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Title Trichloroacetic acid effects on rat liver peroxisomes and enzyme-altered foci
Creator/Author Parnell, M.J. ; Koller, L.D. ; Exon, J.H. ; Arnzen, J.M.
Publication Date1986 Nov 01
OSTI IdentifierOSTI ID: 5554963
Other Number(s)CODEN: EVHPA
Resource TypeJournal Article
Resource RelationEnviron. Health Perspect. ; Vol/Issue: 69
Research OrgUniv. of Idaho, Moscow
Subject560300 -- Chemicals Metabolism & Toxicology; CHLORINATED ALIPHATIC HYDROCARBONS-- BIOLOGICAL EFFECTS;LIVER-- ENZYME ACTIVITY; ACETIC ACID;CARCINOGENESIS;DRINKING WATER;NITROSAMINES;ORAL ADMINISTRATION;OXIDATION;PEPTIDE HYDROLASES;RATS;TUMOR PROMOTERS
Related SubjectAMINES;ANIMALS;BODY;CARBOXYLIC ACIDS;CHEMICAL REACTIONS;DIGESTIVE SYSTEM;ENZYMES;GLANDS;HALOGENATED ALIPHATIC HYDROCARBONS;HYDROGEN COMPOUNDS;HYDROLASES;MAMMALS;MONOCARBOXYLIC ACIDS;NITROSO COMPOUNDS;ORGANIC ACIDS;ORGANIC CHLORINE COMPOUNDS;ORGANIC COMPOUNDS;ORGANIC HALOGEN COMPOUNDS;ORGANIC NITROGEN COMPOUNDS;ORGANS;OXYGEN COMPOUNDS;PATHOGENESIS;PROMOTERS;RODENTS;VERTEBRATES;WATER
Description/Abstract The initiating and promoting effects of trichloroacetic acid (TCA) were investigated using a rat hepatic enzyme-altered foci bioassay.^The experimental protocol used has been shown to induce ..gamma..-glutamyltranspeptidase (GGT)-positive foci in hepatic tissue following an initiating dose with a genotoxic carcinogen.^Twenty-four hours following 2/3 partial hepatectomy, rats received either a single oral dose (1500 mg/kg) or 5000 ppm TCA in drinking water for 10, 20, or 30 days.^Two weeks after the end of TCA exposure, the rats were promoted for 3 or 6 months with 500 ppm phenobarbital in drinking water.^TCA failed to induce GGT-positive foci using this initiation protocol.^In addition, groups of 2/3 partially hepatectomized rats were initiated with a single oral dose of diethylnitrosamine (10 mg/kg) and then administered 50, 500, or 5000 ppm TCA drinking water.^In this promotion protocol, TCA exposure resulted in a significant increase in the number of GGT-positive foci.^The ability of TCA to stimulate peroxisomal-dependent palmitoyl-coenzyme A oxidation was also investigated.^The findings support the hypothesis that TCA may possess weak promoting activity in the rat liver.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 73-79
System Entry Date2001 May 13

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