G. Morelli (new) 658 Diseases of the Dermis Joseph G. Morelli (new) 659 Diseases of Subcutaneous Tissue Joseph G. Morelli (new) 660 Disorders of the Sweat Glands Joseph G. Morelli (new) 661 Disorders of Hair Joseph G. Morelli (new) 662 Disorders of the Nails Joseph G. Morelli (new) 663 Disorders of the Mucous Membranes Joseph G. Morelli (new) 664 Cutaneous Bacterial Infections Joseph G. Morelli (new) 665 Cutaneous Fungal Infections Joseph G. Morelli (new) 666 Cutaneous Viral Infections Joseph G. Morelli (new) 667 Arthropod Bites and Infestations Joseph G. Morelli (new) 668 Acne Joseph G. Morelli (new) 669 Tumors of the Skin Joseph G. Morelli (new) 670 Nutritional Dermatoses Joseph G. Morelli (new) Part XXXI: Bone and Joint Disorders Section 1. Orthopaedic Problems 671 Growth and Development John P. Dormans (new) 672 Evaluation of the Child John P. Dormans (new) 673 The Foot and Toes John P. Dormans (new) 673.1 Metatarsus Adductus John P. Dormans (new) 673.2 Calcaneovalgus Feet John P. Dormans (new) 673.3 Talipes Equinovarus (Clubfoot) John P. Dormans (new) 673.4 Congenital Vertical Talus John P. Dormans (new) 673.5 Hypermobile Pes Planus (Flexible Flatfeet) John P. Dormans (new) 673.6 Tarsal Coalition John P. Dormans (new) 673.7 Cavus Feet John P. Dormans (new) 673.8 Osteochondroses John P. Dormans (new) 673.9 Puncture Wounds of the Foot John P. Dormans (new) 673.10 Toe Deformities John P. Dormans (new) 673.11 Painful Foot John P. Dormans (new) 673.12 Shoes John P. Dormans (new) 674 Torsional and Angular Deformities John P. Dormans (new) 674.1 Normal Developmental of Limb John P. Dormans (new) 674.2 Evaluation John P. Dormans (new) 674.3 Torsional Deformities John P. Dormans (new) 674.4 Coronal Plane Deformities John P. Dormans (new) 674.5 Congenital Angular Deformities of the Tibia and Fibula John P. Dormans (new) 675 Leg Length Discrepancy John P. Dormans (new) 676 The Knee John P. Dormans (new) 676.1 Discoid Lateral Meniscus John P. Dormans (new) 676.2 Popliteal Cyst John P. Dormans (new) 676.3 Osteochondritis Dissecans John P. Dormans (new) 676.4 Osgood-Schlatter Disease John P. Dormans (new) 676.5 Idiopathic Adolescent Anterior Knee Pain Syndrome John P. Dormans (new) 676.6 Patellar Subluxation and Dislocation John P. Dormans (new) 677 The Hip John P. Dormans (new) 677.1 Developmental Dysplasia of the Hip John P. Dormans (new) 677.2 Toxic Synovitis (new title) John P. Dormans (new) 677.3 Legg-Calvé-Perthes Disease John P. Dormans (new) 677.4 Slipped Capital Femoral Epiphysis John P. Dormans (new) 678 The Spine John P. Dormans (new) 678.1 Idiopathic Scoliosis John P. Dormans (new) 678.2 Congenital Scoliosis John P. Dormans (new) 678.3 Neuromuscular Scoliosis, Syndromes, and Compensatory Scoliosis John P. Dormans (new) 678.4 Kyphosis John P. Dormans (new) 678.5 Back Pain in Children John P. Dormans (new) 678.6 Spondylolysis and Spondylolisthesis John P. Dormans (new) 678.7 Disk Space Infection John P. Dormans (new) 678.8 Intervertebral Disk Herniation John P. Dormans (new) 678.9 Tumors John P. Dormans (new) 679 The Neck John P. Dormans (new) 679.1 Torticollis John P. Dormans (new) 679.2 Klippel-Feil Syndrome John P. Dormans (new) 679.3 Atlantoaxial Instability John P. Dormans (new) 680 The Upper Limb John P. Dormans (new) 680.1 Sprengel Deformity John P. Dormans (new) 680.2 Shoulder Dislocation John P. Dormans (new) 680.3 Nursemaid¿s Elbow John P. Dormans (new) 680.4 Panner Disease John P. Dormans (new) 680.5 Ganglion John P. Dormans (new) 680.6 Radial Clubhand John P. Dormans (new) 680.7 Polydactyly John P. Dormans (new) 680.8 Syndactyly John P. Dormans (new) 680.9 Congenital Trigger Thumb and Finger John P. Dormans (new) 681 Arthrogryposis John P. Dormans (new) 681.1 Amyoplasia John P. Dormans (new) 682 Common Fractures John P. Dormans (new) 682.1 Unique Characteristics of Pediatric Fractures John P. Dormans (new) 682.2 Pediatric Fracture Patterns John P. Dormans (new) 682.3 Upper Extremity Fractures John P. Dormans (new) 682.4 Fractures of Lower Extremity John P. Dormans (new) 682.5 Operative Treatment John P. Dormans (new) 682.6 Complications of Fractures in Children John