Functional Class: Energy metabolism; Glycolysis and gluconeogenesis
Gene Ontology:
Pathway:pathway table D-Arginine and D-ornithine metabolism Glycolysis / Gluconeogenesis
Primary Evidence: Figge,R.M. and Cerff,R. GAPDH gene diversity in spirochetes: a paradigm for genetic promiscuity Mol. Biol. Evol. 18 (12), 2240-2249 (2001) PubMed: 21576410
Secondary Evidence: Meinken C, Blencke HM, Ludwig H, Stulke J. Expression of the glycolytic gapA operon in Bacillus subtilis: differential syntheses of proteins encoded by the operon. Microbiology. 2003 Mar;149(Pt 3):751-61. PMID: 12634343
Solem C, Koebmann BJ, Jensen PR. Glyceraldehyde-3-Phosphate Dehydrogenase Has No Control over Glycolytic Flux in Lactococcus lactis MG1363. J Bacteriol. 2003 Mar;185(5):1564-71. PMID: 12591873
Comment: There are numerous significant matches to various classes of Eukaryota in gapped BLAST.
TDE1488 has significant similarity to the Treponema pallidum gene TP0844 (1e-164).
TDE1488 has significant similarity to the Borrelia burgdorferi gene 15594403 (7e-83).
Top Blast Hits:Updated monthly
Click here to view the entire PsiBlast results.
COGS Summary:COGS Search BeTs to clades of COG0057 COG name: Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Functional Class: G The phylogenetic pattern of COG0057 is aompkzyqvdrlbcefghsnuj-itw Number of proteins in this genome belonging to this COG is
Significant hit (7.4e-133) to 6/6 blocks of the IPB000173 family, which is described as "Glyceraldehyde 3-phosphate dehydrogenase". Interpro entry for IPR000173. IPB000173A 2-13 1.2e-08 IPB000173B 95-131 1e-10 IPB000173C 157-191 1.7e-19 IPB000173D 196-249 2e-39 IPB000173E 263-316 5.3e-31 IPB000173F 323-343 2e-17 IPB000173B 96-132 0.016 IPB000173C 158-192 0.028
Residues 187 to 326 match (5e-63) PD:PD000244 which is described as OXIDOREDUCTASE NAD GLYCOLYSIS DEHYDROGENASE GLYCERALDEHYDE 3-PHOSPHATE GAPDH GLYCERALDEHYDE-3-PHOSPHATE MULTIGENE FAMILY
Residues 47 to 131 match (1e-29) PD:PD000250 which is described as OXIDOREDUCTASE NAD GLYCOLYSIS DEHYDROGENASE GLYCERALDEHYDE 3-PHOSPHATE GAPDH GLYCERALDEHYDE-3-PHOSPHATE MULTIGENE FAMILY
Residues 145 to 186 match (6e-15) PD:PD585222 which is described as OXIDOREDUCTASE DEHYDROGENASE NAD GLYCOLYSIS GLYCERALDEHYDE 3-PHOSPHATE COMPLETE PROTEOME GLYCERALDEHYDE-3-PHOSPHATE GAPDH
Residues 145 to 185 match (6e-13) PD:PD559420 which is described as GLYCOLYSIS DEHYDROGENASE OXIDOREDUCTASE GLYCERALDEHYDE-3-PHOSPHATE NAD GLYCOSOMAL PRECURSOR PEPTIDE TRANSIT
Residues 1 to 43 match (4e-11) PD:PD000269 which is described as OXIDOREDUCTASE NAD GLYCOLYSIS DEHYDROGENASE GLYCERALDEHYDE 3-PHOSPHATE GAPDH GLYCERALDEHYDE-3-PHOSPHATE MULTIGENE FAMILY
Residues 145 to 186 match (8e-10) PD:PD586524 which is described as OXIDOREDUCTASE NAD DEHYDROGENASE GLYCOLYSIS GLYCERALDEHYDE 3-PHOSPHATE GAPDH PROTEOME COMPLETE GLYCERALDEHYDE-3-PHOSPHATE
Residues 145 to 186 match (4e-07) PD:PD589901 which is described as OXIDOREDUCTASE NAD GLYCOLYSIS DEHYDROGENASE GLYCERALDEHYDE 3-PHOSPHATE GAPDH FAMILY MULTIGENE GLYCERALDEHYDE-3-PHOSPHATE
Residues 1 to 163 (E-value = 1.9e-87) place TDE1488 in the Gp_dh_N family which is described as Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain (PF00044)
Residues 164 to 330 (E-value = 1.2e-111) place TDE1488 in the Gp_dh_C family which is described as Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain (PF02800)
Top PDB Hits:
PDB hits to TDE1488 from Psi-BLAST round 5 vs. nr database
51.0% similar to PDB:1J0X Crystal Structure Of The Rabbit Muscle Glyceraldehyde-3- Phosphate Dehydrogenase (Chain O,P,Q,R; 0.0) 49.0% similar to PDB:3GPD Twinning In Crystals Of Human Skeletal Muscle D- Glyceraldehyde-3-Phosphate Dehy (Chain R,G; 0.0) 53.0% similar to PDB:1SZJ Structure Of Holo-Glyceraldehyde-3-Phosphate-Dehydrogenase From Palinurus Versic (Chain G,R; 0.0) 53.0% similar to PDB:1CRW Crystal Structure Of Apo-Glyceraldehyde-3-Phosphate Dehydrogenase From Palinurus (Chain G,R; 0.0) 52.7% similar to PDB:1IHX Crystal Structure Of Two D-Glyceraldehyde-3-Phosphate Dehydrogenase Complexes: A (Chain A,B,C,D; 1e-179) 52.7% similar to PDB:1IHY Gapdh Complexed With Adp-Ribose (Chain A,B,C,D; 1e-179) 52.7% similar to PDB:1DSS Structure Of Active-Site Carboxymethylated D-Glyceraldehyde-3-Phosphate Dehydrog (Chain G,R; 1e-179) 53.0% similar to PDB:4GPD Apo-D-Gyceraldehyde-3-Phosphate Dehydrogenase (E.C.1.2.1.12) (Chain 1,2,3,4; 1e-178) 53.0% similar to PDB:1GPD D-Glyceraldehyde-3-Phosphate Dehydrogenase (E.C.1.2.1.12) (Chain G,R; 1e-178) 52.6% similar to PDB:1GAD Mol_id: 1; Molecule: D-Glyceraldehyde-3-Phosphate Dehydrogenase; Chain: O, P; Ec (Chain O,P; 1e-172)
Gene Protein Sequence:
MKVAINGFGRIGRLVFQALVNQNLLGKDKFDVVAVVDLSTDAKYFAYQLK YDSVQGKMDAKIGTDGDDVLVVNGHKIKCISGKGLTPAQLPWKELGIDVV IESTGIYTNEKAYEHLEAGAKKVIISAPGKSKDPAKPIKTFVMGVNENEY KASEHHVVSNASCTTNCLAPVVHVLLKEGFGIETGLMTTIHAYTATQKTV DGVSLKDWRGGRAAAVNIIPSTTGAAKAVGEVLPTTKGKLTGMSFRVPTP TGSVVDLTIRTEKDTSIEEIDKAIKKASESYLKGVLAYCDEEIVSTDIIH DPHSSIYDSKATLQNNLPGEKRFFKLVSWYDNEWGYSNRVIDLLKFITK