Abdominal surgery-induced delayed gastric emptying in rats: role of CRF and sensory neurons.

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Title:	Abdominal surgery-induced delayed gastric emptying in rats: role of CRF and sensory neurons.
Author:	Barquist, E : Zinner, M : Rivier, J : Tache, Y
Citation:	Am-J-Physiol. 1992 Apr; 262(4 Pt 1): G616-20
Abstract:	The role of peripheral corticotropin-releasing factor (CRF) and afferent pathways in mediating abdominal surgery-induced delayed gastric emptying was investigated using an intravenous injection of the competitive CRF antagonist alpha-helical CRF9-41 and capsaicin pretreatment in adult fasted rats. Gastric emptying of a non-caloric solution was measured by the phenol red method. Intravenous CRF (0.13 nmol) inhibited by 65% gastric emptying. CRF effect was completely reversed by simultaneous intravenous injection of alpha-helical CRF9-41 (13 nmol). Abdominal surgery under enflurane anesthesia inhibited gastric emptying by 60% measured 3 h postoperatively. Enflurane anesthesia alone had no effect on gastric emptying 3 h after exposure. Abdominal surgery-induced delay of gastric emptying was reversed by 46, 60, and 100% by capsaicin pretreatment (125 mg/kg, -3 wk), intravenous injection of alpha-helical CRF9-41 (13 nmol), and combined pretreatments with capsaicin and CRF antagonist, respectively. Capsaicin and alpha-helical CRF9-41 given alone or in combination did not influence gastric emptying. These results indicate that peripheral CRF receptors along with capsaicin-sensitive afferent neurons contribute to somatovisceral stress (abdominal surgery)-induced delayed gastric emptying.
Review References:	None
Notes:	Copyright American Physiological Society. Abstracts are reprinted by the permission of the publisher of the journal for volume, pages, and dates cited. Hypertext links to electronic journal sites, if available, can be found in the the Peer Reviewed Journal List on the IBIDS home page.
Language:	English
Publication Type:	Journal-Article
Keywords:	Abdomen surgery : Corticotropin Releasing Hormone physiology : Gastric Emptying drug effects : Neurons, Afferent physiology
URL:	http://ajpcon.physiology.org/