National Toxicology Program

VII. REFERENCES

Aldrich Chemical Company, Aldrich Catalog/Handbook of Fine Chemicals, 1990. Milwaukee, Wisconsin: Aldrich Chemical Company, Inc., 1988, p. 420, F-16, 1266.

American Conference of Governmental Industrial Hygienists, Documentation of the Threshold Limit Values and Biological Exposure Indices, Fifth Edition. Cincinnati: ACGIH, 1986, p. 592.

American Conference of Governmental Industrial Hygienists, Threshold Limit Values and Biological Exposure Indices for 1990-1991. Cincinnati: ACGIH, 1990, pp. 36-37.

Andersen, K.J., Leighty, E.G. and Takahashi, M.T., "Evaluation of Herbicides for Possible Mutagenic Properties." Journal of Agriculture and Food Chemistry, Vol. 2, No. 3 (1972), pp. 649-656.

Bignami, M., Cardamone, G., Comba, P., Ortali, V.A., Morpurgo, G., and Carere, A., "Relationship between Chemical Structure and Mutagenic Activity in some Pesticides: the use of Salmonella typhimurium and Aspergillus nidulans." Mutation Research, Vol. 46(1977), pp. 243-244.

Bhunya, S.P. and Behera, B.C., "Relative Arnototoxicity of Trichloroacetic Acid (TCA) as revealed by Different Cytogenetic ASsays: Bone Marrow Chromosome Aberration, Micronucleus and Sperm-head Abnormality in the Mouse." Mutation Research, Vol. 188 (1987), pp. 215-24.

Bowmer, K.H., "Residues of Dalapon and TCA in Sediments and Irrigation Water." Pesticide Science, Vol. 18 (1987), pp. 1-13.

Brodland, D.G. and Roengk, R.K., "Trichloroacetic ACid Chemexfolaiation (Chemical Peel) for Extensive Premalignant Actinic Damage of the Face and Scalp." Mayo Clinic Proceedings, Vol. 63 (1988), pp. 887-896.

Budavari, S., et al., eds., The Merck Index: An Encyclopedia of Chemicals, Drugs and Biologicals, Eleventh Edition. Rahway, New Jersey: Merck, 1989, pp. 418, 1515.

Bull, R.J., Sanchez, T.M., Nelson, M.A., Larson, J.L. and Lansing, A.J., "Liver Tumor Induction in B6C3F1 Mice by Dichloroacetate and Trichloroacetate." Toxicology, Vol. 63 (1990), pp. 341-359.

Calabrese, E.J. and Leonard, D.A., "The Effects of Di- and Trichloroacetic Acid on Sheep Erythrocytes: An Animal Model with a Glucose-6-Phosphate Dehydrogenase Deficiency." Regulatory Toxicology and Pharmacology, Vol. 4 (1984), pp. 261-264.

Carlberg, G.E., Drangsholt, H. and Gjos, N., "Identification of Chlorinated Compounds in the Spent Chlorination Liquor from Differently Treated Sulphite Pulps with Special Emphasis on Mutagenic Compounds." The SCience of the Total Environment, Vol. 48 (1986), pp. 157-167.

Chang, L.W., DeAngelo, A.B. and Daniel, F.B., "Evaluation of DNA Strand Breaks (SB) by Chloroacetic Acids (CAs) and Chloroacetaldehydes (CADs) In Vivo and In Vitro." Carcinogenesis, Proceedings of the American Association for Cancer Research, Vol. 30 (1989), p. 146.

Christman, R.F., Norwood, D.L., Millingtron, D.S. and Johnson, J.D., "Identity and Yields of Major Halogenated Products of Aquatic Fluvic Acid Chlorination." Environmental Science Technology, Vol. 17 No. 10 (1983), pp. 625-628.

Collins, P.S., "Trichloroacetic Acid Peel Revisited." Journal of Dermatologic Surgery and Oncology, Vol. 15 No. 9 (1989), pp. 933-940.

Curry, S.H. "Lactate-Lowering Effect of Dichloracetic Acid: A Model for Investigation of Anxiolytic Drugs?" Psychopharmacology Bulletin, Vol. 25 No. 2 (1989), pp. 202-203.

Davis, M., "Subacute Toxicity of Trichloroacetic Acid in Male and Female Rats." Toxicology, Vol. 63 (1990), pp. 63-72.

