Bibliographic Citation
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Title | Relations among impaired coronary flow reserve, left ventricular hypertrophy and thallium perfusion defects in hypertensive patients without obstructive coronary artery disease |
Creator/Author | Houghton, J.L. ; Frank, M.J. ; Carr, A.A. ; von Dohlen, T.W. ; Prisant, L.M. (School of Medicine, Medical College of Georgia, Augusta (USA)) |
Publication Date | 1990 Jan 01 |
OSTI Identifier | OSTI ID: 7105492 |
Other Number(s) | ISSN0735-1097; CODEN: JACCD |
Resource Type | Journal Article |
Resource Relation | Journal of the American College of Cardiology ; Vol/Issue: 15:1 |
Subject | 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics; CORONARIES-- BLOOD FLOW;HEART-- SCINTISCANNING;ISCHEMIA-- DIAGNOSIS; ELECTROCARDIOGRAMS;EXERCISE;HYPERTENSION;PERFUSED ORGANS;THALLIUM 201;VASODILATORS |
Related Subject | ARTERIES;BETA DECAY RADIOISOTOPES;BLOOD VESSELS;BODY;CARDIOVASCULAR AGENTS;CARDIOVASCULAR DISEASES;CARDIOVASCULAR SYSTEM;COUNTING TECHNIQUES;DAYS LIVING RADIOISOTOPES;DIAGNOSTIC TECHNIQUES;DIAGRAMS;DISEASES;DRUGS;ELECTRON CAPTURE RADIOISOTOPES;HEAVY NUCLEI;ISOMERIC TRANSITION ISOTOPES;ISOTOPES;NUCLEI;ODD-EVEN NUCLEI;ORGANS;RADIOISOTOPE SCANNING;RADIOISOTOPES;SECONDS LIVING RADIOISOTOPES;SYMPTOMS;THALLIUM ISOTOPES;VASCULAR DISEASES |
Description/Abstract | Invasive Doppler catheter-derived coronary flow reserve, echocardiographic measurements of left ventricular hypertrophy and intravenous dipyridamole-limited stress thallium-201 scintigraphy were compared in 48 patients (40 were hypertensive or diabetic) with clinical ischemic heart disease and no or minor coronary artery disease.^Abnormal vasodilator reserve (ratio less than 3:1) occurred in 50% of the study group and markedly abnormal reserve (less than or equal to 2:1) occurred in 27%.^Coronary vasodilator reserve was significantly lower (2.2 +/- 0.8 versus 3.5 +/- 1.3, p = 0.003) and indexed left ventricular mass significantly higher (152.6 +/- 42.2 versus 113.6 +/- 24.0 g, p = 0.0007) in patients with a positive (n = 11) versus a negative (n = 32) thallium perfusion scan.^Coronary flow reserve was linearly related in coronary basal flow velocity as follows: y = -0.17x + 4.59; r = -0.57; p = 0.00002.^The decrement in flow reserve was not linearly related to the degree of left ventricular hypertrophy.^Abnormal vasodilator reserve subsets found in hypertensive patients were defined on the basis of basal flow velocity, indexed left ventricular mass and clinical factors.^In this series, diabetes did not cause a detectable additional decrement in flow reserve above that found with hypertension alone.^These findings demonstrate that thallium perfusion defects are associated with depressed coronary vasodilator reserve in hypertensive patients without obstructive coronary artery disease.^Left ventricular hypertrophy by indexed mass criteria is predictive of which hypertensive patients are likely to have thallium defects. |
Country of Publication | United States |
Language | English |
Format | Pages: 43-51 |
System Entry Date | 2001 May 13 |
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