Bibliographic Citation
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Title | Response of epididymal duct to the temporary depletion of spermatozoa induced by testicular irradiation in mice |
Creator/Author | Abe, K. ; Takano, H. ; Ito, T. |
Publication Date | 1983 Sep 01 |
OSTI Identifier | OSTI ID: 5010157 |
Other Number(s) | CODEN: ANREA |
Resource Type | Journal Article |
Resource Relation | Anat. Rec. ; Vol/Issue: 207:1 |
Research Org | Hokkaido Univ. School of Medicine, Sapporo, Japan |
Subject | 560152 -- Radiation Effects on Animals-- Animals; ;SPERMATOGENESIS-- INHIBITION;TESTES-- BIOLOGICAL RADIATION EFFECTS; ANIMAL CELLS;EXTERNAL IRRADIATION;MICE |
Related Subject | ANIMALS;BIOLOGICAL EFFECTS;BODY;GAMETOGENESIS;GONADS;IRRADIATION;MALE GENITALS;MAMMALS;ORGANS;RADIATION EFFECTS;RODENTS;VERTEBRATES |
Description/Abstract | The mouse epididymal duct can be histologically divided into five segments (I-V), and the principal cells in segment II appear to secrete periodic acid-Schiff (PAS)-positive material into the lumen.^In this study, male dd-mice received one, two, or four 800-R doses of radiation beginning at age 50 days.^Mice receiving multiple doses were irradiated at 1-week intervals.^After irradiation, marked depletion of spermatozoa, or aspermia, occurred in the epididymal duct for 2 to 16 weeks after a latency period of 3 to 4 weeks according to the times of irradiations.^During oligospermia or aspermia, PAS-positive inclusions appeared in the principal cells in segment IV.^The inclusions occupied a supranuclear position and appeared as round granules and globules measuring 2-15 micron in diameter, and increased in number, size, and staining intensity with time.^They disappeared after reappearance of spermatozoa.^The findings suggest that PAS-positive material may bind to spermatozoa and, if not bound, is reabsorbed by the principal cells in segment IV and deposited as intracellular inclusions, and the principal cells in segment IV are capable of digesting the accumulated PAS-positive material. |
Country of Publication | United States |
Language | English |
Format | Pages: 17-24 |
System Entry Date | 2001 May 13 |
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