Chandwani S, Greco MA, Mittal K, Krasinski K, Borkowsky W; International Conference on AIDS.
Int Conf AIDS. 1989 Jun 4-9; 5: 225 (abstract no. M.B.P.20).
New York University Medical Center, New York, NY, USA
OBJECTIVE: To compare the pathology of term placentas from seropositive HIV infected and seronegative women using routine histologic, immunohistocytochemical, and in situ nucleic acid hybridization techniques. METHODS: Term placentas of seropositive and seronegative women were evaluated by hematoxylin and eosin (H & E) staining for evidence of vasculitis (VA), villitis (VI), chorionitis (CH), and chorioamnionitis (CA). They were also examined by immunoperoxidase (IP) staining using monoclonal anti-p24 antibody. Decidua (DE), trophoblasts (TR), membranes (ME), and uterine glands (UG) were evaluated. Some of these were tested using IP and in situ nucleic acid hybridization (NAH) techniques using an RNA probe complementary to the 3'LTR and envelope region of HIV-1. RESULTS: TABULAR DATA, SEE ABSTRACT VOLUME. Conclusion: HIV infection does not appear to cause significant pathologic abnormalities in the term placenta. HIV antigens can be identified rarely in trophoblastic tissue. HIV nucleic acid can be found in those trophoblastic cells also containing HIV antigen. Examination of the term placentas from HIV infected women has failed to clarify the mechanism of transmission of this virus from mother to fetus. Conceivably, tissue from earlier gestational placentas may be more informative.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Chorioamnionitis
- Decidua
- Female
- HIV
- HIV Antigens
- HIV Infections
- HIV Seronegativity
- HIV Seropositivity
- HIV-1
- Humans
- In Situ Hybridization
- Nucleic Acid Hybridization
- Placenta
- Pregnancy
- Trophoblasts
- Virus Diseases
- immunology
- pathology
Other ID:
UI: 102176873
From Meeting Abstracts