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 EC-number:  3.6.4.6 ----- vesicle-fusing ATPase
EC-NUMBER 3.6.4.6
ENZYME-NAME vesicle-fusing ATPase
ENZYME-SYSNAME A large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger''s syndrome.
ENZYME-CLASS Hydrolases Acting on acid anhydrides Involved in cellular and subcellular movement
SYNONYMS   >>more synonyms
REACTION ATP + H2O = ADP + phosphate [RN:R00086]
PATHWAY EMP-PATHWAYS: NO EMP PATHWAY FOUND
KEGG-PATHWAYS: NO KEGG PATHWAY FOUND
GO_TERM GO: :
ENZYME-COMMENT ATP phosphohydrolase (vesicle-fusing)
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ExternalDB ----- DBLINKS
Diseases
Structure
Gene
Motif
Ortholog
Literature
Other
InterPro Domains found in sequences annotated as EC 3.6.4.6
   IPR000641 CbxX/CfqX
   IPR000642 Peptidase M41
   IPR001086 Prephenate dehydratase
   IPR001220 Legume lectin, beta domain
   IPR001251 Cellular retinaldehyde-binding/triple function, C-terminal
   IPR001951 Histone H4
   IPR001984 Peptidase S16, lon protease
   IPR002453 Beta tubulin
   IPR003338 AAA ATPase VAT, N-terminal
   IPR003593 AAA ATPase
   IPR003959 AAA ATPase, central region
   IPR003960 AAA-protein subdomain
   IPR004201 Cell division protein 48, CDC48, domain 2
   IPR005936 Peptidase M41, FtsH
   IPR005937 26S proteasome subunit P45
   IPR005938 AAA ATPase, CDC48
   IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site
   IPR009010 Aspartate decarboxylase-like fold
   IPR009053 Prefoldin
   IPR010279 Protein of unknown function DUF883, ElaB
   IPR011029 DEATH-like
   IPR011546 Peptidase M41, FtsH extracellular
       
PIR SuperFamilies containing EC 3.6.4.6
SF001172 transitional endoplasmic reticulum ATPase
SF005236 cell division protein ftsH
Taxonomic breakdown of EC 3.6.4.6 sequences
To perform phylogenetic analysis, first select some protein ids by clicking on their checkboxes, then click on one of the buttons below.
  Additional gi numbers:   
Bacteria
Actinobacteria
Actinobacteria (class)
Thermobifida fusca
72162208
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR009053 Prefoldin
72163294
IPR000642 Peptidase M41
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR011546 Peptidase M41, FtsH extracellular
Chlorobi
Chlorobia
Chlorobium chlorochromatii
78187991
78188369
Pelodictyon luteolum
78185968
78186575
78187576
Cyanobacteria
Anabaena variabilis
75812548
IPR001251 Cellular retinaldehyde-binding/triple function, C-terminal
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
75812691
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
75906293
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
75906798
IPR000642 Peptidase M41
IPR001984 Peptidase S16, lon protease
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR011546 Peptidase M41, FtsH extracellular
75907471
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
75908451
IPR000642 Peptidase M41
IPR001984 Peptidase S16, lon protease
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site
IPR011546 Peptidase M41, FtsH extracellular
75908658
IPR000642 Peptidase M41
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site
IPR011546 Peptidase M41, FtsH extracellular
75909397
IPR000642 Peptidase M41
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site
IPR011546 Peptidase M41, FtsH extracellular
75909709
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
75910963
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
Prochlorococcus marinus
72382133
IPR000642 Peptidase M41
IPR001984 Peptidase S16, lon protease
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site
IPR011546 Peptidase M41, FtsH extracellular
72382193
IPR000642 Peptidase M41
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR011546 Peptidase M41, FtsH extracellular
72383431
IPR000642 Peptidase M41
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR011546 Peptidase M41, FtsH extracellular
78778614
78779135
78779330
Synechococcus elongatus
56750609
IPR000642 Peptidase M41
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site
IPR011546 Peptidase M41, FtsH extracellular
56751224
IPR000642 Peptidase M41
IPR001984 Peptidase S16, lon protease
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR011546 Peptidase M41, FtsH extracellular
81299807
81300123
Synechococcus sp. CC9605
78211853
78212852
78212968
Synechococcus sp. CC9902
78184634
78184725
78185610
Proteobacteria
Alphaproteobacteria
Nitrobacter winogradskyi
75676894
IPR000642 Peptidase M41
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR011546 Peptidase M41, FtsH extracellular
Betaproteobacteria
Burkholderia sp. 383
78062370
78065910
Cupriavidus necator
73541858
IPR000642 Peptidase M41
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR011546 Peptidase M41, FtsH extracellular
Deltaproteobacteria
Desulfovibrio desulfuricans
78356558
78358454
Gammaproteobacteria
Nitrosococcus oceani
77163807
IPR000642 Peptidase M41
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR011546 Peptidase M41, FtsH extracellular
77164192
IPR001951 Histone H4
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
77164873
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
77165350
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
77165372
IPR000642 Peptidase M41
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR011546 Peptidase M41, FtsH extracellular
77166027
IPR000642 Peptidase M41
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR011546 Peptidase M41, FtsH extracellular
Pseudoalteromonas haloplanktis
77359819
IPR000642 Peptidase M41
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR011546 Peptidase M41, FtsH extracellular
Pseudomonas fluorescens
77460190
IPR010279 Protein of unknown function DUF883, ElaB
Pseudomonas syringae
63258121
IPR000642 Peptidase M41
IPR001984 Peptidase S16, lon protease
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR011546 Peptidase M41, FtsH extracellular
Thiomicrospira crunogena
78485157
Xylella fastidiosa
28198007
IPR000642 Peptidase M41
IPR001984 Peptidase S16, lon protease
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR005936 Peptidase M41, FtsH
IPR011546 Peptidase M41, FtsH extracellular
Eukaryota
Leishmania major
68126289
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR009010 Aspartate decarboxylase-like fold
Trypanosoma cruzi
71415283
IPR001220 Legume lectin, beta domain
IPR001984 Peptidase S16, lon protease
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR009010 Aspartate decarboxylase-like fold
71419247
IPR001220 Legume lectin, beta domain
IPR001984 Peptidase S16, lon protease
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR009010 Aspartate decarboxylase-like fold
Chordata
Mammalia
Homo sapiens
11079228
IPR001984 Peptidase S16, lon protease
IPR003338 AAA ATPase VAT, N-terminal
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR004201 Cell division protein 48, CDC48, domain 2
IPR009010 Aspartate decarboxylase-like fold
Mus musculus
1171774
IPR001984 Peptidase S16, lon protease
IPR003338 AAA ATPase VAT, N-terminal
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR004201 Cell division protein 48, CDC48, domain 2
IPR009010 Aspartate decarboxylase-like fold
Nematoda
Chromadorea
Caenorhabditis elegans
3881462
IPR003338 AAA ATPase VAT, N-terminal
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR004201 Cell division protein 48, CDC48, domain 2
IPR009010 Aspartate decarboxylase-like fold
Streptophyta
Arabidopsis thaliana
20856713
IPR003338 AAA ATPase VAT, N-terminal
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR003960 AAA-protein subdomain
IPR009010 Aspartate decarboxylase-like fold
  Additional gi numbers:   

To perform phylogenetic analysis:

  1. Select some ids by clicking on their checkboxes.
  2. Click on one of the buttons above.