Are You suprised ?

ABBREVIATED CV

John Richard Raymond, Sr., M.D.

Current Positions: DCI Professor of Medicine, Medical University of South Carolina (MUSC), Charleston

Staff Physician and Investigator, Ralph H. Johnson VA Medical Center, Charleston

Vice President for Academic Affairs and Provost, MUSC

Education: The Ohio State University, B.S. in Psychology, 1978; M.D. in Medicine, 1982

Training: Internship, Residency, Chief Medical Residency, and Nephrology Fellowship

Duke University and Durham VA Medical Centers, 1982-1988

Certifications: American Board of Internal Medicine, Medicine (1986) and Nephrology (1988)

Licensure: North Carolina #30459 (1986-present); South Carolina #18867 (1996-present)

Faculty: Duke: Associate in Medicine (1988-1989), Assistant Professor of Medicine (1989-1993);

Associate Professor of Medicine (1994-1996), tenured (1995)

MUSC: Dialysis Clinics Incorporated Professor of Medicine with tenure (1996-present)

Administrative: Durham VA: Chief of Nephrology (1991-1996)

Ralph H. Johnson VA: Associate Chief of Staff for Research & Development (1998-2002)

MUSC: Associate Provost for Research (2001-2002); Vice President for Academic Affairs and Provost (2002-present)

Publications: Peer-reviewed manuscripts (91); Book chapters (7); Abstracts (125)

Grant Funding: Active as PI: NIH R01s (2), NIH T32, VA Merit Award, VA REAP award

Active as mentor: NIH K-awards (3), minority supplements (2)

Completed: Multiple NIH R01s, K-awards, and SEGs; VA and foundation funding.

Research Trainees: Pre-doctoral trainees (8); Post-doctoral fellows (17); Thesis committees (16)

Peer Review: Chair of NIH MNPS Study Section (2005-2007)

Member of VA Renal Study section (2003-2006)

Very active in study section service for NIH, DOD, VA, NSF, American Heart Association

Editorial Boards: J. Biol. Chem. (2003-2008); Am. J. Physiol. Renal Physiol. (2001-2006);

Assay Drug Devel. Technol. (2004-2006)

Peer reviewer for nearly 50 journals

Selected Awards: Ohio Commission on Aging Individual Service Award (1982)

Haskell Schiff House staff award, Duke (1984-1985)

Alpha Omega Alpha (1987)

American Society for Clinical Investigation (1995-present)

Association of American Physicians (1998-present)

Distinguished Alumnus, Archbishop Hoban High School, Akron, Ohio (2001)

Greater Charleston Area, Federal Executive Association Federal Employee of the Year, Scientific/Professional (2001)

SC Commission on Higher Education, Diversity Advocate of the Year (2004)

Multiple Who’s Who and Best Doctor citations

Research Areas: Mitogenic and proliferative signal transduction pathways in progressive renal diseases

G protein-coupled receptors and ion transport

Clinical Areas: End stage renal disease, hypertension management, general nephrology, internal

medicine

Other: Mentorship, scientific training and faculty development

6-gallon blood donor

Medical University of South Carolina

College of Medicine Curriculum Vitae

Name: John Richard Raymond, Sr., M.D.

Clinical Office: Rm. 829 CSB, 171 Ashley Avenue Phone: 843-792-3031

171 Ashley Avenue Fax: 843-792-5110

Charleston, S.C. 29425 PAGE: 843-792-0590 #14669

Admin. Office: Rm. 101, Office of the Provost Phone: 843-792-5338 (Direct)

135 Cannon St.

Charleston, S.C. 29425 (preferred mailing address)

Education: Place Degree

1974-1978 The Ohio State University, Columbus, Ohio B.S. Psychology (cum laude)

1978-1982 The Ohio State University, Columbus, Ohio M.D. (cum laude)

1982-1983 Duke University Medical Center, Durham, N.C. Internship in Medicine

1983-1985 Duke University Medical Center, Durham, N.C. Residency in Medicine

1985 Duke University Medical Center, Durham, N.C. Assistant Chief Resident

1986-1987 VA Medical Center, Durham, N.C. Chief Medical Resident

1985-1988 Duke University Medical Center, Durham, N.C. Fellowship in Nephrology

Specialty Certification:

1986 (09/10) American Board of Internal Medicine #110594, Internal Medicine (lifetime)

1988 (11/01) American Board of Internal Medicine #110594, Nephrology (lifetime)

Licensure:

1982-1983 Ohio License #47966 (Inactive)

1982-1986 North Carolina Training License

1986-present North Carolina Permanent License #30459 (active)

1996-present South Carolina Permanent License #18867 (active)

Military Service: None

Faculty Appointments:

Institution Rank

1986-1987 Duke University Medical Center Associate in Medicine

Durham, N.C.

1988-1989 Duke University Medical Center Associate in Medicine

1989-1993 Duke University Medical Center Assistant Professor of Medicine

1994-1996 Duke University Medical Center Associate Professor of Medicine

1995 Duke University Medical Center Tenure granted (8/1/95)

1996-present Medical University of South Carolina Dialysis Clinics Incorporated

Professor of Medicine with tenure

1997-present Medical University of South Carolina Graduate Faculty

Hospital Appointments:

Institution Description

1986-1987 Duke University Medical Center Staff physician with full privileges

in Medicine

1988-1996 Duke University Medical Center Staff physician with full privileges

in Medicine and Nephrology

1989-1996 Veterans Affairs Medical Center, Staff physician with full privileges

Durham, N.C. in Medicine and Nephrology

1996-present Medical University of South Carolina Staff physician with full privileges

Hospital in Medicine and Nephrology

1996-present Ralph H. Johnson Veterans Affairs Staff physician with full privileges

Medical Center, Charleston, S.C. in Medicine and Nephrology

1996-present Charleston Memorial Hospital Staff physician with full privileges

Charleston, S.C. in Medicine and Nephrology

1998-2002 Hampton Regional Medical Center, Staff physician with consulting privileges in Hampton, S.C. Medicine and Nephrology

1999-present Specialty Hospital of South Carolina, Staff physician with consulting privileges in Charleston, S.C. Medicine and Nephrology

Administrative Appointments:

Institution Description

1991-1993 Veterans Affairs Medical Center, Director of Dialysis

Durham, N.C.

1991-1993 Veterans Affairs Medical Center, Renal Clinic Director

Durham, N.C.

1991-1996 Veterans Affairs Medical Center, Chief, Nephrology Section

Durham, N.C.

1992-1996 Veterans Affairs Medical Center, Coordinator, Hypertension Detection Durham, N.C. & Screening Program

1999-06/30/02 Ralph H. Johnson VA Medical Center Associate Chief of Staff for Research

Charleston, South Carolina and Development

2001-present Medical University of South Carolina Associate Provost for Research

Charleston, South Carolina

07/02-12/02 Medical University of South Carolina Interim Vice President for Academic Affairs

Charleston, South Carolina and Provost

01/01/03-present Medical University of South Carolina Vice President for Academic Affairs

Charleston, South Carolina and Provost

Awards: Organization Description

1982 Ohio Commission on Aging Outstanding Individual Service Award

1984-1985 Duke University Medical Center Haskell Schiff Housestaff Award

Department of Medicine (most outstanding house officer)