Dean, J.A., ed., Lange's Handbook of Chemistry, Thirteenth Edition, New York, New York: McGraw Hill Book Company, 1985, pp. 7280, 7-281.

DeAngelo, A.B., Daniel, F.B., Stober, J.A. and Olson, G.R., "The Carcinogenicity of Dichloroacetic Acid in the Male B6C3F1 Mouse." Fundamental and Applied Toxicology, Vol. 16 (1991), pp. 337-347.

DeAngelo, A.B., Daniel, F.B., McMillan, L., Wernsing, P. and Savage, R.E., "Species and Strain Sensitivity to the Induction of Peroxisome Proliferation by Chloroacetic Acids." Toxicology and Applied Pharmacology, Vol. 101 No. 2 (1989), pp. 285-298.

Descotes, J., "Identification of Contact Allergens: The Mouse Ear Sensitization Assay." Journal of Toxicology, Vol. 7 No. 4 (1988), pp. 263-272.

Diereekx, P.J., "In Vitre Binding of Acetic Acid and its Chlorinated Derivatives by the Soluble Glutathione-S-Transferases from Root Liver." Research Communications in Chemical Pathology and Pharmacology, Vol. 44, No. 2 (1984), pp. 327-330.

Elcombe, C.R., "Species Different in Carcinogenicity and Peroxisome Proliferation Due to Trichloroethylene: A biochemical Human Hazard Assessment." Archives of Toxicology, Supplement 8 (1985), pp. 6-17.

El-Sadek, L.M., "The Effect of TCA and its Herbicide Forms on Faba Vulgaris Root-Meristems." Egyptian Journal of Genetic Cytology, Vol. 1 (1972), pp. 280-287.

Epstein, D.L., Nolen, G., Randall, J.L., Christ, S.A., Read, E.J., Stober, J.,A. and Smith, M.K., "The Effects of Dichloroacetic Acid (DCA) on Cardiogenesis in the Long-Evans Rat Fetus." Teratology Society Abstracts, Vol. 41. No. 5 (1990), p. 553.

Fisher, J.W., "Physiologically Based Pharmacokinetic Pregnancy and Lactation Models: Validation with Trichloroethylene and its Metabolite, Trichloroacetic Acid." U.M.I. Dissertation Information Service, University Microfilms International A. Bell and Howell Information Company, Ann Arbor, Michigan, Professional Thesis (1987), pp. 1-30.

Frank, H., Vital, J. and Frank, W., "Oxidation of Airborne C_2-Chlorocarbons to Trichloroacetic and Dichloroacetic Acid." Fresenius Z Analytical Chemistry, Vol. 333 (1989), p. 713.

Goldsworthy, T.L., Lyght, O., Neptun, D.A. and Popp, J.A., "Trychloroethylene (TCE) and Perchloroethylene (PERC) Induced Peroxisomal Proliferation (PP) in Relation to Species and Organ Specific Carcinogenicity." Carcinogenesis, Proceedings of American Association of Cancer Research, Vol. 27 (1986), p. 73.

Goldsworthy, T.L., and Popp, J.A., "Chlorinated Hydrocarbon-Induced Peroxisomal Enzyme Activity in Relation to Species and Organ Carcinogenicity." Toxicology and Applied Pharmacology, Vol. 88 (1987), pp. 225-233.

Grant, W.M., Toxicology of the Eye, Third Edition. Springfield, Illinois: C.C. Thomas, 1986, p. 933.

Green, T. and Prout, M.S., "Species Differences in Response to Trichloroethylene. II. Biotransformation in Rats and Mice." Toxicology and Applied Pharmacology, Vol. 79 (1985), pp. 401-411.

Hartwell, J.L., Survey of Compounds Which Have Been Tested for Carcinogenic Activity, Second Edition, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (1951), p.  .

Heithersay, G.S. and Wilson, D.F., "Tissue Responses in the Rat to Trichloroacetic Acid - An Agent Used in the Treatment of Invasive Cervical Resorption." Australian Dental Journal, Vol. 33 No. 6 (1988), pp. 451-461.

Helling, C.S., "Pesticide Mobility in Soils II. Applications of Soil Thin-Layer Chromatography." Soil, Vol. 35 (1971), pp. 737-742.

Heng, M.C.Y. and Beck, F.W.J., "Effects of Trichloroacetic Acid and Anthralin on Epidermal Mitotic Activity and the Cell Cycle." Clinical Research, Vol.30, No. 1 (1982), p. 28A.

