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pfam05786: Barren 
Barren protein
This family consists of several Barren protein homologues from several eukaryotic organisms. In Drosophila Barren (barr) is required for sister-chromatid segregation in mitosis. barr encodes a novel protein that is present in proliferating cells and has homologues in yeast and human. Mitotic defects in barr embryos become apparent during cycle 16, resulting in a loss of PNS and CNS neurons. Centromeres move apart at the metaphase-anaphase transition and Cyclin B is degraded, but sister chromatids remain connected, resulting in chromatin bridging. Barren protein localises to chromatin throughout mitosis. Colocalisation and biochemical experiments indicate that Barren associates with Topoisomerase II throughout mitosis and alters the activity of Topoisomerase II. It has been suggested that this association is required for proper chromosomal segregation by facilitating the decatenation of chromatids at anaphase.
Links
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Statistics
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PSSM-Id: 114508
View PSSM: pfam05786
Aligned: 5 rows
Created: 2-Oct-2008
Updated: 30-Oct-2008
Structure
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Aligned Rows:
pfam05786 is a member of the superfamily cl02167.
Sequence Alignment?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241306  27 SSPSERVFPMPLPRKAP----LNIPGTPvledfpQNDDEKERLQRRRSRVFDLQFSTdsprllasps---srsidisati 99
gi 74765224    1 MTLPRLETPLRRSAVGSyqegVSRMLTP------FNDDEAERREARRRTLLQQHHRS----------------------- 51
gi 75099974    5 LTPNPKQKPASTTt------rIQAPTSPff--lgSNDDRLEREQARAARAAASRrrsvifarg---------sqpetesd 67
gi 30172806   24 SSPLERVPPASRPGKAP----LGTPKTPvledfpQNDDEKERMQRRRSRVFDLQFSTdsihlaspn-----rnidvstti 94
gi 30172764   16 TPDSAFLSPATRP--QP----ISAAATPtllnftSNDDERERKLRRMSRVIDLQLSNanspataispaqsrgadtptsll 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241306 100 PKFTNTQITEHYSTCIKLSTENKITTKNAFGLHLIDFMSEILKQKD--TEPTNFKVAAGTLDASTKIYAVRVDAVHADVY 177
gi 74765224   52 STLESIEDNETIKNCLELYNGNKVSKDNAWNLMLIDSLANLLDHHH--KRMSNFKMAGSSLEASSKVYGLRVDSIYLDAM 129
gi 75099974   68 PCFDKQQILELFQNCIKLASENKINQKNTWELNLIDHLCEIIKVEDenNTETNFQKASCTLEAGVKIYSMRVDSVHSEAY 147
gi 30172806   95 SKFTNTQITEHYSTCIKLSSENKITTKNAFGLHLIDFMSEILKQKD--AEPTNFKVAAGTLDASTKIYAVRVDAVHADVY 172
gi 30172764   90 PKLNNTQISDHYSTCIKLSQENKITTKNAFGLHLIDYMGDILKHKD--SELTNFKVAAGTLDASAKIYAVRVDAVHADVY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241306 178 RVLGGLGKda-----------pSLEEV----E-GHVADGSATEMGTTKKAVKPKKKHLHRTIEQNINNLNvSEADRKCEI 241
