DAVID Gene Report
3028065
interleukin 11 Related Genes Homo sapiens
SP_COMMENT
function:Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.,
pharmaceutical:Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.,
similarity:Belongs to the IL-6 superfamily.,
subcellular location:Secreted.,
REFSEQ_PROTEIN
NP_000632 ,
ENTREZ_GENE_SUMMARY
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells.,
REFSEQ_MRNA
NM_000641 ,
GENPEPT_ACCESSION
AAA59132 ,
AAH12506 ,
AAO13493 ,
BAF83261 ,
CAA41266 ,
EAW72371 ,
Genomic_DNA ,
mRNA ,
GENE_SYMBOL
IL11 ,
GENE_NAME
AGIF,
Adipogenesis inhibitory factor,
IL-11,
Interleukin-11 precursor,
Interleukin-11 precursor (IL-11) (Adipogenesis inhibitory factor) (AGIF) (Oprelvekin),
Oprelvekin,
interleukin 11,
GENERIF_SUMMARY
Interleukin-11 induces proliferation of human T-cells and its activity is associated with downregulation of p27(kip1). ,
Administration of recombinant human IL11 after supralethal radiation exposure promotes survival in mice ,
IL-11 is involved in the endogenous cytokine response to sepsis or NEC in preterm neonates. ,
Respiratory syncytial virus induces IL-11 generation in antigen presenting cells ,
Dinucleotide repeat frequencies of the IL11.A1 allele and of IL11.A1 homozygous individuals is significantly increased among patients with ulcerative colitis. ,
expression and function in human endometrium ,
Recombinant human IL-11 induces from peripheral blood mononuclear cells the formation of osteoclastic cells, which are positive for tartrate-resistant acid phosphatase, vitronectin receptor and calcitonin receptor, and capable of lacunar resorption. ,
Immunoreactive IL-11 & IL-11Ralpha were studied in human first trimester decidua & distinct spatial & temporal patterns were defined. IL-11 has a role during decidualization & placentation in primates. ,
Upregulation of IL-11 mRNA by additive IL-1beta- and TGF-beta1, mediated by p38 MAP kinase-mediated mRNA stabilization. ,
Data suggest that interleukin-6 activation of gp130 promoted cell division in fibroblasts from patients with idiopathic pulmonary fibrosis (IPF), while IL-11 was mitogenic in both normal and IPF cells. ,
IL-11 exerts a cytoprotectve effect in a model of human T-cell mediated allograft rejection that is dependent on induction of survivin in graft endothelial cells. ,
could have a significant role in the progression of gingivitis to periodontitis ,
may participate in the pathogenesis of temporomandibular disorders and induce osseous changes in the condyle ,
IL-11 produced by blastic cells from a patient with acute megakaryocytic leukemia enhanced expression of osteoprotegerin, causing the osteosclerosis observed in this patient. ,
RANKL treatment induced a significant increase of IL-11 secretion by both bone marrow stromal & endothelial cells. ,
production of IL-11 does not increase in response to thrombocytopenia in most children with SAA ,
activation of three major signaling pathways and support a role for IL-11 in the regulation of both transcription and protein synthesis in fully differentiated adipocytes. ,
HGF maintains the hematopoietic microenvironment through stimulating proliferation and adhesion to the extracellular matrix and promoting hematopoiesis through inducing constitutive production of IL-11, SDF-1 alpha, and SCF by stromal cells themselves ,
LCH represents a cytokine-driven condition partially mediated by TNF, IL-11, and LIF. These three cytokines are all osteoclastogenic, suggesting a pathogenetic pathway for the osteolytic lesions in LCH. ,
IL-11 expression is critically important during decidualization in the human endometrium ,
in contrast to IL-6, IL-11 in plasma does not correlate with trauma severity ,
Blocking IL-11 signaling reduced RLrelaxin and medoxyprogesterone or PGE(2)+P-induced decidualization. ,
in human lung fibroblasts ET-1 exerts a profibrogenic action via an ET(A) receptor-dependent, MAPK-mediated induction of IL-11 release and cell proliferation ,
High interleukin 11 is associated with breast cancer ,
role for IL-11 via pSTAT3 and SOCS3 in initiating and progressing decidualization ,
thrombocytopenia in dengue disease is associated with changes in the serum levels of thrombopoietin, but not interleukin-11 ,
IL-11/IL-11R pathway plays an important role in the progression of colorectal adenocarcinoma. ,
There is no receptivity defect with regard to LIF and IL-11 secretions by eutopic endometrium in infertile women with endometriosis. ,
Increased IL-11 in premature senescence of fetal lung fibroblasts induced by both tert-butylhydroperoxide and ethanol. ,
Role of interleukin-11 to prevent chemotherapy-induced thrombocytopenia. ,
The objectives of this study were to clarify the role of IL-11 and IL-11Ralpha in human gastric carcinoma. ,
An important role for IL-11 in placentation. ,
CHROMOSOME
19,
ENTREZ_GENE_ID
3589 ,
PIR_SUMMARY
Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.,
UNIGENE
Hs.467304 ,
UNIREF100_ID
UniRef100_P20809 ,
PIR_NREF_ID
NF00092968,
NF00779432,
UNIPROT_ID
IL11_HUMAN ,
Q96EB4_HUMAN ,
CYTOBAND
19q13.3-q13.4,
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