Biological Sensors
Automated Fluidics for BEADS Sensors (411)
Problem: Need automated fluidic system to provide transport of test analyte, sensor beads, and operational solutions.
Project Activity Scope (from Technical Overview Chart): Sensors and Devices through Instruments
PNNL Solution:
- Designed components and system to allow reliable, long-term independent operation
- Rotary valve gives reliable fluid switching for small fluid volumes
- Cell design allows bead capture and release and signal detection
- Design allows use of blanks and calibration standards
- Practical systems demonstrated
Capabilities Employed to Meet Client Needs: Bead attachment chemistry; antibody development; renewable filter system development; bead handling methodologies; sample bead-trap/flow-cell design for reliable bead exchange (rotating rod concept); interface requirements to multiple sensor/detection technologies. Integration with detection modalities (e.g., absorbance, fluorescence, electrochemical, etc.).
Selected Links to Related Information:
- Related Examples (Same Project)
- Automated Toxin Detection System (412)
- BEADS: A Basic Tool for Bio-Detection (255)
- BEADS Automated Immunoassays (259)
- BEADS: Automated Sample Processing System for Biodetection (260)
- BEADS for Separations, Processing, Sensing (261)
- Renewable Chem-Bio Sensor System (409)
- "Reporters" Indicate Target Analyte Capture (410)
- Similar Technology Examples (Same or Different Application)
- Related Websites
- Breakthroughs, Winter/Spring 2002 (.pdf 7.3MB - see second item)
- BEADS (Biodetection Enabling Analyte Delivery System) Sample Preparation Technology
