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 Thursday, March 16, 2006     Volume 16   Number 11  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
Spotlight
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CDC’s 2006 National Health Promotion Conference Call for Abstracts

CDC’s 2006 National Health Promotion Conference Call for Abstracts
September 12-14, 2006 ~ Atlanta, GA
A joint conference presented by CDC’s Coordinating Center for Health Promotion (CoCHP) as related to birth defects and developmental disabilities, chronic diseases prevention and health promotion and genomics and disease prevention. Submit a genomics and public health abstract today! Abstract due date: April 7, 2006

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CDC Announcements
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ATPM-CDC Preventive Medicine and Public Health Fellowship Program This reference links to a non-governmental website (last accessed 2/2008)
Fellows will gain leadership experience in public health practice and policy, access to state-of-the-art technology and national databases, and will train with leading experts in the field of preventive medicine and public health. ATPM Fellowships related to genomics are listed below.
Applications are due by 4/20/06
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  • Assessing the Health Impact of Advances in Genomics
  • Assessment of Genetic Testing in Clinical and Public Health Practice
  • The Intersection of Genetic Testing, Health Communication, and Technology: Addressing the Clinical and Laboratory Interface toward achieving Public Health Benefits
 
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(March, 2006) HuGENet™ releases the first edition of the HuGENet™ Handbook of Systematic Reviews. This reference links to a non-governmental website Link here to download free  Adobe Reader (167KB) This document has extensive guidance for integrating evidence on gene-disease associations, types of systematic reviews and complete set of points to consider for conducting such reviews.

   
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Inaugural Meeting - CDC Public Health Genomics Collaboration
March 17, 2006 ~ Atlanta, Georgia
Meeting open to CDC employees/contractors only

   
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From public health emergency to public health services: the implications for evolving criteria for newborn screening panels
Grosse S. et al. Pediatrics March 2006
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Gene therapy shows future promise” This reference links to a non-governmental website
(March 15) National Nine News reports, “The disabling bleeding disorder haemophilia is one step closer to being cured, following a world first by Sydney researchers who have successfully used gene therapy to treat the life-threatening condition.”

“Cells in mucus from lungs of high-risk patients can predict tumor development” This reference links to a non-governmental website
(March 15) EurekAlert! reports, “In a group of high-risk patients, a test that examined DNA from cells expelled in sputum for evidence of "silenced" genes correctly identified the majority of patients who were later diagnosed with lung cancer, say researchers in a study published in the March 15 issue of Cancer Research.”

“New York Times Magazine Examines Legal, Moral, Ethical Issues Surrounding Prenatal Testing For Genetic Defects” This reference links to a non-governmental website
(March 15) Medical News Today reports, “The New York Times Magazine on Sunday examined the legal, moral and ethical issues surrounding pregnancy termination because of detected genetic defects.”

“Studying the gene-expression profiles of patients with colorectal cancer might help predict their response to chemotherapy” This reference links to a non-governmental website
(March 15) News Medical.net reports, “In a study published in the open access journal Genome Biology, researchers identified in the tumours of colorectal cancer patients almost 700 genes whose expression was different between patients who subsequently responded well to combined chemotherapy and patients who were resistant to the therapy.”

“Unraveling The Genetics of Schizophrenia” This reference links to a non-governmental website
(March 14) eMaxHealth reports, “Misunderstanding abounds with schizophrenia, beginning with its name.”

“Scientists launch big genetic database project” This reference links to a non-governmental website
(March 14) PlanetArk reports, “A major project to collect DNA samples and medical data from 500,000 people was launched on Wednesday to study how genes, lifestyle and environment affect the risk of disease.”

“Silent Struggle: A New Theory of Pregnancy” This reference links to a non-governmental website
(March 14) Reuters reports, “Pregnancy can be the most wonderful experience life has to offer. But it can also be dangerous.”

“Researchers Identify Gene Variations That May Determine Which Heart Failure Patients Are Likely to Benefit from Treatment With BiDil(R)” This reference links to a non-governmental website
(March 14) Reuters reports, “Today, NitroMed, Inc. (NASDAQ:NTMD) announced preliminary results from ongoing analyses of data collected during the African American Heart Failure Trial (A-HeFT), the clinical trial supporting effectiveness of BiDil(R) (isosorbide dinitrate/hydralazine hydrochloride), that may determine whether specific variations of genes important in cardiovascular diseases can act as genetic markers for heart failure patients who might best respond to treatment with BiDil.”

