Preclinical FindingsCommon to Thiazolidinediones

• Adipocyte hyperplasia

  • subcutis, epididymal, bone marrow

• Increased body weight

• Increased plasma volume and decreased hematocrit

  • increased plasma volume was related to increased retention of sodium and water in association with increased regional blood flow (fat and s/c tissue) and lowered blood pressure

• Cardiac hypertrophy

  • related to increased cardiac preload

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