1987 Alpha Omega Alpha Honor Society Inductee

1987 Duke University Medical School Finalist for Golden Apple Teaching Award from Medical Students

Awards: Organization Description

1991 American Federation for Clinical Henry Christian Award for Research Excellence in Research

1994 Duke University Medical Center Finalist for Eugene Stead Teaching Award from Medicine Housestaff

1995 American Society for Clinical Inductee

Investigation

1995 American Federation for Clinical Henry Christian Award for Research Excellence in Research

1996-present Medical University of South Carolina DCI Endowed Professorship

1998 Association of American Physicians Inductee

2001-2002 Archbishop Hoban High School Distinguished Alumnus

Akron, Ohio

2001 Federal Executive Association Federal Employee of the Year,

Greater Charleston Area Scientific/Professional

2004 SC Commission on Higher Education Diversity Advocate of the Year

Who’s Who: Organization Description

1996,1998, Marquis Who’s Who Who’s Who in Medicine &

& 2000 Healthcare

1996,1998, Marquis Who’s Who Who’s Who in the World

& 2000

1998,2000, Marquis Who’s Who Who’s Who in Science and

& 2002 Engineering

2000 International Who’s Who International Who’s Who of Professionals

2000 Marquis Who’s Who Millenium Edition

2000 Strathmore’s Who’s Who Millenium Edition

2001-2003 Strathmore’s Who’s Who Strathmore’s Who’s Who

2001 & 2002 National Registry of Who’s Who National Registry of Who’s Who

2001-2002 America’s Registry of Outstanding America’s Registry of Outstanding

Professionals Professionals

2002 Marquis Who’s Who Who’s Who in America

Societies: Organization Description

1975-present Phi Kappa Phi Member

1981-present American Medical Association Member

1986-1988 American College of Physicians Associate Member

1988-present Member

1987-present Alpha Omega Alpha Member

1988-present American Society of Nephrology Member, Abstract reviewer

1991,1997,2004 Session Chair

1989-present American Federation for Medical Member

Research

1990-present American Heart Association Member

Fellow (2002-present)

1990-present National Kidney Foundation Member

Societies: Organization Description

1994-2000 New York Academy of Sciences Member

1995-1996 Molecular Medicine Society Member

1997-2004 Fellow

1995-present American Society for Clinical Investigation Member

2001-present MUSC institutional representative

1995-1998 Annals of Internal Medicine Readership Advisory Group

1996-present Hypertension Council of the Member

American Heart Association Fellow (1996-present)

1996-present Southern Society for Clinical Investigation Member

1996-present Southern Salt, Water and Kidney Club Member

1998-present Association of American Physicians Member

1999-present American Society of Pharmacology and Member

Experimental Therapeutics

2003-present American Society for Biochemistry and Member

Molecular Biology

Editorial Positions

Editorial Board Memberships

2001-2006 Am. J. Physiol. Renal Physiol

2003-2008 J. Biol. Chem.

2004-2006 Assay Drug Devel. Technol.

Other Peer-Review Positions:

Organization Position

1989 Medical Research Council of Canada Ad hoc grant referee

1990 Department of Veterans Affairs Ad hoc grant referee

Gastroenterology Study Section

1991-2001 Department of Veterans Affairs Ad hoc grant referee

Nephrology Study Section

1991 Department of Veterans Affairs Ad hoc grant referee

Basic Sciences Study Section

1992-2001 Wellcome Trust Ad hoc grant referee

Individual Investigator Awards

1992-1995 National Kidney Foundation Study section member

Young Investigator Grants

1992 National Institutes of Health NHLBI Ad hoc grant referee

Experimental Cardiovascular Sciences Study Section

1993-1996 National Institutes of Health Ad hoc grant referee

Neurological Sciences 2 Study Section

1993-2000 Jewish Foundation of Louisville Ad hoc grant referee

Biomedical Research Awards

1994-1996 National Science Foundation Ad hoc grant referee

Neural & Glial Mechanisms

1996-1997 National Institutes of Health NINDS Ad hoc grant referee

Neurological Sciences 1 Study Section

1997 National Science Foundation Ad hoc grant referee

Signal Transduction and Molecular Biochemistry

1997 National Institutes of Health NIA Special Emphasis Panel

Mt. Sinai Pharmacology PPG

1997 National Institutes of Health NIA Special Emphasis Panel

New York University Neuroscience PPG

1997-1998 National Institutes of Health NINDS Study section member

Neurological Sciences 1 Study Section (disbanded due to reorganization)

1997 National Institutes of Health NIMH Intramural Review Signaling Laboratory Panel

1998 National Institutes of Health NIDDK Ad hoc grant referee

General Medicine B Study Section

1998 National Institutes of Health NIDDK Special Emphasis Panel

Vanderbilt Nephrology PPG

1998 National Institutes of Health NIDDK Special Emphasis Panel

Yale Physiology PPG

1998-2002 American Heart Association Cardio-Renal Study Section member; co-Chair, 2000 & 2001

1998-1999 National Institutes of Health NINDS Ad hoc grant referee

Molecular Developmental Cellular Neurosciences

5 Study Section (MDCN-5)

1999-2004 National Institutes of Health NINDS Study section member

MDCN-5

1999 National Institutes of Health Ad hoc grant referee

Physiological Sciences Study Section

1999 Department of Veterans Affairs Chair, Research Enhancement Area

Pulmonary, Renal and Gastrointestinal Program, Special Emphasis Panel

1999 Department of Veterans Affairs Adjudicator, Merit Review Appeal

Pulmonary, Renal and Gastrointestinal

2000 Department of Veterans Affairs Member, Middleton Award

Central Office, R & D Service Selection Committee

2000 Department of Veterans Affairs Chair, Nashville VA/JDFI

Central Office, R & D Service Diabetes Research Center Site Visit

2000 Department of Veterans Affairs Chair, Iowa City VA/JDFI

Central Office, R & D Service Diabetes Research Center Site Visit

2000 Department of Veterans Affairs Chair, San Diego VA/JDFI

Central Office, R & D Service Diabetes Research Center Site Visit

2000 National Institutes of Health NHLBI Special Emphasis Panel

2001 National Institutes of Health NINDS Special Emphasis Panel

2001 National Institutes of Health NIGMS Special Emphasis Panel

2001 Medical Research Council, United Kingdom Ad hoc grant referee

2001 National Institutes of Health NIDDK Special Emphasis Panel

Emory University PPG site visit

2001 Department of Veterans Affairs Merit Review Advisory Council

Central Office, R & D Service

2001 National Institutes of Health NIDDK Special Emphasis Panel

NIDDK Centers of Excellence in Pediatric

Nephrology

2002 National Institutes of Health NIDDK Special Emphasis Panel

NIDDK Loan Repayment Program

2003 National Institutes of Health NIDDK Special Emphasis Panel

NIDDK Loan Repayment Program

2003 Department of Veterans Affairs Research Enhancement Award

Central Office, R & D Service Program Advisory Council

2003 National Institutes of Health ZRG1 MDCN-1 Special Emphasis Panel

Center for Scientific Review Functional and Cognitive Neuroscience 1 Study Section (IFCN1)

2003 National Institutes of Health ZRG1 UROL Special Emphasis Panel

Center for Scientific Review Urology Study Section (NIDDK)

2003 National Institutes of Health ZRG1 MDCN-1 Special Emphasis Panel

Center for Scientific Review (SYN)

2003 National Institutes of Health NIDDK Special Emphasis Panel

NIDDK Loan Repayment Program

2003 National Institutes of Health ZRG1 MDCN-5 Special Emphasis Panel

Center for Scientific Review

2003-2006 Department of Veterans Affairs Renal Study Section

Central Office, R & D Service

2004-2006 National Institutes of Health MNPS Study section member

NINDS

2004 National Institutes of Health ZRG1 RUSD (04) Special Emphasis Center for Scientific Review/NIDDK panel, Calcitropic Hormones & Renal Transport

2004 National Institutes of Health Co-Chair ZRG4 UROL Special Center for Scientific Review/NIDDK Emphasis Panel, Roadmap T-90 Grants

2004 National Institutes of Health ZRG3 UROL Special Emphasis Panel Center for Scientific Review/NIDDK Emphasis Panel, Novel Technologies

2004 National Institutes of Health ZDK GRB-3 Special Emphasis Panel

NIDDK Loan Repayment Program

2004 National Institutes of Health ZDK1 GRB-1 (O2) Special Emphasis Emory and Colorado PPGs Panel, PPG Review

2004 National Institutes of Health Chair, ZDK GRB-R (J1) Special NIDDK Emphasis Panel, Training grants

2005 National Institutes of Health ZDK GRB-C (M1) Special Emphasis

NIDDK Panel, Nephrology Ancillary Clinical Trials

2005 National Institutes of Health Chair, ZDK GRB-R (O2) Special

NIDDK Emphasis Panel, Nephrology K awards

2005 National Institutes of Health ZDK GRB-4 (O1) Angiogenesis in Diabetes NIDDK Special Emphasis Panel

2005 National Institutes of Health ZNS1 SRB-G (O1) Special Emphasis Panel

NINDS High Throughput Screening

2005 National Institutes of Health ZRG1 RUS-D (O2) (M) Special Emphasis Panel, Collaborative R01 proposals

National Policy/Advisory Positions:

