Molecular Neuropharmacology Section - Publications

• Kim, O.J., Ariano, M.A., Namkung, Y., Marinec, P., Kim, E., Han, J., and David R. Sibley (2008) D2 dopamine receptor expression and trafficking is regulated through direct interactions with ZIP, Journal of Neurochemistry 106, 83-95. Full Text/Abstract

• O�Sullivan, G., Dunleavy, M., Hakansson, K., Kinsella, A., Croke, D.T., Fienberg, A.A., Greengard, P., Sibley, D.R., Fisone, G., Henshall, D.C., and Waddington, J.L. (2008) Dopamine D1 vs D5 Receptor-Dependent Induction of Seizures Involves DARPP-32 and ERK1/2 Signalling, Neuropharmacology 54, 1051-1061. Full Text/Abstract

• Rex, E.B., Rankin, M.L., Ariano, M.A., and Sibley, D.R. (2008) Ethanol Regulation of D1 Dopamine Receptor Signaling is Mediated by Protein Kinase C in an Isozyme-Specific Fashion, Neuropsychopharmacology 32, 2900-2911. Full Text/Abstract

• Hazelwood, L.A., Free, B.F., Cabrera, D.M., Skinbjerb, M., and Sibley, D.R. (2008) Reciprocal modulation of function between the D1 and D2 dopamine receptors and the Na+, K+-ATPase, Journal of Biological Chemistry 283, 36441-36453. Full Text/Abstract

• Hernandez-Echeagaray, E., Cepeda, C., Ariano, M.A., Lobo, M.K., Sibley, D.R., and Levine, M.S. (2007) Dopamine Reduction of GABA Currents in Medium-sized Spiny Neurons is Principally Mediated by the D1 Receptor Subtype, Neurochemical Research 32, 229-240.

• Wang, Z., Armando, I., Asico, L.D., Escano, C., Wang, X., Felder, R.A., Schnackenberg, C.G., Sibley, D.R., Robillard, J.E., Eisner, G.M., and Jose, P.A. (2007) The Elevated Blood Pressure of Human GRK4γ A142V Transgenic Mice is not Associated with Increased ROS Production, American Journal of Physiology 292(5), H2083-2092.

• Free, R.B., Hazelwood, L.A., Namkung, Y., Cabrera, D.M., Spalding, H.N., Rankin, M.L., and Sibley, D.R., (2007) D1 and D2 Dopamine Receptor Expression is Regulated by Direct Interaction with the Chaperone Protein Calnexin, Journal of Biological Chemistry 282, 2185-21300. Full Text/Abstract

• Tomiyama, K., Makihara, Y., Yamamoto, H., O’Sullivan, G., Nally, R.E., Tighe, O., Kinsella, A., Fienberg, A.A., Grandy, D.K., Greengard, P., Low, M.J., Rubinstein, M., Sibley, D.R., Croke, D.T., Koshikawa, N., and Waddington, J.L. (2006) Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 or DARPP-32 �knockout�, European Neuropsychopharmacology 16, 437-445.

• Yang, Z., Asico, L.D., Yu, P., Wang, Z., Jones, J.E., Escano, C.S., Quinn, M.T., Sibley, D.R., Romero, G.G., Felder, R.A., and Jose, P.A. (2006) D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure in mice, American Journal of Physiology 290(1), R96-R104.

• Rankin, M.L., Marinec, P.S., Cabrera, D.M., and Sibley, D.R. (2006) The D1 Dopamine Receptor is Constitutively Phosphorylated by G Protein Coupled Receptor Kinase 4: evidence for a novel mechanism of regulation, Molecular Pharmacology 69, 759-769 (see "Perspectives" article in same issue). Full Text/Abstract

• Sullivan, G.J., Kinsella, A., Sibley, D.R., Tighe, O., Croke, D.T., and Waddington, J.L. (2005) Ethological Rsolution of Behavioral Topography and D1-like vs D2-like Agonist Responses in Congenic Dopamine D5 Receptor Mutants: Identification of D5:D2-like Interactions, Synapse 55, 201-211. Full Text/Abstract

• Yang, Z., Asico, L.D., Yu, P., Wang, Z., Jones, J.E., Bai, R., Sibley, D.R., Felder, R.A., and Jose, P.A. (2005) D5 Dopamine Receptor Regulation of Phospholipase D, American Journal of Physiology 288(1), H55-61. Full Text/Abstract

• Zeng, C., Yang, Z., Jones, J. Wang, X., Altea, J., Mangrum, A.J., Hopfer, U., Sibley, D.R., Eisner, G.M., Felder, R.A., and Jose, P.A. (2005) Interaction of AT1 and D5 dopamine receptors in renal proximal tubule cells, Hypertension 45, 804-810. Full Text/Abstract

• Kudwa, A.E., Dominguez-Salazar, E., Cabrera, D.M., Sibley, D.R. and Rissman, E.F. (2005) Dopamine D5 Receptor Modulates Male and Female Sexual Behavior in Mice, Psychopharmacology 180, 1620-1627. Full Text/Abstract

