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Our Science – Vinson Website

Charles R. Vinson, Ph.D.

Selected Publications
1)  Rozenberg JM, Shlyakhtenko A, Glass K, Rishi V, Myakishev MV, FitzGerald PC, Vinson C.
All and only CpG containing sequences are enriched in promoters abundantly bound by RNA polymerase II in multiple tissues.
BMC Genomics. 9: 67, 2008. [Journal]
2)  Tomita T, Kido T, Kurotani R, Iemura SI, Sterneck E, Natsume T, Vinson C, Kimura S.
CAATT/enhancer binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression.
J. Biol. Chem. 2008. [Journal]
3)  Uittenbogaard M, Martinka DL, Johnson PF, Vinson C, Chiaramello A.
5'UTR of the neurogenic bHLH Nex1/MATH-2/NeuroD6 gene is regulated by two distinct promoters through CRE and C/EBP binding sites.
J. Neurosci. Res. 85: 1-18, 2007. [Journal]
4)  Takemori K, Gao YJ, Ding L, Lu C, Su LY, An WS, Vinson C, Lee RM.
Elevated blood pressure in transgenic lipoatrophic mice and altered vascular function.
Hypertension. 49: 365-72, 2007. [Journal]
5)  Oh WJ, Rishi V, Pelech S, Vinson C.
Histological and proteomic analysis of reversible H-RasV12G expression in transgenic mouse skin.
Carcinogenesis. 2007. [Journal]
6)  Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Duquaine DC, Brosius FC, Gonzalez FJ, Vinson C, Pierre MA, Milstone DS, Mortensen RM.
Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality.
J. Clin. Invest. 117: 812-22, 2007. [Journal]
7)  Oh WJ, Rishi V, Orosz A, Gerdes MJ, Vinson C.
Inhibition of CCAAT/enhancer binding protein family DNA binding in mouse epidermis prevents and regresses papillomas.
Cancer Res. 67: 1867-76, 2007. [Journal]
8)  Bauer I, Al Sarraj J, Vinson C, Larsen R, Thiel G.
Interleukin-1beta and tetradecanoylphorbol acetate-induced biosynthesis of tumor necrosis factor alpha in human hepatoma cells involves the transcription factors ATF2 and c-Jun and stress-activated protein kinases.
J. Cell. Biochem. 100: 242-55, 2007. [Journal]
9)  Hursting SD, Nunez NP, Varticovski L, Vinson C.
The obesity-cancer link: lessons learned from a fatless mouse.
Cancer Res. 67: 2391-3, 2007. [Journal]
10)  Gerdes MJ, Myakishev M, Frost NA, Rishi V, Moitra J, Acharya A, Levy MR, Park SW, Glick A, Yuspa SH, Vinson C.
Activator protein-1 activity regulates epithelial tumor cell identity.
Cancer Res. 66: 7578-88, 2006. [Journal]
11)  Anzulovich A, Mir A, Brewer M, Ferreyra G, Vinson C, Baler R.
Elovl3: a model gene to dissect homeostatic links between the circadian clock and nutritional status.
J. Lipid Res. 47: 2690-700, 2006. [Journal]
12)  Ross MD, Martinka S, Mukherjee A, Sedor JR, Vinson C, Bruggeman LA.
Math6 expression during kidney development and altered expression in a mouse model of glomerulosclerosis.
Dev. Dyn. 235: 3102-9, 2006. [Journal]
13)  Luan H, Peabody NC, Vinson CR, White BH.
Refined spatial manipulation of neuronal function by combinatorial restriction of transgene expression.
Neuron. 52: 425-36, 2006. [Journal]
14)  Acharya A, Rishi V, Vinson C.
Stability of 100 homo and heterotypic coiled-coil a-a' pairs for ten amino acids (A, L, I, V, N, K, S, T, E, and R).
Biochemistry. 45: 11324-32, 2006. [Journal]
15)  Ablamunits V, Cohen Y, Brazee IB, Gaetz HP, Vinson C, Klebanov S.
Susceptibility to Induced and Spontaneous Carcinogenesis Is Increased in Fatless A-ZIP/F-1 but not in Obese ob/ob Mice.
Cancer Res. 66: 8897-902, 2006. [Journal]
16)  Fitzgerald PC, Sturgill D, Shyakhtenko A, Oliver B, Vinson C.
Comparative genomics of Drosophila and human core promoters.
Genome Biol. 7: R53, 2006. In Press. [Journal]
17)  Acharya A, Rishi V, Moll J, Vinson C.
Experimental identification of homodimerizing B-ZIP families in Homo sapiens.