Organization Position

1999 Department of Veterans Affairs Member, Research Career

Central Office, R & D Service Scientist Program Task Force

2000-2001 Department of Veterans Affairs Member, Task Force

Office of Research Compliance and Assurance

Multi-Assessment Program

2000-2001 Department of Veterans Affairs Chair, Animal Welfare Task Force

Office of Research Compliance and Assurance

Local or State Board Positions:

Organization Position

1999-2002 Charleston Research Institute Secretary-Treasurer, Board of Directors

(VA Non-profit corporation) Directors

2002-present Charleston Research Institute Member, Board of Directors

(VA Non-profit corporation)

2001-present Hollings Marine Laboratory Chair, Board of Directors

(Partnership of MUSC, NOAA, NIST, College of Charleston, and SCDNR)

2001-present University Medical Associates Executive Committee, Board of

(Affiliated Physicians’ Practice of MUSC) Directors

2001-present Foundation for Research Development Vice-Chair, Board of Trustees

(MUSC non-profit foundation)

2001-present SC State EPSCOR/IDEA Committee Chair, Executive Board

2002-present J.B. Edwards College of Dental Medicine Member, Steering Board for MUSC construction of new College of Dental Medicine

2003-present Governor’s School for Science and Math Member, Board of Trustees State of South Carolina

2004-present Health Sciences South Carolina Member, Scientific Committee (VPs of six partners)

Extramural Research Support (Previous Funding): Total Direct Cost

1990-1993 American Heart Association (National) Grant-In-Aid # 900767

Regulation of Phosphate Transport in Transfected Cells

Principal Investigator: John Raymond $105,000

1990-1993 Veterans Administration Merit Award

Cell Biology and Biochemistry of the Human 5-HT_1A Receptor

Principal Investigator: John Raymond $123,000

1992-1995 National Institutes of Health R01 NS30927

Regulation of Signaling of the Human 5-HT_1A Receptor

Principal Investigator: John Raymond $351,000

1993-1998 Veterans Administration Merit Award

Heterologous Expression, Purification and Reconstitution of the 5-HT_1A Receptor

Principal Investigator: John Raymond $367,000

1994-1997 American Heart Association (National) Grant-In-Aid # 940507

Determinants of Polarity in Type IIIb Membrane Proteins

Principal Investigator: John Raymond $120,000

1994-1995 National Institutes of Health SBIR Grant

Characterization of Novel Derivatives of (S) UH-301 for the Study of the 5-HT_1AReceptor

Principal Investigator: Yigong Gao, Research. Biochemicals International,

Co-investigator (subcontract) John Raymond $12,000

1995 Department of Veterans Affairs Equipment Grants Program

Cytosensor® Microphysiometer

Ombudsman: John Raymond $50,000

1995 Molecular Devices Corporation

Cytosensor® Microphysiometer Academic Grant

Ombudsman: John Raymond $47,500

1996-2001 National Institutes of Health R01 DK52448

G_i Regulation of NHE Activity in Renal and Fibroblast Cells

Principal Investigator: John Raymond $650,000

1997-2002 Mentored NIH K01 HL96012, Eddie L. Greene (PI)

Role of Aldosterone in Renal Glomerular Cell Growth and Matrix Production

Sponsor: John Raymond $450,000

1998-2002 Mentored Robert Wood Johnson Minority Faculty Development Award

Eddie L. Greene (PI)

Minority Faculty Development Award

Sponsor: John Raymond $325,000

1998 Shared Equipment Grant NIH S10 RR13005

MUSC Integrated Cellular Fluorescence Facility

Principal Investigator: John Raymond, effort N/A $281,000

1998 Department of Veterans Affairs Equipment Grants Program

Live Cell Fluorescence Microscopy Facility

Principal Investigator: John Raymond $209,000

1998-2001 Mentored Department of Veterans Affairs Merit Award (MREP),

Maria N. Garnovskaya, Ph.D. (PI)

Pathways of Hypertonic Activation of Sodium-Proton Exchange

Sponsor: John Raymond $300,000

1999 Shared Equipment Grant NIH S10 RR13656

Electron Paramagnetic Spin Resonance Facility

Principal Investigator: John Raymond $306,000

2001-2002 Supplement National Institutes of Health R01 DK52448-06

G_i Regulation of NHE Activity in Renal and Fibroblast Cells

Principal Investigator: John Raymond $25,000

2002 Veterans Affairs RFA

Research Security Enhancement Award

Program Director: John Raymond $20,000

2002-2003 NIH/NCRR 1C06RR014516

Sensory Neuroscience Facility Renovation

Principal Investigator: John Raymond (as institutional official) $1,000,000

1998-2003 Veterans Administration Merit Award

Differential Signaling of Serotonin Receptors

Principal Investigator: John Raymond $533,000

2004-2009 NIH R01 NS049515

Role of Calmodulin in 5-HT Receptor Function

Principal Investigator: John Raymond $1,125,000

Declined in lieu of VA Merit Award

Extramural Research Support (Active Funding): Total Direct Cost

2000-2005 National Institutes of Health R01 DK54720-04

NAD(P)H Oxidase & Mesangial Cell Proliferation and Fibrosis

Principal Investigator: John Raymond $700,000

2001-2006 National Institutes of Health R01 GM-63909-04

Down-regulation of EGF Receptors by GPCR Activation

Principal Investigator: John Raymond $700,000

2002-2006 National Institutes of Health R01 DK52448-08

G Protein-Regulation of NHE Activity

Principal Investigator: John Raymond $763,000

1998-2008 Training Grant in Glomerular Function and Disease NIH T32 DK07752-07

MUSC Multidisciplinary Training Grant in Glomerular Function and Disease

Program Director: John Raymond $1,005,000

2004-2009 Veterans Affairs Merit Award

Novel 5-HT Receptor-interacting Proteins

Principal Investigator: John Raymond $715,000

1998-2009 Veterans Affairs Research Enhancement Award Program

Charleston Inflammatory Mediators of Glomerular Diseases REAP Award

Program Director: John Raymond $3,100,000

2001-2006 Mentored NIH K25 DK59950-03, Andrew Gelasco, Ph.D. (P.I.)

Cellular Actions of Indoxyl Sulfate - a Uremic Toxin

Sponsor: John Raymond $590,000

2002-2004 National Institutes of Health 1 S07 RR018244

Human Subjects Research Enhancement Program at MUSC

Principal Investigator: John Raymond $300,000

2002-2005 Mentored K01 DK063252-02, Qing Yang, M.D. (PI)

Angiotensin Receptor Interacting Proteins

Sponsor: John Raymond $250,000

2002-2005 Mentored Minority supplement to NIH R01 DK52448-07

Henry Ayiku, M.D.

NHE-1 Interacting Proteins

Sponsor: John Raymond $200,000

2001-2005 CSP #453 Department of Veterans Affairs

Homocysteinemia in Chronic Renal Failure- Cooperative Trial

Local Principal Investigator: John Raymond $250,000

2003-2005 NIH/NCRR 1C06 RR015455-01A1

Children’s Research Institute Animal Facility

Principal Investigator: John Raymond (as institutional official) $2,000,000

2003-2005 NIH/NCRR 1C06 RR018823

Children’s Research Institute Developmental Neurogenetics

And Cardivascular Biology Floors

Principal Investigator: John Raymond (as institutional official) $2,854,000

2003-2005 Mentored Minority supplement to NIH R01 DK52448-07

Sonya Coaxum, Ph.D.

Proteomics of NHE-1 Activation

Sponsor: John Raymond $115,000

2005-2010 Mentored NIH 1 K01 DK070054-01, Monika Gooz, M.D., Ph.D. (P.I.)

Crosstalk Among Growth Factors, ADAMs and Integrins

Sponsor: John Raymond $520,000

Sponsored Fellowships for Trainees; Extramural Research Support:

Total Direct Cost

1991-1993 National Kidney Foundation Fellowship

Frank J. Albers, M.D. $50,000

1995-1996 National Kidney Foundation Fellowship

John M. Arthur, M.D., Ph.D. $25,000

1997-1999 American Heart Association (S.C. Affiliate) $40,000

Yurii Mukhin, Ph.D.