Herbicide Handbook Committee, Herbicide Handbook of the Weed Science Society of America, Fifth Edition. Champaign, Illinois: Weed Science Society of America, 1983, pp. 447-450.

Herren-Freund, S.L., Pereira, M., Khoury, M.D. and Olson, G., "The Carcinogenicity of Trichloroethylene and Its Metabolites, Trichloroacetic Acid and Dichloroacetic Acid, in Mouse Liver." Toxicology and Applied Pharmacology, Vol. 90 (1987a), pp. 188-189.

Herren-Freund, S.L. and Pereira, M.A., "The Carcinogenicity of Organic Chemicals Found in Drinking Water." Proceedings - Water Quality Technology Conference, Vol. 14 (1987b), pp. 485-500.

Hobara, T., Kobayashi, H. Kawamoto, T. Iwamoto, S. and Sakai, T., "Intestinal Absorption of Chloral Hydrate, Free Trichloroethanol and Trichloroacetic Acid in Dogs." Pharmacology and Toxicology, Vol. 62 (1988b), pp. 250-258.

Hobara, T., Kobayashi, H., and Kawamoto, T., "Intestinal Absorption of Chloral Hydrate, Free Trichloroethanol and Trichloroacetic Acid in Dogs." Environmental Occupational Chemical Hazards, Asia-Pacific Symposium on Environmental and Occupational Toxicology, Singapore (10/87), No. 8 (1988), pp. 423-429.

Hobara, T., Kobayashi, H., Kawamoto, T., Iwamoto, S. and Sakai, T., Extrahepatic Metabolism of Chloral Hydrate, Trichloroethanol and Trichloroacetic Acid in Dogs." Pharmacology and Toxicology, Vol. 61 (1987a), pp. 58-62.

Hobara, T., Kobayashi, H., Kawamoto, T., Sato, T., Iwamoto, S., Hirota, S. and Sakai, T., "Biliary Excretion of Trichloroethylene and its Metabolites in Dogs." Toxicology Letters, Vol. 32 (1986), pp. 119-122.

Hobara, T., Kobayashi, H., Kawamoto, T., Iwamoto, S. and Sakai, T., "The Absorption of Trichloroethylene and its Metabolites from the Urinary Bladder of Anesthetized Dogs." Toxicology, Vol. 48 (1988a), pp. 141-153.

Hobara, T., Kobayashi, H., Kawamoto, T., Iwamoto, J. and Sakai, T.., "The Cholecystohepatic Circulation of Trichloroethylene and its Metabolites in Dogs." Toxicology, Vol. 44 (1987b), pp. 283-295.

Hobara, T., Kobayashi, H., Kawamoto, T., Iwamoto, S. and Sakai, T., "The Absorptional Function of Trichloroethylene and its Metabolites in the Urinary Bladder." Toxicology Letters, Vol. 31 Sup. (1986), p. 206.

Johnson, J.D., Christman, R.F., Norwood, D.L. and Millington, D.S., "Reaction Products of Aquatic Humic Substances with Chlorine." Environmental Health Perspectives, Vol. 46 (1982), pp. 63-71.

Kirk-Othmer Concise Encyclopedia of Chemical Technology. New York: Wiley-Interscience, 1985, pp. 12-13.

Kirk-Othmer Encyclopedia of Chemical Technology. New York: Wiley-Interscience, 1978, pp. 171-178.

Kirk-Othmer Encyclopedia of Chemical Technology. New York: Wiley-Interscience, 1979, pp. 415-422.

Kitagawa, K., Nighino, H. and Iwashima, A., "Insulin-Like Effect of Dichloraoacetic Acid on Hexose Transport in Swiss 3T3 Cells." Experiential, Vol. 43 (1987), pp. 323-324.

Klaunig, J.E., Ruch, R.J. and Lin, E.L.C., "Effects of Trichloroethylene and its Metabolites on Rodent Hepatocyte Intercellular Communication." Toxicology and Applied Pharmacology, Vol. 99 (1989), pp. 454-465.

Knuckles, M.E., "The Effects of Trichloroethylene and its Metabolite TCA on Peroxisome Proliferation and the Induction of Cytochrome P-452." UMI Dissertation Information Service, University of Microfilms International, A Bell and Howell Information Company, Ann Arbor, Michigan, Professional Thesis (1989), pp. 1-124.

