Pyrogallol Table 12

http://ntp.niehs.nih.gov/go/7644

Table 12. Immunotoxicity of Pyrogallol
Test System or Species, Strain, and Age of Animal	Chemical Form, Purity	Dose	Endpoint Response	Comments	Reference
rats (albino, adult)	pyrogallol and carrageenin, purity n.p.	25 mg/kg (0.20 mmol/kg) pyrogallol i.p. 30 min. before carrageenin (0.05 mL of a 1% suspension) injection	Pyrogallol significantly inhibited carrageenin-induced edema.		Bhalla et al. (1970)
lymphocyte cultures from dissociated mouse splenic cells incubated with sheep red blood cells for 4-5 days	pyrogallol, purity n.p.	5 µg/culture (0.04 µmol/culture)	Treatment suppressed plaque formation by >90%.	The Mishell-Dutton system was used. The author stated that the immunosuppressive effect was not due to overt toxicity.	Archer (1978)

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