Bibliographic Citation
| Document | For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field. For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability. |
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| DOI | http://dx.doi.org/10.1006/geno.1996.0131 |
| Title | Characterization of a human glycoprotein with a potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1) |
| Creator/Author | Hayashi, Masaru ; Fujimoto, Seiichiro ; Takano, Hiroko [Hokkaido Univ. School of Medicine, Sapporo (Japan)][and others] |
| Publication Date | 1996 Mar 05 |
| OSTI Identifier | OSTI ID: 459003 |
| Other Number(s) | GNMCEP; ISSN 0888-7543 |
| Resource Type | Journal Article |
| Resource Relation | Genomics ; VOL. 32 ; ISSUE: 3 ; PBD: 5 Mar 1996 |
| Subject | 55 BIOLOGY AND MEDICINE, BASIC STUDIES ; HUMAN CHROMOSOME 6; GENETIC MAPPING; CHROMOSOMES; GLYCOPROTEINS; STRUCTURE-ACTIVITY RELATIONSHIPS; DNA-CLONING; TISSUE DISTRIBUTION; GENE REGULATION; DNA SEQUENCING; FLUORESCENCE; DNA HYBRIDIZATION; SPERMATOGENESIS; FERTILIZATION; NUCLEOTIDES; AMINO ACID SEQUENCE |
| Description/Abstract | Acidic epididymal glycoprotein (AEG), thus far identified only in rodents, is one of the sperm surface proteins involved in the fusion of the sperm and egg plasma membranes. In the present study, we describe the isolation and characterization of cDNA encoding a human glycoprotein related to AEG. Although this protein, designated ARP (AEG-related protein), is not the ortholog of rodent AEG, it resembles AEG in that it is an epididymal secretory glycoprotein that binds to the postacrosomal region of the sperm head. The fact that no AEG mRNA can be detected in the human epididymis suggests that ARP might be the functional counterpart of rodent AEG. The gene encoding ARP (AEGL1) was mapped by fluorescence in situ hybridization to 6p21.1-p21.2. This result indicates that AEGL1 and the mouse gene for AEG are located in the chromosomal segments with conserved syntenies. 43 refs., 6 figs. |
| Country of Publication | United States |
| Language | English |
| Format | pp. 367-374 ; PL: |
| System Entry Date | 2001 May 05 |
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