Stollman N, Rotterdam H, Kotier DP; International Conference on AIDS.

Int Conf AIDS. 1992 Jul 19-24; 8: 137 (abstract no. PuB 7529).

St. Luke's-Roosevelt Hospital Center, Columbia Univ, NY, NY.

OBJECTIVE: To survey gastric histopathology in an unselected series of AIDS patients and to determine the presence of gastrin-containing cells in antrum and acid secretory (parietal) cells in the fundus. Other studies have reported a high incidence of hypochlorhydria, but the cause is uncertain. METHODS: Studies were performed in an unselected group of 43 AIDS patients who underwent endoscopy and biopsy. Indications for endoscopy included esophageal symptoms (13), diarrhea (25), and miscellaneous epigastric symptoms in 5 cases. Histopathologic analysis was blinded. Parietal cells were evaluated on routine sections, while gastrin-containing cells were evaluated in 12 cases with a monoclonal antibody and an indirect immunoperoxidase technique. RESULTS: Specific disease complications were found in 11 cases (3 KS, 2 CMV, 5 Helicobacter pylori). Fundal gastritis was diagnosed in 9 cases (8 superficial, 1 lymphocytic), and chronic antral gastritis was found in 15 cases (13 reflux, 1 superficial, 1 lymphocytic). Reflux gastritis was defined by the presence of foveolar hyperplasia, edema, congestion, smooth muscle proliferation, and fibrosis in the lamina propria, and a lack of significant inflammatory infiltrate. Foveolar hyperplasia alone was seen in 7 cases and focal acute inflammation was seen in 10 cases. Parietal cells were identified in all cases and antral gastrin-containing cells were detected in all 12 cases examined. No cases of atrophic gastritis were seen. CONCLUSIONS: 1) specific gastric histopathology is not often a prominent feature on gastric biopsy, 2) gastric colonization with Helicobacter pylori is not common in AIDS, 3) histopathologic evidence of enterogastric reflux was the most frequent abnormality detected, 4) intragastric buffering of acid by refluxed alkaline duodenal contents may be a cause of apparent hypochlorhydria.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Animals
• Biopsy
• Gastric Fundus
• Gastrin-Secreting Cells
• Gastritis
• Gastritis, Atrophic
• Gizzard
• Helicobacter pylori
• Humans
• Incidence
• Parietal Cells, Gastric
• Stomach
• Stomach Ulcer
• pathology

Other ID:

• 92403593

UI: 102201307

From Meeting Abstracts