Summaries & Associations of Study Results
TR-289 Benzene
Target Organs and Levels of Evidence
NTP Technical Report Number 289
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| BENZENE 71-43-2 |
07/27/84 | IN MANUFACTURE OF MEDICINAL CHEMICALS, DYES, ORGANIC COMPOUNDS, ARTIFICIAL LEATHER, LINOLEUM, OIL CLOTH, VARNISHES, LACQUERS, SOLVENT FOR WAXES, RESINS, OILS. USED TO DESTROY SCREWWORM LARVAE IN WOUNDS-VETINARY USE (MERCK 1989). | Gavage FR&M: 0,25,50,100, MR: 0,50,100,200 MG/KG/50 PER GROUP | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: CLEAR EVIDENCE | ZYMBAL GLAND: CARCINOMA 2/32 6/46 10/42 | |||
| ORAL CAVITY: SQUAMOUS CELL PAPILLOMA 1/50 6/50 11/50 13/50 OR SQUAMOUS CELL CARCINOMA 0/50 3/50 5/50 7/50 COMBINED 1/50 9/50 16/50 19/50 | ||||
| SKIN: SQUAMOUS CELL PAPILLOMA 0/50 2/50 1/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 5/50 3/50 8/50 | ||||
| FR: CLEAR EVIDENCE | ZYMBAL GLAND: CARCINOMA 0/45 5/40 5/44 14/46 | |||
| ORAL CAVITY: SQUAMOUS CELL PAPILLOMA 1/50 4/50 8/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 4/50 5/50 COMBINED 1/50 5/50 12/50 9/50 | ||||
| MM: CLEAR EVIDENCE | ZYMBAL GLAND: SQUAMOUS CELL CARCINOMA 0/43 1/34 4/40 21/39 | |||
| HEMATOPOIETIC SYSTEM: LYMPHOMA 4/49 10/48 10/50 15/49 | ||||
| LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 6/49 6/48 8/50 12/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 5/49 11/48 12/50 14/49 COMBINED 10/49 16/48 19/50 21/49 | ||||
| HARDERIAN GLAND: ADENOMA 0/49 9/46 13/49 11/48 | ||||
| PREPUTIAL GLAND: SQUAMOUS CELL CARCINOMA 0/21 3/28 18/29 28/35 | ||||
| FM: CLEAR EVIDENCE | ZYMBAL GLAND: SQUAMOUS CELL CARCINOMA 0/43 0/32 1/37 3/31 | |||
| HEMATOPOIETIC SYSTEM: LYMPHOMA 15/49 25/45 26/50 22/49 | ||||
| LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 2/42 5/50 9/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 3/42 6/50 6/49 COMBINED 4/49 5/42 10/50 13/49 | ||||
| OVARY: BENIGN MIXED TUMORS 0/47 1/44 12/49 7/48; GRANULOSA CELL TUMOR 1/47 1/44 6/49 7/48 | ||||
| MAMMARY GLAND: CARCINOMA 0/49 2/45 5/50 10/49; CARCINOSARCOMA 0/49 0/45 1/50 4/49 | ||||
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