1998-1999 National Kidney Foundation Fellowship (S.C. Affiliate) $25,000 John C. Andy, M.D.

1998-1999 National Kidney Foundation Fellowship (National) $12,500 John C. Andy, M.D.

1998-2000 American Heart Association (S.C. Affiliate) $50,000 Jasjit Grewal, Ph.D.

2000-2001 Department of Veterans Affairs Associate Investigator $60,000 Andrew Gelasco, Ph.D.

2000-2001 Department of Veterans Affairs Associate Investigator $50,000 David Lefler, D.O.

2002-2004 American Heart Association Pre-doctoral fellowship $17,000 Justin Turner (MSTP student)

2003-2005 NIH Minority Supplement for post-doctoral fellowship $100,000 Henry Ayiku, M.D.

2004-2006 NIH Minority Supplement for post-doctoral fellowship $110,000 Sonya Coaxum, Ph.D.

Academic Committee Activities (Recent):

Institution Description

1996-present Veterans Affairs Medical Center, Research and Development Charleston, S.C. Committee

1996-present Medical University of South Carolina Nephrology Fellowship Training Committee

1996-1997 M.U.S.C. Search Committee for Chairman of Physiology

1997 M.U.S.C. University Planning Committee,

Working Group for Research Issues

1997 M.U.S.C. Search Committee for University Chief Information Officer

1997-2003 Medical University of South Carolina Medical Student Training Program

Steering Committee

1997-1998 M.U.S.C. Cost Accounting Standards Working Group on Indirect Costs

1997-1999 M.U.S.C. University Research Committee

1998-present Department of Veterans Affairs Research Space Committee

1998-1999 M.U.S.C. Provost’s Office Review Committee on the

Dean of College of Dental Medicine

1998-present M.U.S.C. Member, Oversight Committee

Flow Cytometry Facility

1998-present M.U.S.C. Member, Oversight Committee

Monoclonal Antibody Facility

1999-2000 Department of Veterans Affairs Laboratory Panic Values Committee

1999-present Dept. of Veterans Affairs and MUSC Academic Partnership Council

1999-2002 M.U.S.C. University Research Council

1999-2002 M.U.S.C. Interim Funding Committee

1999-2000 M.U.S.C. Department of Medicine Chairman, Committee to Draft

Strategic Research Plan, 2001-2006

1999-present M.U.S.C. College of Health Professions Member, Diversity Advisory Board

1999-2002 M.U.S.C. Department of Biochemistry Member, Faculty Search Committee

2000 Ralph H. Johnson VA Medical Center Chairman, Search Committee for

Chief of Staff

2000 M.U.S.C. College of Medicine Member, Search Committee for the

Chair, Department of Pharmacology

2000 M.U.S.C. College of Medicine Member, Search Committee for the

Chair, Department of Microbiology

and Immunology

2000-2001 M.U.S.C. Member, Search Committee for the

Dean, College of Medicine

2000-2005 Ralph H. Johnson VA Medical Center Chairman, Advisory Committee for the

Charleston Heart Failure Research Enhancement Award Program

2000-present M.U.S.C. Hollings Cancer Center Member, Scientific Advisory Committee

2000-2002 Ralph H. Johnson VA Medical Center Member, Foreign Travel Subcommittee of the Education Committee

2001 M.U.S.C. Department of Medicine Chairman, Search Committee for the

Director, Division of Cardiology

2001 M.U.S.C. College of Graduate Studies Member, Strategic Planning Committee

2001 Ralph H. Johnson VA Medical Center Member, Search Committee for the

Chief, Specialty Services

2001-present Ralph H. Johnson VA Medical Center Member, Resource Allocation Board

2001-2003 M.U.S.C. Member, CIO Search Committee

2001-present M.U.S.C. College of Dental Medicine Member, Steering Committee for Training grant titled “Comprehensive Training in Oral and Craniofacial Research”

2001-present M.U.S.C. Department of Biochemistry Member, Oversight Committee for Program Project Grant

2001-2003 M.U.S.C. Member, Information Management Council

2001-2003 M.U.S.C. Member, Clinical Information Management

Committee

2001-present M.U.S.C. Chair, Executive Research Council

2001-present M.U.S.C. Member, Steering Committee, Children’s Research Institute

2001-present M.U.S.C. Chair, Executive Research Council

2002-present M.U.S.C. Member, Academic Compliance Assurance Council

2002-present M.U.S.C. Member, University Medical Associates

Board of Directors

2002-present M.U.S.C. Member, Steering Committee, James B. Edwards College of Dental Medicine Dental School Planning and Construction project

2002-present M.U.S.C. Member, Internal Advisory Committee for NIH PPG titled “Molecular Mechanisms of Cardiac Hypertrophy”

Major Teaching Responsibilities (Recent):

1998-2005 Pharmacology Departmental Research Conferences

Molecular And Cellular Biology Program Seminars

Medical Grand Rounds

Miscellaneous divisional research conferences, clinical conferences and journal clubs

Medicine Chair rounds at VAMC several times per month

Endocrinology and Medical Genetics Seminars

Biochemistry Seminars

Digestive Diseases Center Grand Rounds

Wednesday VA Nephrology Clinic- every week for 7 years

Nephrology Ward Lectures-every other month

Major Teaching Responsibilities (Recent):

1996-2004 Fluid and Electrolyte and/or Acid Base Lecture(s)

Given several times per year to third and fourth year students on Internal Medicine wards at M.U.S.C.

1997-1999 Two lectures per term in the Advanced Signal Transduction (Department of Pharmacology)

1997-2002 One lecture per term in the Research Instrumentation Graduate Course (Department of Cell Biology)

1998-2005 Chairman’s teaching rounds. Round with long-call team at VA on Mondays for didactic teaching.

Major Clinical and Research Interests:

· Control of cell growth and differentiation; Control of ion transport

· Molecular biology and biochemistry of serotonin receptors

· Molecular mechanisms of hormone signaling in health and disease

· Management of severe hypertension

· Clinical strategies to slow the progression of renal diseases

Invited Academic Lectures (since 1994):

March, 1994 Promiscuous Signal Initiation and Termination through a Prototypical G_i- linkedReceptor

University of Cincinnati Division of Pulmonary Medicine, Cincinnati, OH.

August, 1994 Acquired and Genetic Diseases of G proteins and their Receptors

Clinical Conference, The University of Florida Division of Nephrology, Hypertension and Transplantation, Gainesville, Florida

August, 1994 Multiple Pathways of Signal Initiation and Termination through a Prototypical G_i-linkedReceptor

Research Conference, The University of Florida Division of Nephrology, Hypertension and Transplantation, Gainesville, Florida

December, 1994 Acquired and Genetic Diseases of G proteins and their Receptors

Clinical Conference, The University of Louisville Kidney Disease Program,

December, 1994 Multiple Pathways of Signal Initiation and Termination through a Prototypical G_i-linkedReceptor

Research Conference, The University of Louisville Kidney Disease Program,

April, 1994 Microphysiometry as a Tool to Study Receptors and Sodium-Proton Antiporters.

Satellite Conference, FASEB Meeting, Atlanta, Georgia.

May, 1995 Microphysiometry, a New Tool for the Study of Signal Transduction.

The University of Florida Division of Nephrology, Hypertension and Transplantation, and Department of Pharmacology, Gainesville, Florida

April, 1995 Strategies to Slow the Progression of Diabetic Renal Disease

Medical Grand Rounds, Duke University Medical Center

August, 1995 Strategies to Slow the Progression of Diabetic Renal Disease

Medical Grand Rounds, Marshall University, Huntington, W.Va.

August, 1995 Acquired and Hereditary Diseases of G Proteins and their Receptors

Medical Grand Rounds, Duke University Medical Center

November, 1995 Serotonin (Session Chair)

The Society for Neuroscience Annual Meeting, San Diego, CA

November, 1995 Microphysiometry to Study Orphan Receptors and Signal Transduction Pathways Satellite Symposium, The Society for Neuroscience Annual Meeting, San Diego, CA

December, 1995 The Study of Orphan Receptors Using Microphysiometry

British Pharmacological Society Symposium on Microphysiometry

London, England

April, 1997 The Study of G Protein Function using Microphysiometry

1^st International Symposium on Microphysiometry and FLIPR Technology

Paris, France

April, 1997 Signal Transduction Session (Session Chair)

1^st International Symposium on Microphysiometry and FLIPR Technology

Paris, France

November, 1997 Chair, Signal Transduction Session

American Society of Nephrology Meeting, San Antonio, Texas

June, 1998 The Study of Sodium-Proton Exchange using Microphysiometry

2^nd International Symposium on Microphysiometry and FLIPR Technology

Hilton Head, S.C.

