Bibliographic Citation
| Document | For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field. For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability. |
|---|---|
| Title | Effects of inflammation on copper, iron, and zinc metabolism |
| Creator/Author | Kishore, V. ; Ochillo, R.F. |
| Publication Date | 1986 Mar 05 |
| OSTI Identifier | OSTI ID: 7024675 |
| Report Number(s) | CONF-8604222- |
| Other Number(s) | CODEN: FEPRA |
| Resource Type | Journal Article |
| Resource Relation | Fed. Proc., Fed. Am. Soc. Exp. Biol. ; Vol/Issue: 45:4; 70. annual meeting of the Federation of American Society for Experimental Biology; 13 Apr 1986; St. Louis, MO, USA |
| Research Org | Xavier Univ. of Louisiana, New Orleans |
| Subject | 560300 -- Chemicals Metabolism & Toxicology ;550900 -- Pathology; COPPER-- METABOLISM;COPPER-- TISSUE DISTRIBUTION;INFLAMMATION-- BIOLOGICAL EFFECTS;IRON-- METABOLISM;IRON-- TISSUE DISTRIBUTION;ZINC-- METABOLISM;ZINC-- TISSUE DISTRIBUTION; ABSORPTION SPECTROSCOPY;RATS |
| Related Subject | ANIMALS;DISTRIBUTION;ELEMENTS;MAMMALS;METALS;PATHOLOGICAL CHANGES;RODENTS;SPECTROSCOPY;SYMPTOMS;TRANSITION ELEMENTS;VERTEBRATES |
| Description/Abstract | The objective of the present study was to study changes in copper (Cu), iron (Fe), and zinc (Zn) metabolism due to acute and chronic inflammation in the rat.^Carrageenin-induced foot edema (CE) and adjuvant-induced arthritis (AA) were used as models as acute and chronic inflammation, respectively.^A non-inflamed control group was included in each study.^Rats were sacrificed 72 h post-carrageenin in the CE study, and 21 days post-adjuvant in the AA study.^Samples of bone, brain, heart, kidney, liver, lung, muscle, pancreas, plasma, and spleen were analyzed for Cu, Zn, and Fe by atomic absorption spectrometry.^Only those metal conc. in the inflamed group which showed a significant change with respect to the corresponding control group are reported.^In the CE study: 1) Cu conc. increased in pancreas(75%), lungs(74%), and kidneys(47%), and decreased in the spleen(22%); 2) Zn conc. increased in pancreas(25%), lungs(27%), and in kidneys(18%); and 3) Fe conc. increased in pancreas(50%), lungs(21%), liver(26%), and brain(17%), and decreased in the muscle(21%).^In the AA study: 1) Cu conc. increased in plasma(159%), liver(126%). pancreas(90%), lungs(42%), bone(22%) and in the brain(13%); 2) Zn conc. increased in the liver(88%), pancreas(77%), and in kidneys(15%); and 3) Fe conc. increased in the liver(43%), pancreas(66%), and in the brain(31%).^Results indicate that both acute and chronic inflammation have a pronounced effect on Cu, Zn, and Fe metabolism. |
| Country of Publication | United States |
| Language | English |
| Format | Pages: 1080 |
| System Entry Date | 2001 May 13 |
Top | |
 |
Information
Bridge • Energy
Citations Database • E-print
Network • R&D
Accomplishments
About OSTI Science.gov • USA.gov • USAJOBS • Grants • Regulations.gov |
 |
|---|
Last Updated: 02/16/2009