Bjarnason I, Keating J, Smith T, Macpherson A, Posniac A, Gazzard BG; International Conference on AIDS.

Int Conf AIDS. 1993 Jun 6-11; 9: 440 (abstract no. PO-B19-1831).

Clinical Research Centre, Westminster Hospital, London, UK.

HIV infected patients with intestinal Cryptosporidiosis often have profuse diarrhoea. The pathogenesis is incompletely understood. We assessed ileal function in HIV infected patients with a dual radioisotopic test and compared the results with that obtained in patients with ileal Crohn's disease whose diarrhoea may be in part due to incomplete absorption of bile acids. Twenty healthy controls, 13 patients with ileal Crohn's disease and 7 HIV positive patients, 4 of whom had intestinal Cryptosporidiosis, underwent whole body retention measurements 7 days following ingestion of a synthetic bile acid 75SeHCAT (1 microCi) and 58CoVitB12 (0.5 microCi) with intrinsic factor. The mean (+/- SD) retention of 75SeHCAT from controls, patients with Crohn's and HIV was 38.4 +/- 10.0%, 10.3 +/- 13.4% and 27.6 +/- 22.7% and that of 58CoVitB12 60.8 +/- 16.1%, 41.3 +/- 27.7% and 25.6 +/- 22.8% respectively. All 4 patients with Cryptosporidiosis had malabsorption of 75SeHCAT and/or 58CoVitB12, to a greater extent than patients with Crohn's ileitis. HIV infected patients with Cryptosporidiosis had impaired ileal function with severe malabsorption of Vit B12 and/or SeHCAT. The former explains the frequency of Vit B12 deficiency in these patients and the latter may explain the large volume diarrhoea seen in Cryptosporidiosis.

Publication Types:

• Meeting Abstracts

Keywords:

• 23-seleno-25-homotaurocholic acid
• Acquired Immunodeficiency Syndrome
• Animals
• Bile Acids and Salts
• Crohn Disease
• Diarrhea
• HIV Seropositivity
• Humans
• Ileal Diseases
• Ileum
• Malabsorption Syndromes
• Taurocholic Acid
• Vitamin B 12

Other ID:

• 93335416

UI: 102204794

From Meeting Abstracts