NTP Experiment-Test: 93027-37 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 04/14/05 Route: DOSED FEED Time: 09:34:05 FINAL #3 HAMSTERS Facility: Battelle Columbus Laboratory Chemical CAS #: 50892-23-4 Lock Date: 06/12/96 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 93027-37 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 04/14/05 Route: DOSED FEED Time: 09:34:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN GOLDEN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 10 | Infiltration Cellular, Mixed Cell | 2 3 2 2 2 2 3 1 | 8 2.1| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + M + + + | 9 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 2 2 2 2 | 10 2.0| Pigmentation | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Atrophy | 2 | 1 2.0| Inflammation, Chronic | 2 2 1 2 2 1 2 | 7 1.7| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 2 NTP Experiment-Test: 93027-37 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 04/14/05 Route: DOSED FEED Time: 09:34:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN GOLDEN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + + M M + + M + + + | 7 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + I + + + | 9 | |__________________________________________________________________________|____________| Thyroid Gland | + + + M + + + + + + | 9 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Preputial Gland | M M M M M M M + M M | 1 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | Atrophy | 2 | 1 2.0| |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | Atrophy | 2 | 1 2.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Atrophy | 3 2 | 2 2.5| _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 3 NTP Experiment-Test: 93027-37 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 04/14/05 Route: DOSED FEED Time: 09:34:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN GOLDEN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Hemorrhage | 1 2 | 2 1.5| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 4 NTP Experiment-Test: 93027-37 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 04/14/05 Route: DOSED FEED Time: 09:34:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN GOLDEN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 | 1 1.0| Nephropathy | 1 2 1 1 1 | 5 1.2| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | Infiltration Cellular | 1 | 1 1.0| Mineralization | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 93027-37 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 04/14/05 Route: DOSED FEED Time: 09:34:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN GOLDEN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 5 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Cytoplasmic Alteration | 2 2 2 2 2 2 2 2 2 2 | 10 2.0| Infiltration Cellular, Mixed Cell | 3 2 2 2 2 2 2 2 2 2 | 10 2.1| Pigmentation | 1 | 1 1.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Inflammation, Chronic | 1 1 1 2 1 2 1 | 7 1.3| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + | 2 | Degeneration | 2 1 | 2 1.5| |__________________________________________________________________________|____________| Preputial Gland | M M M M M I M M M | | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | Atrophy | 2 | 1 2.0| Inflammation, Chronic | 2 | 1 2.0| |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | Atrophy | 2 | 1 2.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 93027-37 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 04/14/05 Route: DOSED FEED Time: 09:34:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN GOLDEN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 5 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Atrophy | 3 2 | 2 2.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 | 2 1.0| Nephropathy | 1 1 2 | 3 1.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 93027-37 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 04/14/05 Route: DOSED FEED Time: 09:34:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN GOLDEN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 10 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Cytoplasmic Alteration | 2 2 2 2 2 3 2 3 2 3 | 10 2.3| Infiltration Cellular, Mixed Cell | 2 2 3 2 1 3 2 3 3 2 | 10 2.3| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Inflammation, Chronic | 1 1 1 2 2 1 1 1 2 | 9 1.3| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Preputial Gland | M M M M M + M M M + | 2 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Atrophy | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 93027-37 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 04/14/05 Route: DOSED FEED Time: 09:34:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN GOLDEN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 10 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + | 9 | Mineralization | 1 1 1 | 3 1.0| Nephropathy | 1 1 1 1 1 1 | 6 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 93027-37 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 04/14/05 Route: DOSED FEED Time: 09:34:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN GOLDEN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 50 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Cytoplasmic Alteration | 3 4 4 4 3 3 4 4 3 2 | 10 3.4| Infiltration Cellular, Mixed Cell | 2 2 1 2 1 2 2 1 1 2 | 10 1.6| Vacuolization Cytoplasmic | 2 2 | 2 2.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + | 9 | Inflammation, Chronic | 1 1 2 3 1 1 1 2 2 | 9 1.6| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Preputial Gland | M M M M + M + M M M | 2 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | Atrophy | 1 3 2 | 3 2.0| |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | Atrophy | 1 3 2 | 3 2.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Atrophy | 3 3 3 1 | 4 2.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 93027-37 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 04/14/05 Route: DOSED FEED Time: 09:34:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN GOLDEN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 50 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 1 | 2 1.0| Nephropathy | 1 1 | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 93027-37 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 04/14/05 Route: DOSED FEED Time: 09:34:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN GOLDEN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 100 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Cytoplasmic Alteration | 3 3 2 3 3 4 4 4 4 4 | 10 3.4| Infiltration Cellular, Mixed Cell | 2 1 1 1 1 1 1 2 2 | 9 1.3| Vacuolization Cytoplasmic | 2 1 1 3 2 | 5 1.8| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Inflammation, Chronic | 3 3 1 2 1 2 1 | 7 1.9| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Preputial Gland | M M M M M M M M | | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 10 | Atrophy | 4 2 3 3 4 4 2 2 4 1 | 10 2.9| |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | Atrophy | 3 2 3 3 4 4 2 2 4 1 | 10 2.8| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Atrophy | 3 3 3 3 2 3 3 | 7 2.9| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 93027-37 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 04/14/05 Route: DOSED FEED Time: 09:34:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN GOLDEN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 100 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Nephropathy | 1 1 1 | 3 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 93027-37 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 04/14/05 Route: DOSED FEED Time: 09:34:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN GOLDEN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 500 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 10 | Infiltration Cellular, Mixed Cell | 1 2 2 1 3 3 2 | 7 2.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + M + + + | 9 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Cytoplasmic Alteration | 4 1 4 4 2 4 4 4 4 4 | 10 3.5| Infiltration Cellular, Mixed Cell | 1 2 3 3 2 2 2 1 1 2 | 10 1.9| Vacuolization Cytoplasmic | 1 2 2 2 | 4 1.8| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | Atrophy | 2 | 1 2.0| Inflammation, Chronic | 1 2 3 3 1 2 2 3 | 8 2.1| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 93027-37 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 04/14/05 Route: DOSED FEED Time: 09:34:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN GOLDEN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 500 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + M | 8 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + M | 9 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Preputial Gland | M M + M M M + M M M | 2 | |__________________________________________________________________________|____________| Prostate | + + + M + + + + + + | 9 | Atrophy | 4 4 3 3 1 4 4 4 4 | 9 3.4| |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 10 | Atrophy | 3 3 2 2 3 1 4 3 4 3 | 10 2.8| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Atrophy | 3 3 3 3 3 3 3 3 3 3 | 10 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 93027-37 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 04/14/05 Route: DOSED FEED Time: 09:34:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN GOLDEN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 500 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + I + + + + + + | 9 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + M + + + M + + + | 8 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Hemorrhage | 2 | 1 2.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 93027-37 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: SUBCHRON 90-DAY PEROXISOME PROJECT (WY-14643) Date: 04/14/05 Route: DOSED FEED Time: 09:34:05 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | SYRIAN GOLDEN HAMSTERS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A | 500 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 | 1 1.0| Nephropathy | 1 | 1 1.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------