“Sanofi gene therapy reduces amputations: researchers”
(March 14) Reuters reports, “Injections of a Sanofi-Aventis experimental gene therapy treatment cut the risk of amputations in patients with severely decreased blood flow to the legs, according to results reported on Sunday from a mid-stage trial.”

“L'Oreal Award For Australian Geneticist” This reference links to a non-governmental website
(March 14) Medical News Today reports, “ANU/University of Melbourne evolutionary geneticist, Professor Jenny Graves, has received the Asia-Pacific laureate of the L'Oreal-UNESCO for Women in Science 2006 awards, and a prize of US$100,000.”

“An Introduction to Genetics and Genetic Testing”
(March 13) KidsHealth.org reports, “What do you know about your family tree?”

“A map of recent positive selection in the human genome” This reference links to a non-governmental website
(March 13) News Medical.net reports, “By scanning the entire human genome in search of genetic variations that may signal recent evolution, University of Chicago researchers found more than 700 genetic variants that may be targets of recent natural positive selection during the past 10,000 years of human evolution.”

“Create ‘genetic map’ to identify hereditary diseases, MoH urged; Three-day medical conference kicks off”
(March 13) Arab Times reports, “Kuwait Medi-cal Genetics Center (KMGC) Director, Sadiqa Al-Awadhi, said that mental disabilities and mental paralysis are the most common genetic diseases in Kuwait.”

“Genes 'responsible for cocaine addiction'” This reference links to a non-governmental website
(March 13) Netdoctor.co.uk reports, “Genes could be responsible for turning people into cocaine addicts, a new study has suggested.”

“Drug that switches on genes improves myelodysplastic syndrome treatment” This reference links to a non-governmental website
(March 13) EurekAlert! reports, “A potent member of a new class of drugs increases survival in some patients with myelodysplastic syndrome (MDS), and may become the new standard of therapy for this group of pre-cancer disorders, say researchers at The University of Texas M. D. Anderson Cancer Center who led a national study of the agent.”

“Publicly funded labs shouldn't be allowed to hoard flu data: U.S. researcher” This reference links to a non-governmental website
(March 12) CHealth reports, “A leading scientist in the field of genetic sequencing is calling on publicly funded U.S. researchers and research organizations to throw open their collections of H5N1 avian flu viruses to allow others to work toward lessening the pandemic threat the virus poses.”

“Understanding genes linked to cancer” This reference links to a non-governmental website
(March 10) myDNA reports, “Two researchers from the University of Navarra, Javier Novo and Jose Luis Vizmanos, have performed a bioinformatic study on the genes which have been implicated in the development of cancer.”

“Losing Gene Activity Can Be Good For Your Health” This reference links to a non-governmental website
(March 10) Medical News Today reports, “Some genes are quite simply bad for us, researchers at the Wellcome Trust Sanger Institute suggest today.”

“'Jumping Genes': New Target For Body's Innate Immune Protection System Against Viruses” This reference links to a non-governmental website
(March 9) Science Daily reports, “When HIV and other retroviruses invade a cell in the human body, a fierce battle ensues between the intruder and the cell's defense team: members of the APOBEC family, a handful of closely related antiviral proteins that try to disarm the invading virus by scrambling its genetic information.”

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Genomics in Scientific Literature
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Challenges Identifying Genetic Determinants of Pediatric Cancers - the Childhood Leukemia Experience
Sinnett D, et al.
Fam Cancer 2006 Mar;5(1):35-47

Ovarian cancer and genetic susceptibility in relation to the BRCA1 and BRCA2 genes. Occurrence, clinical importance and intervention
Sogaard M, et al.
Acta Obstet Gynecol Scand 2006;85(1):93-105

Genetic susceptibility to mycobacterial disease in humans
Fernando SL & Britton WJ
Immunol Cell Biol 2006 Apr;84(2):125-37

Host genetics influence tumour metastasis
Hunter K
Nat Rev Cancer 2006 Feb;6(2):141-6