Kopfler, F.C., Ringhand, H.P., Coleman, W.E. and Meier, J.R., "Reactions of Chlorine in Drinking Water, with Humic Acids and In Vivo." Water Chlorination: Chemical Environmental Impact on Health Effects, Proceedings Conference 5th (1985), pp. 161-173.

Krasner, S.W., McGuire, M.J., Jaccanglo, J.G., Patania, N.L., Reagan, K.M. and Aieta, E.M., "The Occurrence of Disinfection By-products in U.S. Drinking Water." american Water Works Association Journal, Vol. 81 No. 8 (1989), pp 41-53.

Lenga, R.E., The Sigma - Aldrich Library of Chemical Safety Data, Edition II. Milwaukee, Wisconsin: Sigma-Aldrich Corp., 1988.

Lindstrom, K. and Mohamed, M., "Selective Removal of Chlorinated Organics from Kraft MIll Total Effluents in Aerated Laggons." Nordic Pulp and Paper Research Journal, Vol. 3 No. 1 (1988), pp. 26-33.

Lober, C.W., "Chemefoliation - Indications and Cautions." Journal of the American Academy for Dermatology, Vol. 17 (1987) pp. 109-112.

"Looking for Carcinogens in Drinking Water," Chemical Week, Vol. 135, No. 12 (September, 1984), p. 66.

Mariash, C.N. and Schwartz, H.L., "Effect of Dichloroacetic Acid on Rat Hepatic Messenger RNA Activity Profiles." Metabolism, Vol. 35, No. 5 (1986), pp. 452-456.

Mather, G.G., Exon, J.H. and Koller, D., "Subchronic 90-Day Toxicity of Dichloroacetic Acid and Trichloroacetic Acid in Rats." Toxicology, Vol. 64 (1990), pp. 71-80.

McGrath, D., "Factors that Influence the Persistence of TCA in Soil." Weed Researach, Vol. 16 (1976), pp. 131-137.

Meister, R.T., ed., Farm Chemicals Handbook '87. Willoughby, Ohio: Meister Publishing Company, 1987, p. C 245.

Meister, R.T., ed., Farm Chemicals Handbook '90. Willoughby, Ohio: Meister Publishing Company, 1990. pp.C 278-279.

Mitchell, A.M., Bridges, J.W. and Elcombe, C.R., "Factors Influencing Peroxisome Proliferation in Cultured Rat Hepatocytes." Archives of Toxicology, Vol. 55 (1984), pp. 239-246.

Mohamed, M., Matayun, M., and Lim, T.S., "Chlorinated Organics in Tropical Hardwood Kraft Pulp and Paper mIll Effluents and their Elimination in an Activated Sludge Treatment System." Pertaniks, Vol 12, No. 3 (1989) pp. 387-394.

Moriya, M., Ohta, T., Watanabe, K., Miyazawe, T., Kato, K. and Shirasu, Y., "Further Mutagenicity Studies on Pesticides in Bacterial Reversion Assay Systems." Mutation Research, Vol. 116 (1983), pp. 185-216.

Müller, G., Spassovski, M. and Henschler, D., "Metabolism of Trichloroethylene in Man II. Pharmacokinetics of Metabolites." Archives of Toxicology, Vol. 32 (1974), pp. 283-295.

National Safety Council (NSC), Trichloroacetic Acid - Data Sheet 1-698-82, Chicago, Illinois, (date unspecified), pp. 1-3.

National Toxicology Program (NTP), NTP Results Report - Results and Status Information on all NTP Chemicals PRoduced from NTP (Lemtrack System, 7/8/91 National Toxicology Program /National Institute of Environmental Health Sciences (NTP/NIEHS), Unpublished results from Salmonella Study conducted at SRI International, 1991.

Nelson, M.A., "The Importance of DNA Strand Breaks to the Hepatocarcinogenic Effects of Trichloroethylene." U.M.I. Dissertation Information Service, University Microfilms International A. Bell and Howell Information Company, Ann Arbor, Michigan, Professional Thesis (1989), pp. 1- .

NIOSH, National Institute for Occupational Safety and Health, National Occupational Exposure Survey (NOES), data communicated by Joseph A.Seta, Acting Section Chief, Division of Surveillance, Hazard Evaluations and Field Studies. January 1991a.