June, 1998 Signal Transduction Session (Session Chair)

2^nd International Symposium on Microphysiometry and FLIPR Technology

Hilton Head, S.C.

June, 1998 Unusual Signal Transduction Pathways of Serotonin Receptors

Invited Symposium Speaker

International Union of Pharmacologists Meeting, Rotterdam, the Netherlands

June, 1999 Signal Transduction Session (Session Chair)

3^rd International Symposium on Microphysiometry and FLIPR Technology

Monterey, California

June, 1999 Probing Cellular Metabolic Pathways with Noninvasive Methods

3^rd International Symposium on Microphysiometry and FLIPR Technology

Monterey, California

June, 1999 Redox Signaling in the Kidney

University of Pittsburgh, Departments of Medicine and Physiology

July, 1999 Molecular and Clinical Aspects of Diabetes Insipidus

Clinical Conference, The University of Louisville Kidney Disease Program,

July, 1999 Redox Signaling in the Kidney

Research Conference, The University of Louisville Kidney Disease Program,

November, 1999 G protein Signaling in Polarized Epithelial Cells

Invited Speaker, American Society of Nephrology Meeting, Miami Beach, Fla.

June, 2000 Reactive Oxygen Species as Second Messengers in the Kidney

Case Western Reserve University-Metro Health Medical Center, Division of Nephrology and Department of Physiology

July, 2000 Molecular and Clinical Aspects of Diabetes Insipidus

Case Western Reserve University-University Hospital Medical Center, Division of Nephrology and Department of Physiology

November, 2000 Role of Glomerular Mesangial Cells in Chronic Renal Failure

Invited Speaker, American Society of Nephrology Meeting, Montreal, Canada

November, 2000 Free Radicals as Second Messengers in Chronic Renal Failure

Invited Speaker, International Society of Free Radical Biologists, Kyoto, Japan

April, 2001 Role of Reactive Oxygen Species as Second Messengers

Symposium Organizer, American Society of Pharmacology and Experimental Therapeutics Meeting, Orlando, Florida

September, 2001 Proteomic Methods in Signal Transduction

Invited Speaker, P. Universidad Católica de Chile, Santiago, Chile

September, 2001 Reactive Oxygen Intermediates as Signals in Kidney Cells

Invited Speaker, FONDAP Center for Cell Regulation and Physiology, Pucón, Chile

November, 2001 Unusual Signal Transduction Linkages of Serotonin Receptors

Vanderbilt University Department of Pharmacology

May, 2002 A Novel Pathway of Activation for Type I Sodium-Proton Exchangers

University of Minnesota Departments of Pharmacology and Psychiatry

May, 2005 CaM is a Modulator of GPCR Function

Case Western Reserve University Department of Biochemistry

June, 2006 Regulation of 5-HT Function by Receptor Accessory Proteins

Serotonin Club Meeting, Kyoto, Japan

Publications in Refereed Journals:

1. Raymond, J.R. (1984) Nephrotoxicities of antineoplastic and immunosuppressive agents. Current Problems in Cancer 8:2-32.

2. Regan, J.W., Raymond, J.R., Lefkowitz, R.J., DeMarinis, R.M. (1986) Photoaffinity labeling of human platelet and rabbit kidney a₂-adrenergic receptors with [³H]-SKF 102229. Biochem. Biophys. Res. Comm. 137:606-613.

3. Raymond, J.R. (1988) Amphotericin B nephrotoxicity. Am. Family Physician 38: 199-203.

4. Raymond, J.R., Raymond, P.A. (1988) Post-lumbar puncture headache. West. J. Med. 148: 551- 554.

5. Raymond, J.R., Yarger, W.E. (1988) Abnormal urine color; differential diagnosis. South. Med. J. 81:837- 841.

6. Raymond, J.R., van den Berg, E.K. Jr., Knapp, M. (1988) Nontraumatic prehospital sudden death in young adults. Arch. Intern. Med. 148:303-308.

7. Fargin, A., Raymond, J.R., Lohse, M., Kobilka, B.K., Caron, M.G., Lefkowitz, R.J. (1988) A genomic clone which resembles a ß-adrenergic receptor encodes the 5-HT_lA receptor. Nature 335:358-360.

8. Schwab, S.J., Raymond, J.R., Saeed, M., Dennis, P., Bollinger, R. (1989) Prevention of hemodialysis fistula thrombosis; early detection and elective treatment of venous stenoses. Kidney Int. 36:707-711.

9. Raymond, J.R., Fargin, A., Lohse, M.J., Regan, J.W., Senogles, S., Lefkowitz, R.J., Caron, M.G. (1989) Identification of the ligand binding subunit of the 5-HT_1Areceptor with a radioiodinated probe. Mol. Pharmacol. 36:15-21.

10. Fargin, A., Raymond, J.R., Regan, J.W., Cotecchia, S., Lefkowitz, R.J., Caron, M.G. (1989) Effector coupling mechanisms of the cloned 5-HT_1A receptor. J. Biol. Chem. 264:14848-14852.

11. Raymond, J.R., Fargin, A., Middleton, J.P., Graff, J.M., Haupt, D.M., Caron, M.G., Lefkowitz, R.J., Dennis, V.W. (1989) The human 5-HT_1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate transport via protein kinase C. J. Biol. Chem. 264:21943-21950.

12. Thevaniau, M., Raymond, J.R., Rougon, G.N. (1989) Antipeptide antibodies to the b₂-adrenergic receptor confirm the extracellular orientation of the amino terminus and the putative first extracellular loop. J. Membr. Biol. 111:141-153.

13. Raymond, J.R., Hnatowich, M.R., Lefkowitz, R.J., Caron, M.G. (1990) Adrenergic receptors: proto-types for the study of structure and function of G-protein-coupled receptors. Hypertension 15:119-131.

14. Raymond, J.R., Middleton, J.P., Dennis, V.W. (1990) HeLa cells express cAMP–inhibitable sodium-dependent phosphate uptake. Am. J. Physiol 258: (Renal Fluid Electrolyte Physiol. 27) F433-F437.

15. Middleton, J.P., Albers, F.J., Dennis, V.W., Raymond, J.R. (1990) Thapsigargin provides evidence for Ca²⁺-mediated increases in sodium-dependent phosphate uptake in HeLa cells. Am. J. Physiol 259: (Renal Fluid Electrolyte Physiol. 28) F727-F731.

16. Middleton, J.P., Raymond, J.R., Whorton, A.R., Dennis, V.W. (1990) Recombinant 5-HT_lA receptors stimulate Na⁺/K⁺-ATPase by a Ca²⁺-dependent pathway in HeLa cells. J. Clin. Invest. 86:1799-1805.

17. Raymond, J.R., Albers, F.J., Middleton, J.P., Caron, M.G., Lefkowitz, R.J., Dennis,V.W. (1991) Serotonin 5-HT_lA and histamine H_lreceptors expressed in HeLa cells stimulate phosphatidylinositol hydrolysis and phosphate uptake through distinct G protein pools. J. Biol. Chem. 266:372-379.

18. Bates, M.D., Caron, M.G., Raymond, J.R. (1991) Desensitization of DA_l dopamine receptors coupled to adenylate cyclase in opossum kidney (OK) cells. Am. J. Physiol 260: (Renal Fluid Electrolyte Physiol. 29) F937-F945.

19. Raymond, J.R. (1991) Protein kinase C induces phosphorylation and desensitization of the human 5-HT_lA receptor. J. Biol. Chem. 266:14747-14753.

20. El Mestikawy, S., Fargin, A., Raymond, J.R., Gozlan, H., Hnatowich, M. (1991) The 5-HT_lA receptor: an overview of recent advances. Neurochemical Res. 16:1-10.

