Dr. Winslow's research efforts represent a continuing interest in the influence of traumatic social stress at various stages of development as a risk factor for psychiatric disorders. This interest has ranged from the long-term consequences of social defeat in adult animals to the persistent changes associated with disturbed parental-offspring relationships. For these efforts, he has sought to collaborate in the application of multidisciplinary techniques from pharmacology, biochemistry, and molecular neurobiology, combined with comparative and ethological analyses of behavior in rodent and non-human primate species. His interests in non-human primate research also include neural systems related to social cognition and fear conditioning. He is particularly interested in the application of in vivo imaging including fMRI and PET as valuable tools for longitudinal studies of development and maturation of neural process associated with social and emotional behavior in non-human primates.

Dr. Winslow is the director of the NIMH IRP Neurobiology Non-Human Primate Core, whose mission is to develop and provide support for assessment of non-human primate models of psychopathology to assist NIMH IRP research objectives, particularly those related to causes and treatment of psychiatric disorders. The staff of the Core is well experienced in with the examination of persistent behavioral, endocrine, and neural changes associated with differential, adverse rearing histories. In addition, Core staff has extensive training in behavioral pharmacological treatment techniques, particularly for assessment of emotional and physiological indices.

The Core provides opportunities to examine gene-environment interactions in complex social, emotional, and cognitive systems with a focus on early developmental sensitivity to stress. Further, the Core can provide support for studies of acute and chronic pharmacological effects on juvenile non-human primate development.

• Winslow, J.T., Noble, P.L., Lyon, C.K., Sterk, S.M., Insel, T.R.: Rearing effects on cerebrospinal fluid oxytocin concentration and social buffering in rhesus monkeys. Neuropsychopharmacology, May;28(5), 910-918, 2003.
• Winslow, J.T., Parr, L.H., Davis, M., Acoustic Startle, Prepulse Inhibition and Fear Potentiated Startle Measured in Rhesus Monkeys. Biological Psychiatry, 51(11), 859-66, 2002.
• Parr, L.H., Winslow, J.T., Davis, M., Affective modulation of heart-rate and acoustic startle in the rhesus macaque. Behavioral Neuroscience, 116, (3), 378–386, 2002.
• Rilling J.K, Winslow J.T., O'Brien D., Hoffman J.M., and Kilts C., Effect of maternal separation stress on regional cerebral glucose metabolism in juvenile rhesus monkeys. Biological Psychiatry, 49, 2, 146-157, 2001.
• Ferguson, J.E., Hearn, E., Young, L., Matzuk, M.M., Insel, T.R., Winslow, J.T., Social amnesia in a mouse lacking the oxytocin gene, Nature Genetics, 25, 284-287, 2000
• Parr, L.A., Winslow, J.T., Hopkins, W.D., de Waal, F.B.M.: Understanding facial cues: Individual recognition in chimpanzees (Pan troglodytes) and rhesus monkeys (Macaca mulatta). Journal of Comparative Psychology, 114, 1-14, 2000