J Struct Biol. 2006. In Press. [Journal]
18)  Nunez NP, Oh WJ, Rozenberg J, Perella C, Anver M, Barrett JC, Perkins SN, Berrigan D, Moitra J, Varticovski L, Hursting SD, Vinson C.
Accelerated tumor formation in a fatless mouse with type 2 diabetes and inflammation.
Cancer Res. 66: 5469-76, 2006. [Journal]
19)  Stefano L, Al Sarraj J, Rössler OG, Vinson C, Thiel G.
Up-regulation of tyrosine hydroxylase gene transcription by tetradecanoylphorbol acetate is mediated by the transcription factors Ets-like protein-1 (Elk-1) and Egr-1.
J. Neurochem. 97: 92-104, 2006. [Journal]
20)  Serebriiskii IG, Fang R, Latypova E, Hopkins R, Vinson C, Joung JK, Golemis EA.
A combined yeast/bacteria two-hybrid system: development and evaluation.
Mol Cell Proteomics. 4: 819-26, 2005. [Journal]
21)  Rishi V, Potter T, Laudeman J, Reinhart R, Silvers T, Selby M, Stevenson T, Krosky P, Stephen AG, Acharya A, Moll J, Oh WJ, Scudiero D, Shoemaker RH, Vinson C.
A high-throughput fluorescence-anisotropy screen that identifies small molecule inhibitors of the DNA binding of B-ZIP transcription factors.
Anal Biochem. 340: 259-71, 2005. [Journal]
22)  Vinson C.
A rationally designed small molecule that inhibits the HIF-1alpha-ARNT heterodimer from binding to DNA in vivo.
Sci STKE. 2005: pe23, 2005. [Journal]
23)  Jeong MY, Kinugawa K, Vinson C, Long CS.
AFos dissociates cardiac myocyte hypertrophy and expression of the pathological gene program.
Circulation. 111: 1645-51, 2005. [Journal]
24)  Sandberg MB, Fridriksson J, Madsen L, Rishi V, Vinson C, Holmsen H, Berge RK, Mandrup S.
Glucose-induced lipogenesis in pancreatic beta-cells is dependent on SREBP-1.
Mol Cell Endocrinol. 240: 94-106, 2005. [Journal]
25)  Suganami T, Mukoyama M, Mori K, Yokoi H, Koshikawa M, Sawai K, Hidaka S, Ebihara K, Tanaka T, Sugawara A, Kawachi H, Vinson C, Ogawa Y, Nakao K.
Prevention and reversal of renal injury by leptin in a new mouse model of diabetic nephropathy.
FASEB J. 19: 127-9, 2005. [Journal]
26)  Al Sarraj J, Vinson C, Thiel G.
Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP.
Biol. Chem. 386: 873-9, 2005. [Journal]
27)  Al Sarraj J, Vinson C, Han J, Thiel G.
Regulation of GTP cyclohydrolase I gene transcription by basic region leucine zipper transcription factors.
J. Cell. Biochem. 96: 1003-20, 2005. [Journal]
28)  Thiel G, Al Sarraj J, Vinson C, Stefano L, Bach K.
Role of basic region leucine zipper transcription factors cyclic AMP response element binding protein (CREB), CREB2, activating transcription factor 2 and CAAT/enhancer binding protein alpha in cyclic AMP response element-mediated transcription.
J Neurochem. 92: 321-36, 2005. [Journal]
29)  Dennis PA, Van Waes C, Gutkind JS, Kellar KJ, Vinson C, Mukhin AG, Spitz MR, Bailey-Wilson JE, Yeh GC, Anderson LM, Wiest JS.
The biology of tobacco and nicotine: bench to bedside.
Cancer Epidemiol Biomarkers Prev. 14: 764-7, 2005. [Journal]
30)  Bauer I, Hohl M, Al-Sarraj A, Vinson C, Thiel G.
Transcriptional activation of the Egr-1 gene mediated by tetradecanoylphorbol acetate and extracellular signal-regulated protein kinase.
Arch Biochem Biophys. 438: 36-52, 2005. [Journal]
31)  FitzGerald PC, Shlyakhtenko A, Mir AA, Vinson C.
Clustering of DNA sequences in human promoters.
Genome Res. 14: 1562-74, 2004. [Journal]
32)  FitzGerald PC, Shlyakhtenko A, Mir AA, Vinson C.
Clustering of DNA sequences in human promoters.
Genome Res. 14: 1562-74, 2004. [Journal]
33)  Deppmann CD, Acharya A, Rishi V, Wobbes B, Smeekens S, Taparowsky EJ, Vinson C.