21. Jose, P.A., Raymond, J.R., Bates, M.D., Aperia, A., Felder, R.A., Carey, R.M. (1992) The renal dopamine receptors. J. Am. Soc. Nephrol. 2:1265-1278.

22. Liggett, S.B., Ostrowski, J., Chesnut, L.C., Kurose, H., Raymond, J.R., Caron, M.G., Lefkowitz, R.J. (1992) Sites in the third intracellular loop of the a₂-adrenergic receptor confer short-term term agonist-promoted desensitization: evidence for a receptor kinase mediated mechanism. J. Biol. Chem. 267:4740-4746.

23. Boddeke, H.W.G.M., Fargin, A., Raymond, J.R., Schoeffter, P., Hoyer, D. (1992) Agonist/antagonist interactions with cloned human 5-HT_lA receptors: variations in intrinsic activity in HeLa cells. Naunyn-Schmied. Arch. Pharmacol. 345:257-263.

24. Ho, B.Y., Karschin, A., Raymond, J.R., Branchek, T, Lester, H.A., Davidson, N. (1992) Expression in animal cells of the 5-HT_1A receptor by a vaccinia virus vector system. FEBS Lett. 301:303-306.

25. Mangel, A.W., Basavappa, S., Gabriel, S., Raymond, J.R., Stutts, M.J., Fitz, J.G. (1992) cAMP-regulated chloride currents in CHO cells. Biochem. Biophys. Res. Commun. 186:251-255.

26. Eason, M., Kurose, H., Holt, B., Raymond, J.R., Liggett, S.B. (1992) Simultaneous coupling of a₂-adrenergic receptors to two G-proteins with opposing effects. J. Biol. Chem. 267:15795-15801.

27. Raymond, J.R., Albers, F.J., Middleton, J.P. (1992) Functional expression of human 5-HT_lA receptors and differential coupling in CHO cells. Naunyn-Schmied. Arch. Pharmacol. 346:127-137.

28. Becker, B.B., Gettys, T.W., Albers, F.J., Middleton, J.P., Lee, S.-L., Fanburg, B., Raymond, J.R. (1992) 8-OH-DPAT–responsive 5-HT₄-like receptor expressed in bovine pulmonary artery smooth muscle cells. Mol. Pharmacol. 42:817-825.

29. Raymond, J.R., Kim, J.L., Beach, R.E., and Tisher, C.C. (1993) Immunohistochemical mapping of the cellular & subcellular distribution of 5-HT_1A receptors in rat and human kidney. Am. J. Physiol. 264: (Renal Fluid Electrolyte Physiol. 33) F9-F19.

30. Mangell, A., Raymond, J.R., Fitz, J.G. (1993) Regulation of high-conductance anion channels by G proteins and 5-HT_lA receptors in CHO cells. Am. J. Physiol. 264: (Renal Fluid Electrolyte Physiol. 33) F490-F495.

31. Arthur, J.M., Casañas, S.J., Raymond, J.R. (1993) Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT_1A receptors. Biochem. Pharmacol. 45: 2337-2341.

32. Bates, M.D., Olsen, C.L., Becker, B.N., Albers, F.J., Middleton, J.P., Mulheron, J.G., Jin, C., Conti, M., Raymond, J.R. (1993) Elevation of cAMP is required for down-regulation, but not agonist-induced desensitization of dopamine D₁receptors. Studies in opossum kidney cells that stably express a rat phosphodiesterase 3 cDNA J. Biol. Chem. 269:14757-14763.

33. Bian, X., Seidler, F., Olsen, C.L, Raymond, J.R., Slotkin, T. (1993) Effects of fetal dexamethasone exposure on postnatal control of cardiac adenylate cyclase: b-adrenergic receptor coupling to G_s regulatory protein. Teratology 48:169-177.

34. Raymond, J.R., Olsen, C.L., Gettys, T.W. (1993) Cell-specific physical and functional coupling of human 5-HT_1A receptors to inhibitory G protein a-subunits and lack of coupling to G_s_a. Biochemistry 32:11064-11073.

35. Gettys, T.W., Fields, T.A., Raymond, J.R. (1994) Selective activation of inhibitory G protein a- subunits by partial agonists of the human 5-HT_lA receptor. Biochemistry 33:4283-4290.

36. Mulheron, J.G., Casañas, S.J., Arthur, J.M., Garnovskaya, M.N., Gettys, T.W., Raymond, J.R. (1994) Human 5-HT_lA receptors expressed in insect cells activate endogenous G_o-like G proteins. J. Biol. Chem. 269:12954-12962.

37. Raymond, J.R., Arthur, J.M., Olsen, C.L., Gettys, T.W, Mortensen, R.M. (1994) a_2A Adrenergic receptors inhibit cAMP accumulation in embryonic stem cells which lack G_i_a. J. Biol. Chem. 269:13073-13075.

38. Spurney, R.F., Middleton, J.P, Raymond, J.R., Coffman, T.M. (1994) Modulation of thromboxane receptor activation in rat glomerular mesangial cells. Am. J. Physiol. 267: (Renal Fluid Electrolyte Physiol. 36) F467-F478.

39. Quarles, L.D., Middleton, J.P., Zhang, J., Arthur, J.M., Raymond, J.R. (1994) Aluminum-induced DNA synthesis in MC3T3-E1 osteoblasts: mediation by G-protein and protein kinase C dependent pathways. J. Cell. Biochem. 56:106-117.

40. Gettys, T.W., Sheriff-Carter, K., Moomaw, J., Taylor, I.L., Raymond, J.R. (1994) Characterization and use of crude a-subunit preparations for quantitative immunoblotting of G proteins. Anal. Biochem. 220:82-91.

41. Raymond, J.R., Olsen, C.L. (1994) Protein kinase A induces phosphorylation of the human 5-HT_1A receptor and augments its desensitization by protein kinase C in CHO-K1 cells. Biochemistry 33:11264-11269.

42. Raymond, J.R., Arthur, J.M., Mannon, R. (1994) Practical management of hypertensive urgencies and emergencies. N. Carolina Med. J. 55:295-303.

43. Raymond, J.R., Arthur, J.M., Kovalik, E. (1994) Strategies for preventing diabetic nephropathy. N. Carolina Med. J. 55:362-369.

44. Raymond, J.R. (1994) Hereditary and acquired defects in signaling through the hormone-receptor-G protein complex. Am. J. Physiol. 266: (Renal Fluid Electrolyte Physiol. 35) F163-F174.

45. Raymond, J.R. (1995) Multiple mechanisms of receptor/G protein signaling specificity. Am. J. Physiol. 268: (Renal Fluid Electrolyte Physiol. 37) F141-F158.

46. Nebigil, C.G., Garnovskaya, M.N., Spurney. R.F., Raymond, J.R. (1995) Identification of a rat glomerular mesangial cell mitogenic 5-HT_2A receptor. Am. J. Physiol. 268: (Renal Fluid Electrolyte Physiol. 37) F122-F127.

47. Garnovskaya, M.N., Nebigil C.G., Arthur, J.M., Spurney, R.F., Raymond, J.R. (1995) 5-HT_2A receptors expressed in rat mesangial cells inhibit cAMP accumulation. Mol. Pharmacol. 48:230-237.

48. Nebigil, C.G., Garnovskaya, M.N., Casañas, S.J., Mulheron, J.G., Parker, E.M., Gettys, T.W., Raymond, J.R. (1995) Agonist-induced phosphorylation and desensitization of 5-HT_1A receptor expressed in Sf9 insect cells. Biochemistry 34:11954-11962.

49. van Biesen, T., Hawes, B.E., Raymond, J.R., Luttrell, L.M., Koch, W.J., Lefkowitz, R.J. (1996) G_o- protein a-subunits mediate Ras-independent MAP kinase activation. J. Biol. Chem. 271:1266-1269.

50. Wang, Y., Sostman, A., Roman, R., Vigna, S., Raymond, J.R., Fitz, J.G. (1996) Metabolic stress activates K⁺ channels through a Ca²⁺ and protein kinase Ca-dependent mechanism. J. Biol. Chem. 271:18107-18113.

51. Kovalik, E.C., Raymond, J.R., Berkoben, M.S., Butterly, D.W., Montello, B.J., Conlon, P.J. (1996) A cluster of epidural abscesses in chronic hemodialysis patients. J. Am. Soc. Nephrol. 7:2264-2267.

