CNS Relationships With RetinoidsRats and Mice

Zetterstrom et al 1999, Krezel, 1999, Le Doze et al. 2000

• Specific dopamine enriched brain regions have retinoid receptors (cortex, hippocampus, caudate/putamen, nucleus accumbens, olfactory tubercle)

• Localization of proteins differs from localization by mRNA

• Dopamine 2 receptor genes have retinoid response elements

• Isotretinoin can be found in the brain after injections

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