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Personal Information
Afonso C. Silva Unit Head NIH, NINDS, LFMI-10 Center Drive Bldg. 10, Rm. B1D106, MSC 1065 Bethesda, MD 20892-1065 Phone: (301)402-9703 FAX: (301)480-2558 Email: SilvaA at ninds.nih.gov
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Back to People/Contact Page Personal History Current Research Interests Recent Publications Curriculum Vitae or Resume
Afonso C. Silva was born on October 7, 1967, in São Paulo, Brazil.
He has B.S. (1990) and M.S. (1992) degrees in Electrical
Engineering from Universidade Federal de Pernambuco (UFPE), in
Recife, Brazil.
In the Fall of 1992, Dr. Silva joined Dr. Alan Koretsky's lab at
Carnegie Mellon University, in Pittsburgh, PA, to work on the
Arterial Spin Labeling model to map and quantify cerebral blood
flow. Dr. Silva earned his Ph.D. degree in Biomedical Engineering in
September of 1996. His thesis, entitled "NMR Measurements of Rat
Brain Perfusion Using Arterial Spin Labeling", made fundamental
contributions to the development of the Arterial Spin Labeling
method to measure CBF non-invasively using MRI.
In 1997, Dr. Silva joined the laboratory of Dr. Seong-Gi Kim in the
Center for Magnetic Resonance Research at the University of
Minnesota, in Minneapolis, MN. At the CMRR, Dr. Silva was able to
implement the Arterial spin Labeling technique in a rodent
functional brain activation model to study the spatial and temporal
characteristics of CBF changes during increased neuronal activity.
In 1999, Dr. Silva came to NINDS to continue his research on
cerebral blood flow regulation during functional neuronal activity.
Dr. Silva lives in Germantown with his wife and two children.
Current Research Interests
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- The mechanisms of Cerebral Blood Flow (CBF) regulation
- The mechanisms of functional MRI of brain activity, in particular related to measurements of CBF and of blood oxygenation level dependent (BOLD) induced responses to neural activity at high temporal and spatial resolution
- Methods for three-dimensional high spatial resolution images of the brain
- Ultra-fast MRI sequences and their application to functional MRI and MRSI of the brain
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- A.G. Goloshevsky, A.C. Silva, S.J. Dodd, A.P. KoretskyBOLD fMRI and somatosensory evoked potentials are well correlated over a broad range of frequency content of somatosensory stimulation of the rat forepaw, Brain Research 1195: 67-76(2008)
Link to PubMed
- A.C. Silva, J. Lee, C.W. Wu, J. Tucciarone, G. Pelled, I. Aoki, A.P. KoretskyDetection of cortical laminar architecture using manganese-enhanced MRI, Journal of Neuroscience Methods 167: 246-257(2008)
Link to PubMed
- B. Stefanovic, E. Hutchinson, V. Yakovleva, V. Schram, J.T. Russell, L. Belluscio, A.P. Koretsky, A.C. SilvaFunctional reactivity of cerebral capillaries, Journal of Cerebral Blood Flow and Metabolism 28: 961-972(2008)
Link to PubMed
- A.C. Silva, A.P. Koretsky, J.H. DuynFunctional MRI impulse response for BOLD and CBV contrast in rat somatosensory cortex, Magnetic Resonance in Medicine 57: 1110-1118(2007)
Link to PubMed
- S.D. Keilholz, A.C. Silva, M. Raman, H. Merkle, A.P. KoretskyBOLD and CBV-weighted functional magnetic resonance imaging of the rat somatosensory system, Magnetic Resonance in Medicine 55: 316-324(2006)
Link to PubMed
- I. Aoki, Y. Takahashi, K. Chuang, A.C. Silva, T. Igarashi, C. Tanaka, R.W. Childs, A.P. KoretskyCell labeling for magnetic resonance imaging with the T1 agent manganese chloride, NMR in Biomedicine 19: 50-59(2006)
Link to PubMed
