Sperm/Egg Function Following Toxic Insult

SD Perreault

22.31.10.08

A wide variety of xenobiotic agents are thought to impair fertility in humans and laboratory animals. It is necessary to define and characterize toxicant action regarding mechanisms and sites to facilitate risk assessment and interspecies extrapolation. Research opportunities focus on (1) in vitro and in vivo assessments of sperm motility and fertilizing ability and (2) oocyte maturation and activation during fertilization. Methods in gamete micromanipulation are also available.

References

Perreault SD, Jeffry SC: Strategies and Methods for Evaluating the Functional Capacity of Oocytes and Zygotes in vitro, in Methods in Toxicology, 3B. Edited by Heindel JJ, Chapin RE. New York: Academic Press, 1993: 92

Slott VL, et al: Fundamentals of Applied Toxicology 21: 298, 1993

Research Opportunities | Guidance & FAQs | Grants | Fellowships | Small Business | Research Centers | Other Programs
Research Results | Science Topics
About NCER | Publications | Events | Search | Personalize

EPA Home | Privacy and Security Notice | Contact Us