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Sponsored by: |
University of Aarhus |
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Information provided by: | University of Aarhus |
ClinicalTrials.gov Identifier: | NCT00817440 |
Hypothesis: under fasting there will primarily be an activation of growth hormone(GH) signalpathways and a inhibition of insulin signalpathways, and the opposite will happen under physical activity.
Primarily we will investigate markers for GH and insulin signaltransduction in muscle- and fat-biopsies after fasting for 72 hours and after 1 hour of ergometer-cycling at 65% Vo2max.
In addition to this we will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.
Condition | Intervention |
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Healthy |
Other: Exercise Other: Fasting |
Study Type: | Interventional |
Study Design: | Basic Science, Randomized, Open Label, Uncontrolled, Crossover Assignment, Efficacy Study |
Official Title: | Effects of Fasting and Exercise on Insulin and GH Signaltransduction in Muscle and Fat |
Estimated Enrollment: | 8 |
Study Start Date: | December 2008 |
Estimated Primary Completion Date: | May 2009 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
---|---|
Control: No Intervention
control: muscle and fat biopsies and basal aminoacid and glucose turnover
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Exercise: Experimental
1 hour ergometer cycling on 65% of Vo2max, and then the same as arm 1.
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Other: Exercise
1 hour ergometer cycling on 65% of Vo2max, and then the same as arm 1.
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Fasting: Experimental
3 days of fasting and then the same as arm 1
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Other: Fasting
3 days of fasting and then the same as arm 1
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Ages Eligible for Study: | 18 Years to 45 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: mikkel vendelbo, MD | mikkel.vendelbo@ki.au.dk |
Denmark, Jylland | |
Aarhus sygehus | Recruiting |
Aarhus, Jylland, Denmark, 8000 | |
Contact: mikkel vendelbo, MD mikkel.vendelbo@ki.au.dk | |
Principal Investigator: mikkel vendelbo, MD |
Responsible Party: | endokrinologiskforskningslaboratorium M, Aarhus sygehus ( Mikkel Vendelbo MD ) |
Study ID Numbers: | 16.12.2008 |
Study First Received: | January 5, 2009 |
Last Updated: | January 5, 2009 |
ClinicalTrials.gov Identifier: | NCT00817440 |
Health Authority: | Denmark: Ethics Committee |
growth hormone insulin signaltransduction signalpathways growth hormone and insulin signalpathways |
Healthy Insulin |
Hypoglycemic Agents Physiological Effects of Drugs Pharmacologic Actions |