• Laplante, F., Sibley, D.R. and Quirion, R. (2004) Reduction in Acetylcholine Release in the Hippocampus of Dopamine D5 Receptor Deficient Mice, Neuropsychopharmacology 29, 1620-1629. Full Text/Abstract

• Kim, O.-J., Gardner, B.R., Williams, D.B., Marinec, P.S., Cabrera, D.M., Peters, J.D., Mak, C.C., Kim, K.-M. and Sibley, D.R. (2004) The Role of Phosphorylation in D1 Dopamine Receptor Desensitization: Evidence for a Novel Mechanism of Arrestin Association, Journal of Biological Chemistry 279, 7999-8010. Full Text/Abstract

• Yang, Z., Sibley, D.R., and Jose, P.A. (2004) D5 Dopamine Receptor Knockout Mice and Hypertension, Journal of Receptors and Signal Transduction 24, 149-164. Full Text/Abstract

• O'Sullivan, G.J., Clifford, J.J., Tomiyama, K., Koshikawa, N., Drago, J., Sibley, D.R., Croke, D.T., an Waddington, J.L. (2004) D1-like Dopamine Receptor-Mediated Function in Congenic Mouse Mutants with D1 versus D5 Receptor Knockout, Journal of Receptors and Signal Transduction 24, 107-116. Full Text/Abstract

• Homes, A., Lachowicz, J.E. and Sibley, D.R. (2004) Dopamine Receptor Knockout Mice Reveal New Insights into Receptor Function and Pharmacology, Neuropharmacology 47/8, 1117-1134. Full Text/Abstract

• Namkung, Y. and Sibley, D.R. (2004) Protein Kinase C Mediates Phosphorylation, Desensitization and Trafficking of the D2 Dopamine Receptor, Journal of Biological Chemistry 279, 49533-49541. Full Text/Abstract

• Elliot, E.E., Sibley, D.R., and Katz, J.L. (2003) Behavioral Effects of Cocaine in Dopamine D5 Receptor Knockout Mice, Psychopharmacology 169, 161-168. Full Text/Abstract

• Schetz, J.A., Kim, O.J., Sibley, D.R. (2003) Pharmacological Characterization of Mammalian D1 and D2 Dopamine Receptors Expressed in Drosophila Schneider-2 Cells, Journal of Receptors and Signal Transduction 23, 99-109. Full Text/Abstract

• Lachowicz, J.E. and Sibley, D.R. (2003) Dopaminergic Receptor Function Defined by Studying Genetically Alterered Mice, In Dopamine Receptors and Transporters , pp 295-320.

• Shapiro, D.A., Renock, S., Arington, E., Chiodo, L.A., Sibley, D.R., Roth, B.L., and Mailman, R., (2003) Aripiprazole, a Novel Atypical Antipsychotic with a Unique and Robust Pharmacology, Neuropsychopharmacology 28, 1400-1411. Full Text/Abstract

• Sibley, D.R., Gardner, B, Peters, J.D., and Kim, O.-J. (2002) Structural Insights into D1 Dopamine Receptor Phosphorylation and Desensitization, In Catecholamine Research: From Molecular Insights to Clinical Medicine , pp 159-162.

• Hollon, T.R., Bek, M.J., Lachowicz, J.E., Ariano, M.A., Mezey, E., Ramachandran, R., Wersinger, S.R., Soares-da-Silva, P., Liu, Z.F., Grinberg, A., Drago, J., Young, W.S., III, Westphal, H., Jose, P.A., and Sibley, D.R. (2002) Mice Lacking D5 Dopamine Receptors Have Increased Sympathetic Tone and Are Hypertensive, The Journal of Neuroscience 22, 10801-10810. Full Text/Abstract

• Ariano, M.A., Aronin, N., DiFiglia, M., Tagle, D.A., Sibley, D.R., Leavitt, B.R., Hayden, M.R. and Levine, M.S. (2002) Striatal Neurochemical Changes in Transgenic Models of Huntington's Disease, Journal of Neuroscience Research 68, 716-729. Full Text/Abstract

• Kim, O.J., Ariano, M.A., Lazzarini, R.A., Levine, M.S., and Sibley, D.R (2002) Neurofilament-M Interacts with the D1 Dopamine Receptor to Regulate Cell Surface Expression and Desensitization, Journal of Neuroscience 22, 5920-5930. Full Text/Abstract

• Schetz, J.A. and Sibley, D.R. (2001) The Binding Site Crevice of the D4 receptor is Coupled to Three Unique Sites of Allosteric Regulation, Journal of Pharmacology and Experimental Therapeutics 296, 359-363. Full Text/Abstract

• Gardner, B. Liu, Z.F., Jiang, D., and Sibley, D.R. (2001) The Role of Phosphorylation/Dephosphorylation in Agonist-Induced Desensitization of D1 Receptor Function: Evidence for a Novel Pathway for Receptor Dephosphorylation, Molecular Pharmacology 59, 310-321. Full Text/Abstract

• Holmes, A., Hollon, T.R., Gleason, T.C., Liu, Z., Dreiling, J., Sibley, D.R., and Crawley, J.N., (2001) Dopamine D5 Receptor Null Mutant Mice Show Attenuated Behavioral Responses to a Dopamine Agonist, Behavioral Neuroscience 115, 1129-1144.

