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There are a total of 85 record(s) matching your query.
Sorted by: Date Added To NTRS in Descending order
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Template polymerization of nucleotide analogues
Author(s): Orgel, L. E.
Abstract: Recent work on the template-directed reactions of the natural D-nucleotides has made it clear that l-nucleotides and nucleotide-like derivatives of other sugars would strongly inhibit the formation of long oligonucleotides. ...
NASA Center: NASA (non Center Specific) Publication Year: 1991
Added to NTRS: 2008-06-01
Accession Number: 92N13617; Document ID: 19920004399
Cyclization of nucleotide analogues as an obstacle to polymerization
Author(s): Hill, A. R. Jr; Nord, L. D.; Orgel, L. E.; Robins, R. K.
Abstract: Cyclization of activated nucleotide analogues by intramolecular phosphodiester-bond formation is likely to compete very effectively with template-directed condensation except in the cases of ribo- and arabinonucleotides. ...
NASA Center: NASA (non Center Specific) Publication Year: 1988
Added to NTRS: 2006-08-02
Document ID: 20050000913
The origin of life--how long did it take
Author(s): Orgel, L. E.
Abstract: We do not understand the steps leading from the abiotic early earth to the RNA world. Consequently, we cannot estimate the time required for the origins of life. Attempts to circumvent this essential difficulty are based on ...
NASA Center: NASA (non Center Specific) Publication Year: 1998
Added to NTRS: 2006-08-02
Document ID: 20040112187
A highly enantio-selective hexitol nucleic acid template for nonenzymatic oligoguanylate synthesis
Author(s): Kozlov, I. A.; Politis, P. K.; Pitsch, S.; Herdewijn, P.; Orgel, L. E.
Abstract: No abstract available
NASA Center: Goddard Space Flight Center Publication Year: 1999
Added to NTRS: 2006-08-02
Document ID: 20040089230
PCR with detachable primers
Author(s): Silveira, M. H.; Orgel, L. E.
Abstract: No abstract available
NASA Center: NASA (non Center Specific) Publication Year: 1995
Added to NTRS: 2006-08-02
Document ID: 20050000218
Nucleic acid duplexes incorporating a dissociable covalent base pair
Author(s): Gao, K.; Orgel, L. E.
Abstract: We have used molecular modeling techniques to design a dissociable covalently bonded base pair that can replace a Watson-Crick base pair in a nucleic acid with minimal distortion of the structure of the double helix. We ...
NASA Center: NASA (non Center Specific) Publication Year: 1999
Added to NTRS: 2006-08-02
Document ID: 20040141727
The origin of life--a review of facts and speculations
Author(s): Orgel, L. E.
Abstract: Three popular hypotheses attempt to explain the origin of prebiotic molecules: synthesis in a reducing atmosphere, input in meteorites and synthesis on metal sulfides in deep-sea vents. It is not possible to decide which is ...
NASA Center: NASA (non Center Specific) Publication Year: 1998
Added to NTRS: 2006-08-02
Document ID: 20040142128
Polymerization on the rocks: negatively-charged alpha-amino acids
Author(s): Hill, A. R. Jr; Bohler, C.; Orgel, L. E.
Abstract: Oligomers of the negatively-charged amino acids, glutamic acid, aspartic acid, and O-phospho-L-serine are adsorbed by hydroxylapatite and illite with affinities that increase with oligomer length. In the case of ...
NASA Center: NASA (non Center Specific) Publication Year: 1998
Added to NTRS: 2006-08-02
Document ID: 20040172675
Information transfer from DNA to peptide nucleic acids by template-directed syntheses
Author(s): Schmidt, J. G.; Christensen, L.; Nielsen, P. E.; Orgel, L. E.
Abstract: Peptide nucleic acids (PNAs) are analogs of nucleic acids in which the ribose-phosphate backbone is replaced by a backbone held together by amide bonds. PNAs are interesting as models of alternative genetic systems because ...
NASA Center: NASA (non Center Specific) Publication Year: 1997
Added to NTRS: 2006-08-02
Document ID: 20040172811
Nonenzymatic oligomerization reactions on templates containing inosinic acid or diaminopurine nucleotide residues
Author(s): Kozlov, I. A.; Orgel, L. E.
Abstract: The template-directed oligomerization of nucleoside-5'-phosphoro-2-methyl imidazolides on standard oligonucleotide templates has been studied extensively. Here, we describe experiments with templates in which inosinic acid ...
NASA Center: Goddard Space Flight Center Publication Year: 1999
Added to NTRS: 2006-08-02
Document ID: 20040088800
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