NIOSH, National Institute for Occupational Safety and Health, National Occupational Exposure Survey (NOES), data communicated by Joseph A.Seta, Acting Section Chief, Division of Surveillance, Hazard Evaluations and Field Studies. January 1991b.

Nomiyama, H. and Nomiyama, K., "Pathway and Rate of Metabolism of Trichloroethylene in Rats and Rabbits." Industrial Health, Vol. 17 (1979), pp. 29-37.

Nonaka, S., Ohgami, T., Yamashita, K., Irifune, H., Watanabe, M., Tsukazaki, N., Tanaka, K. and Yoshida, H., "The Effect of Chlorinated Chemicals on Porphyrin Metabolism - The Synergistic Effect with Chlorinated Chemicals and Low Concentrations of Griseofulvin." Fukuoka Acta. Med., Vol. 80 No.5 (1989), pp. 221-226.

Norwood, D.L., Thompson, G.P., Johnson, J.D. and Christman, R.F., "Monitoring Trichloroacetic Acid in Municipal Drinking Water." Wter Chlorination-Chemistry, Environmental Impact and Health Effects, Vol. 5, Lewis Publishers, Inc., Chelsea, Michigan (1985), pp. 1115-1122.

OPD Chemical Buyers Directory (OPD), Chemical Marketing Reporter, Seventy fifth Annual Edition. New York, New York: pp. 842, 900, 903, 905, 910-911, 42-44, 420.

Oblath, S.B., "Organic Compounds at the SRP Old Burial Ground for Low Level RAdioactive Waste." Proceedings for the Symposium on Wste Mangement, Vol. 3 (1987), pp. 235-239.

Office of the Federal Register, National Archives and Records Administration. Code of Federal Regulations, Title 21, Labor, Part 1910. U.S. Government Printing Office. Washington, D.C. January 19, 1989, pp. 2605, 2612-2513, 2620-2621, 2642-2644.

Ono, Y., Somiya, I. and Kawamura, M., "The Evaluation of Genotoxicity Using DNA Repairing Test for Chemicals Produced in Chlorination and Ozonation Processes." Water Science Technology, Vol. 23 (1991), pp. 329-338.

Ortali, V.A., Cardamone, G., Salvini, P., DiGuiseppe, G. and Carere, A., "Relazione Tra Attiviter Mutagena E Struttura Chimica in Alcumi Pesticidi: Impiego della Salmonella typhimurium edello Streptonyces coelicolor." Atti Associazione Genetrica Italiana, Vol. 22 (1977), pp. 53-54.

Parnell, M.J., "Toxicological Evaluation of Trichloroacetic Acid: Effects on Rat Liver Peroxisomes and Enzyme-Altered Foci." U.M.I. Dissertation Information Service, University Microfilms International A. Bell and Howell Information Company, Ann Arbor, Michigan, Professional Thesis (1986), pp. 1- .

Parnell, M.J., Exon, J.H. and Koller, L.D., "Assessment of Hepatic Initiation-Promotion Properties of Trichloroacetic Acid." Archives of Environmental Contamination Toxicology, Vol. 17 (1988), pp. 429-436.

Parnell, M.J., Koller, LD., Exon, J.H. and Arnzen, J.M., "Trichloroacetic Acid Effects on Rat Liver Peroxisomes and Enzyme-Altered Foci.," Environmental Health Perspectives, Vol. 69 (1986), pp. 73-79.

Physician's Desk Reference, Forty-fifth Edition. Oradell, New Jersey: Medical Economics, 1991, pp. 1043-1044.

Plotnikow, V.A. and Petrov, A.P., "Combined Action of Trichloroacetic Acid and Dimethyl Sulfate on Anabidopsis in Relation to the Theory of the Role of Histones in the Mutation Process." Cytology and Genetics (English Edition), Vol. 10, No. 1 (1976), pp. 33-36.

Plunkett, E.R., Handbook of Industrial Toxicology, Third Edition. New York: Chemical Publishing Company, Inc., 1987, pp. 541-542.

Poitrast, B.J., Keller, W.C. and Elves, R.G., "Estimation of Chemical Hazards in Brest Milk." aviation, Space, and Environmental Medicine, Vol. 59 No. 11 Section 2 (1988), pp. A87-A92.

Potter, C.L., DeAngelo, A.B. and Daniel, F.B., "Effects on Dichloroacetic Acid on Hepatic Growth and Ornithine Decarboxylase Activity in B6C3F1 Mice." The Toxicologist: Society of Toxicology, 29th Annual Meeting, Miami Beach, Florida (1990), p. 182 (Poster Paper).

