National Toxicology Program

CASRN: 141-32-2

Formula: C7 H12 O2

Synonyms/Common Names:

• ACRYLIC ACID, N-BUTYL ESTER
• BUTYL ACRYLATE
• 2-PROPENOIC ACID BUTYL ESTER (9CI)

Known Uses:

MONOMER FOR EMULSION & SOLUTION POLYMERS, RESINS FOR TEXTILE & LEATHER FINISHES, PAINTS (TDB)

Special Studies

• Absorption Disposition Metabolism Elimination  (S0731) Completed 
  • Citation: SANDERS, J.M., BRKA, L.T., MATTHEWS, H.B., METABOLISM AND DISPOSITION OF N-BUTYL ACRYLATE IN MALE FISCHER RATS, DRUG METABOLISM AND DISPOSITION VOL 16, #3, 429-434, 1988
  • M Rats: F344/N
• Metabolism  (S0123) Completed 
  • Citation: NO REPORTS OR PUBLICATIONS WILL BE PUBLISHED
  • Dose: NVITRO STUDIES

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (679128) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (038839) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Salmonella  (398442) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative 

Organ Systems Toxicity

• 4 DAY, 8 DAY Immunotoxicity (Topical Application)  (IMM95005) Completed 
  • F Mice: B6C3F1
  • Dose: 10, 20, AND 30% IN ACETONE (99.8%) FOR SENSITIZATION AND 30% FOR CHALLENGE; 0.25% DNFB AS POSITIVE CONTROL AND 0.5% FOR CHALLENGE
• GD 6-15 Conventional Teratology (Oral)  (T0103) Completed 
  • F Mice: Swiss
  • Dose: 0, 0.1, 1.0, 1.5, 2.0, 2.5, 3.0 GM/KG/DAY