gi 74765224  130 RISAGLSArtltdk---qinaaEDDDGpqgeQaTGEGQDSAQQAAKEAAPKPKRQKKPISTVTKNRETLN-SRLDTAPLQ 205
gi 75099974  148 KVLGGITRaghddggdhedaagAVENA------------------TNQKKQPEKKISPLSTLEPSFDALNvKKFDVAFAV 209
gi 30172806  173 RVLGGLGKdtpp----------------qgeE-SHSGDGSTLETERTKKPAKPKKKQSCKTIEQNLSNINvSEADGKCAV 235
gi 30172764  168 KVLGGLGKes--------------------qAtEDTENQETDTGPQDGRKNPKRRKCSYKTIERNLNSINrSETERKSEI 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241306 242 DPMFQKTAASFDECSTAGVFLSTLHCQDYRSELLFPSD---VQTLST-GEPLElpel----------------------- 294
gi 74765224  206 DPVFGKLNSTCGASINASNRLMHNILPSFDSELRLRTTynfWNSEEStEEVQDhttlna-------------------em 266
gi 75099974  210 DPLYHQTSAQFDEGGAKGLLLNNLGVYG-GCQVLFDSQeipGKLVSSaNKHDKsetidlsfvkglalladmprstivhvl 288
gi 30172806  236 DPMFQKTAASFDECSTTGVFLSTLHCQDYRSELLFPSD---MQTLSS-GEPLElpdl----------------------- 288
gi 30172764  228 DPLFQKAAASFDEFSTAGVFLSTLKCHSYHSELHFDAD---VKPLST-AEETEppsp----------------------- 280
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241306 295 gcveMTDLK----APLqq----cAEDRQICPSLAGFQF--------------TQWDSETHNESVSALVDK-FKKNDQVFD 351
gi 74765224  267 eqwpATSLMstnlMRKll---phAERSNLRPLHTGYIItsapnpksanekaaEVVQDEDHDEGLDNADDVcVNKISMAFD 343
gi 75099974  289 lhyaFSDVVvkfvECVeqmvlnmRKKDEIVPSLRAIi---------------NQFDEENQRPSDTFSCGQqTTESFDISH 353
gi 30172806  289 gfvdMTDLE----ASLqq----cVEDRPLCPSLAGFQF--------------TKWDSETHNESVSALVDK-FKKNDQVFD 345
gi 30172764  281 gsmdSTELK----SLFlq----cVEKRPLCPSLSGFRF--------------MQWNSDAQNENLSLLMDK-FKKSDHVFD 337
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241306 352 INAEVdESDCGd---FPDGSLGDDFDANDEPDHTAVGDHeefrswkepcqvqscQEEMISLGDGDIRTMCPLLSMKPGEY 428
gi 74765224  344 INAEC-EPMPDl---DGPPPLVLEVDSNELEELTAEEQMvi------------nNCRRLRKQTEFIEDLRPVDGNSKLEY 407
gi 75099974  354 GNDAS-YADddegyeNFGTSFDYEGQSGDVDENFGPNEAepiy--------snfhEEVEPASLQDMDSDDRLENVDDYLF 424
gi 30172806  346 INAEA-EDDEEd---VPDGPLVEDFVDNDEPDLSAAGDHeefrswkelcqvqsnQEEVISLEDRDIQVMCSFLSMKPGEY 421
gi 30172764  338 INAEV-EDDFV----ESEAPVADEFDA-DVCEGMDAGDIgefaehreacrlerkGAQLTQIGNGDIGTMCLQLSSCPGEY 411
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241306 429 SYFSP-RTMSMWAGPDHWRFRPRRKQ--------DAPSQSENKKKSTKKDFEIDFE---DDIDF----DVYF--RKTKAA 490
gi 74765224  408 SYRPMdQISQFWAGPSHWKFKRTRPRstfs-qtnGQVDTQPIRTQRAKKSAHLNANrraKALDYgnvtENFF--QQLDTT 484
gi 75099974  425 LSLGIsSKQNSWAGPDHWKYRKTKGPdvqpaseiKSSPPAKKTRKKKQAEPELDFA---KALEEe---MPDIfaPPKNPK 498
gi 30172806  422 SYFSP-RTMKMWAGPDHWRFRPRPKQ--------DATSCTEHKKKSAKKDFEINFD---DDIDF----DAYF--QKTKAA 483