Pound, A.W. and Withers, H.R., "The Influence of Some Irritant Chemicals and Scarification on Tumour Initiation by Urethane in Mice." British Journal of Cancer, Vol. 17 (1963), pp. 460-470.

Physician's Desk Reference (PDR), Forty-fifth Edition. Onadell, New Jersey: Medical Economics, 1991. pp. 1043-1044.

Qiong, A., Wenheng, Q, Wei, T. and Ruwei, X., "Study on TCA Residue Behaviours in Soil, Wheat, and Corn." Acta Pedologica Sinica, Vol. 26 No. 2 (1989), pp. 173-178.

Rapson, W.H., Nazar, M.A. and Butsky, V.V., "Mutagenicity Produced by Aqueous Chlorination of Organic Compounds." Bulletin of Environmental Contamination and Toxicology, Vol. 24 (1980), pp. 590-596.

Reckhow, D.A., "Chlorination of Humic Materials: Byproduct Formation and Chemical Interpretations." Environmental Science Technology, Vol. 24 (1990), pp. 1655-1664.

Sato, T., Mukaida, M. Ose, Y., Nagase, H. and Ishikawa, T. "Mutagenicity of Chlorinated Products from Soil Humic Substances." The Science of the Total Environment, Vol. 46 (1985), pp. 229-241.

Sax, N.I. and Lewis, R.J. Sr., Hawley's Condensed Chemical Dictionary, Eleventh Edition. New York: Van Nostrand Reinhold, 1987, pp. 375, 1175.

Sax, N.I. and Lewis, R.J. Sr., Dangerous Properties of Industrial Materials, Volumes I, II, III. Seventh Edition. New York: Van Nostrand Reinhold, 1989, pp. 766, 1129, 3323-3324, .

Seilern-Aspang, F. and Kratochwil, K., "Induction and Differentiation of an Epithelial Tumour in the Newt (Triturus cristatus)." Journal of Embryology exp. Morph., Vol. 10, Part 3 (1962), pp. 337-356.

Shelley, W.B. and Raque, C.J., "Delayed Patterned Hair Depigmentation in CBA Mice Following Application of Laundry Ink." The Journal of Investigative Dermatology, Vol. 59, No. 2 (1972), pp. 202-205.

Sittig, M., Handbook of Toxic and Hazardous Chemicals, Second Edition. Park Ridge, New Jersey: Noyes Publications, 1985, pp. 877-878.

Smith, M.K., Randall, J.L., Read, E.J., Stober, J.A. and York, R.G., "Developmental Effects of Dichloroacetic Acid in Long-Evans Rats." Teratology Society Abstracts, Vol. 39, No. 5 (1989), p. 482.

Smith, M.K., Randall, J.L. read, E.J. and Stober, J.A., "Teratogenic Activity of Trichloracetic Acid in the Rat." teratology, Vol. 40 (1989b), pp. 445-451.

Smith, M.K., Randall, J.L. and Stober, J.A., "Developmental Effects of Trichloracetic Acid in Long-Evans Rates." Teratology Scoiety Abstracts Vol. 37, No. 5 (1988), p. 495.

Smyth, H.F., Carpenter, C.P. and Weil, C.S., "Range-Finding Toxicity Data: List IV." AMA Archives of Industrial Hygiene and Occupational Medicine, Vol. 4 (1951), pp. 119-112.

SRI, Chemical Economics Handbook Online. database available from SRI, Menlo Park California, March, 1991.

SRI International, 1990b Directory of Chemical Producers, Western Europe, Menlo Park, California, 1991, pp. 1888, 2331, 238, 1638, 240-241, 248, 307, 1119, 312.

SRI International, 1990a Directory of Chemical Producers, United States of America, Menlo Stagnone, G.J., Orgel, M.G. and Stagnone, J.J., "Cardiovascular Effects of Topical 50% Trichloroacetic Acid and Bakers' Phenol Solution." Journal of Dermatologic Surgery and Oncology, Vol. 13, No. 9 (1987), pp. 999-1002.

Streibig, J.C., "Phytotoxicity and Adsorption of TCA and Chloridazon in Nine Danish Soils." Acta Agriculturae Scandinavica, Vol. 30 (1980), pp. 364-368.