52. Kirchgessner, A.L., Liu, M.-T., Raymond, J.R., Gershon, M.D. (1996) Identification of cells that express 5-HT_lA receptors in the nervous systems of the bowel and pancreas. J. Comp. Neurol. 364:439-455.

53. Garnovskaya, M.N., van Biesen, T., Hawes, B.E., Canañas Ramos, S.J., Lefkowitz, R.J., Raymond, J.R. (1996) Ras-dependent activation of mitogen-activated protein kinase by 5-HT_1A receptor. Biochemistry 35:13716-13722.

54. Chuprun, J.K., Raymond, J.R., Blackshear, P.J. (1997) Heterotrimeric G protein G_i_a₂mediates LPA- stimulated mitogenic signalling in mouse fibroblasts. J. Biol. Chem. 272:773-780.

55. Garnovskaya, M.N., Gettys, T.W., van Biesen, T., Chuprun, J.K., Prpic, V., Raymond, J.R. (1997) G protein-coupled 5-HT_lA receptor activates Na⁺/H⁺ exchange in CHO-K1 cells through G_i_a₂ and G_i_a₃. J. Biol. Chem. 272: 7770-7776.

56. Wang, Y., Roman, R., Hannun, Y., Raymond, J.R., Fitz, J.G. (1997) Activation of protein kinase Ca couples cellular metabolism to membrane K⁺ in a human biliary cell line. J. Clin. Invest. 99:2890- 2897.

57. Arthur, J.M., Collinsworth, G.P., Quarles, L.D., Gettys, T.W., Raymond, J.R. (1997) Specific coupling of a cation-sensing receptor to G protein a-subunits in MDCK cells. Am. J. Physiol. 273: (Renal Fluid Electrolyte Physiol. 42) F129-F135.

58. Ullian, M.E., Raymond, J.R., Paul, R.V. (1997) Regulation of vascular angiotensin II receptors by EGF. Am. J. Physiol. 273: (Cell Physiol. 42) C1241-C1249.

59. Garnovskaya, M.N., Mukhin, Y., Raymond, J.R. (1998) Rapid activation of sodium-proton exchange and extracellular signal-regulated protein kinase in fibroblasts by G protein-coupled 5-HT_1Areceptor involves distinct signaling cascades. Biochem. J. 330:489-495.

60. Mannon, P.J., Raymond, J.R. (1998) The neuropeptide Y/peptide YY Y1 receptor is coupled to MAP kinase via PKC and Ras in CHO cells. Biochem. Biophys. Res. Comm. 246:91-94.

61. Prpic, V.J., Fitz, J.G., Raymond, J.R., Garnovskaya, M.N., Liddle, R.A. (1998) Inhibition of Na⁺/H⁺ exchange stimulates cholecystokinin secretion in STC-1 cells. Am. J. Physiol. 275:G689-95

62. Moiseiwitsch, J.R.D., Raymond, J.R., Tamir, H, Lauder, J.M. (1998) Serotonin regulates tooth germ morphogenesis and gene expression in mouse mandibular explant cultures. Arch. Oral Biol. 43:789-800.

63. Roman, R., Bodily, K.O., Wang, Y., Raymond, J.R., Fitz, J.G. (1998) Activation of protein kinase Ca couples increases in cell volume to membrane Cl^- permeability in HTC hepatoma and Mz-ChA-1 cells. Hepatology. 28:1073-1080.

64. Della Rocca, G.J., Mukhin, Y.V., Garnovskaya, M.N., Daaka, Y., Clark, G., Luttrell, L.M., Lefkowitz, R.J., Raymond, J.R. (1999) Serotonin 5-HT_1A receptor-mediated MAP kinase activation requires calcium/calmodulin-mediated receptor endocytosis. J. Biol. Chem. 274:4749-4753.

65. Pahan, K., Raymond, J.R., Singh, I. (1999) Inhibition of phosphatidylinositol 3-kinase induces nitric oxide synthase in LPS or cytokine stimulated C₆ glial cells. J. Biol. Chem. 274:7528-7536.

66. Chen, R., Greene, E.L., Collinsworth, G., Grewal, J., Houghton, O., Wackym. P., Zang, H., Paul, R.V., Raymond, J.R. (1999) A method for efficient expression of cDNA constructs in primary cultures of rat renal mesangial cells. Am. J. Physiol. 276:F777-F785.

67. Grewal, J., Mukhin, Y.V., Garnovskaya, M.N., Raymond, J.R., Greene, E.L. (1999) Serotonin 5-HT_2A receptor induces TGF-b1 mRNA and protein in rat mesangial cells via ERK. Linkage between proliferative and fibrotic signals. Am. J. Physiol. 276:F922-F930.

68. Arthur, J.M., Collinsworth, G.P., Gettys, T.W., Raymond, J.R. (1999) Agonist-induced translocation of G_q/11adirectly from plasma membranes in MDCK cells. Am. J. Physiol. 276:F528-F534.

69. Raymond, J.R., Mukhin, Y.V., Garnovskaya, M.N. (1999) The recombinant 5-HT_1A receptor: G protein coupling and signalling pathways. British J. Pharmacol. 127:1751-1764.

70. Tholanikunnel, B.G., Raymond, J.R., Malbon, C.C. (1999) Detailed mutational sequence analysis of the destabilizing (A+U)-rich 3’-untranslated region of the b₂-adrenergic receptor mRNA across different species. Biochemistry 38:15564-15572.

71. Mukhin, Y.V., Garnovskaya, M.N., Collinsworth, G., Nagai, T., Pinckney, S., Pendergrass, D., Greene, E.L., Raymond, J.R. (2000) 5-HT_1A receptor couples through G_bg and Src to stimulate mitogen-activated protein kinase via reactive oxygen species in fibroblasts. Biochem. J. 347:61-67.

72. Greene, E.L Houghton, O., Collinsworth, G., Garnovskaya, M.N., Nagai, T., Sajjad, T.,Bheemanathini, V., Grewal, J., Paul, R.V., Raymond, J.R. (2000) 5HT_2A receptors stimulate mitogen-activated protein kinase via ROS in rat renal mesangial cells. Am. J. Physiol. 278: F650-F658.

73. Pahan K., Liu, X., McKinney, M.J., Wood, C., Sheikh, F.G., Raymond, J.R. (2000) Expression of a dominant-negative mutant of p21ras inhibits induction of nitric oxide synthase and activation of NF-kB in primary astrocytes. J. Neurochem. 74:2288-2295.

74. Pahan K., Liu, X., McKinney, M.J., Wood, C., Sheikh, F.G., Raymond, J.R. (2000) Expression of a constitutively active form of phosphatidylinositol 3-kinase inhibits the induction of nitric oxide synthase in human astrocytes. FEBS Lett. 472:203-207.

75. Chen, R. Garnovskaya, M., Thielen, T., Iijima, Y., Huang, C., Raymond, J.R., Ullian, M.E., and Paul, R.V. (2000) Increase in nuclear localization of an angiotensin II type I receptor-GFP fusion protein after angiotensin II exposure. Am. J. Physiol. Renal Physiol. 279:F44-F448, 2000.

76. Mukhin, Y.V., Garnovskaya, M.N., Collinsworth, G., Bell,J.L., Tholanikunnel, B.G., Pettus,T., Jaffa, A.A., Fitzgibbon, W., Ploth, D.W., Raymond, J.R., Garnovskaya, M.N. (2001) Bradykinin B₂ receptors activate Na⁺/H⁺ exchange in mIMCD-3 cells via Ca²⁺/calmodulin. J. Biol. Chem. 276: 17339-17346.

77. Grewal, J.S., Luttrell, L.M., Raymond, J.R. (2001). G protein-coupled receptors desensitize and down- regulate EGF receptors in renal mesangial cells. J. Biol. Chem. 276:27335-27344.

78. Raymond, J.R., Mukhin, Y.V., Gelasco,A., Turner, J., Collinsworth, G., Gettys, T.W., Grewal, J.S., Garnovskaya, M.N. (2002) Multiplicity of Mechanisms of Serotonin Receptor Signal Transduction. Pharmacology and Therapeutics 92:1-34.

