Energy Citations Database

Bibliographic Citation

 
Document
For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field.
For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability.
Title Relations among impaired coronary flow reserve, left ventricular hypertrophy and thallium perfusion defects in hypertensive patients without obstructive coronary artery disease
Creator/Author Houghton, J.L. ; Frank, M.J. ; Carr, A.A. ; von Dohlen, T.W. ; Prisant, L.M. (School of Medicine, Medical College of Georgia, Augusta (USA))
Publication Date1990 Jan 01
OSTI IdentifierOSTI ID: 7105492
Other Number(s)ISSN0735-1097; CODEN: JACCD
Resource TypeJournal Article
Resource RelationJournal of the American College of Cardiology ; Vol/Issue: 15:1
Subject550601 -- Medicine-- Unsealed Radionuclides in Diagnostics; CORONARIES-- BLOOD FLOW;HEART-- SCINTISCANNING;ISCHEMIA-- DIAGNOSIS; ELECTROCARDIOGRAMS;EXERCISE;HYPERTENSION;PERFUSED ORGANS;THALLIUM 201;VASODILATORS
Related SubjectARTERIES;BETA DECAY RADIOISOTOPES;BLOOD VESSELS;BODY;CARDIOVASCULAR AGENTS;CARDIOVASCULAR DISEASES;CARDIOVASCULAR SYSTEM;COUNTING TECHNIQUES;DAYS LIVING RADIOISOTOPES;DIAGNOSTIC TECHNIQUES;DIAGRAMS;DISEASES;DRUGS;ELECTRON CAPTURE RADIOISOTOPES;HEAVY NUCLEI;ISOMERIC TRANSITION ISOTOPES;ISOTOPES;NUCLEI;ODD-EVEN NUCLEI;ORGANS;RADIOISOTOPE SCANNING;RADIOISOTOPES;SECONDS LIVING RADIOISOTOPES;SYMPTOMS;THALLIUM ISOTOPES;VASCULAR DISEASES
Description/Abstract Invasive Doppler catheter-derived coronary flow reserve, echocardiographic measurements of left ventricular hypertrophy and intravenous dipyridamole-limited stress thallium-201 scintigraphy were compared in 48 patients (40 were hypertensive or diabetic) with clinical ischemic heart disease and no or minor coronary artery disease.^Abnormal vasodilator reserve (ratio less than 3:1) occurred in 50% of the study group and markedly abnormal reserve (less than or equal to 2:1) occurred in 27%.^Coronary vasodilator reserve was significantly lower (2.2 +/- 0.8 versus 3.5 +/- 1.3, p = 0.003) and indexed left ventricular mass significantly higher (152.6 +/- 42.2 versus 113.6 +/- 24.0 g, p = 0.0007) in patients with a positive (n = 11) versus a negative (n = 32) thallium perfusion scan.^Coronary flow reserve was linearly related in coronary basal flow velocity as follows: y = -0.17x + 4.59; r = -0.57; p = 0.00002.^The decrement in flow reserve was not linearly related to the degree of left ventricular hypertrophy.^Abnormal vasodilator reserve subsets found in hypertensive patients were defined on the basis of basal flow velocity, indexed left ventricular mass and clinical factors.^In this series, diabetes did not cause a detectable additional decrement in flow reserve above that found with hypertension alone.^These findings demonstrate that thallium perfusion defects are associated with depressed coronary vasodilator reserve in hypertensive patients without obstructive coronary artery disease.^Left ventricular hypertrophy by indexed mass criteria is predictive of which hypertensive patients are likely to have thallium defects.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 43-51
System Entry Date2001 May 13

Top