| Infect Immun. 1997 January; 65(1): 335–338. | PMCID: PMC174599 |
Infestation with pathogen-free nymphs of the tick Ixodes scapularis induces host resistance to transmission of Borrelia burgdorferi by ticks. S K Wikel, R N Ramachandra, D K Bergman, T R Burkot, and J Piesman Department of Entomology, Oklahoma State University, Stillwater 74078, USA. Abstract Female BALB/c mice were infested four times with pathogen-free Ixodes scapularis nymphs prior to infestation with nymphs infected with Borrelia burgdorferi B31. Each infestation was separated by a 14-day tick-free period. Mean weights of fed ticks and percentage reaching repletion did not indicate development of acquired resistance. Only 16.7% of mice repeatedly infested with pathogen-free ticks prior to infected I. scapularis nymph challenge became positive for B. burgdorferi. One hundred percent of control mice infested only with infected ticks were culture positive for B. burgdorferi. Full Text The Full Text of this article is available as a PDF (181K). These references are in PubMed. This may not be the complete list of references from this article. - Allen, JR. Immunology of interactions between ticks and laboratory animals. Exp Appl Acarol. 1989 Jun;7(1):5–13. [PubMed]
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