Dimerization specificity of all 67 B-ZIP motifs in Arabidopsis thaliana: a comparison to Homo sapiens B-ZIP motifs.
Nucleic Acids Res. 32: 3435-45, 2004. [Journal]
34)  Deppmann CD, Acharya A, Rishi V, Wobbes B, Smeekens S, Taparowsky EJ, Vinson C.
Dimerization specificity of all 67 B-ZIP motifs in Arabidopsis thaliana: a comparison to Homo sapiens B-ZIP motifs.
Nucleic Acids Res. 32: 3435-45, 2004. [Journal]
35)  Cheung C, Akiyama TE, Ward JM, Nicol CJ, Feigenbaum L, Vinson C, Gonzalez FJ.
Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha.
Cancer Res. 64: 3849-54, 2004. [Journal]
36)  Cheung C, Akiyama TE, Ward JM, Nicol CJ, Feigenbaum L, Vinson C, Gonzalez FJ.
Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha.
Cancer Res. 64: 3849-54, 2004. [Journal]
37)  Zhang JW, Tang QQ, Vinson C, Lane MD.
Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes.
Proc Natl Acad Sci U S A. 101: 43-7, 2004. [Journal]
38)  Zhang JW, Tang QQ, Vinson C, Lane MD.
Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes.
Proc Natl Acad Sci U S A. 101: 43-7, 2004. [Journal]
39)  Appierto V, Villani MG, Cavadini E, Lotan R, Vinson C, Formelli F.
Involvement of c-Fos in fenretinide-induced apoptosis in human ovarian carcinoma cells.
Cell Death Differ. 11: 270-9, 2004. [Journal]
40)  Suganami T, Mukoyama M, Mori K, Yokoi H, Koshikawa M, Sawai K, Hidaka S, Ebihara K, Tanaka T, Sugawara A, Kawachi H, Vinson C, Ogawa Y, Nakao K.
Prevention and reversal of renal injury by leptin in a new mouse model of diabetic nephropathy.
FASEB J. 2004. [Journal]
41)  Zhang JW, Klemm DJ, Vinson C, Lane MD.
Role of CREB in transcriptional regulation of CCAAT/enhancer-binding protein beta gene during adipogenesis.
J Biol Chem. 279: 4471-8, 2004. [Journal]
42)  Elefteriou F, Takeda S, Ebihara K, Magre J, Patano N, Kim CA, Ogawa Y, Liu X, Ware SM, Craigen WJ, Robert JJ, Vinson C, Nakao K, Capeau J, Karsenty G.
Serum leptin level is a regulator of bone mass.
Proc Natl Acad Sci U S A. 101: 3258-63, 2004. [Journal]
43)  Elefteriou F, Takeda S, Ebihara K, Magre J, Patano N, Kim CA, Ogawa Y, Liu X, Ware SM, Craigen WJ, Robert JJ, Vinson C, Nakao K, Capeau J, Karsenty G.
Serum leptin level is a regulator of bone mass.
Proc Natl Acad Sci U S A. 101: 3258-63, 2004. [Journal]
44)  Rishi V, Gal J, Krylov D, Fridriksson J, Boysen MS, Mandrup S, Vinson C.
SREBP-1 dimerization specificity maps to both the helix-loop-helix and leucine zipper domains: use of a dominant negative.
J Biol Chem. 279: 11863-74, 2004. [Journal]
45)  Rishi V, Gal J, Krylov D, Fridriksson J, Boysen MS, Mandrup S, Vinson C.
SREBP-1 dimerization specificity maps to both the helix-loop-helix and leucine zipper domains: use of a dominant negative.
J Biol Chem. 279: 11863-74, 2004. [Journal]
46)  Hahm SH, Chen Y, Vinson C, Eiden LE.
A calcium-initiated signaling pathway propagated through calcineurin and cAMP response element-binding protein activates proenkephalin gene transcription after depolarization.
Mol Pharmacol. 64: 1503-11, 2003. [Journal]
47)  Mir AA, Myakishev MV, Polesskaya OO, Moitra J, Petersen D, Miller L, Orosz A, Vinson C.
A search for candidate genes for lipodystrophy, obesity and diabetes via gene expression analysis of A-ZIP/F-1 mice.
Genomics. 81: 378-90, 2003. [Journal]
48)  Cataisson C, Joseloff E, Murillas R, Wang A, Atwell C, Torgerson S, Gerdes M, Subleski J, Gao JL, Murphy PM, Wiltrout RH, Vinson C, Yuspa SH.
Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways.
