US 7,329,502 B2
	ZAP-70 expression as a marker for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)
Louis M. Staudt, Silver Spring, Md. (US); Andreas Rosenwald, Bethesda, Md. (US); Wyndham Wilson, Washington, D.C. (US); Todd S. Barry, Seattle, Wash. (US); and Adrian Wiestner, Bethesda, Md. (US)
Assigned to The United States of America as represented by the Department of Health and Human Services, Washington, D.C. (US)
Filed on Dec. 03, 2002, as Appl. No. 10/309,548.
Claims priority of provisional application 60/375966, filed on Apr. 25, 2002.
Prior Publication US 2003/0203416 A1, Oct. 30, 2003
Int. Cl. G01N 33/574 (2006.01)

U.S. Cl. 435—7.23  [530/350; 530/387.7]

14 Claims

1. A method of detecting the presence of Ig-unmutated chronic lymphocytic leukemia (CLL) in a subject having CLL, comprising: determining in a sample comprising CLL cells from the subject whether the subject overexpresses the ZAP-70 protein of SEQ ID NO: 2, thereby detecting Ig-unmutated chronic lymphocytic leukemia in the subject.