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1: rseP zinc metallopeptidase [ Escherichia coli str. K-12 substr. MG1655 ]

GeneID: 944871 updated 03-Feb-2009

[Top][Help]Summary

Gene name
rseP
Primary source
ECOCYC:EG12436
Locus tag
b0176
See related
EcoGene:EG12436
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
Also known as
ECK0175; yaeL; JW0171; ecfE; rseP

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Genomic context[Top][Help]

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Related Articles in PubMed

GeneRIFs: Gene References Into FunctionWhat's a GeneRIF?

PubMed 1. RseP catalyzes proteolytic cleavage of the membrane-bound anti-sigma(E) protein RseA as an essential step in transmembrane signal transduction in the sigma(E) extracytoplasmic stress response pathway.
PubMed 2. RseP, which is required for normal sigmaE activation, prevents toxicity due to the presence of two specific outer membrane proteins that are down-regulated by RseX
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[Top][Help]General gene information

Primary Source

[Top][Help]General protein information

Names
zinc metallopeptidase
NP_414718.1
EC 3.4.24.-

[Top][Help]NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

mRNA and Protein(s)

  1. NP_414718.1 zinc metallopeptidase [Escherichia coli str. K-12 substr. MG1655]

    UniProtKB/Swiss-Prot
    P0AEH1
    Conserved Domains (4) summary
    cd00989
    Location:211–289
    Blast Score:228
    PDZ_metalloprotease; PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...
    cd06163
    Location:8–118
    Blast Score:434
    Location:380–449
    Blast Score:278
    S2P-M50_PDZ_RseP-like; RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...
    PRK10779
    Location:1–450
    Blast Score:2250
    PRK10779; zinc metallopeptidase; Provisional

[Top][Help]Related Sequences

Nucleotide   Protein
Genomic   U00096.2   AAC73287.1