• Hunyady, B., Toth, Z., Palkovits, M., Mossik, G., Molnar, J., Feher, K., Zolyomi, A., Sibley, D.R. and Mezey, E. (2001) Susceptibility of Dopamine D5 Receptor Targeted Mice to Cysteamine, Journal of Physiology (Paris) 95(1-6), 147-151. Full Text/Abstract

• Schetz, J.A., Benjamin, P.S., and Sibley, D.R. (2000) Non-Conserved Residues in the Second Transmembrane-Spanning Domain of the D4 Dopamine Receptor are Molecular Determinants of D4-Selective Pharmacology, Molecular Pharmacology 57, 144-152. Full Text/Abstract

• Ventura, A.L.M and Sibley, D.R. (2000) Altered Regulation of the D1 Dopamine Receptor in Mutant Chinese Hamster Ovary Cells Deficient in Cyclic AMP-dependent Protein Kinase Activity, Journal of Pharmacology and Experimental Therapeutics 293, 426-434. Full Text/Abstract

• Schetz, J.A. and Sibley, D.R. (2000) Tandem Sulfer-Containing Amino Acids are Epicritical Determinants of D2 Dopamine Receptor Pharmacology, European Journal of Pharmacology 388, R5-R7. Full Text/Abstract

• El-Ghundi, M., Fletcher, P.J., Drago, J., Sibley, D.R., O'Dowd, B.F., and George, S.R. (1999) Spatial Learning Deficit in Dopamine D1 Receptor Knockout Mice, , European Journal of Pharmacology 383 , 95-106. Full Text/Abstract

• Clifford, J.J., Tighe, O., Croke, D.T., Kinsella, A., Sibley, D.R., Drago, J. and Waddington, J.L. (1999) Conservation of Behavioral Topography to Dopamine D1-like Receptor Agonists in Mutant Mice Lacking the D1A Receptor Implicates a D1-like Receptor not Coupled to Adenylyl Cyclase, Neuroscience 93, 1483-1489. Full Text/Abstract

• Cepeda, C., Li, Z., Cromwell, H.C., Altemus, K.L., Crawford, C.A., Nansen, E.A., Ariano, M.A., Sibley, D.R., Peacock, W.J., Mathern, G.G., and Levine, M.S. (1999) Electrophysiological and Morphological Analyses of Cortical Neurons Obtained from Childen with Catastrophic Epilepsy: Dopamine Receptor Modulation of Glutaminergic Responses, Developmental Neuroscience 21, 223-235. Full Text/Abstract

• Schetz, J.A. and Sibley, D.R. (1999) Metal Cations as Atomic Scale Probes of G-Protein Coupled Receptor Structure and Function, Receptor Biochemistry and Methodology 3, 121-140.

• Lawler, C.P., Prioleau, C., Lewis, M.M., Mak, C., Jiang, D., Schetz, J.A., Gonzalez, A.M., Sibley, D.R. and Mailman, R.B. (1999) The Molecular Pharmacology of the Novel Antipsychotic Aripiprazole (OPC-14597), Neuropsychopharmacology 20, 612-627. Full Text/Abstract

• Cravchik, A., Sibley, D.R., and Gejman, P.V. (1999) Differences in Neuroleptic Activity at the Human D2 Dopamine Receptor Missense Variants, Pharmacogenetics 9, 17-23. Full Text/Abstract

• Clifford, J.J., Tighe, O., Croke, D.T., Sibley, D.R., Drago, J., and Waddington, J.L. (1999) Ethologically-based Topographical Evaluation of the Phenotype of Spontaneous Behaviour in Mice with Targeted Deletion of the D1A Dopamine Receptor: Paradoxical Elevation of Grooming Syntax, Neuroharmacology 37, 1595-1602. Full Text/Abstract

• Liu, L.-X., Burgess, L.H., Gonzalez, A.M., Sibley, D.R. and Chiodo, L.A. (1999) D2S, D2L, D3 and D4 Dopamine Receptors Couple to a Voltage-Dependent Potassium Current in N18TG2 X Mesencephalon Hybrid Cells (MES-23.5) via Distinct G Proteins, Synapse 31, 108-118. Full Text/Abstract

• Schetz, J.A., Chu, A., and Sibley, D.R. (1999) Zinc Modulates Antagonist Interactions with D2-like Dopamine Receptors Through Distinct Molecular Mechanisms, Journal of Pharmacology and Experimental Therapeutics 289, 956-964. Full Text/Abstract

• Sibley, D.R. (1999) New Insights Into Dopaminergic Receptor Function Using Antisense and Genetically Altered Animals, Annual Review of Pharmacology and Toxicology 39, 313-341. Full Text/Abstract

• Jiang, D. and Sibley, D.R. (1999) Agonist-induced Desensitization of D1 Dopamine Receptors with Mutations of Cyclic AMP-dependent Protein Kinase Phosphorylation Sites: Attenuation of the Rate of Agonist-induced Desensitization, Molecular Pharmacology 56, 675-683. Full Text/Abstract