de Jose MI, Miguel MJ, del Campo M, Villota J, Ruiz Contreras J, Gubindo D; International Conference on AIDS.

Int Conf AIDS. 1993 Jun 6-11; 9: 405 (abstract no. PO-B13-1621).

We describe 3 cases of Non-Hodgkin Lymphoma and one case of Acute Lymphoblastic Leukemia from a series of 212 HIV infected pediatric patients in four hospitals of the Madrid area. The 3 patients with the diagnosis of Non-Hodgkin Lymphoma were males, aged 3, 4 and 7 years, had been infected through the vertical route, and, at the time of diagnosis 2 had been treated with the antiretroviral agent AZT for periods of 6 and 1 year. Weight loss, fever and abdominal pain were the main symptoms initially, the three patients showed multiple adenomegalles and increasing hepatosplenomegaly, and one had several palpable abdominal masses. They all had anemia and thrombopenia. P24 Ag was positive and the number of CD4 was 0.59 (2%), and 96 (8%). Only one of the patients received two cycles of chemotherapy, dying of a septic complication, the other two deceased before the initiation of treatment. Our last patient was a hemophiliac male diagnosed of HIV infection at 7 years of age, with LIP and recurrent respiratory infections, receiving treatment with AZT for 5 years before the diagnosis of Neoplasia. He developed an important weight loss and paresthesias in the area of the chin, showing later diplopia and progressive bilateral papilledema. He had hepatosplenomegaly and blood tests showed anemia and thrombopenia. The number of CD4 was 96 (3%), and P24 Ag was positive. CT scan revealed left frontal lobe porencephaly and thickening of the left optic nerve, and the bone marrow study confirmed the diagnosis of ALL type L3. The patient died one month after the diagnosis. The estimated incidence of tumors in HIV infected pediatric patients in our series is = 2%. Among the factors thought to contribute to the development of neoplasia in these patients are HIV infection itself and other infections. Antiretroviral treatment, sustained immunosuppression, the state of nutrition of the patients, and the longer survival achieved with more efficient antiinfectious treatments... It seems important to study the incidence of neoplasia in these patients to increase our knowledge of their pathogenesis and focus on the optimal treatment for them.

Publication Types:

• Meeting Abstracts

Keywords:

• AIDS Vaccines
• Acquired Immunodeficiency Syndrome
• Anti-HIV Agents
• Anti-Retroviral Agents
• Child
• HIV Infections
• HIV Protease Inhibitors
• HIV Seropositivity
• Humans
• Incidence
• Lymphoma, Non-Hodgkin
• Male
• Population Groups
• Reverse Transcriptase Inhibitors
• Zidovudine

Other ID:

• 93335188

UI: 102204565

From Meeting Abstracts