- B. Stefanovic, F. Bosetti, A.C. SilvaModulatory Role of Cylcooxygenase-2 in Cerebrovasular Coupling, NeuroImage 32: 23-32(2006)
Link to PubMed
- Z. Chen, A.C. Silva, J. Yang, J. ShenElevated endogenous GABA level correlates with decreased fMRI signals in the rat brain during acute inhibition of GABA transaminase, Journal of Neuroscience Research 79: 383-391(2005)
Link to PubMed
- J. Lee, A.C. Silva, H. Merkle, A.P. KoretskyManganese-enhanced magnetic resonance imaging of mouse brain after systemic administration of MnCl2: dose-dependent and temporal evolution of T1 contrast, Magnetic Resonance in Medicine 53: 640-648(2005)
Link to PubMed
- A.P. Koretsky, L.S. Talagala, S.D. Keilholz, A.C. SilvaMRI detection of regional blood flow using arterial spin labeling, Cambridge University Press : 119-140(2005)
- A.C. SilvaPerfusion-based fMRI: insights from animal models, Journal of Magnetic Resonance Imaging 22: 745-750(2005)
Link to PubMed
- J.A. de Zwart, A.C. Silva, P. van Gelderen, P. Kellman, M. Fukunaga, R. Chu, A.P. Koretsky, J.A. Frank, J.H. DuynTemporal dynamics of the BOLD fMRI impulse response, NeuroImage 24: 667-677(2005)
Link to PubMed
- S.D. Keilholz, A.C. Silva, M. Raman, H. Merkle, A.P. KoretskyFunctional MRI of the rodent somatosensory pathway using multislice echo planar imaging, Magnetic Resonance in Medicine 52: 89-99(2004)
Link to PubMed
- I. Aoki, Y.L. Wu, A.C. Silva, R.M. Lynch, A.P. KoretskyIn vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI, NeuroImage 22: 1046-1059(2004)
Link to PubMed
- A.C. Silva, J. Lee, I. Aoki, A.P. KoretskyManganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations, NMR in Biomedicine 17: 532-543(2004)
Link to PubMed
- A.P. Koretsky, A.C. SilvaManganese-enhanced magnetic resonance imaging (MEMRI), NMR in Biomedicine 17: 527-531(2004)
Abstract PDF Full Text
- A.C. Silva, H. MerkleHardware considerations for functional magnetic resonance imaging, Concepts in Magnetic Resonance Part A: Magnetic Resonance Engineering 16: 35-49(2003)
- K.A. Hinds, J.M. Hill, E.M. Shapiro, M.O. Laukkanen, A.C. Silva, C.A. Combs, T.R. Varney, R.S. Balaban, A.P. Koretsky, D.E. CynthiaHighly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells, Blood 102: 144-156(2003)
Link to PubMed
- C. Grabill, A.C. Silva, S.S. Smith, A.P. Koretsky, T.A. RouaultMRI detection of ferritin iron overload and associated neuronal pathology in iron regulatory protein-2 knockout mice, Brain Research 971: 144-156(2003)
Link to PubMed
- S.J. Dodd, D.S. Williams, C. Olsen, A.C. Silva, A.P. Koretsky, C. HoAn open transverse z-gradient coil designs for magnetic resonance imaging, Rev. Sci. Instru. 73: 2208-2210(2002)
- I. Aoki, C. Tanaka, T. Takegami, T. Ebisu, M. Umeda, M. Fukunaga, K. Fukuda, A.C. Silva, A.P. Koretsky, S. NaruseDynamic Activity-Induced Manganese-Dependent Contrast Magnetic Resonance Imaging (DAIM MRI), Magnetic Resonance in Medicine 48: 144-156(2002)
Link to PubMed
- A.C. Silva, A.P. KoretskyLaminar Specificity of fMRI Onset Times During Somatosensory Stimulation in the Rat, Proc. Natl. Acad. Sci. 99: 144-156(2002)
Link to PubMed
- E.L. Barbier, A.C. Silva, S. Kim, A.P. KoretskyPerfusion Imaging Using Dynamic Arterial Spin Labeling(DASL), Magnetic Resonance in Medicine 45: 144-156(2001)
Link to PubMed
- E.L. Barbier, A.C. Silva, H. Kim, D. Will, A.P. KoretskyPerfusion Analysis Using Dynamic Arterial Spin Labeling, Magnetic Resonance in Medicine 41: 144-156(1999)
Link to PubMed
- A.C. Silva, S. KimPseudo-continuous arterial spin labeling technique for measuring CBF dynamics with high temporal resolution, Magnetic Resonance in Medicine 42: 144-156(1999)
Link to PubMed
Curriculum Vitae ro Resume
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