J Immunol. 171: 2703-13, 2003. [Journal]
49)  Williams KL, Zullo AJ, Kaplan MH, Brutkiewicz RR, Deppmann CD, Vinson C, Taparowsky EJ.
BATF transgenic mice reveal a role for activator protein-1 in NKT cell development.
J Immunol. 170: 2417-26, 2003. [Journal]
50)  Baccam M, Woo SY, Vinson C, Bishop GA.
CD40-mediated transcriptional regulation of the IL-6 gene in B lymphocytes: involvement of NF-kappa B, AP-1, and C/EBP.
J Immunol. 170: 3099-108, 2003. [Journal]
51)  Rishi V, Vinson C.
Dominant-negative mutants of helix-loop-helix proteins: transcriptional inhibition.
Methods Enzymol. 370: 454-66, 2003. [Journal]
52)  Rishi V, Vinson C.
Dominant-negative mutants of helix-loop-helix proteins: transcriptional inhibition.
Methods Enzymol. 370: 454-66, 2003. [Journal]
53)  Gavrilova O, Haluzik M, Matsusue K, Cutson JJ, Johnson L, Dietz KR, Nicol CJ, Vinson C, Gonzalez FJ, Reitman ML.
Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass.
J Biol Chem. 278: 34268-76, 2003. [Journal]
54)  Colombo C, Haluzik M, Cutson JJ, Dietz KR, Marcus-Samuels B, Vinson C, Gavrilova O, Reitman ML.
Opposite effects of background genotype on muscle and liver insulin sensitivity of lipoatrophic mice. Role of triglyceride clearance.
J Biol Chem. 278: 3992-9, 2003. [Journal]
55)  Minn AH, Patterson NB, Pack S, Hoffmann SC, Gavrilova O, Vinson C, Harlan DM, Shalev A.
Resistin is expressed in pancreatic islets.
Biochem Biophys Res Commun. 310: 641-5, 2003. [Journal]
56)  Tkach V, Tulchinsky E, Lukanidin E, Vinson C, Bock E, Berezin V.
Role of the Fos family members, c-Fos, Fra-1 and Fra-2, in the regulation of cell motility.
Oncogene. 22: 5045-54, 2003. [Journal]
57)  Szentirmay MN, Yang HX, Pawar SA, Vinson C, Sawadogo M.
The IGF2 receptor is a USF2-specific target in nontumorigenic mammary epithelial cells but not in breast cancer cells.
J Biol Chem. 278: 37231-40, 2003. [Journal]
58)  Chen WG, West AE, Tao X, Corfas G, Szentirmay MN, Sawadogo M, Vinson C, Greenberg ME.
Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons.
J Neurosci. 23: 2572-81, 2003. [Journal]
59)  Acharya A, Ruvinov SB, Gal J, Moll JR, Vinson C.
A heterodimerizing leucine zipper coiled coil system for examining the specificity of a position interactions: amino acids I, V, L, N, A, and K.
Biochemistry. 41: 14122-31, 2002. [Journal]
60)  Bonovich M, Olive M, Reed E, O'Connell B, Vinson C.
Adenoviral delivery of A-FOS, an AP-1 dominant negative, selectively inhibits drug resistance in two human cancer cell lines.
Cancer Gene Ther. 9: 62-70, 2002. [Journal]
61)  Couldrey C, Moitra J, Vinson C, Anver M, Nagashima K, Green J.
Adipose tissue: a vital in vivo role in mammary gland development but not differentiation.
Dev Dyn. 223: 459-68, 2002. [Journal]
62)  Ménard C, Hein P, Paquin A, Savelson A, Yang XM, Lederfein D, Barnabé-Heider F, Mir AA, Sterneck E, Peterson AC, Johnson PF, Vinson C, Miller FD.
An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis.
Neuron. 36: 597-610, 2002. [Journal]
63)  Fassler J, Landsman D, Acharya A, Moll JR, Bonovich M, Vinson C.
B-ZIP proteins encoded by the Drosophila genome: evaluation of potential dimerization partners.
Genome Res. 12: 1190-200, 2002. [Journal]
64)  Vinson C, Myakishev M, Acharya A, Mir AA, Moll JR, Bonovich M.
Classification of human B-ZIP proteins based on dimerization properties.
Mol Cell Biol. 22: 6321-35, 2002. [Journal]
65)  Watson PA, Vinson C, Nesterova A, Reusch JE.
Content and activity of cAMP response element-binding protein regulate platelet-derived growth factor receptor-alpha content in vascular smooth muscles.