Acute lymphoblastic leukaemia: a model for the pharmacogenomics of cancer therapy
Cheok MH & Evans WE
Nat Rev Cancer 2006 Feb;6(2):117-29

Relative and absolute risk of colorectal cancer for individuals with a family history: a meta-analysis
Butterworth AS, et al.
Eur J Cancer 2006 Jan;42(2):216-27

Haplotype analysis in the presence of informatively missing genotype data
Liu N, et al.
Genet Epidemiol 2006 Mar

Democratising access to genetic services
Williams-Jones B & Burgess MM
Fam Cancer 2006;5(1):117-21

Guidelines for disclosing genetic information to family members: from development to use
Godard B, et al.
Fam Cancer 2006;5(1):103-16

The European Opposition Against the BRCA Gene Patents*
Matthijs G
Fam Cancer 2006;5(1):95-102

The challenge of developing evidence-based genetics health care in practice
Wilson BJ
Fam Cancer 2006;5(1):55-9

BRCA1 and BRCA2 Mutations in Breast and Ovarian Cancer Syndrome: Reflection on the Creighton University Historical Series of High Risk Families
Sinilnikova OM, et al.
Fam Cancer 2006;5(1):15-20

Ascertainment adjustment in genetic studies of ordinal traits
Feng R & Zhang H
Hum Genet 2006 Mar

Patient responses to the disclosure of BRCA mutation tests in hereditary breast-ovarian cancer families
Lynch HT, et al.
Cancer Genet Cytogenet 2006 Mar;165(2):91-7

Searching for genetic clues to the causes of pre-eclampsia
Chappell S & Morgan L
Clin Sci (Lond) 2006 Apr;110(4):443-58

Attitudes to Genetic Testing for Deafness: The Importance of Informed Choice
Guillemin M & Gillam L
J Genet Couns 2006 Mar

The Relationship of Nondirectiveness to Genetic Counseling: Report of a Workshop at the 2003 NSGC Annual Education Conference
Weil J, et al.
J Genet Couns 2006 Mar

Acceptance of genetic testing for hereditary breast ovarian cancer among study enrollees from an African American kindred
Kinney AY, et al.
Am J Med Genet A 2006 Mar

Acceptance of fragile X premutation genetic screening in women with ovarian dysfunction
Pastore LM, et al.
Am J Obstet Gynecol 2006 Mar;194(3):738-43

           
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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending March 15, 2006, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Certain Conditions Originating in the Perinatal Period
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New this week

European Human Genetics Conference 2006 This reference links to a non-governmental website
May 6-9, 2006 ~ Amsterdam, Netherlands
New this week Clinical Genetics Society Spring Conference 2006 This reference links to a non-governmental website
March 23-24, 2006 ~ Glasgow, UK
   
  Atherothrombosis This reference links to a non-governmental website
April 2-7, 2006 ~ Keystone, Colorado
   
New this week
Cancer Genetics Moving Beyond the Basics This reference links to a non-governmental website Link here to download free  Adobe Reader (144 KB)
April 26, 2006 ~ Brooklyn Center, MN
   
New this week

Psychosocial Aspects of Genetics 2006 This reference links to a non-governmental website
May 6-9, 2006 ~ Amsterdam, Netherlands

   
New this week The National Fragile X Foundation 10th International Fragile X Conference This reference links to a non-governmental website
July 19-23, 2006 ~ Atlanta, Georgia
   
New this week 5th Hugo Mutation Detection Training Course This reference links to a non-governmental website
August 31- September 4, 2006 ~ Leiden, Netherlands
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Let's Go Surfing
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European Society of Human Genetics (ESHG) This reference links to a non-governmental website
ESHG is an international professional society founded in 1967 which promotes research in basic and applied human and medical genetics and facilitates contact between all persons who share these aims.

Orphanet This reference links to a non-governmental website
A database dedicat ed to information on rare diseases and orphan drugs.

ImMunoGeneTics Information System This reference links to a non-governmental website
“IMGT is a high-quality integrated knowledge resource specialized in the immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC), immunoglobulin superfamily and related proteins of the immune system (RPI) of human and other vertebrate species.”

 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: March 16, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: CDC's Office of Public Health Genomics