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Title Platelet deposition on vascular grafts. The accuracy of in vivo quantitation and the significance of in vivo platelet reactivity
Creator/Author Allen, B.T. ; Mathias, C.J. ; Sicard, G.A. ; Welch, M.J. ; Clark, R.E.
Publication Date1986 Mar 01
OSTI IdentifierOSTI ID: 5530756
Other Number(s)CODEN: ANSUA
Resource TypeJournal Article
Resource RelationAnn. Surg. ; Vol/Issue: 3
Research OrgWashington Univ. School of Medicine, St. Louis, MO
Subject550601 -- Medicine-- Unsealed Radionuclides in Diagnostics; BLOOD PLATELETS-- DEPOSITION;BLOOD PLATELETS-- IMAGES;BLOOD VESSELS-- GRAFTS; BIOLOGICAL MODELS;CAROTID ARTERIES;DOGS;ERYTHROCYTES;IN VITRO;INDIUM 111;POLYTETRAFLUOROETHYLENE;TECHNETIUM 99;THROMBOSIS;VEINS
Related SubjectANIMALS;ARTERIES;BETA DECAY RADIOISOTOPES;BETA-MINUS DECAY RADIOISOTOPES;BIOLOGICAL MATERIALS;BLOOD;BLOOD CELLS;BLOOD VESSELS;BODY;BODY FLUIDS;CARDIOVASCULAR DISEASES;CARDIOVASCULAR SYSTEM;DAYS LIVING RADIOISOTOPES;DISEASES;ELECTRON CAPTURE RADIOISOTOPES;FLUORINATED ALIPHATIC HYDROCARBONS;HALOGENATED ALIPHATIC HYDROCARBONS;HOURS LIVING RADIOISOTOPES;INDIUM ISOTOPES;INTERMEDIATE MASS NUCLEI;ISOMERIC TRANSITION ISOTOPES;ISOTOPES;MAMMALS;MATERIALS;MINUTES LIVING RADIOISOTOPES;NUCLEI;ODD-EVEN NUCLEI;ORGANIC COMPOUNDS;ORGANIC FLUORINE COMPOUNDS;ORGANIC HALOGEN COMPOUNDS;ORGANIC POLYMERS;ORGANS;POLYETHYLENES;POLYMERS;POLYOLEFINS;RADIOISOTOPES;TECHNETIUM ISOTOPES;TRANSPLANTS;VASCULAR DISEASES;VERTEBRATES;YEARS LIVING RADIOISOTOPES
Description/Abstract An in vivo platelet imaging system utilizing indium-111-labeled platelets and technetium-99m-labeled red cells was used to serially study and compare platelet deposition on autologous external jugular vein grafts, autologous arterial grafts, polytetrafluoroethylene (Gore-tex) and two Dacron (Meadox and USCI) small diameter (4mm) vascular grafts implanted end-to-end in canine carotid and femoral arteries.^This method of quantitating platelet deposition was validated by correlating deposition measured in vivo with deposition measured directly on explanted grafts (r = 0.94, p less than 0.01).^Platelet accumulation on all grafts was greatest immediately after implantation and declined over time.^None of the artery or vein grafts thrombosed, and they had the lowest level of platelet deposition at all times.^Platelet deposition on Gore-tex grafts was significantly less than on USCI Dacron grafts from 24 hours to 1 month after implantation.^There was no statistical difference in 1-month patency among the synthetic graft groups.^Synthetic grafts that thrombosed during the first month accumulated significantly more platelets immediately after operation than did those grafts that remained patent.^Patent Dacron grafts with low levels of platelet deposition had less thrombotic debris at explantation on the luminal surface than did those grafts with high levels of platelet deposition.^Differences in initial platelet deposition appeared to be more a function of platelet reactivity within each dog rather than the material used in graft construction.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 318-328
System Entry Date2001 May 13

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