Research
Interests
Statistical methodology for
cDNA and oligonucleotide microarray analysis.
Applications of microarray analysis to the Molecular classification
of Lymphoma
Selected Publications
As of April 3, 2006
Iqbal J, Neppalli VT, Wright G, Dave
LJ, Horsman DE, Rosenwald A, Lynch J, Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Campo E, Ott G, Muller-Hermelink HK, Delabie J, Jaffe ES, Grogan TM, Connors JM, Vose JM, Armitage JO, Staudt
LM, Chan WC. BCL2 expression is a
prognostic marker for the activated B-cell-like type of diffuse large B-cell lymphoma
JOURNAL OF CLINICAL ONCOLOGY
24 (6): 961-968
FEB 20 2006
Fu K, Weisenburger DD, Greiner
TC, Dave S, Wright G,
Rosenwald A, Chiorazzi M, Iqbal J, Gesk S, Siebert
R, De Jong D, Jaffe ES, Wilson WH, Delabie J, Ott G, Dave
BJ, Sanger WG, Smith LM, Rimsza L, Braziel RM,
Muller-Hermelink HK, Campo E, Gascoyne RD, Staudt
LM, Chan WCCyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene
expression profiling BLOOD 106 (13):
(2005)
Bea S, Zettl A, Wright G, Salaverria
I, Jehn P, Moreno V, Burek
C, Ott G, Puig X, Yang
LM, Lopez-Guillermo A, Chan WC, Greiner TC, Weisenburger
DD, Armitage JO, Gascoyne RD, Connors JM, Grogan
TM, Braziel R, Fisher RI, Smeland
EB, Kvaloy S, Holte H, Delabie J, Simon R, Powell J, Wilson WH, Jaffe ES,
Montserrat E, Muller-Hermelink HK, Staudt LM, Campo
E, Rosenwald A.Diffuse large B-cell lymphoma subgroups have distinct genetic profiles
that influence tumor biology and improve gene-expression-based survival prediction. BLOOD 106 (9): 3183-3190(2005)
Dunleavy K., Hakim F., Kim HK, Janik
JE, Grant N, Nakayama T, White T, Wright G, Kwak L,
Gress R, Tosato G. Wilson
W.B-cell recovery following rituximab-based therapy is associated with perturbations
in stromal derived factor-1 and granulocyte homeostais.
Blood 106 (3): 795-802 (2005)
Dave SS, Wright G, Tan B, Rosenwald A,
Gascoyne RD, Chan WC, Fisher RI, Braziel RM, Rimsza
LM, Grogan TM, Miller TP, LeBlanc M, Greiner TC, Weisenburger
DD, Lynch JC, Vose J, Armitage
JO, Smeland EB, Kvaloy S,
Holte H, Delabie J, Connors
JM, Lansdorp PM, Ouyang
Q, Lister TA, Davies AJ, Norton AJ, Muller-Hermelink
HK, Ott G, Campo E, Montserrat E, Wilson WH, Jaffe
ES, Simon R, Yang LM, Powell J, Zhao H, Goldschmidt N, Chiorazzi M, Staudt
LM.Prediction of survival in follicular lymphoma based on molecular features of
tumor-infiltrating immune cells New
England Journal of Medicine
351 (21): 2159-2169 (2004)
Simon RM, Korn EL, McShane LM, Radmacher
MD, Wright GW, Zhao Y. Design and Analysis of DNA Microarray Investigations: New
York, Springer (2003)
Wright GW, Simon RM.
A random variance model for detection of differential gene expression
in small microarray experiments Bioinformatics 19: 2448-2455, 2003
Rosenwald A, Wright G, Leroy K, Yu X, Gaulard
P, Gascoyne RD, Chan WC, Zhao T, Haioun C, Greiner
TC, Weisenburger DD, Lynch JC, Vose
J, Armitage JO, Smeland
EB, Kvaloy S, Holte H, Delabie J, Campo E, Montserrat E, Lopez-Guillermo A, Ott G, Muller-Hermelink HK,
Connors JM, Braziel R, Grogan TM, Fisher RI, Miller
TP, LeBlanc M, Chiorazzi M, Zhao H, Yang LM, Powell J, Wilson WH, Jaffe ES,
Simon R, Klausner RD, Staudt LM. Molecular
diagnosis of primary mediastinal B cell lymphoma
identifies a clinically favorable subgroup of diffuse large B cell lymphoma
related to Hodgkin lymphoma. Journal of Experimental Medicine
198: 851-862, 2003
Wright G, Tan B, Rosenwald A, Hurt EH, Wiestner A, Staudt
LM A gene expression-based method to diagnose clinically distinct subgroups
of diffuse large B cell lymphoma. Proceedings of the National
Academy of Sciences
of the United States of America
100: 9991-9996, 2003
Glebov OK, Rodriguez LM, Nakahara K, Jenkins J, Cliatt J, Humbyrd CJ, DeNobile J, Soballe P, Simon R,
Wright G, Lynch P, Patterson S, Lynch H, Gallinger
S, Buchbinder A, Gordon G, Hawk E, Kirsch IR
Distinguishing right from left colon by the pattern of gene expression. Cancer
Epidemiology Biomarkers & Prevention 12: 755-762, 2003
Wiestner A, Rosenwald A, Barry TS, Wright G, Davis
RE, Henrickson SE, Zhao H, Ibbotson RE, Orchard JA,
Davis Z, Stetler-Stevenson
M, Raffeld M, Arthur DC, Marti GE, Wilson
WH, Hamblin TJ, Oscier DG, Staudt LM. ZAP-70
expression identifies a chronic lymphocytic
leukemia subtype with unmutated immunoglobulin
genes, inferior clinical outcome, and distinct gene expression profile. Blood
101: 4944-4951, 2003
Rosenwald A, Wright G, Wiestner A, Chan WC, Connors JM, Campo E,
Gascoyne RD, Grogan TM, et. al. The proliferation
gene expression signature is a quantitative integrator of oncogenic
events that predicts survival in mantle cell lymphoma. Cancer Cell 2003 3: 185-197.
Kovanen PE, Rosenwald A, Fu J, Hurt
EM, Lam LT, Giltnane JM, Wright G,
Staudt LM, Leonard WJ. Analysis of
c-Family Cytokine Target Genes. IDENTIFICATION OF DUAL-SPECIFICITY
PHOSPHATASE 5 (DUSP5) AS A REGULATOR OF
MITOGEN-ACTIVATED PROTEIN KINASE ACTIVITY IN INTERLEUKIN-2 SIGNALING. J. Biol. Chem,
Feb 2003; 278: 5205-5213
Rosenwald A., Wright G., Chan W. C., Connors
J. M., Campo E., Fisher R. I., Gascoyne R. D., Muller- Hermelink H.
K., Smeland E. B., Giltnane, J. M., et al. The use of molecular profiling
to predict survival after chemotherapy for diffuse large-B-cell
lymphoma, N Engl J Med 2002 346, 1937-47.
Rieves D, Wright G, Gupta G, Shacter
E. Clinical trial (GUSTO-1 and INJECT) Evidence of Earlier
Death for men than Women after Acute Myocardial Infarction.
Am. J Cardiol 2000; 85:147-153.
brb@linus.nci.nih.gov