The International Technical Information Institute, Toxic and Hazardous Industrial Chemicals Safety Manual for Handling and Disposal: With Toxicity and Hazard Data, Revised. Tokyo: The International Technical Information Institute, 1988, pp. 535, 161.

Torstensson, L. and Hammarström. "Degradation Capacity of TCA at Different Levels in some Soil Profiles." Journal and date not available.

United Stated Environmental Protection Agency (USEPA), Telephone communication with D. Lott, USEPA-FIFRA section, PHila. PA, September 24, 1991B.

United States Environmental Protection AGency (USEPA), Telephone convestation with D. Seter, USEPA-Drinking Water section, Phila., PA, September 25, 1991A.

United States Environmental Protection Agency (USEPA), 1988, Letter from L.S. Rosenstein, Chief Risk Analysis Branch, to Dr. D. Canten, Assistant to the Director, NTP.

United States Environmental Protection Agency (USEPA), 1988, Letter from L.S. Rosenstein, Chief, Risk Analysis Branch, Represtntative to the National Institute of Environmental Health Sciences, to Dr. D. Canter, NTP. February 1988.

United States Environmental Protection Agency (USEPA), 1991a U.S. Environmental Protection Agency, Computer Printout (TSCAPP): 1977 Production Statistics for Chemicals in the Nonconfidential Initial TSCA Chemical Substances Inventory. Washington, D.C.: Office of Pesticides and Toxic Substances.

United States Environmental Protection Agency (USEPA), 1991b U.S. Environmental Protection Agency, Computer Printout (TSCAPP): 1977 Production Statistics for Chemicals in the Nonconfidential Initial TSCA Chemical Substances Inventory. Washington, D.C.: Office of Pesticides and Toxic Substances.

United States International Trade Commission (USITC), Synthetic Organic Chemicals, United States Production and Sales, 1985. U.S, Government Printing Office. Publication No. 1892. Washington, D. C., 1986.

United States International Trade Commission (USITC), Synthetic Organic Chemicals, United States Production and Sales, 1986. U.S, Government Printing Office. Publication No. 2009. Washington, D. C., 1987.

United States International Trade Commission (USITC), Synthetic Organic Chemicals, United States Production and Sales, 1987. U.S, Government Printing Office. Publication No. 2118. Washington, D. C., 1988.

United States International Trade Commission (USITC), Synthetic Organic Chemicals, United States Production and Sales, 1988. U.S, Government Printing Office. Publication No. 2219. Washington, D. C., 1989.

United States International Trade Commission (USITC), Synthetic Organic Chemicals, United States Production and Sales, 1989. U.S, Government Printing Office. Publication No. 2219. Washington, D. C., 1990.

Verschueren, K., Handbook of Environmental Data on Organic Chemicals, Second Edition. New York: Van Nostrand Reinhold, 1983, pp. 473-474.

Voogd, C.E., Van der Stel, J.J., van Bruchem, M.C., Peters, J.B. and deLees, E.W.B., "Research on the Mutagenic Activity Chlorinated Product of Cyanoethanoic Acid in an Aqueous Environment: "Rijksinstituit voor de Volksgezondheid on Milieuhygiene, Bilthourd (Netherlands). Varkgroep Analytische Scheikunde (1989), pp 1-83.

Waskell, L., "A Study of the Mutagenicity of Anesthetics and Their Metabolites." Mutation Research, Vol. 57 (1978), pp. 141-153.

Weast, R.C., ed., CRC Handbook of Chemistry and Physics, Seventieth Edition. Boca Raton, Florida: CRC Press, Inc., 1989, pp. C-243, C-530.

Woodyard, G., Lane, S.W., Nelson, K.W. and Calvery, H.O. "The Acute Oral Toxicity of Acetic, Chlorocetic, Dichloracetic and Trichloracetic Acids." Journal of Industrial Hygiene and Toxicology, Vol. 23, No. 2 (1941), pp. 78-82.

Worthing, C.R., ed., The Pesticide Manual: A World Compendium, Eighth Edition. Croydon: The British Crop Protection Council, 1987, pp.765-766.

Ziglio, G., Beltramelli, G., Pregliasco, F. and Ferrari, G., "Metabolites of Chlorinated Solvents in Blood and Urine of Subjects Exposed at Environmental Level." The Science of the Total Environment, Vol. 47 (1985), pp. 473-477.