Jennings MB, Lowenstine LL, Rosenthal A, Yee JL, Cotterman R, Antipa L, Hendrickx A, Gardner MB; Symposium on Nonhuman Primate Models for AIDS.
J Med Primatol. 1992 Sep-Oct; 21: abstract no. 39.
Department of Pathology, School of Medicine, University of California, Davis.
Four healthy juvenile male rhesus (Macaca mulatta) were inoculated IV with SIVmac and put in a group cage with 4 control animals and 4 animals immunized with inactivated, whole-virus vaccine previously shown to protect against cell-free, IV challenge with SIVmac. All four inoculates were antigenemic and PBMC culture positive at week 1. By week 10, two controls and two immunized animals were infected. One control was infected by week 2 and another by week 8, while one immunized animal was infected by week 3 and another by week 10. All of the animals were involved in fighting and had wounds. Mounting was observed, but intromission and ejaculation were unlikely. From this data, we conclude that SIVmac can be transmitted asexually among juvenile male rhesus monkeys. But inactivated, whole-virus vaccine does not protect against transmission.
Publication Types:
Keywords:
- Animals
- Macaca mulatta
- Male
- Simian immunodeficiency virus
- Vaccines, Inactivated
Other ID:
UI: 102202370
From Meeting Abstracts