gi 30172764  412 SYFSP-RTMSMWAGPEHWRFRPRQKA---------STDSDQQRVKKAKKVFELNFE---DDIDF----EVHF--RKTRAA 472
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241306 491 TILTKS-TLENQNWRATTLPTDFNYNVDTLVQLHLKPGTRLLKMAQGHRVETEHYEEIeDYDYNNPNDTSNFCPGLQAAD 569
gi 74765224  485 IRQRKAnFQKKWDPRKLILPTKFELDPDLFFKYESAPSIKLSKRAGEPDSDEGGDLGI-DMDADMHHDDDNDQELFNNEH 563
gi 75099974  499 TLL----LPASRTPCQTKLPEDCHYQPENLIKLFLLPNVMVWLAKHRPSETSRQQPDDyEHGESWGND------------ 562
gi 30172806  484 TILTKS-TLENQNWKATTLPTDFHYETDNLIQLHLKPGKRSLKMDQDQKAKTEHYEEIeDYDYNNPNDTSNYCPGLQAAD 562
gi 30172764  473 TTLTKS-TLESQNKKSTTLPADFHYDPDNIARMSLRPKDRIRKTT-VQESVSEPEDDIgDYDYNNPNDTSNFCPALQAAD 550
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241306 570 ------SDDEDLDDL---------FVGpvgnsdlspypchppKTAQQNGD-TPEAQGLDIT-TYGESNLVAEPQKVNKIE 632
gi 74765224  564 ftdavpANVSVIAAIaaeqaaeasMMN---------------VSAGEIGL-TQMNATCNNTvFEIGTEFEGAPSQVAKVI 627
gi 75099974  563 ------------------------------------------NVYDDDDG-PFDDNENDQSdAEDTNTLISQPRQVNKID 599
gi 30172806  563 ------SDYEEADDL---------FADpvgtld----lesdpKTTQENGHiSPENQGVDIT-TYQELNLVAEPQKVNKIE 622
gi 30172764  551 ------SDDDDg-----------aFLGp------------------eSNS-AGFSAENQMNiTSYGESNLVAGQKVNKIE 594
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116241306 633 IHYAKTAKKMDMKKLKQSMWSLLTALS---GKEADAEANHREAGKEAALaevaDEKMLSGLTKDLQ-RSLPPVMAQNLSI 708
gi 74765224  628 VPFAKRAKVIDMKNLKKSCNSLIQKQLlnaVPEETIPSHPKKKGEHYSK----GFASFQQVYQKLP-DLLTTKMSDSLSP 702
gi 75099974  600 VQYDKASKQVDVQVLKETLWECLQESH---QPPIQNLI----VQDEEHQqeppESRSFKVLLASFPdDCQAAERTQDISP 672
gi 30172806  623 IHYAKTAKKMDMKKLKQSMWSLLTKFS---RKEADTEANHTESGQEGAPeevaDEKKLSGLTKDLQ-TRLPPLMAQNLSI 698
gi 30172764  595 IQYAKTAKKMDMKRLKSSMWSLLANCP---ESQEEMPS----SKEEIDAalitDEQVFSSVTHGLQ-KRLPPVMAQNLSV 666
                        810       820       830
                 ....*....|....*....|....*....|..
gi 116241306 709 PLAFACLLHLANEKNLKLEGTEDLSDVLVRQG 740
gi 74765224  703 SVAFYAVLHLANDLKLRLIPQEDLEDFQIRQV 734
gi 75099974  673 HLCFICLLHLANEHNLSLIGSQNLDDLTIHLA 704
gi 30172806  699 PLAFACLLHLANEKNLKLEGTEDLSDVLVMQG 730
gi 30172764  667 PLAFACLLHLANEKNLKLQGMDDLSDVMIMQD 698
Citing CDD
Marchler-Bauer A, Anderson JB, Derbyshire MK, DeWeese-Scott C, Gonzales NR, Gwadz M, Hao L, He S, Hurwitz DI, Jackson JD, Ke Z, Krylov D, Lanczycki CJ, Liebert CA, Liu C, Lu F, Lu S, Marchler GH, Mullokandov M, Song JS, Thanki N, Yamashita RA, Yin JJ, Zhang D, Bryant SH. (2007) CDD: a conserved domain database for interactive domain family analysis. Nucleic Acids Res. 35: D237-40
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