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fluorine F 18 fluoroethylcholine
Ethylcholine labeled with fluorine F 18, a positron-emitting isotope. Fluorine F 18 fluoroethylcholine incorporates into tumor cells through an active, carrier-mediated transport mechanism for choline and then is phosphorylated intracellularly by choline kinase, yielding a phosphoryl derivative, and finally is integrated into cellular phospholipids, probably primarily into a phosphatidyl derivative; concentration of this agent in tumor cells as various fluorine F 18 fluoroethylcholine derivatives enables tumor imaging using positron emission tomography (PET). Choline kinase, the enzyme responsible for the phosphorylation of choline, is frequently up-regulated in human tumor cell lines. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Abbreviation: | | 18F-ethylcholine | | |
| Previous: | fludeoxyglucose F 18, fludrocortisone acetate, FluMist, fluorine F 18 EF5, fluorine F 18 FEQA | | Next: | fluorine F 18 RGD-based integrin peptide-polymer AH111585, fluorine F 18 sodium fluoride, Fluorofur, Fluoroplex, fluorouracil |
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