Endocrinology. 143: 2922-9, 2002. [Journal]
66)  Katz BZ, Miyamoto S, Teramoto H, Zohar M, Krylov D, Vinson C, Gutkind JS, Yamada KM.
Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation.
Biochim Biophys Acta. 1592: 141-52, 2002. [Journal]
67)  Moll JR, Acharya A, Gal J, Mir AA, Vinson C, Gal J.
Magnesium is required for specific DNA binding of the CREB B-ZIP domain.
Nucleic Acids Res. 30: 1240-6, 2002. [Journal]
68)  Gong P, Stewart D, Hu B, Vinson C, Alam J.
Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite.
Arch Biochem Biophys. 405: 265-74, 2002. [Journal]
69)  Iwama A, Osawa M, Hirasawa R, Uchiyama N, Kaneko S, Onodera M, Shibuya K, Shibuya A, Vinson C, Tenen DG, Nakauchi H.
Reciprocal roles for CCAAT/enhancer binding protein (C/EBP) and PU.1 transcription factors in Langerhans cell commitment.
J Exp Med. 195: 547-58, 2002. [Journal]
70)  Colombo C, Cutson JJ, Yamauchi T, Vinson C, Kadowaki T, Gavrilova O, Reitman ML.
Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy.
Diabetes. 51: 2727-33, 2002. [Journal]
71)  Chou CJ, Haluzik M, Gregory C, Dietz KR, Vinson C, Gavrilova O, Reitman ML.
WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha ) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice.
J Biol Chem. 277: 24484-9, 2002. [Journal]
72)  Moll JR, Ruvinov SB, Pastan I, Vinson C.
Designed heterodimerizing leucine zippers with a ranger of pIs and stabilities up to 10(-15) M.
Protein Sci. 10: 649-55, 2001. [Journal]
73)  Rutberg SE, Adams TL, Glick A, Bonovich MT, Vinson C, Yuspa SH.
Activator protein 1 transcription factors are fundamental to v-rasHa-induced changes in gene expression in neoplastic keratinocytes.
Cancer Res. 60: 6332-8, 2000. [Journal]
74)  Chao L, Marcus-Samuels B, Mason MM, Moitra J, Vinson C, Arioglu E, Gavrilova O, Reitman ML.
Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones.
J Clin Invest. 106: 1221-8, 2000. [Journal]
75)  Moll JR, Olive M, Vinson C.
Attractive interhelical electrostatic interactions in the proline- and acidic-rich region (PAR) leucine zipper subfamily preclude heterodimerization with other basic leucine zipper subfamilies.
J Biol Chem. 275: 34826-32, 2000. [Journal]
76)  Gavrilova O, Marcus-Samuels B, Leon LR, Vinson C, Reitman ML.
Leptin and diabetes in lipoatrophic mice.
Nature. 403: 850; discussion 850-1, 2000. [Journal]
77)  Gavrilova O, Marcus-Samuels B, Graham D, Kim JK, Shulman GI, Castle AL, Vinson C, Eckhaus M, Reitman ML.
Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice.
J Clin Invest. 105: 271-8, 2000. [Journal]
78)  Rutberg SE, Adams TL, Olive M, Alexander N, Vinson C, Yuspa SH.
CRE DNA binding proteins bind to the AP-1 target sequence and suppress AP-1 transcriptional activity in mouse keratinocytes.
Oncogene. 18: 1569-79, 1999. [Journal]
79)  Gavrilova O, Leon LR, Marcus-Samuels B, Mason MM, Castle AL, Refetoff S, Vinson C, Reitman ML.
Torpor in mice is induced by both leptin-dependent and -independent mechanisms.
Proc Natl Acad Sci U S A. 96: 14623-8, 1999. [Journal]
80)  Reitman ML, Mason MM, Moitra J, Gavrilova O, Marcus-Samuels B, Eckhaus M, Vinson C.
Transgenic mice lacking white fat: models for understanding human lipoatrophic diabetes.
Ann N Y Acad Sci. 892: 289-96, 1999. [Journal]
81)  Moitra J, Mason MM, Olive M, Krylov D, Gavrilova O, Marcus-Samuels B, Feigenbaum L, Lee E, Aoyama T, Eckhaus M, Reitman ML, Vinson C.
Life without white fat: a transgenic mouse.
Genes Dev. 12: 3168-81, 1998. [Journal]
82)  Vinson C, Acharya A, Taparowsky EJ.
Deciphering B-ZIP transcription factor interactions in vitro and in vivo.
Biochim. Biophys. Acta. 1759: 4-12, , ,. [Journal]

This page was last updated on 7/23/2008.