79. Lefler, D., Mukhin, Y.V., Pettus, T., Leeb-Lundberg, L.M.F., Garnovskaya, M.N, Raymond, J.R. (2003) Jak2 and Ca²⁺/calmodulin are key intermediates for bradykinin B₂ receptor-mediated activation of Na⁺/H⁺ exchange in KNRK and CHO Cells. Assay Drug Devel. Technol. 1:281-289.

80. Garnovskaya, M.N., Mukhin, Y.V., Vlasova, T., Raymond, J.R. (2003) Hypertonicity activates Na⁺/H⁺ exchange through Janus kinase 2 and Ca²⁺/calmodulin. J. Biol. Chem. 278:16908-16915.

81. Garnovskaya, M.N., Mukhin, Y.V., Turner, J., Vlasova, T., Ullian, M.E., Raymond, J.R. (2003) Mitogen- induced activation of Na⁺/H⁺ exchange in vascular smooth muscle cells involves Janus kinase 2 and Ca²⁺/calmodulin. Biochemistry 42:7178-7187.

82. Budisavljevic, M.N., Hodge, L., Barber, K., Fulmer, J.R., Durazo-Arvizu, R.A., Self, S.E., Kuhlmann, M., Raymond, J.R., Greene, E.L. (2003) Oxidative stress in the pathogenesis of experimental mesangial proliferative glomerulonephritis. Am. J. Physiol. Renal Physiol. 285:F1138-1148.83.

83. Mukhin, Y.V., Garnovskaya, M.N., Ullian, M.E., Raymond, J.R. (2004) ERK is regulated by sodium- proton exchanger in rat aortic vascular smooth muscle cells. J. Biol. Chem. 279:1845-1852.

84. Turner, J.H., Gelasco, A.K., RAYMOND, J.R. (2004) Calmodulin interacts with the third intracellular loop of the serotonin 5-HT_1A receptor: Possible role in receptor phosphorylation by protein kinase C. J. Biol. Chem. 279:17027-17037.

85. Garnovskaya, M.N., Mukhin, Y.V., Grewal, J.S., Tholanikunnel, B.G., Ullian, M.E., Raymond, J.R. (2004) MEK is an intermediate for rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells. J. Biol. Chem. 279:24899-24905.

86. Subramaniam, K., Chen, K., Joseph, K., RAYMOND, J.R., and Tholanikunnel, B.G. (2004) The 3’- untranslated region of the b₂-adrenergic receptor mRNA regulates receptor synthesis. J. Biol. Chem. 279:27108-27115.

87. Lefler, D.M., Pafford, R.G., Black, N., RAYMOND, J.R., and Arthur, J.M. (2004) Identification of proteins in slow continuous ultrafiltrate by reverse phase chromatography and proteomics. J. Proteome Res. 3:1254-1260.

88. Dave, S., Honney, S., RAYMOND, J.R., and Flume, P.A. (2005) An unusual case of cystic fibrosis presenting in adulthood with hypokalemic metabolic alkalosis. Am. J. Kidney Dis. In Press.

89. Kandasamy, K., Joseph, K., Subramaniam, K., Joseph, K., RAYMOND, J.R., and Tholanikunnel, B.G. (2005) Translational control of the b₂-adrenergic receptor mRNA by T-cell-restricted intracellular antigen- related protein (TIAR). J. Biol. Chem. 280:1931-1943.

90. Jamison, R.L., Hartigan, P., Gaziano, J.M., Fortmann, S.P., Goldfarb, D.S., Haroldson, J.A., Kaufman, J., Lavori, P., McCully, K.S., Robinson, K. and the HOST investigators* (2004) Design and statistical issues in the Homocysteinemia in kidney and end stage renal disease (HOST) study. Clinical Trials 1:451-460. *Dr. Raymond is a HOST investigator.

91. Turner, J.H., and RAYMOND, J.R. (2005) Interaction of calmodulin with the serotonin 5- hydroxytryptamine_2A receptor: A putative regulator of G protein coupling and receptor phosphorylation by protein kinase C. J. Biol. Chem. In Press.

Chapters in Books:

92. Raymond, J.R., Hnatowich, M.R., Caron, M.G., Lefkowitz, R.J. (1990) Structure-function relationships of G protein-coupled receptors. In: ADP-Ribosylating Toxins and G Proteins: Insights into Signal Transduction (Moss, J., and Vaughan, M., Eds.). Am. Soc. Microbiol., pp 163-188.

93. Dennis, V.W., Middleton, J.P., Raymond, J.R., Dunham, C., Sens, D. (1990) Phosphate uptake in human proximal renal cells. In Diuretics 3: Chemistry, Pharmacology,and Clinical Applications (Puschett, J.B., and Greenberg, A., Eds.). Elsevier, New York, pp 131-155.

94. Fargin, A., Raymond, J.R., Caron, M.G. (1990) Biochemical characterization of the human 5-HT_lA receptor, genomic clone (G21), expressed in mammalian cells. In Serotonin: from Cell Biology to Pharmacology and Therapeutics (Paoletti, R., and Vanhoutte, P.M., Eds.). Kluwer Academic Publishers, Netherlands, pp 19-24.

95. Raymond, J.R., El Mestikawy, S., Fargin, A. (1992) The 5-HT_lA receptor: from molecular characteristics to clinical correlates. In: Molecular Biology of Receptors which Couple to G Proteins (Brann, M., Ed.). Birkhauser Boston, Cambridge, MA, pp. 113-141.

96. Liggett, S.B., Raymond, J.R. (1993) Pharmacology and molecular biology of adrenergic receptors. In: The Catecholamines (Bouloux, E., Ed.). W.B. Saunders, London, UK, pp. 279-305.

97. Raymond, J.R., Turner, J., Ayiku, H., Lefler, D., Gelasco, A., Arthur, J.M. (2005) Use of mass spectrometry to identify receptor-interacting proteins. In: G Protein-coupled Receptor Interacting Proteins. pps. 179-199. (George, S., O’Dowd, B, and Sibley, D., Eds.). Wiley Press, Indianapolis.

98. Raymond, J.R., Turner, J.H., Gelasco, A, Ayiku, H., Coaxum, S., Arthur, J.M., and Garnovskaya, M.N. (2005) 5-HT Receptor Signal Transduction Pathways. In The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics. (Roth, B. Ed.). The Humana Press, Inc., Totowa, NJ.

Manuscripts Submitted or in Revision:

99. Andy, J.C., Grewal, J.S., Collinsworth, G.P., Joseph, A., Wendell, R.P, Mukhin, Y.V., Garnovskaya, M.N., Greene, E.L., and Raymond, J.R. (2005). Redox-sensitive activation of mesangial cell ERK by 3-indoxyl sulfate, a putative uremic toxin. Submitted.

100. Mukhin, Y.V., Garnovskaya, M.N., Collinsworth, G., Bell,J.L., Tholanikunnel, B.G., Pettus,T., Jaffa, A.A., Fitzgibbon, W., Ploth, D.W., Raymond, J.R., Garnovskaya, M.N. (2005) B₂Bradykinin receptors activate two distinct proton efflux pathways exchange in M-1 cells. Submitted.

101. Turner, J.H., RAYMOND, J.R., Vlasova, T., Mukhin, Y.V. Garnovskaya, M.N. (2005) Ca²⁺/calmodulin and Jak2 are required for activation of sodium-proton exchange by the G_i-coupled 5-hydroxytryptamine5-HT_1A receptor. Submitted.

102. Gelasco, A.K., and RAYMOND, J.R., (2005) Indoxyl sulfate induces complex redox alterations in mesangial cells. Am. J. Physiol. Renal Physiol. In Revision.

103. Tholanikunnel, B.G., Kandasamy, K., Joseph, K., RAYMOND, J.R., and Subramaniam, K. (2005) The 3’- untranslated region length and AU-rich RNA location modulate translational control of b₂-adrenergic receptor mRNA. Submitted.

Editorials:

104. Inglese, J, and Raymond, J.R (2003) Robert J. Lefkowitz, M.D., Mentor extraordinaire. Assay Drug Devel. Technol 1:227-232.

Published Abstracts:

Titles of over 120 published abstracts from 1985-2005 can be furnished on request.