P. Dormans (new) 682.7 Outcomes Assessment John P. Dormans (new) 683 Osteomyelitis (new title) Richard M. Lampe 684 Septic Arthritis Richard M. Lampe Section 2. Sports Medicine 685 Epidemiology and Prevention Gregory L. Landry (new) 686 Management of Musculoskeletal Injury Gregory L. Landry (new) 686.1 Growth Plate Injuries Gregory L. Landry (new) 686.2 Shoulder Injuries Gregory L. Landry (new) 686.3 Elbow Injuries Gregory L. Landry (new) 686.4 Back Injuries Gregory L. Landry (new) 686.5 Hip and Pelvis Injuries Gregory L. Landry (new) 686.6 Knee Injuries Gregory L. Landry (new) 686.7 Shin Splints and Stress Fractures of the Lower Leg Gregory L. Landry (new) 686.8 Ankle Injuries Gregory L. Landry (new) 686.9 Foot Injuries Gregory L. Landry (new) 687 Head and Neck Injuries Gregory L. Landry (new) 688 Heat Injuries Gregory L. Landry (new) 689 Female Athletes: Menstrual Problems and Risk for Osteopenia Gregory L. Landry (new) 690 Ergogenic Aids Gregory L. Landry (new) 691 Specific Sports and Associated Injuries Gregory L. Landry (new) Section 3. The Skeletal Dysplasias 692 General Considerations William A. Horton and Jacqueline T. Hecht 693 Disorders of Involving Cartilage Matrix Proteins William A. Horton and Jacqueline T. Hecht 694 Disorders Involving Transmembrane Receptors William A. Horton and Jacqueline T. Hecht 695 Disorders Involving Ion Transporter William A. Horton and Jacqueline T. Hecht 696 Disorders Involving Transcription Factors William A. Horton and Jacqueline T. Hecht 697 Disorders Involving Defective Bone Resorption William A. Horton and Jacqueline T. Hecht 698 Disorders for Which Defects Are Poorly Understood or Unknown William A. Horton and Jacqueline T. Hecht 699 Osteogenesis Imperfecta (OI) Joan C. Marini 700 Marfan Syndrome Luther K. Robinson and Emily Fitzpatrick (new) Section 4. Metabolic Bone Disease 701 Bone Structure, Growth, and Hormonal Regulation Russell W. Chesney 702 Primary Chondrodystrophy (Metaphyseal Dysplasia) Russell W. Chesney 703 Hypophosphatasia Russell W. Chesney 704 Hyperphosphatasia Russell W. Chesney 705 Osteoporosis Russell W. Chesney Part XXXII: Environmental Health Hazards 706 Pediatric Radiation Injuries Thomas L. Slovis (new) 707 Chemical Pollutants Philip J. Landrigan and Joel A. Forman 708 Heavy Metal Intoxication Collin S. Goto 709 Lead Poisoning Morri Markowitz 710 Poisonings: Drugs, Chemicals, and Plants George C. Rodgers, Jr., and Tania Condurache 710.1 Epidemiology and Approach to Management George C. Rodgers, Jr., and Tania Condurache 710.2 Acetaminophen George C. Rodgers, Jr., and Tania Condurache 710.3 Salicylates George C. Rodgers, Jr., and Tania Condurache 710.4 Ibuprofen George C. Rodgers, Jr., and Tania Condurache 710.5 Antidepressants George C. Rodgers, Jr., and Tania Condurache 710.6 Clonidine George C. Rodgers, Jr., and Tania Condurache 710.7 Calcium Channel Blockers George C. Rodgers, Jr., and Tania Condurache 710.8 Iron George C. Rodgers, Jr., and Tania Condurache 710.9 Caustics George C. Rodgers, Jr., and Tania Condurache 710.10 Methanol and Ethylene Glycol George C. Rodgers, Jr., and Tania Condurache 710.11 Hydrocarbons George C. Rodgers, Jr., and Tania Condurache 710.12 Cholinesterase-Inhibiting Insecticides George C. Rodgers, Jr., and Tania Condurache 710.13 Toxic Gases George C. Rodgers, Jr., and Tania Condurache 710.14 Plants George C. Rodgers, Jr., and Tania Condurache 711 Nonbacterial Food Poisoning Stephen C. Aronoff 711.1 Mushroom Poisoning Stephen C. Aronoff 711.2 Solanine Poisoning Stephen C. Aronoff 711.3 Seafood Poisoning Stephen C. Aronoff 712 Biologic and Chemical Terrorism Theodore J. Cieslak and Fred M. Henretig 713 Animal and Human Bites Charles M. Ginsburg 713.1 Rat-Bite Fever Charles M. Ginsburg 713.2 Monkeypox Charles M. Ginsburg 714 Envenomations Steve Holve PART XXXIII: Laboratory Medicine 715 Laboratory Testing in Infants and Children John F. Nicholson and Michael A. Pesce 716 Reference Ranges for Laboratory Tests and Procedures John F. Nicholson and Michael A. Pesce 717 Medications Peter Gal, Michael D. Reed
Library of Congress Subject Headings for this publication:
Pediatrics.
Pediatrics.