National Toxicology Program

CASRN: 4405-13-4

Related: GLYOXAL, 107-22-2

Formula: C6 H10 O8

Synonyms/Common Names:

• (1,4)DIOXINO(2,3-B)-1,4-DIOXIN-2,3,6,7-TETROL, HEXAHYDRO- (9CI)

Known Uses:

PURE FORM OF GLYOXAL IS USED FOR PERMANENT-PRESS FABRICS, LEATHER TANNING, PAPER COATING, TEXTILE DYEING,EMBALMING FLUIDS, MANUFACTURE OF TOBACCO PRODUCTS; PHARMACEUTICALS, PESTICIDES

Organ Systems Toxicity

• GD 6 THROUGH 15 Conventional Teratology (Gavage)  (TER92116) Completed 
  • NTIS No. PB94-151974
    Citation: Final Report on the Developmental Toxicity of Glyoxal Trimeric Dihydrate in Sprague-Dawley (CD) Rats
  • NTIS No. PB94-152113
    Citation: Final Report on the Developmental Toxicity of Glyoxal Trimeric Dihydrate in Sprague-Dawley (CD) Rats
  • F Rats: Sprague Dawley
  • Rats Maternal Positive 
  • Rats Fetal Negative 
  • Dose: 0, 50, 150, 300 MG/KG
• GD 6 THROUGH 19 Conventional Teratology (Gavage)  (TER92121) Completed 
  • NTIS No. PB94-104064
    Citation: Final Report on the Developmental Toxicity of Glyoxal Trimeric Dihydrate in New Zealand White Rabbits
  • NTIS No. PB94-104072
    Citation: Final Report on the Developmental Toxicity of Glyoxal Trimeric Dihydrate in New Zealand White Rabbits
  • Rabbit: New Zealand White
  • Rabbits Maternal Positive 
  • Rabbits Fetal Negative 
  • Dose: REP I: 0, 50, 200, 400 REP II: 0, 50 MG/KG/DAY
• GD 6 THROUGH 15 Teratology Pilot Studies (Gavage)  (TRP90035) Completed 
  • F Rats: Sprague Dawley
  • Dose: 0, 200, 800, 1200, 1600, OR 2000 MG/KG
• GD 6 THROUGH 19 Teratology Pilot Studies (Gavage)  (TRP91016) Completed 
  • F Rabbit: New Zealand White
  • Dose: 0, 200, 800, 1000, 1200, OR 1500 MG/KG
• GD 6 THROUGH 19 Teratology Pilot Studies (Gavage)  (TRP92059) Completed 
  • F Rabbit: New Zealand White
  • Dose: 0, 400, OR 600 MG/KG